Comparing H281DRAFT_04595 H281DRAFT_04595 3-hydroxyacyl-CoA dehydrogenase to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6aa8E Crystal structure of (s)-3-hydroxybutyryl-coenzymea dehydrogenase from clostridium acetobutylicum complexed with NAD+ (see paper)
38% identity, 54% coverage: 9:288/521 of query aligns to 1:279/281 of 6aa8E
P00348 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; HCDH; L-3-hydroxyacyl CoA dehydrogenase; Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase; Short-chain 3-hydroxyacyl-CoA dehydrogenase; EC 1.1.1.35 from Sus scrofa (Pig) (see paper)
38% identity, 54% coverage: 8:289/521 of query aligns to 27:314/314 of P00348
1f0yA L-3-hydroxyacyl-coa dehydrogenase complexed with acetoacetyl-coa and NAD+ (see paper)
39% identity, 54% coverage: 8:289/521 of query aligns to 4:291/291 of 1f0yA
1f17A L-3-hydroxyacyl-coa dehydrogenase complexed with nadh (see paper)
39% identity, 54% coverage: 8:289/521 of query aligns to 4:291/293 of 1f17A
1f12A L-3-hydroxyacyl-coa dehydrogenase complexed with 3-hydroxybutyryl-coa (see paper)
39% identity, 54% coverage: 8:289/521 of query aligns to 4:291/293 of 1f12A
Q16836 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; HCDH; Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase; Short-chain 3-hydroxyacyl-CoA dehydrogenase; EC 1.1.1.35 from Homo sapiens (Human) (see 7 papers)
39% identity, 54% coverage: 8:289/521 of query aligns to 27:314/314 of Q16836
4pzeA Crystal structure of (s)-3-hydroxybutyryl-coa dehydrogenase paah1 in complex with acetoacetyl-coa (see paper)
39% identity, 54% coverage: 7:288/521 of query aligns to 1:281/283 of 4pzeA
4pzdA Crystal structure of (s)-3-hydroxybutyryl-coa dehydrogenase paah1 in complex with NAD+ (see paper)
39% identity, 54% coverage: 7:288/521 of query aligns to 1:281/283 of 4pzdA
4kugA Crystal structure of 3-hydroxybutylryl-coa dehydrogenase with NAD from clostridium butyricum
36% identity, 54% coverage: 8:288/521 of query aligns to 1:280/282 of 4kugA
4kuhA Crystal structure of 3-hydroxybutylryl-coa dehydrogenase with acetoacetyl-coa from clostridium butyricum
36% identity, 54% coverage: 8:288/521 of query aligns to 1:280/280 of 4kuhA
P9WNP7 3-hydroxybutyryl-CoA dehydrogenase; Beta-hydroxybutyryl-CoA dehydrogenase; BHBD; EC 1.1.1.157 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
36% identity, 54% coverage: 7:288/521 of query aligns to 4:286/286 of P9WNP7
7o4uA Structure of the alpha subunit of mycobacterium tuberculosis beta- oxidation trifunctional enzyme in complex with oxidized nicotinamide adenine dinucleotide (see paper)
34% identity, 55% coverage: 8:293/521 of query aligns to 316:603/711 of 7o4uA
8oqrA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-80
34% identity, 55% coverage: 8:293/521 of query aligns to 334:621/728 of 8oqrA
Sites not aligning to the query:
8oqsB Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-83
34% identity, 55% coverage: 8:293/521 of query aligns to 340:627/735 of 8oqsB
Sites not aligning to the query:
8pf8A Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-72
34% identity, 55% coverage: 8:293/521 of query aligns to 334:621/729 of 8pf8A
Sites not aligning to the query:
8oquA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-92
34% identity, 55% coverage: 8:293/521 of query aligns to 335:622/730 of 8oquA
Sites not aligning to the query:
8oqtA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-91
34% identity, 55% coverage: 8:293/521 of query aligns to 334:621/729 of 8oqtA
Sites not aligning to the query:
8oqnA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-53
34% identity, 55% coverage: 8:293/521 of query aligns to 334:621/729 of 8oqnA
Sites not aligning to the query:
8opvA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with resveratrol (fragment-b-h11)
34% identity, 55% coverage: 8:293/521 of query aligns to 334:621/729 of 8opvA
Sites not aligning to the query:
8opuA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with sulfamethoxazole (fragment-b-e1)
34% identity, 55% coverage: 8:293/521 of query aligns to 334:621/729 of 8opuA
Sites not aligning to the query:
>H281DRAFT_04595 H281DRAFT_04595 3-hydroxyacyl-CoA dehydrogenase
MTSRNFSIETIGIVGTGAMGRGIAQIAALAGLTVRLYDANPAAIGAARDYLAETFAKLTA
KGKLEQARSLAALANVTAAHAITDLADCDLVIEAIVEKLEVKQALFRELETVVSGRCVLA
SNTSSLSITAIAAGCTDPSRVAGYHFFNPVPLMKVVEVIDGLRSDRQAGDALMDLARRMG
HTPVRAKDMPGFIVNHAGRGMNTEGLRVAGEGVASFVDIDRIMREQAGFRLGPFELLDLT
ALDVSHPVMESIYHQFYEEPRFTPSPITGTRLAGGLLGRKTGEGFYRYEDGKQQAPAETP
APAALPTSVWVSKRYREAYQAVVELVGKAGVKLDDGASPAADSLIVVTPFGHDATTAAVD
EALDASRVVAIDALFPLVGTQRRTLMTTPATTRAARDAGHALFSADGVPVTVIRDSTGFV
AQRVVATIVNIGCDIAQKQIATPEDIDLAVMLGLGYPRGPLALGDALGAKTILTILRNMF
DVLGDPRYRPSPWLARRAQLGMSLTQSDAADTQTENPETQQ
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory