SitesBLAST
Comparing H281DRAFT_04458 FitnessBrowser__Burk376:H281DRAFT_04458 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6demA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide bensulfuron methyl (see paper)
23% identity, 82% coverage: 57:597/661 of query aligns to 27:553/597 of 6demA
- active site: Y33 (≠ H63), G35 (vs. gap), G36 (= G64), A37 (≠ N65), I38 (≠ V66), E59 (= E88), T82 (= T111), F121 (≠ L152), Q122 (= Q153), E123 (≠ Q154), K171 (≠ Q211), K228 (≠ D270), M264 (≠ V306), V291 (≠ T333), V407 (≠ A442), L432 (≠ Y467), G433 (≠ S468), M435 (= M470), D460 (= D495), N487 (= N522), E489 (≠ G524), Q490 (≠ Y525), M492 (≠ C527), V493 (≠ I528), W496 (≠ L531), L518 (≠ H562), N523 (≠ G567), V524 (≠ A568)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: M264 (≠ V306), D289 (= D331), R290 (≠ F332), M492 (≠ C527), W496 (≠ L531)
- binding flavin-adenine dinucleotide: R161 (≠ S201), G217 (= G260), A218 (≠ G261), G219 (= G262), N222 (≠ Y265), T244 (= T286), L245 (≠ Q287), Q246 (≠ A288), L262 (= L304), G284 (= G326), A285 (≠ T327), R286 (= R328), D288 (≠ Q330), R290 (≠ F332), V291 (≠ T333), E317 (vs. gap), I318 (= I348), N322 (≠ A352), D336 (= D366), V337 (≠ A367), M412 (≠ L452), G430 (≠ Y465)
- binding magnesium ion: D460 (= D495), N487 (= N522), E489 (≠ G524)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (≠ A442), G408 (= G443), Q409 (≠ T444), H410 (= H450), M435 (= M470), G459 (= G494), D460 (= D495), A461 (≠ G496), S462 (= S497), M465 (= M500), N487 (= N522), E489 (≠ G524), Q490 (≠ Y525), G491 (= G526), M492 (≠ C527), V493 (≠ I528)
Sites not aligning to the query:
6delA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide chlorimuron ethyl (see paper)
23% identity, 82% coverage: 57:597/661 of query aligns to 27:553/597 of 6delA
- active site: Y33 (≠ H63), G35 (vs. gap), G36 (= G64), A37 (≠ N65), I38 (≠ V66), E59 (= E88), T82 (= T111), F121 (≠ L152), Q122 (= Q153), E123 (≠ Q154), K171 (≠ Q211), K228 (≠ D270), M264 (≠ V306), V291 (≠ T333), V407 (≠ A442), L432 (≠ Y467), G433 (≠ S468), M435 (= M470), D460 (= D495), N487 (= N522), E489 (≠ G524), Q490 (≠ Y525), M492 (≠ C527), V493 (≠ I528), W496 (≠ L531), L518 (≠ H562), N523 (≠ G567), V524 (≠ A568)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: D289 (= D331), R290 (≠ F332), W496 (≠ L531)
- binding flavin-adenine dinucleotide: R161 (≠ S201), G217 (= G260), A218 (≠ G261), G219 (= G262), N222 (≠ Y265), T244 (= T286), L245 (≠ Q287), Q246 (≠ A288), L262 (= L304), G284 (= G326), A285 (≠ T327), R286 (= R328), D288 (≠ Q330), R290 (≠ F332), V291 (≠ T333), E317 (vs. gap), I318 (= I348), N322 (≠ A352), D336 (= D366), V337 (≠ A367), M412 (≠ L452), G430 (≠ Y465)
- binding (3Z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}-3-sulfanylpent-3-en-1-yl trihydrogen diphosphate: V407 (≠ A442), G408 (= G443), Q409 (≠ T444), H410 (= H450), G433 (≠ S468), M435 (= M470), G459 (= G494), D460 (= D495), A461 (≠ G496), S462 (= S497), M465 (= M500), N487 (= N522), E489 (≠ G524), Q490 (≠ Y525), G491 (= G526), M492 (≠ C527), V493 (≠ I528)
- binding magnesium ion: D460 (= D495), N487 (= N522), E489 (≠ G524)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (≠ A442), G408 (= G443), Q409 (≠ T444), H410 (= H450), G433 (≠ S468), M435 (= M470), G459 (= G494), D460 (= D495), A461 (≠ G496), S462 (= S497), M465 (= M500), N487 (= N522), E489 (≠ G524), Q490 (≠ Y525), G491 (= G526), M492 (≠ C527), V493 (≠ I528)
6denA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron ethyl (see paper)
23% identity, 82% coverage: 57:597/661 of query aligns to 29:555/599 of 6denA
- active site: Y35 (≠ H63), G37 (vs. gap), G38 (= G64), A39 (≠ N65), I40 (≠ V66), E61 (= E88), T84 (= T111), F123 (≠ L152), Q124 (= Q153), E125 (≠ Q154), K173 (≠ Q211), K230 (≠ D270), M266 (≠ V306), V293 (≠ T333), V409 (≠ A442), L434 (≠ Y467), G435 (≠ S468), M437 (= M470), D462 (= D495), N489 (= N522), E491 (≠ G524), Q492 (≠ Y525), M494 (≠ C527), V495 (≠ I528), W498 (≠ L531), L520 (≠ H562), N525 (≠ G567), V526 (≠ A568)
- binding flavin-adenine dinucleotide: R163 (≠ S201), G219 (= G260), A220 (≠ G261), G221 (= G262), N224 (≠ Y265), T246 (= T286), L247 (≠ Q287), Q248 (≠ A288), L264 (= L304), G286 (= G326), A287 (≠ T327), R288 (= R328), D290 (≠ Q330), R292 (≠ F332), V293 (≠ T333), E319 (vs. gap), I320 (= I348), N324 (≠ A352), D338 (= D366), V339 (≠ A367), M414 (≠ L452), G432 (≠ Y465)
- binding ethyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M266 (≠ V306), D291 (= D331), R292 (≠ F332), W498 (≠ L531)
- binding magnesium ion: D462 (= D495), N489 (= N522), E491 (≠ G524)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V409 (≠ A442), G410 (= G443), Q411 (≠ T444), H412 (= H450), G435 (≠ S468), M437 (= M470), G461 (= G494), D462 (= D495), A463 (≠ G496), S464 (= S497), N489 (= N522), E491 (≠ G524), Q492 (≠ Y525), G493 (= G526), M494 (≠ C527), V495 (≠ I528)
6derA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide metosulam (see paper)
23% identity, 82% coverage: 57:597/661 of query aligns to 29:556/600 of 6derA
- active site: Y35 (≠ H63), G37 (vs. gap), G38 (= G64), A39 (≠ N65), I40 (≠ V66), E61 (= E88), T84 (= T111), F123 (≠ L152), Q124 (= Q153), E125 (≠ Q154), K173 (≠ Q211), K231 (≠ D270), M267 (≠ V306), V294 (≠ T333), V410 (≠ A442), L435 (≠ Y467), G436 (≠ S468), M438 (= M470), D463 (= D495), N490 (= N522), E492 (≠ G524), Q493 (≠ Y525), M495 (≠ C527), V496 (≠ I528), W499 (≠ L531), L521 (≠ H562), N526 (≠ G567), V527 (≠ A568)
- binding flavin-adenine dinucleotide: R163 (≠ S201), G220 (= G260), A221 (≠ G261), G222 (= G262), N225 (≠ Y265), T247 (= T286), L248 (≠ Q287), Q249 (≠ A288), L265 (= L304), H268 (≠ T307), G287 (= G326), A288 (≠ T327), R289 (= R328), D291 (≠ Q330), R293 (≠ F332), V294 (≠ T333), E320 (vs. gap), I321 (= I348), N325 (≠ A352), G338 (≠ A365), D339 (= D366), V340 (≠ A367), Q414 (≠ K451), M415 (≠ L452), G433 (≠ Y465)
- binding Metosulam: R293 (≠ F332), M495 (≠ C527), W499 (≠ L531)
- binding magnesium ion: D463 (= D495), N490 (= N522), E492 (≠ G524)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V410 (≠ A442), G411 (= G443), Q412 (≠ T444), H413 (= H450), G436 (≠ S468), M438 (= M470), G462 (= G494), D463 (= D495), A464 (≠ G496), S465 (= S497), N490 (= N522), E492 (≠ G524), Q493 (≠ Y525), G494 (= G526), M495 (≠ C527), V496 (≠ I528)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V410 (≠ A442), G411 (= G443), Q412 (≠ T444), H413 (= H450), G436 (≠ S468), M438 (= M470), G462 (= G494), D463 (= D495), A464 (≠ G496), S465 (= S497), M468 (= M500), N490 (= N522), E492 (≠ G524), Q493 (≠ Y525), G494 (= G526), V496 (≠ I528)
Sites not aligning to the query:
6desA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide propoxycarbazone (see paper)
23% identity, 82% coverage: 57:597/661 of query aligns to 27:554/598 of 6desA
- active site: Y33 (≠ H63), G35 (vs. gap), G36 (= G64), A37 (≠ N65), I38 (≠ V66), E59 (= E88), T82 (= T111), F121 (≠ L152), Q122 (= Q153), E123 (≠ Q154), K171 (≠ Q211), K229 (≠ D270), M265 (≠ V306), V292 (≠ T333), V408 (≠ A442), L433 (≠ Y467), G434 (≠ S468), M436 (= M470), D461 (= D495), N488 (= N522), E490 (≠ G524), Q491 (≠ Y525), M493 (≠ C527), V494 (≠ I528), W497 (≠ L531), L519 (≠ H562), N524 (≠ G567), V525 (≠ A568)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: M265 (≠ V306), D290 (= D331), R291 (≠ F332), W497 (≠ L531)
- binding flavin-adenine dinucleotide: R161 (≠ S201), G218 (= G260), A219 (≠ G261), G220 (= G262), N223 (≠ Y265), T245 (= T286), L246 (≠ Q287), Q247 (≠ A288), L263 (= L304), G285 (= G326), A286 (≠ T327), R287 (= R328), D289 (≠ Q330), R291 (≠ F332), V292 (≠ T333), E318 (vs. gap), I319 (= I348), N323 (≠ A352), D337 (= D366), V338 (≠ A367), Q412 (≠ K451), M413 (≠ L452), G431 (≠ Y465)
- binding magnesium ion: D461 (= D495), N488 (= N522), E490 (≠ G524)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (≠ A442), G409 (= G443), Q410 (≠ T444), H411 (= H450), G434 (≠ S468), M436 (= M470), G460 (= G494), D461 (= D495), A462 (≠ G496), S463 (= S497), N488 (= N522), E490 (≠ G524), Q491 (≠ Y525), G492 (= G526), M493 (≠ C527), V494 (≠ I528)
6depA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide sulfometuron methyl (see paper)
23% identity, 82% coverage: 57:597/661 of query aligns to 27:554/598 of 6depA
- active site: Y33 (≠ H63), G35 (vs. gap), G36 (= G64), A37 (≠ N65), I38 (≠ V66), E59 (= E88), T82 (= T111), F121 (≠ L152), Q122 (= Q153), E123 (≠ Q154), K171 (≠ Q211), K229 (≠ D270), M265 (≠ V306), V292 (≠ T333), V408 (≠ A442), L433 (≠ Y467), G434 (≠ S468), M436 (= M470), D461 (= D495), N488 (= N522), E490 (≠ G524), Q491 (≠ Y525), M493 (≠ C527), V494 (≠ I528), W497 (≠ L531), L519 (≠ H562), N524 (≠ G567), V525 (≠ A568)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D290 (= D331), R291 (≠ F332), M493 (≠ C527), W497 (≠ L531)
- binding flavin-adenine dinucleotide: R161 (≠ S201), G218 (= G260), A219 (≠ G261), G220 (= G262), N223 (≠ Y265), T245 (= T286), L246 (≠ Q287), Q247 (≠ A288), L263 (= L304), G264 (= G305), G285 (= G326), A286 (≠ T327), R287 (= R328), D289 (≠ Q330), R291 (≠ F332), V292 (≠ T333), E318 (vs. gap), I319 (= I348), N323 (≠ A352), D337 (= D366), V338 (≠ A367), M413 (≠ L452), G431 (≠ Y465)
- binding magnesium ion: D461 (= D495), N488 (= N522), E490 (≠ G524)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V408 (≠ A442), G409 (= G443), Q410 (≠ T444), H411 (= H450), G434 (≠ S468), M436 (= M470), G460 (= G494), D461 (= D495), A462 (≠ G496), S463 (= S497), M466 (= M500), N488 (= N522), E490 (≠ G524), Q491 (≠ Y525), G492 (= G526), M493 (≠ C527), V494 (≠ I528)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (≠ A442), G409 (= G443), Q410 (≠ T444), H411 (= H450), G434 (≠ S468), M436 (= M470), G460 (= G494), D461 (= D495), A462 (≠ G496), S463 (= S497), M466 (= M500), N488 (= N522), E490 (≠ G524), Q491 (≠ Y525), G492 (= G526), M493 (≠ C527), V494 (≠ I528)
6deoA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron methyl (see paper)
23% identity, 82% coverage: 57:597/661 of query aligns to 25:549/593 of 6deoA
- active site: Y31 (≠ H63), G33 (vs. gap), G34 (= G64), A35 (≠ N65), I36 (≠ V66), E57 (= E88), T80 (= T111), F119 (≠ L152), Q120 (= Q153), E121 (≠ Q154), K169 (≠ Q211), K224 (≠ D270), M260 (≠ V306), V287 (≠ T333), V403 (≠ A442), L428 (≠ Y467), G429 (≠ S468), M431 (= M470), D456 (= D495), N483 (= N522), E485 (≠ G524), Q486 (≠ Y525), M488 (≠ C527), V489 (≠ I528), W492 (≠ L531), L514 (≠ H562), N519 (≠ G567), V520 (≠ A568)
- binding flavin-adenine dinucleotide: R159 (≠ S201), G213 (= G260), A214 (≠ G261), G215 (= G262), N218 (≠ Y265), T240 (= T286), L241 (≠ Q287), Q242 (≠ A288), L258 (= L304), G280 (= G326), A281 (≠ T327), R282 (= R328), D284 (≠ Q330), R286 (≠ F332), V287 (≠ T333), E313 (vs. gap), I314 (= I348), N318 (≠ A352), D332 (= D366), V333 (≠ A367), M408 (≠ L452), G426 (≠ Y465)
- binding methyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M260 (≠ V306), D285 (= D331), R286 (≠ F332), M488 (≠ C527), W492 (≠ L531)
- binding magnesium ion: D456 (= D495), N483 (= N522), E485 (≠ G524)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V403 (≠ A442), G404 (= G443), Q405 (≠ T444), H406 (= H450), G429 (≠ S468), M431 (= M470), G455 (= G494), D456 (= D495), A457 (≠ G496), S458 (= S497), M461 (= M500), N483 (= N522), E485 (≠ G524), Q486 (≠ Y525), G487 (= G526), M488 (≠ C527), V489 (≠ I528)
6dekA Crystal structure of candida albicans acetohydroxyacid synthase catalytic subunit (see paper)
23% identity, 82% coverage: 57:597/661 of query aligns to 28:551/595 of 6dekA
- active site: Y34 (≠ H63), G36 (vs. gap), G37 (= G64), A38 (≠ N65), I39 (≠ V66), E60 (= E88), T83 (= T111), Q118 (= Q153), E119 (≠ Q154), K167 (≠ Q211), K226 (≠ D270), M262 (≠ V306), V289 (≠ T333), V405 (≠ A442), L430 (≠ Y467), G431 (≠ S468), M433 (= M470), D458 (= D495), N485 (= N522), E487 (≠ G524), Q488 (≠ Y525), M490 (≠ C527), V491 (≠ I528), W494 (≠ L531), L516 (≠ H562), N521 (≠ G567), V522 (≠ A568)
- binding flavin-adenine dinucleotide: R157 (≠ S201), G215 (= G260), A216 (≠ G261), G217 (= G262), N220 (≠ Y265), T242 (= T286), L243 (≠ Q287), Q244 (≠ A288), L260 (= L304), M262 (≠ V306), G282 (= G326), A283 (≠ T327), R284 (= R328), D286 (≠ Q330), R288 (≠ F332), V289 (≠ T333), E315 (vs. gap), I316 (= I348), N320 (≠ A352), D334 (= D366), V335 (≠ A367), M410 (≠ L452), G428 (≠ Y465)
- binding magnesium ion: D458 (= D495), N485 (= N522), E487 (≠ G524)
- binding thiamine diphosphate: V405 (≠ A442), G406 (= G443), Q407 (≠ T444), H408 (= H450), M433 (= M470), G457 (= G494), D458 (= D495), A459 (≠ G496), S460 (= S497), N485 (= N522), E487 (≠ G524), Q488 (≠ Y525), G489 (= G526), M490 (≠ C527), V491 (≠ I528)
6deqA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
23% identity, 82% coverage: 57:597/661 of query aligns to 29:557/601 of 6deqA
- active site: Y35 (≠ H63), G37 (vs. gap), G38 (= G64), A39 (≠ N65), I40 (≠ V66), E61 (= E88), T84 (= T111), F123 (≠ L152), Q124 (= Q153), E125 (≠ Q154), K173 (≠ Q211), K232 (≠ D270), M268 (≠ V306), V295 (≠ T333), V411 (≠ A442), L436 (≠ Y467), G437 (≠ S468), M439 (= M470), D464 (= D495), N491 (= N522), E493 (≠ G524), Q494 (≠ Y525), M496 (≠ C527), V497 (≠ I528), W500 (≠ L531), L522 (≠ H562), N527 (≠ G567), V528 (≠ A568)
- binding flavin-adenine dinucleotide: R163 (≠ S201), G221 (= G260), A222 (≠ G261), G223 (= G262), N226 (≠ Y265), T248 (= T286), L249 (≠ Q287), Q250 (≠ A288), L266 (= L304), G288 (= G326), A289 (≠ T327), R290 (= R328), D292 (≠ Q330), R294 (≠ F332), V295 (≠ T333), E321 (vs. gap), I322 (= I348), D340 (= D366), V341 (≠ A367), M416 (≠ L452), G434 (≠ Y465)
- binding magnesium ion: D464 (= D495), N491 (= N522), E493 (≠ G524)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M268 (≠ V306), R294 (≠ F332), M496 (≠ C527), V497 (≠ I528), W500 (≠ L531)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V411 (≠ A442), G412 (= G443), Q413 (≠ T444), H414 (= H450), M439 (= M470), G463 (= G494), D464 (= D495), A465 (≠ G496), S466 (= S497), N491 (= N522), E493 (≠ G524), Q494 (≠ Y525), G495 (= G526), M496 (≠ C527), V497 (≠ I528)
Sites not aligning to the query:
2djiA Crystal structure of pyruvate oxidase from aerococcus viridans containing fad (see paper)
26% identity, 82% coverage: 56:598/661 of query aligns to 18:534/590 of 2djiA
- active site: I25 (vs. gap), S27 (≠ H63), G28 (= G64), T29 (≠ N65), L30 (≠ V66), E52 (= E88), S75 (= S113), F114 (= F158), Q115 (≠ H159), G163 (≠ Q211), R257 (≠ V306), E284 (≠ T334), V387 (= V439), A413 (≠ S468), M415 (= M470), D440 (= D495), N467 (= N522), E469 (≠ G524), Y470 (= Y525), F472 (≠ C527), I473 (= I528), K476 (≠ L543)
- binding flavin-adenine dinucleotide: G213 (= G260), I214 (≠ G261), G215 (= G262), T237 (= T286), G238 (≠ Q287), K239 (≠ A288), T255 (≠ L304), Y256 (≠ G305), R257 (≠ V306), V258 (≠ T307), G277 (= G326), S278 (≠ T327), N279 (≠ R328), F280 (≠ L329), P281 (≠ Q330), F282 (= F332), D299 (≠ N349), I300 (≠ A350), M304 (≠ F353), D318 (= D366), A319 (= A367), P410 (≠ T457)
Sites not aligning to the query:
1v5gA Crystal structure of the reaction intermediate between pyruvate oxidase containing fad and tpp, and substrate pyruvate (see paper)
26% identity, 81% coverage: 56:591/661 of query aligns to 17:525/589 of 1v5gA
- binding flavin-adenine dinucleotide: G212 (= G260), I213 (≠ G261), G214 (= G262), T236 (= T286), G237 (≠ Q287), K238 (≠ A288), T254 (≠ L304), Y255 (≠ G305), R256 (≠ V306), V257 (≠ T307), G276 (= G326), S277 (≠ T327), N278 (≠ R328), F279 (≠ L329), F281 (= F332), D298 (≠ N349), I299 (≠ A350), M303 (≠ F353), D317 (= D366), A318 (= A367), P409 (≠ T457)
- binding 2-acetyl-thiamine diphosphate: V386 (= V439), N388 (≠ C440), M414 (= M470), G438 (= G494), G440 (= G496), A441 (≠ S497), N466 (= N522), E468 (≠ G524), Y469 (= Y525), A470 (≠ G526), F471 (≠ C527), I472 (= I528)
- binding magnesium ion: D439 (= D495), N466 (= N522), E468 (≠ G524)
1v5fA Crystal structure of pyruvate oxidase complexed with fad and tpp, from aerococcus viridans (see paper)
26% identity, 81% coverage: 56:591/661 of query aligns to 17:525/589 of 1v5fA
- binding flavin-adenine dinucleotide: G212 (= G260), I213 (≠ G261), G214 (= G262), T236 (= T286), G237 (≠ Q287), K238 (≠ A288), T254 (≠ L304), Y255 (≠ G305), R256 (≠ V306), V257 (≠ T307), G276 (= G326), S277 (≠ T327), N278 (≠ R328), F279 (≠ L329), P280 (≠ Q330), F281 (= F332), D298 (≠ N349), I299 (≠ A350), M303 (≠ F353), D317 (= D366), A318 (= A367), P409 (≠ T457)
- binding magnesium ion: D439 (= D495), N466 (= N522)
- binding thiamine diphosphate: N388 (≠ C440), S389 (≠ A441), M414 (= M470), G438 (= G494), G440 (= G496), N466 (= N522), Y469 (= Y525), A470 (≠ G526), F471 (≠ C527), I472 (= I528)
1t9dB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
22% identity, 82% coverage: 57:600/661 of query aligns to 22:541/582 of 1t9dB
- active site: Y28 (≠ H63), G30 (vs. gap), G31 (= G64), A32 (≠ N65), I33 (≠ V66), E54 (= E88), T77 (= T111), F116 (≠ L152), Q117 (= Q153), E118 (≠ Q154), K166 (≠ Q211), R213 (≠ D270), M249 (≠ V306), V276 (≠ T333), V392 (≠ A442), L417 (≠ Y467), G418 (≠ S468), M420 (= M470), D445 (= D495), N472 (= N522), E474 (≠ G524), Q475 (≠ Y525), M477 (≠ C527), V478 (≠ I528), W481 (≠ L531), L503 (≠ H562), G508 (= G567), L509 (≠ A568)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G31 (= G64), A32 (≠ N65), V106 (≠ I142), P107 (≠ F143), F116 (≠ L152), K166 (≠ Q211), M249 (≠ V306), D274 (= D331), R275 (≠ F332), W481 (≠ L531)
- binding flavin-adenine dinucleotide: R156 (≠ S201), G202 (= G260), A203 (≠ G261), G204 (= G262), N207 (vs. gap), T229 (= T286), L230 (≠ Q287), Q231 (≠ A288), L247 (= L304), M249 (≠ V306), H250 (≠ T307), G269 (= G326), A270 (≠ T327), R271 (= R328), D273 (≠ Q330), R275 (≠ F332), V276 (≠ T333), E302 (≠ G347), V303 (≠ I348), N307 (≠ A352), G320 (≠ A365), D321 (= D366), A322 (= A367), Q396 (≠ K451), M397 (≠ L452), G415 (≠ Y465), G416 (= G466)
- binding magnesium ion: D445 (= D495), N472 (= N522), E474 (≠ G524)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E54 (= E88), P80 (= P116), G418 (≠ S468), M420 (= M470), M450 (= M500)
Sites not aligning to the query:
1t9bA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
22% identity, 82% coverage: 57:600/661 of query aligns to 23:542/583 of 1t9bA
- active site: Y29 (≠ H63), G31 (vs. gap), G32 (= G64), A33 (≠ N65), I34 (≠ V66), E55 (= E88), T78 (= T111), F117 (≠ L152), Q118 (= Q153), E119 (≠ Q154), K167 (≠ Q211), R214 (≠ D270), M250 (≠ V306), V277 (≠ T333), V393 (≠ A442), L418 (≠ Y467), G419 (≠ S468), M421 (= M470), D446 (= D495), N473 (= N522), E475 (≠ G524), Q476 (≠ Y525), M478 (≠ C527), V479 (≠ I528), W482 (≠ L531), L504 (≠ H562), G509 (= G567), L510 (≠ A568)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (≠ I142), P108 (≠ F143), F117 (≠ L152), D275 (= D331), R276 (≠ F332), M478 (≠ C527), W482 (≠ L531)
- binding flavin-adenine dinucleotide: R157 (≠ S201), G203 (= G260), A204 (≠ G261), G205 (= G262), N208 (vs. gap), T230 (= T286), L231 (≠ Q287), Q232 (≠ A288), M247 (≠ S303), L248 (= L304), M250 (≠ V306), H251 (≠ T307), G270 (= G326), A271 (≠ T327), R272 (= R328), D274 (≠ Q330), R276 (≠ F332), V277 (≠ T333), E303 (≠ G347), V304 (≠ I348), N308 (≠ A352), D322 (= D366), A323 (= A367), Q397 (≠ K451), M398 (≠ L452), G416 (≠ Y465), G417 (= G466)
- binding magnesium ion: D446 (= D495), N473 (= N522), E475 (≠ G524)
Sites not aligning to the query:
1n0hA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorimuron ethyl (see paper)
22% identity, 82% coverage: 57:600/661 of query aligns to 25:558/599 of 1n0hA
- active site: Y31 (≠ H63), G33 (vs. gap), G34 (= G64), A35 (≠ N65), I36 (≠ V66), E57 (= E88), T80 (= T111), F119 (≠ L152), Q120 (= Q153), E121 (≠ Q154), K169 (≠ Q211), R230 (≠ D270), M266 (≠ V306), V293 (≠ T333), V409 (≠ A442), L434 (≠ Y467), G435 (≠ S468), M437 (= M470), D462 (= D495), N489 (= N522), E491 (≠ G524), Q492 (≠ Y525), M494 (≠ C527), V495 (≠ I528), W498 (≠ L531), L520 (≠ H562), G525 (= G567), L526 (≠ A568)
- binding 4-{[(4'-amino-2'-methylpyrimidin-5'-yl)methyl]amino}pent-3-enyl diphosphate: V409 (≠ A442), G410 (= G443), Q411 (≠ T444), H412 (= H450), G435 (≠ S468), M437 (= M470), G461 (= G494), D462 (= D495), A463 (≠ G496), S464 (= S497), M467 (= M500), N489 (= N522), E491 (≠ G524), Q492 (≠ Y525), G493 (= G526), V495 (≠ I528)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: G34 (= G64), A35 (≠ N65), V109 (≠ I142), P110 (≠ F143), F119 (≠ L152), K169 (≠ Q211), M266 (≠ V306), D291 (= D331), R292 (≠ F332), V495 (≠ I528), W498 (≠ L531)
- binding flavin-adenine dinucleotide: R159 (≠ S201), G219 (= G260), A220 (≠ G261), G221 (= G262), N224 (vs. gap), T246 (= T286), L247 (≠ Q287), Q248 (≠ A288), L264 (= L304), G265 (= G305), M266 (≠ V306), H267 (≠ T307), G286 (= G326), A287 (≠ T327), R288 (= R328), D290 (≠ Q330), R292 (≠ F332), V293 (≠ T333), E319 (≠ G347), V320 (≠ I348), N324 (≠ A352), G337 (≠ A365), D338 (= D366), A339 (= A367), M414 (≠ L452), G432 (≠ Y465), G433 (= G466)
- binding magnesium ion: D462 (= D495), N489 (= N522), E491 (≠ G524)
- binding thiamine diphosphate: Y31 (≠ H63), E57 (= E88), P83 (= P116)
Sites not aligning to the query:
P09342 Acetolactate synthase 1, chloroplastic; ALS I; Acetohydroxy-acid synthase I; Acetolactate synthase I; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see 2 papers)
24% identity, 79% coverage: 77:597/661 of query aligns to 134:636/667 of P09342
- C161 (≠ M108) modified: Disulfide link with 307
- P194 (= P148) mutation to Q: In C3; highly resistant to sulfonylurea herbicides.
- C307 (≠ V263) modified: Disulfide link with 161
1t9bB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
23% identity, 82% coverage: 57:600/661 of query aligns to 23:554/595 of 1t9bB
- active site: Y29 (≠ H63), G31 (vs. gap), G32 (= G64), A33 (≠ N65), I34 (≠ V66), E55 (= E88), T78 (= T111), F117 (≠ L152), Q118 (= Q153), E119 (≠ Q154), K167 (≠ Q211), R226 (≠ D270), M262 (≠ V306), V289 (≠ T333), V405 (≠ A442), L430 (≠ Y467), G431 (≠ S468), M433 (= M470), D458 (= D495), N485 (= N522), E487 (≠ G524), Q488 (≠ Y525), M490 (≠ C527), V491 (≠ I528), W494 (≠ L531), L516 (≠ H562), G521 (= G567), L522 (≠ A568)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (≠ I142), P108 (≠ F143), D287 (= D331), R288 (≠ F332), M490 (≠ C527), W494 (≠ L531)
- binding flavin-adenine dinucleotide: R157 (≠ S201), G215 (= G260), A216 (≠ G261), G217 (= G262), N220 (vs. gap), T242 (= T286), L243 (≠ Q287), Q244 (≠ A288), M259 (≠ S303), L260 (= L304), M262 (≠ V306), H263 (≠ T307), G282 (= G326), A283 (≠ T327), R284 (= R328), D286 (≠ Q330), R288 (≠ F332), V289 (≠ T333), E315 (≠ G347), V316 (≠ I348), N320 (≠ A352), G333 (≠ A365), D334 (= D366), A335 (= A367), Q409 (≠ K451), M410 (≠ L452), G428 (≠ Y465), G429 (= G466)
- binding magnesium ion: D458 (= D495), N485 (= N522), E487 (≠ G524)
Sites not aligning to the query:
1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
22% identity, 82% coverage: 57:600/661 of query aligns to 23:555/596 of 1t9cA
- active site: Y29 (≠ H63), G31 (vs. gap), G32 (= G64), A33 (≠ N65), I34 (≠ V66), E55 (= E88), T78 (= T111), F117 (≠ L152), Q118 (= Q153), E119 (≠ Q154), K167 (≠ Q211), R227 (≠ D270), M263 (≠ V306), V290 (≠ T333), V406 (≠ A442), L431 (≠ Y467), G432 (≠ S468), M434 (= M470), D459 (= D495), N486 (= N522), E488 (≠ G524), Q489 (≠ Y525), M491 (≠ C527), V492 (≠ I528), W495 (≠ L531), L517 (≠ H562), G522 (= G567), L523 (≠ A568)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G64), V107 (≠ I142), P108 (≠ F143), F117 (≠ L152), K167 (≠ Q211), D288 (= D331), R289 (≠ F332), W495 (≠ L531)
- binding flavin-adenine dinucleotide: R157 (≠ S201), G216 (= G260), A217 (≠ G261), G218 (= G262), N221 (vs. gap), T243 (= T286), L244 (≠ Q287), Q245 (≠ A288), L261 (= L304), M263 (≠ V306), H264 (≠ T307), G283 (= G326), A284 (≠ T327), R285 (= R328), D287 (≠ Q330), R289 (≠ F332), V290 (≠ T333), E316 (≠ G347), V317 (≠ I348), N321 (≠ A352), G334 (≠ A365), D335 (= D366), A336 (= A367), M411 (≠ L452), G429 (≠ Y465), G430 (= G466)
- binding magnesium ion: D459 (= D495), N486 (= N522), E488 (≠ G524)
Sites not aligning to the query:
1t9aA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
22% identity, 82% coverage: 57:600/661 of query aligns to 24:556/597 of 1t9aA
- active site: Y30 (≠ H63), G32 (vs. gap), G33 (= G64), A34 (≠ N65), I35 (≠ V66), E56 (= E88), T79 (= T111), F118 (≠ L152), Q119 (= Q153), E120 (≠ Q154), K168 (≠ Q211), R228 (≠ D270), M264 (≠ V306), V291 (≠ T333), V407 (≠ A442), L432 (≠ Y467), G433 (≠ S468), M435 (= M470), D460 (= D495), N487 (= N522), E489 (≠ G524), Q490 (≠ Y525), M492 (≠ C527), V493 (≠ I528), W496 (≠ L531), L518 (≠ H562), G523 (= G567), L524 (≠ A568)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: G33 (= G64), V108 (≠ I142), P109 (≠ F143), F118 (≠ L152), K168 (≠ Q211), M264 (≠ V306), D289 (= D331), R290 (≠ F332), M492 (≠ C527), V493 (≠ I528), W496 (≠ L531)
- binding flavin-adenine dinucleotide: R158 (≠ S201), G217 (= G260), A218 (≠ G261), G219 (= G262), N222 (vs. gap), T244 (= T286), L245 (≠ Q287), Q246 (≠ A288), L262 (= L304), M264 (≠ V306), H265 (≠ T307), G284 (= G326), A285 (≠ T327), R286 (= R328), D288 (≠ Q330), R290 (≠ F332), V291 (≠ T333), E317 (≠ G347), V318 (≠ I348), N322 (≠ A352), G335 (≠ A365), D336 (= D366), A337 (= A367), Q411 (≠ K451), M412 (≠ L452), G430 (≠ Y465), G431 (= G466)
- binding magnesium ion: D460 (= D495), N487 (= N522), E489 (≠ G524)
- binding propyl trihydrogen diphosphate: V407 (≠ A442), G408 (= G443), Q409 (≠ T444), H410 (= H450), M435 (= M470), G459 (= G494), D460 (= D495), A461 (≠ G496), S462 (= S497), N487 (= N522), E489 (≠ G524), Q490 (≠ Y525), G491 (= G526), M492 (≠ C527)
- binding 5-{[ethyl(methyl)amino]methyl}-2-methyl-5,6-dihydropyrimidin-4-amine: G433 (≠ S468), M435 (= M470), M465 (= M500)
Sites not aligning to the query:
1t9dA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
22% identity, 82% coverage: 57:600/661 of query aligns to 23:555/596 of 1t9dA
- active site: Y29 (≠ H63), G31 (vs. gap), G32 (= G64), A33 (≠ N65), I34 (≠ V66), E55 (= E88), T78 (= T111), F117 (≠ L152), Q118 (= Q153), E119 (≠ Q154), K167 (≠ Q211), R227 (≠ D270), M263 (≠ V306), V290 (≠ T333), V406 (≠ A442), L431 (≠ Y467), G432 (≠ S468), M434 (= M470), D459 (= D495), N486 (= N522), E488 (≠ G524), Q489 (≠ Y525), M491 (≠ C527), V492 (≠ I528), W495 (≠ L531), L517 (≠ H562), G522 (= G567), L523 (≠ A568)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G64), A33 (≠ N65), V107 (≠ I142), P108 (≠ F143), F117 (≠ L152), K167 (≠ Q211), M263 (≠ V306), D288 (= D331), R289 (≠ F332), W495 (≠ L531)
- binding flavin-adenine dinucleotide: R157 (≠ S201), G216 (= G260), A217 (≠ G261), G218 (= G262), N221 (vs. gap), T243 (= T286), L244 (≠ Q287), Q245 (≠ A288), M260 (≠ S303), L261 (= L304), H264 (≠ T307), G283 (= G326), A284 (≠ T327), R285 (= R328), D287 (≠ Q330), R289 (≠ F332), V290 (≠ T333), E316 (≠ G347), V317 (≠ I348), N321 (≠ A352), G334 (≠ A365), D335 (= D366), A336 (= A367), Q410 (≠ K451), M411 (≠ L452), G429 (≠ Y465), G430 (= G466)
- binding magnesium ion: D459 (= D495), N486 (= N522), E488 (≠ G524)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E55 (= E88), P81 (= P116), Q118 (= Q153), G432 (≠ S468), M434 (= M470), M464 (= M500)
Sites not aligning to the query:
Query Sequence
>H281DRAFT_04458 FitnessBrowser__Burk376:H281DRAFT_04458
MNQRELQHGHDEAASAGAVVSGTTIRLTTAQALVRYLAAQRVATEDGSGTEPLFGGVFAI
FGHGNVAGMGEALYQHRDELPTLRAHNEQAMAHSAIAYAKAHFRRRMMAVTTSIGPGATN
LLTAAALAHVNRLPVLLLPGDIFVSRAPDPVLQQVEDFHDGGVSANDAFKPVSRYFDRIM
HPAQLLSALPRALRVLTDAASCGPVTLALPQDVQAQAWDFPADFFAPRIVTFYAPAPRVD
EIDAAVARLQRAKRPLIVAGGGVLYGRATDALQRFAAAHGIPVAETQAGKSSLAWDDPLN
AGSLGVTGSPAANALARDADCVLALGTRLQDFTTGSNTLFTQADVIGINANAFDALKHRA
QVVEADARLALDALAERLQDWQADRAWTSRAHELAASWRDTVHTLTHAPQRESVLPYEGD
VIGAVQRSSTDSPANDIVVCAAGTLPGELHKLWRAGTPGAYHVEYGYSCMGYEIAGGLGV
KLARPEREVIVMVGDGSYLMMNSEIATSVMLGAKLIVVVLDNRGYGCINRLQQACGGAPF
NNLLEDSMQGPLGAPQIDFAAHARALGARAEHAANVAELEAALQRARSADRTYVISIDTD
PARTTSDGGWWWEVAVPEVSPRASVREARANYDAQISARGKPPASAENSGNGSNSNDQAN
D
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory