SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing H281DRAFT_04486 FitnessBrowser__Burk376:H281DRAFT_04486 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

7kb1C Complex of o-acety-l-homoserine aminocarboxypropyltransferase (mety) from thermotoga maritima and a key reaction intermediate (see paper)
49% identity, 91% coverage: 12:433/465 of query aligns to 7:428/428 of 7kb1C

query
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7kb1C

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binding pyridoxal-5'-phosphate: Y57 (= Y61), R59 (= R63)
binding (2E)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)imino]but-3-enoic acid: G87 (= G91), Q88 (= Q92), Y112 (= Y116), N160 (= N163), D185 (= D188), S206 (= S210), T208 (= T212), K209 (= K213), N369 (= N374), I370 (≠ V375), R404 (= R409)

7kb1A Complex of o-acety-l-homoserine aminocarboxypropyltransferase (mety) from thermotoga maritima and a key reaction intermediate (see paper)
49% identity, 91% coverage: 12:433/465 of query aligns to 7:428/428 of 7kb1A

query
sites
7kb1A

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binding (2E)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)imino]but-3-enoic acid: Y57 (= Y61), R59 (= R63), G87 (= G91), Q88 (= Q92), Y112 (= Y116), N160 (= N163), D185 (= D188), S206 (= S210), T208 (= T212), K209 (= K213), N369 (= N374), I370 (≠ V375), R404 (= R409)

8wkoA Crystal structure of o-acetylhomoserine sulfhydrylase from lactobacillus plantarum in the closed form (see paper)
49% identity, 90% coverage: 12:428/465 of query aligns to 9:422/425 of 8wkoA

query
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8wkoA

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I

V

A

T

E

P

G

D

T

L

I

I

R

R

L

I

S

S

I

V

G

G

L

V

E

E

D

N

P

A

D

D

D

D

L

L

I

I

D

A

D

D

L

L

K

D

R

Q

G

A

L

L

binding (2S)-2-amino-6-[[3-hydroxy-2-methyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]hexanoic acid: G87 (= G91), S88 (≠ Q92), Y112 (= Y116), E155 (= E159), D184 (= D188), T186 (= T190), S206 (= S210), A207 (= A211), T208 (= T212), F209 (= F214), G212 (= G217), M217 (≠ I222), V369 (= V375), A370 (≠ G376)
binding proline: H213 (= H218), Q284 (= Q290), S288 (≠ T294)

8erbK Crystal structure of fub7 in complex with vinylglycine ketimine (see paper)
49% identity, 91% coverage: 10:431/465 of query aligns to 4:427/429 of 8erbK

query
sites
8erbK

N

Q

R

N

F

F

D

E

T

T

L

L

A

Q

L

L

H

H

A

A

G

G

A

Y

A

T

P

P

D

D

P

P

A

H

T

T

G

R

A

S

R

T

A

A

T

V

P

P

I

I

Y

Y

Q

A

T

T

T

S

S

S

F

Y

S

T

F

F

R

N

D

D

S

S

D

A

H

H

A

G

A

A

A

R

L

L

F

F

N

G

M

L

E

K

R

E

A

L

G

G

H

N

V

I

Y
|
Y

S

S

R
|
R

I

L

S

M

N

N

P

P

T

T

V

V

A

D

V

V

F

F

E

E

E

K

R

R

V

I

A

A

A

A

L

L

E

E

N

G

G

G

A

I

G

A

A

A

I

A

G

A

T

T

A

S

S

S

G
|
G

Q
|
Q

A

A

A

A

L
x
Q

H

F

L

L

A

T

I

I

V

A

T

T

L

L

M

A

G

K

R

A

G

G

S

D

H

N

I

I

V

V

A

A

S

S

S

S

A

H

L

L

Y
|
Y

G

G

G

G

S

T

H

Y

N

N

L

Q

L

L

H

N

Y

V

T

L

L

L

R

P

R

R

F

F

G

G

I

I

E

K

T

T

T

K

F

F

V

V

K

R

P

S

G

G

D

K

I

L

D

E

A

D

W

Y

R

A

A

A

A

A

L

I

R

D

P

D

N

Q

T

T

R

R

L

A

L

I

F

Y

G

V

E

E

T

S

L

M

G

S

N
|
N

P

P

G

D

L

Y

D

V

V

V

L

P

D

D

V

F

A

E

T

G

V

I

A

A

Q

K

I

I

A

A

H

H

E

E

H

H

R

G

V

I

P

P

L

L

L

V

V

V

D
|
D

S

N

T

T

F

L

-

G

T

A

T

G

P

G

Y

Y

L

Y

L

I

K

R

P

P

F

I

E

E

H

H

G

G

A

A

D

D

F

I

V

V

Y

V

H

H

S
|
S

A

A

T
|
T

K
|
K

F

W

L

I

G

G

G

G

H

H

G

G

T

T

T

T

I

I

G

G

G

G

V

V

L

I

V

V

D

D

G

S

G

G

T

R

F

F

D

N

F

W

D

N

A

K

-

H

S

S

G

D

R

R

F

F

P

P

E

E

F

M

T

V

E

E

P

P

Y

S

E

P

G

S

F

Y

H

H

G

G

I

L

I

K

F

Y

S

W

E

E

E

A

S

F

T

G

A

P

A

A

P

T

F

F

L

I

L

T

R

R

A

I

R

R

R

V

E

E

G

M

L

L

R

R

D

D

F

I

G

G

A

A

C

C

L

L

H

S

P

P

Q

F

A

S

A

A

W

Q

Q

Q

L

L

L

L

Q

L

G

G

I

I

E

E

T

T

L

L

P

G

L

L

R

R

M

A

E

E

R

R

H

H

V

A

A

Q

N

N

T

T

R

E

R

K

V

L

V

S

E

K

F

Y

L

F

A

E

G

S

H

S

A

P

A

N

V

V

E

S

A

W

V

V

A

L

Y

W

P

P

E

G

L

S

P

E

T

S

H

H

P

P

D

T

H

Y

A

S

L

Q

A

A

K

K

R

K

L

Y

L

L

P

T

R

R

G

G

A

F

G

G

A

A

V

M

F

L

S

S

F

I

N

G

L

V

R

K

G

G

D

D

R

A

A

S

A

A

G

G

R

S

S

K

F

V

I

V

E

D

A

G

L

L

S

K

L

L

F

V

S

S

H

N

L

L

A

A

N

N

V

V

G

G

D

D

A

A

R

K

S

S

L

L

V

A

I

I

H

H

P

P

A

W

S

S

T

T

T
|
T

H

H

F

E

R

Q

M

L

D

S

A

E

A

D

A

E

L

R

A

L

A

A

A

S

G

G

I

V

A

T

E

E

G

D

T

M

I

I

R
|
R

L

I

S

S

I

V

G

G

L

I

E

E

D

H

P

V

D

D

D

D

L

I

I

I

D

A

D

D

L

F

K

E

R

Q

G

S

L

F

K

Q

A

K

A

A

binding (2E)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)imino]but-3-enoic acid: Y55 (= Y61), R57 (= R63), G85 (= G91), Q86 (= Q92), Q89 (≠ L95), Y110 (= Y116), N157 (= N163), D182 (= D188), S205 (= S210), T207 (= T212), K208 (= K213), T385 (= T389), R405 (= R409)

8erjB Crystal structure of fub7 in complex with e-2-aminocrotonate (see paper)
49% identity, 92% coverage: 10:436/465 of query aligns to 3:428/428 of 8erjB

query
sites
8erjB

N

Q

R

N

F

F

D

E

T

T

L

L

A

Q

L

L

H

H

A

A

G

G

A

Y

A

T

P

P

D

D

P

P

A

H

T

T

G

R

A

S

R

T

A

A

T

V

P

P

I

I

Y

Y

Q

A

T

T

T

S

S

S

F

Y

S

T

F

F

R

N

D

D

S

S

D

A

H

H

A

G

A

A

A

R

L

L

F

F

N

G

M

L

E

K

R

E

A

L

G

G

H

N

V

I

Y

Y

S

S

R

R

I

L

S

M

N

N

P

P

T

T

V

V

A

D

V

V

F

F

E

E

E

K

R

R

V

I

A

A

A

A

L

L

E

E

N

G

G

G

A

I

G

A

A

A

I

A

G

A

T

T

A

S

S

S

G
|
G

Q
|
Q

A

A

A

A

L
x
Q

H

F

L

L

A

T

I

I

V

A

T

T

L

L

M

A

G

K

R

A

G

G

S

D

H

N

I

I

V

V

A

A

S

S

S

S

A

H

L

L

Y
|
Y

G

G

G

G

S

T

H

Y

N

N

L

Q

L

L

H

N

Y

V

T

L

L

L

R

P

R

R

F

F

G

G

I

I

E

K

T

T

T

K

F

F

V

V

K

R

P

S

G

G

D

K

I

L

D

E

A

D

W

Y

R

A

A

A

A

A

L

I

R

D

P

D

N

Q

T

T

R

R

L

A

L

I

F

Y

G

V

E

E

T

S

L

M

G

S

N

N

P

P

G

D

L

Y

D

V

V

V

L

P

D

D

V

F

A

E

T

G

V

I

A

A

Q

K

I

I

A

A

H

H

E

E

H

H

R

G

V

I

P

P

L

L

L

V

V

V

D
|
D

S

N

T

T

F

L

-

G

T

A

T

G

P

G

Y

Y

L

Y

L

I

K

R

P

P

F

I

E

E

H

H

G

G

A

A

D

D

F

I

V

V

Y

V

H

H

S
|
S

A

A

T

T

K
|
K

F

W

L

I

G

G

G

G

H

H

G

G

T

T

T

T

I

I

G

G

G

G

V

V

L

I

V

V

D

D

G

S

G

G

T

R

F

F

D

N

F

W

D

N

A

K

-

H

S

S

G

D

R

R

F

F

P

P

E

E

F

M

T

V

E

E

P

P

Y

S

E

P

G

S

F

Y

H

H

G

G

I

L

I

K

F

Y

S

W

E

E

E

A

S

F

T

G

A

P

A

A

P

T

F

F

L

I

L

T

R

R

A

I

R

R

R

V

E

E

G

M

L

L

R

R

D

D

F

I

G

G

A

A

C

C

L

L

H

S

P

P

Q

F

A

S

A

A

W

Q

Q

Q

L

L

L

L

Q

L

G

G

I

I

E

E

T

T

L

L

P

G

L

L

R

R

M

A

E

E

R

R

H

H

V

A

A

Q

N

N

T

T

R

E

R

K

V

L

V

S

E

K

F

Y

L

F

A

E

G

S

H

S

A

P

A

N

V

V

E

S

A

W

V

V

A

L

Y

W

P

P

E

G

L

S

P

E

T

S

H

H

P

P

D

T

H

Y

A

S

L

Q

A

A

K

K

R

K

L

Y

L

L

P

T

R

R

G

G

A

F

G

G

A

A

V

M

F

L

S

S

F

I

N

G

L

V

R

K

G

G

D

D

R

A

A

S

A

A

G

G

R

S

S

K

F

V

I

V

E

D

A

G

L

L

S

K

L

L

F

V

S

S

H

N

L

L

A
|
A

N
|
N

V

V

G

G

D

D

A

A

R

K

S

S

L

L

V

A

I

I

H

H

P

P

A

W

S

S

T

T

T
|
T

H

H

F

E

R

Q

M

L

D

S

A

E

A

D

A

E

L

R

A

L

A

A

A

S

G

G

I

V

A

T

E

E

G

D

T

M

I

I

R
|
R

L

I

S

S

I

V

G

G

L

I

E

E

D

H

P

V

D

D

D

D

L

I

I

I

D

A

D

D

L

F

K

E

R

Q

G

S

L

F

K

-

A

-

A

-

Q

Q

K

K

A

A

S

Y

G

G

binding (2S)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]but-3-enoic acid: G84 (= G91), Q85 (= Q92), Q88 (≠ L95), Y109 (= Y116), D181 (= D188), S204 (= S210), K207 (= K213), A368 (= A373), N369 (= N374), T384 (= T389), R404 (= R409)

8erjA Crystal structure of fub7 in complex with e-2-aminocrotonate (see paper)
49% identity, 92% coverage: 10:436/465 of query aligns to 3:428/428 of 8erjA

query
sites
8erjA

N

Q

R

N

F

F

D

E

T

T

L

L

A

Q

L

L

H

H

A

A

G

G

A

Y

A

T

P

P

D

D

P

P

A

H

T

T

G

R

A

S

R

T

A

A

T

V

P

P

I

I

Y

Y

Q

A

T

T

T

S

S

S

F

Y

S

T

F

F

R

N

D

D

S

S

D

A

H

H

A

G

A

A

A

R

L

L

F

F

N

G

M

L

E

K

R

E

A

L

G

G

H

N

V

I

Y

Y

S

S

R

R

I

L

S

M

N

N

P

P

T

T

V

V

A

D

V

V

F

F

E

E

E

K

R

R

V

I

A

A

A

A

L

L

E

E

N

G

G

G

A

I

G

A

A

A

I

A

G

A

T

T

A

S

S
|
S

G
|
G

Q
|
Q

A

A

A

A

L
x
Q

H

F

L

L

A

T

I

I

V

A

T

T

L

L

M

A

G

K

R

A

G

G

S

D

H

N

I

I

V

V

A

A

S

S

S

S

A

H

L

L

Y
|
Y

G

G

G

G

S

T

H

Y

N

N

L

Q

L

L

H

N

Y

V

T

L

L

L

R

P

R

R

F

F

G

G

I

I

E

K

T

T

T

K

F

F

V

V

K

R

P

S

G

G

D

K

I

L

D

E

A

D

W

Y

R

A

A

A

A

A

L

I

R

D

P

D

N

Q

T

T

R

R

L

A

L

I

F

Y

G

V

E

E

T

S

L

M

G

S

N
|
N

P

P

G

D

L

Y

D

V

V

V

L

P

D

D

V

F

A

E

T

G

V

I

A

A

Q

K

I

I

A

A

H

H

E

E

H

H

R

G

V

I

P

P

L

L

L

V

V

V

D
|
D

S

N

T

T

F

L

-

G

T

A

T

G

P

G

Y

Y

L

Y

L

I

K

R

P

P

F

I

E

E

H

H

G

G

A

A

D

D

F

I

V

V

Y

V

H

H

S
|
S

A

A

T
|
T

K
|
K

F

W

L

I

G

G

G

G

H

H

G

G

T

T

T

T

I

I

G

G

G

G

V

V

L

I

V

V

D

D

G

S

G

G

T

R

F

F

D

N

F

W

D

N

A

K

-

H

S

S

G

D

R

R

F

F

P

P

E

E

F

M

T

V

E

E

P

P

Y

S

E

P

G

S

F

Y

H

H

G

G

I

L

I

K

F

Y

S

W

E

E

E

A

S

F

T

G

A

P

A

A

P

T

F

F

L

I

L

T

R

R

A

I

R

R

R

V

E

E

G

M

L

L

R

R

D

D

F

I

G

G

A

A

C

C

L

L

H

S

P

P

Q

F

A

S

A

A

W

Q

Q

Q

L

L

L

L

Q

L

G

G

I

I

E

E

T

T

L

L

P

G

L

L

R

R

M

A

E

E

R

R

H

H

V

A

A

Q

N

N

T

T

R

E

R

K

V

L

V

S

E

K

F

Y

L

F

A

E

G

S

H

S

A

P

A

N

V

V

E

S

A

W

V

V

A

L

Y

W

P

P

E

G

L

S

P

E

T

S

H

H

P

P

D

T

H

Y

A

S

L

Q

A

A

K

K

R

K

L

Y

L

L

P

T

R

R

G

G

A

F

G

G

A

A

V

M

F

L

S

S

F

I

N

G

L

V

R

K

G

G

D

D

R

A

A

S

A

A

G

G

R

S

S

K

F

V

I

V

E

D

A

G

L

L

S

K

L

L

F

V

S

S

H

N

L

L

A

A

N

N

V

V

G

G

D

D

A

A

R

K

S

S

L

L

V

A

I

I

H

H

P

P

A

W

S

S

T

T

T

T

H

H

F

E

R

Q

M

L

D

S

A

E

A

D

A

E

L

R

A

L

A

A

A

S

G

G

I

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A

T

E

E

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D

T

M

I

I

R
|
R

L

I

S

S

I

V

G

G

L

I

E

E

D

H

P

V

D

D

D

D

L

I

I

I

D

A

D

D

L

F

K

E

R

Q

G

S

L

F

K

-

A

-

A

-

Q

Q

K

K

A

A

S

Y

G

G

binding (2E)-2-{[(1E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}but-2-enoic acid: S83 (= S90), G84 (= G91), Q85 (= Q92), Q88 (≠ L95), Y109 (= Y116), N156 (= N163), D181 (= D188), S204 (= S210), T206 (= T212), K207 (= K213), R404 (= R409)

O13326 Homocysteine synthase; O-acetylhomoserine sulfhydrylase; OAH SHL; OAH sulfhydrylase; EC 2.5.1.49 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
48% identity, 91% coverage: 7:431/465 of query aligns to 3:429/429 of O13326

query
sites
O13326

M

V

S

E

A

S

N

E

R

H

F

F

D

E

T

T

L

L

A

Q

L

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H

H

A

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G

A

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D

D

P

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T

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S

A

S

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R

A

A

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P

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I

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Y

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A

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Y

S

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F

F

R

R

D

D

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D

D

H

H

A

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A

G

A

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L

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F

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E

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P

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G

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Y

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I

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N

N

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A

A

D

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F

E

E

E

K

R

R

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I

A

A

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A

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L

E

E

N

H

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G

A

A

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A

A

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A

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S

S

G

G

Q

T

A

S

A

A

L

L

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F

L

M

A

A

I

L

V

T

T

T

L

L

M

A

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K

R

A

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D

H

N

I

I

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A

S

S

T

S

S

A

Y

L

L

Y

Y

G

G

G

G

S

T

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Y

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N

L

L

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Y

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L

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P

R

R

F

L

G

G

I

I

E

T

T

T

T

K

F

F

V

V

K

N

P

G

G

D

D

D

I

P

D

N

A

D

W

L

R

A

A

A

A

Q

L

I

R

D

P

E

N

N

T

T

R

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L

A

L

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F

Y

G

V

E

E

T

S

L

I

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G

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N

P

P

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M

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D

N

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D

D

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A

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I

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A

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H

H

E

A

H

A

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G

V

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P

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L

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M

V

V

D

D

S

N

T

T

F

F

-

G

T

G

T

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P

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Y

Y

L

L

L

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K

R

P

P

F

I

E

D

H

H

G

G

A

A

D

D

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I

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T

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H

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S

A

A

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T

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K

F

W

L

I

G

G

G

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H

H

G

G

T

T

T

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I

I

G

G

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L

I

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V

D

D

G

S

G

G

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K

F

F

D

D

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W

D

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A

K

-

N

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G

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F

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A

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T

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Q

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T

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R

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D

F

V

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G

A

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C

N

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A

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A

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G

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I

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D

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G411 (= G413) mutation to D: Impairs homocysteine synthase activity.

2ctzA Crystal structure of o-acetyl homoserine sulfhydrylase from thermus thermophilus hb8
47% identity, 90% coverage: 11:428/465 of query aligns to 2:420/421 of 2ctzA

query
sites
2ctzA

R

R

F

F

D

E

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T

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L

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Q

L

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H

A

A

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G

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D

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A

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A

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G

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N

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R

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M

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N

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T

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|
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G

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x
H

A

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x
Q

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A

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A

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N

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A

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L

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Y
|
Y

G

G

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F

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N

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T

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T

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-

S

K

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G

E

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R

I

P

D

E

A

E

W

F

R

L

A

A

A

L

L

T

R

D

P

E

N

K

T

T

R

R

L

A

L

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F

W

G

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I

G

G

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N

P

P

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A

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D

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L

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E

T

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A

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E

E

H

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R

G

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P

A

L

L

L

I

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D
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D

S

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T
|
T

F

F

T

G

T

M

P

G

-

G

Y

Y

L

L

L

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R

P

P

F

L

E

A

H

W

G

G

A

A

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A

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S

A

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T

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K

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W

L

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G

G

G

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H

H

G

G

T

A

T

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I

I

G

A

G

G

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A

L

I

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V

D

D

G

G

G

G

T

N

F

F

D

P

F

W

D

E

A

G

S

-

G

G

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R

F

Y

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A

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E

D

G

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D

F

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G

A

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C

A

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W

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L

G

G

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T

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L

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L

L

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M

A

E

E

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H

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E

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N

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L

V

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E

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L

L

A

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G

E

H

Q

A

P

A

Q

V

V

E

A

A

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V

A

N

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Y

P

P

E

G

L

L

P

P

T

H

H

H

P

P

D

H

H

H

A

D

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A

A

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Q

R

K

L

Y

L

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R

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G

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A

P

G

G

A

A

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V

F

L

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T

F

F

N

G

L

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G

G

D

G

R

Y

A

E

A

A

G

A

R

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R

F

F

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I

E

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A

R

L

L

S

K

L

L

F

I

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S

H

H

L

L

A

A

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N

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V

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G

D

D

A

T

R

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A

E

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A

A

A

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A

A

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G

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P

G

E

T

M

I

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R

L

L

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S

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V

G

G

L

L

E

E

D

H

P

V

D

E

D

D

L

L

I

K

D

A

D

E

L

L

K

K

R

E

G

A

L

L

active site: R54 (= R63), Y107 (= Y116), D180 (= D188), K206 (= K213)
binding pyridoxal-5'-phosphate: S81 (= S90), G82 (= G91), H83 (≠ Q92), Q86 (≠ L95), Y107 (= Y116), D180 (= D188), T182 (= T190), S203 (= S210), T205 (= T212), K206 (= K213)

Q5SK88 O-acetyl-L-homoserine sulfhydrylase 1; OAH-sulfhydrylase 1; EC 2.5.1.- from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
47% identity, 90% coverage: 11:428/465 of query aligns to 2:420/421 of Q5SK88

query
sites
Q5SK88

R

R

F

F

D

E

T

T

L

L

A

Q

L

L

H

H

A

A

G

G

A

Y

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D

E

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P

A

T

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L

A

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R

A

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P

I

I

Y

Y

Q

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F

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S

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F

F

R

K

D

S

S

P

D

E

H

H

A

A

A

A

A

N

L

L

F

F

N

A

M

L

E

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R

E

A

F

G

G

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I

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N

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A

D

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V

F

L

E

E

E

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L

A

A

A

A

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L

E

E

N

G

G

G

A

K

G

A

A

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A

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A

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G

G

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H

A

A

A

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Q

H

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L

L

A

A

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T

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T

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A

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R

A

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A

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P

A

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Y

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F

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N

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Q

L

F

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K

Y

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T

L

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R

R

F

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G

I

I

E

E

T

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T

R

F

F

V

T

-

S

K

R

P

E

G

E

D

R

I

P

D

E

A

E

W

F

R

L

A

A

A

L

L

T

R

D

P

E

N

K

T

T

R

R

L

A

L

W

F

W

G

V

E

E

T

S

L

I

G

G

N

N

P

P

G

A

L

L

D

N

V

I

L

P

D

D

V

L

A

E

T

A

V

L

A

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Q

I

A

A

A

H

R

E

E

H

K

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G

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V

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A

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L

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I

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V

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T

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P

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-

G

Y

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L

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R

P

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E

A

H

W

G

G

A

A

D

A

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L

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T

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H

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S

A

L

T

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K
|
K

F

W

L

V

G

G

G

G

H

H

G

G

T

A

T

V

I

I

G

A

G

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L

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D

D

G

G

G

G

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F

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D

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-

G

G

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E

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K

A

A

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E

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G

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C

A

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A

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L

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G

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T

L

L

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S

L

L

R

R

M

A

E

E

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R

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E

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N

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H

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A

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L

L

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H

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A

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A

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L

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A

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A

A

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F

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I

S

S

H

H

L

L

A

A

N

N

V

V

G

G

D

D

A

T

R

R

S

T

L

L

V

A

I

I

H

H

P

P

A

A

S

S

T

T

T

T

H

H

F

S

R

Q

M

L

D

S

A

P

A

E

A

E

L

Q

A

A

A

Q

A

A

G

G

I

V

A

S

E

P

G

E

T

M

I

V

R

R

L

L

S

S

I

V

G

G

L

L

E

E

D

H

P

V

D

E

D

D

L

L

I

K

D

A

D

E

L

L

K

K

R

E

G

A

L

L

K206 (= K213) modified: N6-(pyridoxal phosphate)lysine

4omaA The crystal structure of methionine gamma-lyase from citrobacter freundii in complex with l-cycloserine pyridoxal-5'-phosphate (see paper)
39% identity, 90% coverage: 12:431/465 of query aligns to 8:395/396 of 4omaA

query
sites
4omaA

F

F

D

N

T

T

L

Q

A

I

L

V

H

H

A

A

G

G

A

Q

A

Q

P

P

D

D

P

P

A

S

T

T

G

G

A

A

R

L

A

S

T

T

P

P

I

I

Y

F

Q

Q

T

T

T

S

S

T

F

F

S

V

F

F

R

D

D

S

S

A

D

E

H

Q

A

G

A

A

A

A

L

R

F

F

N

A

M

L

E

E

R

E

A

S

G

G

H

Y

V

I

Y

Y

S

T

R
|
R

I

L

S

G

N

N

P

P

T

T

V

T

A

D

V

A

F

L

E

E

E

K

R

K

V

L

A

A

A

V

L

L

E

E

N

R

G

G

A

E

G

A

A

G

I

L

G

A

T

T

A

A

S

S

G
|
G

Q
x
I

A

S

A

A

L

I

H

T

L

T

A

T

I

L

V

L

T

T

L

L

M

C

G

Q

R

Q

G

G

S

D

H

H

I

I

V

V

A

S

S

A

S

S

A

A

L

I

Y
|
Y

G

G

G

C

S

T

H

H

N

A

L

F

L

L

H

S

Y

H

T

S

L

M

R

P

R

K

F

F

G

G

I

I

E

N

T

V

T

S

F

F

V

V

K

D

P

A

G

A

D

K

I

P

D

E

A

E

W

I

R

R

A

A

A

A

L

M

R

R

P

P

N

E

T

T

R

K

L

V

L

V

F

Y

G

I

E

E

T

T

L

P

G

A

N

N

P

P

G

T

L

L

D

S

V

L

L

V

D

D

V

I

A

E

T

T

V

V

A

A

Q

G

I

I

A

A

H

H

E

Q

H

Q

R

G

V

A

P

L

L

L

L

V

V

V

D
|
D

S

N

T

T

F

F

T

M

T

S

P

P

Y

Y

L

C

L

Q

K

Q

P

P

F

L

E

Q

H

L

G

G

A

A

D

D

F

I

V

V

Y

V

H

H

S
|
S

A

V

T
|
T

K
|
K

F

Y

L

I

G

N

G

G

H

H

G

G

T

D

T

V

I

I

G

G

G

G

V

I

L

I

V

V

D

G

G

-

G

-

T

-

F

-

D

-

F

-

D

-

A

-

S

-

G

-

R

-

F

-

P

-

E

-

F

-

T

-

E

-

P

-

Y

-

E

-

G

-

F

-

H

-

G

-

I

-

I

-

F

-

S

-

E

-

E

-

S

-

T

-

A

K

A

Q

P

E

F

F

L

I

L

D

R

Q

A

A

R

R

R

F

E

V

G

G

L

L

R

K

D

D

F

I

-

T

G

G

A

G

C

C

L

M

H

S

P

P

Q

F

A

N

A

A

W

W

Q

L

L

T

L

L

Q

R

G

G

I

V

E

K

T

T

L

L

P

G

L

I

R

R

M

M

E

E

R

R

H

H

V

C

A

E

N

N

T

A

R

L

R

K

V

I

V

A

E

R

F

F

L

L

A

E

G

G

H

H

A

P

A

S

V

I

E

T

A

R

V

V

A

Y

Y

Y

P

P

E

G

L

L

P

S

T

S

H

H

P

P

D

Q

H

Y

A

E

L

L

A

G

K

Q

R

R

L

Q

L

M

P

S

R

L

G

-

A

P

G

G

A

G

V

I

F

I

S

S

F

F

N

E

L

I

R

A

G

G

D

G

R

L

A

E

A

A

G

G

R

R

S

R

F

M

I

I

E

N

A

S

L

V

S

E

L

L

F

C

S

L

H

L

L

A

A
x
V

N
x
S

V

L

G

G

D

D

A

T

R

E

S

T

L

L

V

I

I

Q

H

H

P

P

A

A

S

S

T

M

T

T

H

H

F

S

R

P

M

V

D

A

A

P

A

E

A

E

L

R

A

L

A

K

A

A

G

G

I

I

A

T

E

D

G

G

T

L

I

I

R
|
R

L

L

S

S

I

V

G

G

L

L

E

E

D

D

P

P

D

E

D

D

L

I

I

I

D

N

D

D

L

L

K

E

R

H

G

A

L

I

K

R

A

K

A

A

active site: R59 (= R63), Y112 (= Y116), D184 (= D188), K209 (= K213)
binding [5-hydroxy-6-methyl-4-({[(4E)-3-oxo-1,2-oxazolidin-4-ylidene]amino}methyl)pyridin-3-yl]methyl dihydrogen phosphate: G87 (= G91), I88 (≠ Q92), Y112 (= Y116), D184 (= D188), S206 (= S210), T208 (= T212), K209 (= K213), V337 (≠ A373), S338 (≠ N374), R373 (= R409)

3jwbA Crystal structure of l-methionine gamma-lyase from citrobacter freundii with norleucine (see paper)
39% identity, 90% coverage: 12:431/465 of query aligns to 8:395/396 of 3jwbA

query
sites
3jwbA

F

F

D

N

T

T

L

Q

A

I

L

V

H

H

A

A

G

G

A

Q

A

Q

P

P

D

D

P

P

A

S

T

T

G

G

A

A

R

L

A

S

T

T

P

P

I

I

Y

F

Q

Q

T

T

T

S

S

T

F

F

S

V

F

F

R

D

D

S

S

A

D

E

H

Q

A

G

A

A

A

A

L

R

F

F

N

A

M

L

E

E

R

E

A

S

G

G

H

Y

V

I

Y

Y

S

T

R
|
R

I

L

S

G

N

N

P

P

T

T

V

T

A

D

V

A

F

L

E

E

E

K

R

K

V

L

A

A

A

V

L

L

E

E

N

R

G

G

A

E

G

A

A

G

I

L

G

A

T

T

A

A

S

S

G

G

Q

I

A

S

A

A

L

I

H

T

L

T

A

T

I

L

V

L

T

T

L

L

M

C

G

Q

R

Q

G

G

S

D

H

H

I

I

V

V

A

S

S

A

S

S

A

A

L

I

Y
|
Y

G

G

G

C

S

T

H

H

N

A

L

F

L

L

H

S

Y

H

T

S

L

M

R

P

R

K

F

F

G

G

I

I

E

N

T

V

T

S

F

F

V

V

K

D

P

A

G

A

D

K

I

P

D

E

A

E

W

I

R

R

A

A

A

A

L

M

R

R

P

P

N

E

T

T

R

K

L

V

L

V

F

Y

G

I

E

E

T

T

L

P

G

A

N

N

P

P

G

T

L

L

D

S

V

L

L

V

D

D

V

I

A

E

T

T

V

V

A

A

Q

G

I

I

A

A

H

H

E

Q

H

Q

R

G

V

A

P

L

L

L

L

V

V

V

D
|
D

S

N

T

T

F

F

T

M

T

S

P

P

Y

Y

L

C

L

Q

K

Q

P

P

F

L

E

Q

H

L

G

G

A

A

D

D

F

I

V

V

Y

V

H

H

S

S

A

V

T

T

K
|
K

F

Y

L

I

G

N

G

G

H

H

G

G

T

D

T

V

I

I

G

G

G

G

V

I

L

I

V

V

D

G

G

-

G

-

T

-

F

-

D

-

F

-

D

-

A

-

S

-

G

-

R

-

F

-

P

-

E

-

F

-

T

-

E

-

P

-

Y

-

E

-

G

-

F

-

H

-

G

-

I

-

I

-

F

-

S

-

E

-

E

-

S

-

T

-

A

K

A

Q

P

E

F

F

L

I

L

D

R

Q

A

A

R

R

R

F

E

V

G

G

L

L

R

K

D

D

F

I

-

T

G

G

A

G

C

C

L

M

H

S

P

P

Q

F

A

N

A

A

W

W

Q

L

L

T

L

L

Q

R

G

G

I

V

E

K

T

T

L

L

P

G

L

I

R

R

M

M

E

E

R

R

H

H

V

C

A

E

N

N

T

A

R

L

R

K

V

I

V

A

E

R

F

F

L

L

A

E

G

G

H

H

A

P

A

S

V

I

E

T

A

R

V

V

A

Y

Y

Y

P

P

E

G

L

L

P

S

T

S

H

H

P

P