SitesBLAST

P39976 D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3; D-2HG--pyruvate transhydrogenase DLD3; (R)-2-hydroxyglutarate--pyruvate transhydrogenase; D-lactate dehydrogenase [cytochrome] 3; D-lactate ferricytochrome C oxidoreductase; D-LCR; EC 1.1.99.40; EC 1.1.2.4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
23% identity, 45% coverage: 29:192/362 of query aligns to 98:263/496 of P39976

query
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P39976

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Sites not aligning to the query:

17 modified: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

5ae3A Ether lipid-generating enzyme agps in complex with antimycin a (see paper)
27% identity, 48% coverage: 4:176/362 of query aligns to 122:294/539 of 5ae3A

query
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5ae3A

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binding flavin-adenine dinucleotide: P140 (≠ V26), I141 (≠ R27), G142 (= G28), G143 (= G29), G144 (= G30), T145 (= T31), S146 (≠ K32), V147 (≠ D33), L151 (≠ Q37), P208 (= P88), D209 (≠ P89), S210 (≠ H90), S214 (≠ A95), T215 (= T96), G218 (= G99), W219 (≠ C100), S221 (≠ A102), T222 (≠ A103), A224 (≠ I105), S225 (≠ A106), E274 (≠ L156), V279 (≠ L161), I280 (= I162)

Sites not aligning to the query:

5adzC Ether lipid-generating enzyme agps in complex with inhibitor 1a (see paper)
27% identity, 48% coverage: 4:176/362 of query aligns to 136:308/557 of 5adzC

query
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5adzC

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binding flavin-adenine dinucleotide: P154 (≠ V26), I155 (≠ R27), G156 (= G28), G157 (= G29), G158 (= G30), T159 (= T31), S160 (≠ K32), P222 (= P88), D223 (≠ P89), S224 (≠ H90), S228 (≠ A95), T229 (= T96), G232 (= G99), W233 (≠ C100), S235 (≠ A102), T236 (≠ A103), A238 (≠ I105), S239 (≠ A106), E288 (≠ L156), G289 (= G157), I294 (= I162)
binding (3S)-3-(2-fluorophenyl)-N-((2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)methyl)butanamide): D223 (≠ P89)

Sites not aligning to the query:

6gouA Development of alkyl glycerone phosphate synthase inhibitors: complex with inhibitor 2i (see paper)
27% identity, 48% coverage: 4:176/362 of query aligns to 136:308/554 of 6gouA

query
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6gouA

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binding (3~{S})-3-[2,6-bis(fluoranyl)phenyl]-~{N}-[(2-oxidanylidene-1,3-dihydrobenzimidazol-5-yl)methyl]butanamide: D223 (≠ P89)
binding flavin-adenine dinucleotide: P154 (≠ V26), I155 (≠ R27), G156 (= G28), G157 (= G29), G158 (= G30), T159 (= T31), S160 (≠ K32), V161 (≠ D33), G164 (= G36), P222 (= P88), D223 (≠ P89), S224 (≠ H90), S228 (≠ A95), T229 (= T96), G232 (= G99), W233 (≠ C100), S235 (≠ A102), T236 (≠ A103), A238 (≠ I105), S239 (≠ A106), E288 (≠ L156), V293 (≠ L161), I294 (= I162)

Sites not aligning to the query:

4bc9A Mammalian alkyldihydroxyacetonephosphate synthase: wild-type, adduct with cyanoethyl (see paper)
27% identity, 48% coverage: 4:176/362 of query aligns to 127:299/555 of 4bc9A

query
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4bc9A

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binding propanenitrile: D214 (≠ P89)
binding flavin-adenine dinucleotide: P145 (≠ V26), I146 (≠ R27), G147 (= G28), G148 (= G29), G149 (= G30), T150 (= T31), S151 (≠ K32), V152 (≠ D33), G155 (= G36), L156 (≠ Q37), P213 (= P88), D214 (≠ P89), S215 (≠ H90), S219 (≠ A95), T220 (= T96), G223 (= G99), W224 (≠ C100), S226 (≠ A102), T227 (≠ A103), A229 (≠ I105), S230 (≠ A106), E279 (≠ L156), V284 (≠ L161), I285 (= I162)

Sites not aligning to the query:

P97275 Alkyldihydroxyacetonephosphate synthase, peroxisomal; Alkyl-DHAP synthase; Alkylglycerone-phosphate synthase; EC 2.5.1.26 from Cavia porcellus (Guinea pig) (see 4 papers)
27% identity, 48% coverage: 4:176/362 of query aligns to 216:388/658 of P97275

query
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P97275

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234:240 (vs. 26:32, 57% identical) binding
H300 (≠ F86) mutation to A: Loss of activity.
303:309 (vs. 89:96, 13% identical) binding
T309 (= T96) mutation to I: Impaired FAD binding and protein stability. Loss of activity.
TRAS 316:319 (≠ AGIA 103:106) binding
S367 (= S155) mutation to A: Strongly reduced activity.
368:374 (vs. 156:162, 71% identical) binding

Sites not aligning to the query:

1:58 modified: transit peptide, Peroxisome
419 Important for enzyme activity; R→H: Loss of activity.; R→K: Strongly reduced activity.
469 L→P: Impaired FAD binding and protein stability. Loss of activity.
515 binding ; R→L: Impaired FAD binding and protein stability. Loss of activity.
576 C→A: No effect on activity.
578 active site, Proton donor/acceptor; Y→F: Loss of activity.
615 H→A: Loss of activity.
615:617 Important for enzyme activity
616 H→A: Loss of activity.
617 H→A: Loss of activity.
654:658 Important for enzyme activity

5ae1B Ether lipid-generating enzyme agps in complex with inhibitor zinc69435460 (see paper)
27% identity, 48% coverage: 4:176/362 of query aligns to 122:294/539 of 5ae1B

query
sites
5ae1B

D

D

I

V

V

V

A

K

M

I

W

-

S

-

E

-

R

-

V

V

R

N

S

L

A

A

S

C

A

K

A

Y

G

N

R

L

A

C

L

I

R

I

V
x
P

R
x
I

G
|
G

T
|
T

K
x
S

D

V

W

S

Y

Y

G
|
G

Q
x
L

T

M

L

C

E

P

G

A

E

D

-

E

-

T

-

R

-

T

-

I

I

S

L

L

D

D

T

T

R

S

A

Q

Y

M

R

N

G

R

I

I

I

L

A

W

Y

V

D

D

P

E

A

N

E

N

L

L

V

T

I

A

T

H

A

V

R

E

A

A

G

G

T

I

P

T

L

G

L

Q

E

E

I

L

E

E

A

R

A

Q

L

L

A

K

E

E

H

S

H

G

Q

Y

M

C

L

T

A

G

F

H

E

E

P
|
P

P
x
D

H
x
S

F

L

G

-

P

E

Q

F

A
x
S

T
|
T

F

V

G

G

G
|
G

C
x
W

I

I

A
x
S

A
x
T

G

R

I
x
A

A
x
S

G

G

P

M

R

K

P

N

S

I

A

Y

G

G

A

N

A

I

R

E

D

D

F

L

V

V

L

V

G

H

A

M

V

K

V

V

M

V

N

T

G

P

Q

R

G

G

Q

-

A

V

L

I

H

E

F

K

G

S

G

C

Q

Q

V

G

V

P

K

R

N

M

V

S

A

T

G

G

Y

P

D

D

V

I

S

H

R

H

L

F

M

I

A

M

G

G

S

S

L
x
E

G

G

T

T

L

L

G

G

L
x
V

I
|
I

L

T

E

E

L

A

S

T

V

I

K

K

V

I

L

R

P

P

Q

T

P

P

Q

E

A

Y

E

Q

binding flavin-adenine dinucleotide: P140 (≠ V26), I141 (≠ R27), G142 (= G28), G143 (= G29), G144 (= G30), T145 (= T31), S146 (≠ K32), G150 (= G36), L151 (≠ Q37), P208 (= P88), D209 (≠ P89), S210 (≠ H90), S214 (≠ A95), T215 (= T96), G218 (= G99), W219 (≠ C100), S221 (≠ A102), T222 (≠ A103), A224 (≠ I105), S225 (≠ A106), E274 (≠ L156), V279 (≠ L161), I280 (= I162)

Sites not aligning to the query:

4bc9B Mammalian alkyldihydroxyacetonephosphate synthase: wild-type, adduct with cyanoethyl (see paper)
27% identity, 48% coverage: 4:176/362 of query aligns to 122:294/542 of 4bc9B

query
sites
4bc9B

D

D

I

V

V

V

A

K

M

I

W

-

S

-

E

-

R

-

V

V

R

N

S

L

A

A

S

C

A

K

A

Y

G

N

R

L

A

C

L

I

R

I

V
x
P

R

I

G
|
G

T
|
T

K
x
S

D
x
V

W

S

Y

Y

G
|
G

Q
x
L

T

M

L

C

E

P

G

A

E

D

-

E

-

T

-

R

-

T

-

I

I

S

L

L

D

D

T

T

R

S

A

Q

Y

M

R

N

G

R

I

I

I

L

A

W

Y

V

D

D

P

E

A

N

E

N

L

L

V

T

I

A

T

H

A

V

R

E

A

A

G

G

T

I

P

T

L

G

L

Q

E

E

I

L

E

E

A

R

A

Q

L

L

A

K

E

E

H

S

H

G

Q

Y

M

C

L

T

A

G

F

H

E

E

P
|
P

P
x
D

H
x
S

F

L

G

-

P

E

Q

F

A
x
S

T
|
T

F

V

G

G

G
|
G

C
x
W

I

I

A
x
S

A
x
T

G

R

I
x
A

A
x
S

G

G

P

M

R

K

P

N

S

I

A

Y

G

G

A

N

A

I

R

E

D

D

F

L

V

V

L

V

G

H

A

M

V

K

V

V

M

V

N

T

G

P

Q

R

G

G

Q

-

A

V

L

I

H

E

F

K

G

S

G

C

Q

Q

V

G

V

P

K

R

N

M

V

S

A

T

G

G

Y

P

D

D

V

I

S

H

R

H

L

F

M

I

A

M

G

G

S

S

L
x
E

G
|
G

T

T

L

L

G

G

L

V

I
|
I

L

T

E

E

L

A

S

T

V

I

K

K

V

I

L

R

P

P

Q

T

P

P

Q

E

A

Y

E

Q

binding propanenitrile: D209 (≠ P89)
binding flavin-adenine dinucleotide: P140 (≠ V26), G142 (= G28), G143 (= G29), G144 (= G30), T145 (= T31), S146 (≠ K32), V147 (≠ D33), G150 (= G36), L151 (≠ Q37), P208 (= P88), D209 (≠ P89), S210 (≠ H90), S214 (≠ A95), T215 (= T96), G218 (= G99), W219 (≠ C100), S221 (≠ A102), T222 (≠ A103), A224 (≠ I105), S225 (≠ A106), E274 (≠ L156), G275 (= G157), I280 (= I162)

Sites not aligning to the query:

5ae2B Ether lipid-generating enzyme agps in complex with inhibitor 1e (see paper)
27% identity, 48% coverage: 4:176/362 of query aligns to 122:294/542 of 5ae2B

query
sites
5ae2B

D

D

I

V

V

V

A

K

M

I

W

-

S

-

E

-

R

-

V

V

R

N

S

L

A

A

S

C

A

K

A

Y

G

N

R

L

A

C

L

I

R

I

V
x
P

R

I

G
|
G

T
|
T

K
x
S

D

V

W

S

Y

Y

G
|
G

Q
x
L

T

M

L

C

E

P

G

A

E

D

-

E

-

T

-

R

-

T

-

I

I

S

L

L

D

D

T

T

R

S

A

Q

Y

M

R

N

G

R

I

I

I

L

A

W

Y

V

D

D

P

E

A

N

E

N

L

L

V

T

I

A

T

H

A

V

R

E

A

A

G

G

T

I

P

T

L

G

L

Q

E

E

I

L

E

E

A

R

A

Q

L

L

A

K

E

E

H

S

H

G

Q

Y

M

C

L

T

A

G

F

H

E

E

P
|
P

P
x
D

H
x
S

F

L

G

-

P

E

Q

F

A
x
S

T
|
T

F

V

G

G

G
|
G

C
x
W

I

I

A
x
S

A
x
T

G

R

I
x
A

A
x
S

G

G

P

M

R

K

P

N

S

I

A

Y

G

G

A

N

A

I

R

E

D

D

F

L

V

V

L

V

G

H

A

M

V

K

V

V

M

V

N

T

G

P

Q

R

G

G

Q

-

A

V

L

I

H

E

F

K

G

S

G

C

Q

Q

V

G

V

P

K

R

N

M

V

S

A

T

G

G

Y

P

D

D

V

I

S

H

R

H

L

F

M

I

A

M

G

G

S

S

L
x
E

G
|
G

T

T

L

L

G

G

L
x
V

I
|
I

L

T

E

E

L

A

S

T

V

I

K

K

V

I

L

R

P

P

Q

T

P

P

Q

E

A

Y

E

Q

binding flavin-adenine dinucleotide: P140 (≠ V26), G142 (= G28), G143 (= G29), G144 (= G30), T145 (= T31), S146 (≠ K32), G150 (= G36), L151 (≠ Q37), P208 (= P88), D209 (≠ P89), S210 (≠ H90), S214 (≠ A95), T215 (= T96), G218 (= G99), W219 (≠ C100), S221 (≠ A102), T222 (≠ A103), A224 (≠ I105), S225 (≠ A106), E274 (≠ L156), G275 (= G157), V279 (≠ L161), I280 (= I162)

Sites not aligning to the query:

4bc7B Mammalian alkyldihydroxyacetonephosphate synthase: arg419his mutant (see paper)
27% identity, 48% coverage: 4:176/362 of query aligns to 122:294/543 of 4bc7B

query
sites
4bc7B

D

D

I

V

V

V

A

K

M

I

W

-

S

-

E

-

R

-

V

V

R

N

S

L

A

A

S

C

A

K

A

Y

G

N

R

L

A

C

L

I

R

I

V
x
P

R

I

G
|
G

T
|
T

K
x
S

D
x
V

W

S

Y

Y

G
|
G

Q
x
L

T

M

L

C

E

P

G

A

E

D

-

E

-

T

-

R

-

T

-

I

I

S

L

L

D

D

T

T

R

S

A

Q

Y

M

R

N

G

R

I

I

I

L

A

W

Y

V

D

D

P

E

A

N

E

N

L

L

V

T

I

A

T

H

A

V

R

E

A

A

G

G

T

I

P

T

L

G

L

Q

E

E

I

L

E

E

A

R

A

Q

L

L

A

K

E

E

H

S

H

G

Q

Y

M

C

L

T

A

G

F

H

E

E

P
|
P

P
x
D

H
x
S

F

L

G

-

P

E

Q

F

A
x
S

T
|
T

F

V

G

G

G
|
G

C

W

I

I

A
x
S

A
x
T

G

R

I
x
A

A
x
S

G

G

P

M

R

K

P

N

S

I

A

Y

G

G

A

N

A

I

R

E

D

D

F

L

V

V

L

V

G

H

A

M

V

K

V

V

M

V

N

T

G

P

Q

R

G

G

Q

-

A

V

L

I

H

E

F

K

G

S

G

C

Q

Q

V

G

V

P

K

R

N

M

V

S

A

T

G

G

Y

P

D

D

V

I

S

H

R

H

L

F

M

I

A

M

G

G

S

S

L
x
E

G
|
G

T

T

L

L

G

G

L

V

I
|
I

L

T

E

E

L

A

S

T

V

I

K

K

V

I

L

R

P

P

Q

T

P

P

Q

E

A

Y

E

Q

binding flavin-adenine dinucleotide: P140 (≠ V26), G142 (= G28), G143 (= G29), G144 (= G30), T145 (= T31), S146 (≠ K32), V147 (≠ D33), G150 (= G36), L151 (≠ Q37), P208 (= P88), D209 (≠ P89), S210 (≠ H90), S214 (≠ A95), T215 (= T96), G218 (= G99), S221 (≠ A102), T222 (≠ A103), A224 (≠ I105), S225 (≠ A106), E274 (≠ L156), G275 (= G157), I280 (= I162)

Sites not aligning to the query:

5ae2A Ether lipid-generating enzyme agps in complex with inhibitor 1e (see paper)
27% identity, 48% coverage: 4:176/362 of query aligns to 127:299/561 of 5ae2A

query
sites
5ae2A

D

D

I

V

V

V

A

K

M

I

W

-

S

-

E

-

R

-

V

V

R

N

S

L

A

A

S

C

A

K

A

Y

G

N

R

L

A

C

L

I

R

I

V
x
P

R
x
I

G
|
G

T
|
T

K
x
S

D

V

W

S

Y

Y

G
|
G

Q
x
L

T

M

L

C

E

P

G

A

E

D

-

E

-

T

-

R

-

T

-

I

I

S

L

L

D

D

T

T

R

S

A

Q

Y

M

R

N

G

R

I

I

I

L

A

W

Y

V

D

D

P

E

A

N

E

N

L

L

V

T

I

A

T

H

A

V

R

E

A

A

G

G

T

I

P

T

L

G

L

Q

E

E

I

L

E

E

A

R

A

Q

L

L

A

K

E

E

H

S

H

G

Q

Y

M

C

L

T

A

G

F

H

E

E

P
|
P

P
x
D

H
x
S

F

L

G

-

P

E

Q

F

A
x
S

T
|
T

F

V

G

G

G
|
G

C
x
W

I

I

A
x
S

A
x
T

G

R

I
x
A

A
x
S

G

G

P

M

R

K

P

N

S

I

A

Y

G

G

A

N

A

I

R

E

D

D

F

L

V

V

L

V

G

H

A

M

V

K

V

V

M

V

N

T

G

P

Q

R

G

G

Q

-

A

V

L

I

H

E

F

K

G

S

G

C

Q

Q

V

G

V

P

K

R

N

M

V

S

A

T

G

G

Y

P

D

D

V

I

S

H

R

H

L

F

M

I

A

M

G

G

S

S

L
x
E

G

G

T

T

L

L

G

G

L
x
V

I
|
I

L

T

E

E

L

A

S

T

V

I

K

K

V

I

L

R

P

P

Q

T

P

P

Q

E

A

Y

E

Q

binding flavin-adenine dinucleotide: P145 (≠ V26), I146 (≠ R27), G147 (= G28), G148 (= G29), G149 (= G30), T150 (= T31), S151 (≠ K32), G155 (= G36), L156 (≠ Q37), P213 (= P88), D214 (≠ P89), S215 (≠ H90), S219 (≠ A95), T220 (= T96), G223 (= G99), W224 (≠ C100), S226 (≠ A102), T227 (≠ A103), A229 (≠ I105), S230 (≠ A106), E279 (≠ L156), V284 (≠ L161), I285 (= I162)

Sites not aligning to the query:

5adzA Ether lipid-generating enzyme agps in complex with inhibitor 1a (see paper)
27% identity, 48% coverage: 4:176/362 of query aligns to 124:296/566 of 5adzA

query
sites
5adzA

D

D

I

V

V

V

A

K

M

I

W

-

S

-

E

-

R

-

V

V

R

N

S

L

A

A

S

C

A

K

A

Y

G

N

R

L

A

C

L

I

R

I

V
x
P

R
x
I

G
|
G

T
|
T

K
x
S

D

V

W

S

Y

Y

G
|
G

Q

L

T

M

L

C

E

P

G

A

E

D

-

E

-

T

-

R

-

T

-

I

I

S

L

L

D

D

T

T

R

S

A

Q

Y

M

R

N

G

R

I

I

I

L

A

W

Y

V

D

D

P

E

A

N

E

N

L

L

V

T

I

A

T

H

A

V

R

E

A

A

G

G

T

I

P

T

L

G

L

Q

E

E

I

L

E

E

A

R

A

Q

L

L

A

K

E

E

H

S

H

G

Q

Y

M

C

L

T

A

G

F

H

E

E

P
|
P

P
x
D

H
x
S

F

L

G

-

P

E

Q

F

A
x
S

T
|
T

F

V

G

G

G
|
G

C
x
W

I

I

A
x
S

A
x
T

G

R

I
x
A

A
x
S

G

G

P

M

R

K

P

N

S

I

A

Y

G

G

A

N

A

I

R

E

D

D

F

L

V

V

L

V

G

H

A

M

V

K

V

V

M

V

N

T

G

P

Q

R

G

G

Q

-

A

V

L

I

H

E

F

K

G

S

G

C

Q

Q

V

G

V

P

K

R

N

M

V

S

A

T

G

G

Y

P

D

D

V

I

S

H

R

H

L

F

M

I

A

M

G

G

S

S

L
x
E

G
|
G

T

T

L

L

G

G

L
x
V

I
|
I

L

T

E

E

L

A

S

T

V

I

K

K

V

I

L

R

P

P

Q

T

P

P

Q

E

A

Y

E

Q

binding flavin-adenine dinucleotide: P142 (≠ V26), I143 (≠ R27), G144 (= G28), G145 (= G29), G146 (= G30), T147 (= T31), S148 (≠ K32), G152 (= G36), P210 (= P88), D211 (≠ P89), S212 (≠ H90), S216 (≠ A95), T217 (= T96), G220 (= G99), W221 (≠ C100), S223 (≠ A102), T224 (≠ A103), A226 (≠ I105), S227 (≠ A106), E276 (≠ L156), G277 (= G157), V281 (≠ L161), I282 (= I162)
binding (3S)-3-(2-fluorophenyl)-N-((2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)methyl)butanamide): D211 (≠ P89)

Sites not aligning to the query:

5ae1A Ether lipid-generating enzyme agps in complex with inhibitor zinc69435460 (see paper)
27% identity, 48% coverage: 4:176/362 of query aligns to 121:293/560 of 5ae1A

query
sites
5ae1A

D

D

I

V

V

V

A

K

M

I

W

-

S

-

E

-

R

-

V

V

R

N

S

L

A

A

S

C

A

K

A

Y

G

N

R

L

A

C

L

I

R

I

V
x
P

R
x
I

G
|
G

T
|
T

K
x
S

D
x
V

W

S

Y

Y

G
|
G

Q
x
L

T

M

L

C

E

P

G

A

E

D

-

E

-

T

-

R

-

T

-

I

I

S

L

L

D

D

T

T

R

S

A

Q

Y

M

R

N

G

R

I

I

I

L

A

W

Y

V

D

D

P

E

A

N

E

N

L

L

V

T

I

A

T

H

A

V

R

E

A

A

G

G

T

I

P

T

L

G

L

Q

E

E

I

L

E

E

A

R

A

Q

L

L

A

K

E

E

H

S

H

G

Q

Y

M

C

L

T

A

G

F

H

E

E

P
|
P

P
x
D

H
x
S

F

L

G

-

P

E

Q

F

A
x
S

T
|
T

F

V

G
|
G

C
x
W

I

I

A
x
S

A
x
T

G

R

I
x
A

A
x
S

G

G

P

M

R

K

P

N

S

I

A

Y

G

G

A

N

A

I

R

E

D

D

F

L

V

V

L

V

G

H

A

M

V

K

V

V

M

V

N

T

G

P

Q

R

G

G

Q

-

A

V

L

I

H

E

F

K

G

S

G

C

Q

Q

V

G

V

P

K

R

N

M

V

S

A

T

G

G

Y

P

D

D

V

I

S

H

R

H

L

F

M

I

A

M

G

G

S

S

L
x
E

G
|
G

T

T

L

L

G

G

L
x
V

I
|
I

L

T

E

E

L

A

S

T

V

I

K

K

V

I

L

R

P

P

Q

T

P

P

Q

E

A

Y

E

Q

binding flavin-adenine dinucleotide: P139 (≠ V26), I140 (≠ R27), G141 (= G28), G142 (= G29), G143 (= G30), T144 (= T31), S145 (≠ K32), V146 (≠ D33), G149 (= G36), L150 (≠ Q37), P207 (= P88), D208 (≠ P89), S209 (≠ H90), S213 (≠ A95), T214 (= T96), G216 (= G98), G217 (= G99), W218 (≠ C100), S220 (≠ A102), T221 (≠ A103), A223 (≠ I105), S224 (≠ A106), E273 (≠ L156), G274 (= G157), V278 (≠ L161), I279 (= I162)

Sites not aligning to the query:

Q8N465 D-2-hydroxyglutarate dehydrogenase, mitochondrial; EC 1.1.99.39 from Homo sapiens (Human) (see 7 papers)
26% identity, 46% coverage: 11:175/362 of query aligns to 113:278/521 of Q8N465

query
sites
Q8N465

S

S

E

H

R

I

V

L

R

R

S

H

A

C

S

H

A

E

A

R

G

N

R

L

A

A

L

V

R
x
N

V

P

R

Q

G

G

G
|
G

G

N

T

T

K

G

D

M

W

V

Y

G

G

G

Q

S

T

V

-

P

-

V

L

F

E

D

G

E

E

I

I
|
I

L

L

D

S

T

T

R

A

A

R

Y
x
M

R

N

G

R

I

V

I

L

A

S

Y

F

D

H

P

S

A

V

E

S

L

G

V

I

I

L

T

V

A

C

R
x
Q

A
|
A

G
|
G

T
x
C

P
x
V

L
|
L

L
x
E

E
|
E

I
x
L

E
x
S

A
x
R

A
x
Y

L
x
V

A
x
E

E
|
E

H
x
R

H
x
D

Q
x
F

M
x
I

L
x
M

A
x
P

F
x
L

E
x
D

P
x
L

P
x
G

H
x
A

F
x
K

G
|
G

P

-

Q
x
S

A
x
C

T
x
H

F
x
I

G
|
G

C
x
N

I
x
V

A
|
A

A
x
T

G
x
N

I
x
A

A
x
G

G
|
G

P
x
L

R
|
R

R
x
F

P
x
L

S
x
R

A
x
Y

G
|
G

A
x
S

A
x
L

R
x
H

D
x
G

F
x
T

V
|
V

L
|
L

G
|
G

A
x
L

V
x
E

V
|
V

M
x
V

N
x
L

G
x
A

Q
x
D

G
|
G

Q
x
T

A
x
V

L
|
L

H
x
D

F
x
C

G
x
L

G
x
T

Q
x
S

V
x
L

V
x
R

K
|
K

N
x
D

V
x
N

A
x
T

G
|
G

Y
|
Y

D
|
D

V
x
L

S
x
K

R
x
Q

L
|
L

M
x
F

A
x
I

G
|
G

S
|
S

L
x
E

G
|
G

T
|
T

L
|
L

G
|
G

L
x
I

I
|
I

L
x
T

E
x
T

L
x
V

S
|
S

V
x
I

K
x
L

V
x
C

L
x
P

P
|
P

Q
x
K

P
|
P

Q
x
R

A
|
A

N127 (≠ R25) to K: in D2HGA1; uncertain significance; complete loss of catalytic activity; dbSNP:rs762857195
G131 (= G29) to V: in D2HGA1; uncertain significance; complete loss of catalytic activity
I147 (= I43) to S: in D2HGA1; uncertain significance; severe phenotype; almost complete loss of catalytic activity; dbSNP:rs121434361
M153 (≠ Y49) to T: in D2HGA1; uncertain significance; significant loss of catalytic activity; to V: in D2HGA1; uncertain significance; significant loss of catalytic activity; dbSNP:rs1432270139
C172 (≠ T68) to Y: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs773735172
P189 (≠ A85) to L: in D2HGA1; uncertain significance; almost complete loss of catalytic activity; dbSNP:rs587783517
A205 (= A102) to V: in D2HGA1; uncertain significance; almost complete loss of catalytic activity; dbSNP:rs750889931
A231 (≠ G128) to V: in D2HGA1; uncertain significance; significant loss of catalytic activity
G233 (= G130) to S: in D2HGA1; uncertain significance; no effect on catalytic activity; dbSNP:rs374535734

Sites not aligning to the query:

15 R → G: in dbSNP:rs4675887
109 S → W: in D2HGA1; uncertain significance; significant loss of catalytic activity; dbSNP:rs142050154
169:521 natural variant: Missing (in D2HGA1; uncertain significance)
375 D → Y: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs267606759
386 binding ; binding ; binding ; R→A: Loss of catalytic activity.
390 binding ; binding ; T→A: Significantly reduced catalytic activity.
399 V → M: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs746519212
400:521 natural variant: Missing (in D2HGA1; uncertain significance; complete loss of catalytic activity)
401 binding ; binding ; K→A: Loss of catalytic activity.
419 R → H: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs199908032
426 A → T: in D2HGA1; uncertain significance; no effect on catalytic activity; dbSNP:rs146578303
434 binding ; H→A: Loss of catalytic activity.
436 G → V: slight reduction in catalytic activity
439 N → D: in D2HGA1; uncertain significance; mild phenotype; moderate reduction in catalytic activity; dbSNP:rs121434362
441 binding ; H→A: Loss of catalytic activity.
443 binding ; N→A: Significantly reduced catalytic activity.
444 V → A: in D2HGA1; uncertain significance; severe phenotype; significant reduction in catalytic activity; dbSNP:rs121434360
446 A → V: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs746956176
475 binding ; E→A: Loss of catalytic activity.
476 binding ; binding ; binding ; H→A: Loss of catalytic activity.
477 G → R: in D2HGA1; uncertain significance; almost complete loss of catalytic activity; dbSNP:rs1453924640

6lpxA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with 2-oxoglutarate (2-og) (see paper)
27% identity, 46% coverage: 11:175/362 of query aligns to 60:225/466 of 6lpxA

query
sites
6lpxA

S

S

E

H

R

I

V

L

R

R

S

H

A

C

S

H

A

E

A

R

G

N

R

L

A

A

L

V

R

N

V
x
P

R
x
Q

G
|
G

G
x
N

T
|
T

K
x
G

D
x
M

W

V

Y

G

G
|
G

Q
x
S

T

V

-

P

-

V

L

F

E

D

G

E

E

I

I

I

L

L

D

S

T

T

R

A

A

R

Y

M

R

N

G

R

I

V

I

L

A

S

Y

F

D

H

P

S

A

V

E

S

L

G

V

I

I

L

T

V

A

C

R

Q

A

A

G

G

T

C

P

V

L

L

L

E

E

E

I

L

E

S

A

R

A

Y

L

V

A

E

E

E

H

R

H

D

Q

F

M

I

L

M

A

-

F

-

E

-

P

P

P

L

H

D

F
x
L

G
|
G

P
x
A

Q

K

A

G

T

S

-
x
C

-

H

F

I

G

G

G
|
G

C
x
N

I

V

A
|
A

A
x
T

G

N

I

A

A

G

G
|
G

P

L

R

R

R

F

P

L

S

R

A

Y

G

G

A

S

A

L

R

H

D

G

F

T

V

V

L

L

G

G

A

L

V

E

V

V

M

V

N

L

G

A

Q

D

G

G

Q

T

A

V

L

L

H

D

F

C

G

L

G

T

Q

S

V

L

V

R

K

K

N

D

V

N

A

T

G

G

Y

Y

D

D

V

L

S

K

R

Q

L

L

M

F

A

I

G

G

S

S

L

E

G
|
G

T

T

L

L

G

G

L

I

I
|
I

L

T

E

T

L

V

S

S

V

I

K

L

V

C

L

P

P

P

Q

K

P

P

Q

R

A

A

binding flavin-adenine dinucleotide: P75 (≠ V26), Q76 (≠ R27), G77 (= G28), G78 (= G29), N79 (≠ G30), T80 (= T31), G81 (≠ K32), M82 (≠ D33), G85 (= G36), S86 (≠ Q37), L139 (≠ F91), G140 (= G92), A141 (≠ P93), C145 (vs. gap), G149 (= G99), N150 (≠ C100), A152 (= A102), T153 (≠ A103), G157 (= G107), G207 (= G157), I212 (= I162)

Sites not aligning to the query:

binding 2-oxoglutaric acid: 333, 337, 348, 379, 381, 388, 423
binding flavin-adenine dinucleotide: 39, 422, 459
binding zinc ion: 381, 388, 422

6lpuA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with l-2-hydroxyglutarate (l-2-hg) (see paper)
27% identity, 46% coverage: 11:175/362 of query aligns to 60:225/466 of 6lpuA

query
sites
6lpuA

S

S

E

H

R

I

V

L

R

R

S

H

A

C

S

H

A

E

A

R

G

N

R

L

A

A

L

V

R

N

V
x
P

R

Q

G
|
G

G
x
N

T
|
T

K
x
G

D

M

W

V

Y

G

G
|
G

Q
x
S

T

V

-

P

-

V

L

F

E

D

G

E

E

I

I

I

L

L

D

S

T

T

R

A

A

R

Y

M

R

N

G

R

I

V

I

L

A

S

Y

F

D

H

P

S

A

V

E

S

L

G

V

I

I

L

T

V

A

C

R

Q

A

A

G

G

T

C

P

V

L

L

L

E

E

E

I

L

E

S

A

R

A

Y

L

V

A

E

E

E

H

R

H

D

Q

F

M

I

L

M

A

-

F

-

E

-

P

P

P

L

H

D

F
x
L

G
|
G

P
x
A

Q

K

A

G

T

S

-
x
C

-
x
H

F

I

G
|
G

C
x
N

I

V

A
|
A

A
x
T

G

N

I
x
A

A

G

G

G

P

L

R

R

R

F

P

L

S

R

A

Y

G

G

A

S

A

L

R

H

D

G

F

T

V

V

L

L

G

G

A

L

V

E

V

V

M

V

N

L

G

A

Q

D

G

G

Q

T

A

V

L

L

H

D

F

C

G

L

G

T

Q

S

V

L

V

R

K

K

N

D

V

N

A

T

G

G

Y

Y

D

D

V

L

S

K

R

Q

L

L

M

F

A

I

G

G

S

S

L
x
E

G
|
G

T

T

L

L

G

G

L
x
I

I
|
I

L

T

E

T

L

V

S

S

V

I

K

L

V

C

L

P

P

P

Q

K

P

P

Q

R

A

A

binding flavin-adenine dinucleotide: P75 (≠ V26), G77 (= G28), G78 (= G29), N79 (≠ G30), T80 (= T31), G81 (≠ K32), G85 (= G36), S86 (≠ Q37), L139 (≠ F91), G140 (= G92), A141 (≠ P93), C145 (vs. gap), H146 (vs. gap), G148 (= G98), G149 (= G99), N150 (≠ C100), A152 (= A102), T153 (≠ A103), A155 (≠ I105), E206 (≠ L156), G207 (= G157), I211 (≠ L161), I212 (= I162)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 39, 422, 459
binding (2s)-2-hydroxypentanedioic acid: 333, 337, 348, 379, 381, 388, 423
binding zinc ion: 381, 388, 422

6lpqA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with d-malate (d-mal) (see paper)
27% identity, 46% coverage: 11:175/362 of query aligns to 60:225/466 of 6lpqA

query
sites
6lpqA

S

S

E

H

R

I

V

L

R

R

S

H

A

C

S

H

A

E

A

R

G

N

R

L

A

A

L

V

R

N

V
x
P

R

Q

G
|
G

G
x
N

T
|
T

K
x
G

D
x
M

W

V

Y

G

G
|
G

Q
x
S

T

V

-

P

-

V

L

F

E

D

G

E

E

I

I

I

L

L

D

S

T

T

R

A

A

R

Y

M

R

N

G

R

I

V

I

L

A

S

Y

F

D

H

P

S

A

V

E

S

L

G

V

I

I

L

T

V

A

C

R

Q

A

A

G

G

T

C

P

V

L

L

L

E

E

E

I

L

E

S

A

R

A

Y

L

V

A

E

E

E

H

R

H

D

Q

F

M

I

L

M

A

-

F

-

E

-

P

P

P

L

H

D

F
x
L

G
|
G

P
x
A

Q

K

A

G

T

S

-
x
C

-
x
H

F

I

G

G

G
|
G

C
x
N

I

V

A
|
A

A
x
T

G

N

I
x
A

A

G

G
|
G

P

L

R

R

R

F

P

L

S

R

A

Y

G

G

A

S

A

L

R

H

D

G

F

T

V

V

L

L

G

G

A

L

V

E

V

V

M

V

N

L

G

A

Q

D

G

G

Q

T

A

V

L

L

H

D

F

C

G

L

G

T

Q

S

V

L

V

R

K

K

N

D

V

N

A

T

G

G

Y

Y

D

D

V

L

S

K

R

Q

L

L

M

F

A

I

G

G

S

S

L
x
E

G
|
G

T

T

L

L

G

G

L
x
I

I
|
I

L

T

E

T

L

V

S

S

V

I

K

L

V

C

L

P

P

P

Q

K

P

P

Q

R

A

A

binding flavin-adenine dinucleotide: P75 (≠ V26), G77 (= G28), G78 (= G29), N79 (≠ G30), T80 (= T31), G81 (≠ K32), G85 (= G36), S86 (≠ Q37), L139 (≠ F91), G140 (= G92), A141 (≠ P93), C145 (vs. gap), H146 (vs. gap), G149 (= G99), N150 (≠ C100), A152 (= A102), T153 (≠ A103), A155 (≠ I105), G157 (= G107), E206 (≠ L156), G207 (= G157), I211 (≠ L161), I212 (= I162)
binding d-malate: M82 (≠ D33)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 39, 422, 459
binding d-malate: 333, 337, 348, 379, 381, 388, 422, 423
binding zinc ion: 381, 388, 422

Query Sequence

>H281DRAFT_04682 FitnessBrowser__Burk376:H281DRAFT_04682
MEEDDIVAMWSERVRSASAAGRALRVRGGGTKDWYGQTLEGEILDTRAYRGIIAYDPAEL
VITARAGTPLLEIEAALAEHHQMLAFEPPHFGPQATFGGCIAAGIAGPRRPSAGAARDFV
LGAVVMNGQGQALHFGGQVVKNVAGYDVSRLMAGSLGTLGLILELSVKVLPQPQAEATLK
FDVNGTDAVRKLNEWGGRPLPITASAWRHGTLAVRLAGAESAVKSARASLGGEVVDAVEA
ERFWAGLREQTDTFFAAIPPKAALWRLALPSITEPLQLPGAQLMEWGGAQRWWITDTDAQ
TVRISAKQAGGHATIFRTGHGYDRGAGVFTPLPAPLMKIHRGLKTAFDPARIFNRGRLYP
DF

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory