SitesBLAST – Find functional sites

 

SitesBLAST

Comparing H281DRAFT_03996 H281DRAFT_03996 chorismate mutase (EC 5.4.99.5) to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 4 hits to proteins with known functional sites (download)

P9WIB9 Secreted chorismate mutase; CM; *MtCM; EC 5.4.99.5 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
31% identity, 95% coverage: 3:191/198 of query aligns to 6:195/199 of P9WIB9

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P9WIB9
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Sites not aligning to the query:

2ao2B The 2.07 angstrom crystal structure of mycobacterium tuberculosis chorismate mutase reveals unexpected gene duplication and suggests a role in host-pathogen interactions (see paper)
30% identity, 80% coverage: 33:190/198 of query aligns to 3:160/165 of 2ao2B

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2ao2B
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2ao2A The 2.07 angstrom crystal structure of mycobacterium tuberculosis chorismate mutase reveals unexpected gene duplication and suggests a role in host-pathogen interactions (see paper)
30% identity, 80% coverage: 33:190/198 of query aligns to 3:160/165 of 2ao2A

query
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2ao2A
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Q

2fp2B Secreted chorismate mutase from mycobacterium tuberculosis (see paper)
30% identity, 80% coverage: 33:190/198 of query aligns to 1:158/163 of 2fp2B

query
sites
2fp2B
T
 
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Query Sequence

>H281DRAFT_03996 H281DRAFT_03996 chorismate mutase (EC 5.4.99.5)
MNRLFRFAAPCALALLASLLAAPGSALADGDDTALTNLIALASQRLALAEPVARWKWANH
QAITDTPREQALLADVEKRAAAANVDPAFARAFFQDQIDASKDVQNALFASWRATQPPQE
PAPDLATSTRPQLDRLTQSLVAGLARVQPLRAAPDCPSRVAQSLASWKSMTRYDSARSTA
LNRALAHVCESGGVGATG

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory