SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing H281DRAFT_04823 FitnessBrowser__Burk376:H281DRAFT_04823 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

6n0uA Crystal structure of a glucose-1-phosphate thymidylyltransferase from burkholderia phymatum bound to 2'-deoxy-thymidine-b-l-rhamnose
93% identity, 99% coverage: 1:294/297 of query aligns to 2:295/295 of 6n0uA

query
sites
6n0uA

M

M

A

A

R

R

K

K

G

G

I

I

L
|
L

A

A

G
|
G

S

S

G

G

T

T

R

R

L

L

Y

Y

P

P

I

I

T

T

H

H

V

V

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S

S

T

T

L

L

M

M

V

V

A

A

G

G

I

I

R

R

D

D

V

V

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

T

T

P

P

R

R

F

F

E

E

A

A

M

M

L

L

G

G

D

D

G

G

S

S

Q

Q

W

W

G

G

M

M

N

N

I

I

Q

Q

Y

Y

A

A

V

V

Q
|
Q

P

P

S

S

P
|
P

D

D

G
|
G

L
|
L

A

A

Q

Q

A

A

F

F

I

I

G

G

R

R

E

E

F

F

V

V

G

G

N

N

D

D

P

P

S

S

A

A

L

L

I

I

L
|
L

G

G

D
|
D

N

N

I

I

F

F

Y

Y

G

G

H

H

D

D

L

L

A

A

K

K

Q

Q

L

L

E

E

R

R

A

A

N

N

D

A

Q

R

A

T

D

D

G

G

A

A

T

T

V

V

F

F

A

A

Y

Y

H

H

V

V

H

H

D

D

P

P

E

E

R

R

Y
|
Y

G
|
G

V

V

E

E

F

F

D

D

K

K

Q

D

F

F

R

R

A

A

L

L

S

S

I

I

E

E

E
|
E

K
|
K

P

P

A

A

R

K

P

P

R

R

S

S

N

N

Y

Y

A

A

V
|
V

T

T

G
|
G

L

L

Y
|
Y

F

F

Y

Y

D

D

K

N

Q

Q

V

V

C

C

D

D

I

I

A

A

E

D

I

I

R

K

P

P

S

S

P

A

R
|
R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

S

S

H

R

Y

Y

L

L

A

S

N

Q

A

K

A

T

L

L

N

D

V

V

E

E

I

I

M

M

G

G

R

R

G

G

Y

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

I

I

E

E

A

A

T

T

F

F

I

I

A

A

T

T

L

L

Q

Q

K

K

R

R

Q

Q

G

G

L

L

V

V

A

A

C

C

P

P

E

E

I

I

A

A

Y

Y

R

R

Q

R

Q

K

W

W

I

I

G

N

A

A

E

E

Q

Q

L

L

T

A

L

L

A

A

A

R

P

P

L

L

A

S

K

K

N

N

A

A

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

Q

N

N

I

L

L

L

T

T

D

D

Q

Q

V

V

A

A

W

W

binding 2'-deoxy-thymidine-beta-l-rhamnose: L9 (= L8), G11 (= G10), G12 (= G11), Q83 (= Q82), P86 (= P85), G88 (= G87), L89 (= L88), L109 (= L108), D111 (= D110), Y146 (= Y145), G147 (= G146), E162 (= E161), K163 (= K162), V173 (= V172), G175 (= G174), Y177 (= Y176), R195 (= R194)

5ifyA Crystal structure of glucose-1-phosphate thymidylyltransferase from burkholderia vietnamiensis in complex with 2 -deoxyuridine-5'- monophosphate and 2'-deoxy-thymidine-b-l-rhamnose
87% identity, 99% coverage: 2:294/297 of query aligns to 1:293/293 of 5ifyA

query
sites
5ifyA

A

A

R

R

K

K

G

G

I

I

L
|
L

A

A

G
|
G

G

G

S

S

G

G

T

T

R

R

L

L

Y

Y

P

P

I

I

T

T

H

H

V

A

V

V

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S

S

T

T

L

L

M

M

V

I

A

A

G

G

I

I

R

R

D

D

V

V

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

T

T

P

P

R

R

F

F

E

E

A

S

M

M

L

L

G

G

D

D

G

G

S

S

Q

Q

W

W

G

G

M

M

N

N

I

I

Q

Q

Y

Y

A

A

V

T

Q
|
Q

P

P

S

S

P
|
P

D

D

G
|
G

L
|
L

A

A

Q

Q

A

A

F

F

I

V

I

I

G

G

R

R

E

D

F

F

V

V

G

G

N

N

D

E

P

P

S

S

A

A

L

L

I

I

L

L

G

G

D
|
D

N

N

I

I

F

F

Y
|
Y

G
|
G

H
|
H

D
|
D

L

L

A

A

K

K

Q

Q

L

L

E

E

R

R

A

A

N

S

D

A

Q

K

A

D

D

T

G

G

A

A

T

T

V

V

F

F

A

A

Y

Y

H

H

V

V

H

Q

D

D

P

P

E

E

R

R

Y
|
Y

G
|
G

V

V

E

E

F

F

D

D

K

R

Q

E

F

F

R

R

A

A

L

I

S

S

I

I

E

E

E
|
E

K
|
K

P

P

A

A

R

K

P

P

R

R

S

S

N

S

Y

Y

A

A

V
|
V

T

T

G

G

L

L

Y
|
Y

F

F

Y

Y

D

D

K

R

Q

Q

V

V

C

C

D

D

I

I

A

A

E

D

I

I

R

K

P

P

S

S

P

A

R
|
R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

S

S

H

R

Y

Y

L

L

A

A

N

A

A

G

A

Q

L

L

N

D

V

V

E

E

I

L

M

M

G
|
G

R
|
R

G
|
G

Y

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

I

I

E

E

A

A

A

G

T

T

F

F

I

I

A

A

T

T

L

L

Q

Q

K

K

R

R

Q

Q

G

G

L

L

V

M

V

V

A

A

C

C

P

P

E

E

E
|
E

I
|
I

A

A

Y

Y

R

R

Q

R

Q

N

W

W

I

I

G

D

A

A

E

E

Q

Q

L

V

L

L

T

K

L

L

A

A

A

Q

P

P

L

L

A

A

K

K

N

N

A

A

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

R

N

N

I

L

L

L

T

T

D

H

Q

Q

V

V

A

A

W

W

binding 2'-deoxy-thymidine-beta-l-rhamnose: L7 (= L8), G9 (= G10), Q81 (= Q82), P84 (= P85), G86 (= G87), L87 (= L88), D109 (= D110), Y144 (= Y145), G145 (= G146), E160 (= E161), K161 (= K162), V171 (= V172), Y175 (= Y176), R193 (= R194)
binding 2'-deoxyuridine 5'-monophosphate: Y113 (= Y114), G114 (= G115), H115 (= H116), D116 (= D117), G217 (= G218), R218 (= R219), G219 (= G220), E254 (= E255), I255 (= I256)

4b5bA Pseudomonas aeruginosa rmla in complex with allosteric inhibitor (see paper)
74% identity, 98% coverage: 1:292/297 of query aligns to 1:292/293 of 4b5bA

query
sites
4b5bA

M

M

A

K

R

R

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

Y

H

P

P

I

A

T

T

H

L

V

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S
|
S

T

T

L

L

M

M

V
x
L

A

A

G

G

I

I

R

R

D

E

V

I

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

T

T

P

P

R

R

F

F

E

Q

A

Q

M

L

L

L

G

G

D

D

G

G

S

S

Q

N

W

W

G

G

M

L

N

D

I

L

Q

Q

Y

Y

A

A

V

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

I

L

I

I

G

G

R

E

E

S

F

F

V

I

G

G

N

N

D

D

P

L

S

S

A

A

L

L

I

V

L

L

G

G

D

D

N

N

I

L

F
x
Y

Y

Y

G
|
G

H

H

D

D

L

F

A

H

K

E

Q

L

L

L

E

G

R

S

A

A

N

S

D

Q

Q

R

A

Q

D

T

G

G

A

A

T

S

V

V

F

F

A

A

Y

Y

H

H

V

V

H

L

D

D

P

P

E

E

R

R

Y

Y

G

G

V

V

E

E

F

F

D

D

K

Q

Q

G

F

G

R

K

A

A

L

I

S

S

I

L

E

E

K

K

P

P

A

L

R

E

P

P

R

K

S

S

N

N

Y

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

K

Q

Q

Q

V

V

C

V

D

D

I

I

A

A

A

R

E

D

I

L

R

K

P

P

S

S

P

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

S

R

H

A

Y

Y

L

L

A

E

N

R

A

G

A

Q

L

L

N

S

V

V

E

E

I

I

M

M

G

G

R

R

G

G

Y

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

I

L

E

E

A

A

A

G

T

Q

F

F

I

I

A

A

T

T

L

L

Q

E

K

N

R

R

Q

Q

G

G

L

L

V

K

V
|
V

A
|
A

C

C

P

P

E

E

E
|
E

I
|
I

A

A

Y

Y

R

R

Q

Q

Q

K

W

W

I

I

G

D

A

A

E

A

Q

Q

L

L

L

E

T

K

L

L

A

A

P

P

L

L

A

A

K

K

N

N

A

G

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

K

N

R

I

L

L

L

T

T

D

E

Q

T

V

V

binding N-(6-amino-1-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N,3-dimethylbenzenesulfonamide: S41 (= S41), L45 (≠ V45), Y113 (≠ F113), G115 (= G115), V250 (= V250), A251 (= A251), E255 (= E255), I256 (= I256)

4b4gA Pseudomonas aeruginosa rmla in complex with allosteric inhibitor (see paper)
74% identity, 98% coverage: 1:292/297 of query aligns to 1:292/293 of 4b4gA

query
sites
4b4gA

M

M

A

K

R

R

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

Y

H

P

P

I

A

T

T

H

L

V

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S

S

T

T

L

L

M

M

V
x
L

A

A

G

G

I

I

R

R

D

E

V

I

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

T

T

P

P

R

R

F

F

E

Q

A

Q

M

L

L

L

G

G

D

D

G

G

S

S

Q

N

W

W

G

G

M

L

N

D

I

L

Q

Q

Y

Y

A

A

V

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

I

L

I

I

G

G

R

E

E

S

F

F

V

I

G

G

N

N

D

D

P

L

S

S

A

A

L

L

I

V

L

L

G

G

D

D

N

N

I

L

F
x
Y

Y

Y

G
|
G

H

H

D

D

L
x
F

A

H

K

E

Q

L

L

L

E

G

R

S

A

A

N

S

D

Q

Q

R

A

Q

D

T

G

G

A

A

T

S

V

V

F

F

A

A

Y

Y

H

H

V

V

H

L

D

D

P

P

E

E

R

R

Y

Y

G

G

V

V

E

E

F

F

D

D

K

Q

Q

G

F

G

R

K

A

A

L

I

S

S

I

L

E

E

K

K

P

P

A

L

R

E

P

P

R

K

S

S

N

N

Y

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

K

Q

Q

Q

V

V

C

V

D

D

I

I

A

A

A

R

E

D

I

L

R

K

P

P

S

S

P

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

S

R

H

A

Y

Y

L

L

A

E

N

R

A

G

A

Q

L

L

N

S

V

V

E

E

I

I

M

M

G

G

R

R

G

G

Y

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

I

L

E

E

A

A

A

G

T

Q

F

F

I

I

A

A

T

T

L

L

Q

E

K

N

R

R

Q

Q

G

G

L

L

V

K

V
|
V

A
|
A

C

C

P

P

E

E

E
|
E

I
|
I

A

A

Y

Y

R
|
R

Q

Q

Q

K

W

W

I

I

G

D

A

A

E

A

Q

Q

L

L

L

E

T

K

L

L

A

A

P

P

L

L

A

A

K

K

N

N

A

G

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

K

N

R

I

L

L

L

T

T

D

E

Q

T

V

V

binding N-(6-amino-1-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylbutane-1-sulfonamide: L45 (≠ V45), Y113 (≠ F113), G115 (= G115), F118 (≠ L118), V250 (= V250), A251 (= A251), E255 (= E255), I256 (= I256), R259 (= R259)

4b42A Pseudomonas aeruginosa rmla in complex with allosteric inhibitor (see paper)
74% identity, 98% coverage: 1:292/297 of query aligns to 1:292/293 of 4b42A

query
sites
4b42A

M

M

A

K

R

R

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

Y

H

P

P

I

A

T

T

H

L

V

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S
|
S

T
|
T

L

L

M

M

V

L

A

A

G

G

I

I

R

R

D

E

V

I

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

T

T

P

P

R

R

F

F

E

Q

A

Q

M

L

L

L

G

G

D

D

G

G

S

S

Q

N

W

W

G

G

M

L

N

D

I

L

Q

Q

Y

Y

A

A

V

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

I

L

I

I

G

G

R

E

E

S

F

F

V

I

G

G

N

N

D

D

P

L

S

S

A

A

L

L

I

V

L

L

G

G

D

D

N

N

I

L

F
x
Y

Y

Y

G

G

H

H

D

D

L
x
F

A

H

K

E

Q

L

L

L

E

G

R

S

A

A

N

S

D

Q

Q

R

A

Q

D

T

G

G

A

A

T

S

V

V

F

F

A

A

Y

Y

H

H

V

V

H

L

D

D

P

P

E

E

R

R

Y

Y

G

G

V

V

E

E

F

F

D

D

K

Q

Q

G

F

G

R

K

A

A

L

I

S

S

I

L

E

E

K

K

P

P

A

L

R

E

P

P

R

K

S

S

N

N

Y

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

K

Q

Q

Q

V

V

C

V

D

D

I

I

A

A

A

R

E

D

I

L

R

K

P

P

S

S

P

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

S

R

H

A

Y

Y

L

L

A

E

N

R

A

G

A

Q

L

L

N

S

V

V

E

E

I

I

M

M

G

G

R

R

G

G

Y

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

I

L

E

E

A

A

A

G

T

Q

F

F

I

I

A

A

T

T

L

L

Q

E

K

N

R

R

Q

Q

G

G

L

L

V

K

V
|
V

A

A

C

C

P

P

E

E

E
|
E

I
|
I

A

A

Y

Y

R

R

Q

Q

Q

K

W

W

I

I

G

D

A

A

E

A

Q

Q

L

L

L

E

T

K

L

L

A

A

P

P

L

L

A

A

K

K

N

N

A

G

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

K

N

R

I

L

L

L

T

T

D

E

Q

T

V

V

binding N-[6-azanyl-1-butyl-2,4-bis(oxidanylidene)pyrimidin-5-yl]-N-methyl-benzamide: S41 (= S41), T42 (= T42), Y113 (≠ F113), F118 (≠ L118), V250 (= V250), E255 (= E255), I256 (= I256)

4b3uA Pseudomonas aeruginosa rmla in complex with allosteric inhibitor (see paper)
74% identity, 98% coverage: 1:292/297 of query aligns to 7:298/299 of 4b3uA

query
sites
4b3uA

M

M

A

K

R

R

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

Y

H

P

P

I

A

T

T

H

L

V

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S

S

T

T

L

L

M

M

V
x
L

A

A

G

G

I

I

R

R

D

E

V

I

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

T

T

P

P

R

R

F

F

E

Q

A

Q

M

L

L

L

G

G

D

D

G

G

S

S

Q

N

W

W

G

G

M

L

N

D

I

L

Q

Q

Y

Y

A

A

V

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

I

L

I

I

G

G

R

E

E

S

F

F

V

I

G

G

N

N

D

D

P

L

S

S

A

A

L

L

I

V

L

L

G

G

D

D

N

N

I

L

F

Y

Y

Y

G

G

H

H

D

D

L

F

A

H

K

E

Q

L

L

L

E

G

R

S

A

A

N

S

D

Q

Q

R

A

Q

D

T

G

G

A

A

T

S

V

V

F

F

A

A

Y

Y

H

H

V

V

H

L

D

D

P

P

E

E

R

R

Y

Y

G

G

V

V

E

E

F

F

D

D

K

Q

Q

G

F

G

R

K

A

A

L

I

S

S

I

L

E

E

K

K

P

P

A

L

R

E

P

P

R

K

S

S

N

N

Y

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

K

Q

Q

Q

V

V

C

V

D

D

I

I

A

A

A

R

E

D

I

L

R

K

P

P

S

S

P

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

S

R

H

A

Y

Y

L

L

A

E

N

R

A

G

A

Q

L

L

N

S

V

V

E

E

I

I

M

M

G

G

R

R

G

G

Y

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

I

L

E

E

A

A

A

G

T

Q

F

F

I

I

A

A

T

T

L

L

Q

E

K

N

R

R

Q

Q

G

G

L

L

V

K

V

V

A

A

C

C

P

P

E

E

E
|
E

I
|
I

A

A

Y

Y

R
|
R

Q
|
Q

Q

K

W

W

I

I

G

D

A

A

E

A

Q

Q

L

L

L

E

T

K

L

L

A

A

P

P

L

L

A

A

K

K

N

N

A

G

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

K

N

R

I

L

L

L

T

T

D

E

Q

T

V

V

binding 6-amino-1-benzyl-5-(ethylamino)pyrimidine-2,4(1H,3H)-dione: L51 (≠ V45), E261 (= E255), I262 (= I256), R265 (= R259), Q266 (= Q260)

4asyA Pseudomonas aeruginosa rmla in complex with allosteric inhibitor (see paper)
74% identity, 98% coverage: 1:292/297 of query aligns to 1:292/293 of 4asyA

query
sites
4asyA

M

M

A

K

R

R

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

Y

H

P

P

I

A

T

T

H

L

V

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S
|
S

T
|
T

L

L

M

M

V
x
L

A

A

G

G

I

I

R

R

D

E

V

I

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

T

T

P

P

R

R

F

F

E

Q

A

Q

M

L

L

L

G

G

D

D

G

G

S

S

Q

N

W

W

G

G

M

L

N

D

I

L

Q

Q

Y

Y

A

A

V

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

I

L

I

I

G

G

R

E

E

S

F

F

V

I

G

G

N

N

D

D

P

L

S

S

A

A

L

L

I

V

L

L

G

G

D

D

N

N

I

L

F
x
Y

Y

Y

G
|
G

H

H

D

D

L

F

A

H

K

E

Q

L

L

L

E

G

R

S

A

A

N

S

D

Q

Q

R

A

Q

D

T

G

G

A

A

T

S

V

V

F

F

A

A

Y

Y

H

H

V

V

H

L

D

D

P

P

E

E

R

R

Y

Y

G

G

V

V

E

E

F

F

D

D

K

Q

Q

G

F

G

R

K

A

A

L

I

S

S

I

L

E

E

K

K

P

P

A

L

R

E

P

P

R

K

S

S

N

N

Y

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

K

Q

Q

Q

V

V

C

V

D

D

I

I

A

A

A

R

E

D

I

L

R

K

P

P

S

S

P

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

S

R

H

A

Y

Y

L

L

A

E

N

R

A

G

A

Q

L

L

N

S

V

V

E

E

I

I

M

M

G

G

R

R

G

G

Y

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

I

L

E

E

A

A

A

G

T

Q

F

F

I

I

A

A

T

T

L

L

Q

E

K

N

R

R

Q

Q

G

G

L

L

V

K

V
|
V

A

A

C

C

P

P

E

E

E
|
E

I

I

A

A

Y

Y

R

R

Q

Q

Q

K

W

W

I

I

G

D

A

A

E

A

Q

Q

L

L

L

E

T

K

L

L

A

A

P

P

L

L

A

A

K

K

N

N

A

G

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

K

N

R

I

L

L

L

T

T

D

E

Q

T

V

V

binding N-(6-amino-1-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylbenzamide: S41 (= S41), T42 (= T42), L45 (≠ V45), Y113 (≠ F113), G115 (= G115), V250 (= V250), E255 (= E255)

4b2xB Pseudomonas aeruginosa rmla in complex with allosteric inhibitor (see paper)
74% identity, 98% coverage: 1:292/297 of query aligns to 10:301/302 of 4b2xB

query
sites
4b2xB

M

M

A

K

R

R

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

Y

H

P

P

I

A

T

T

H

L

V

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S

S

T

T

L

L

M

M

V
x
L

A

A

G

G

I

I

R

R

D

E

V

I

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

T

T

P

P

R

R

F

F

E

Q

A

Q

M

L

L

L

G

G

D

D

G

G

S

S

Q

N

W

W

G

G

M

L

N

D

I

L

Q

Q

Y

Y

A

A

V

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

I

L

I

I

G

G

R

E

E

S

F

F

V

I

G

G

N

N

D

D

P

L

S

S

A

A

L

L

I

V

L

L

G

G

D

D

N

N

I

L

F
x
Y

Y

Y

G

G

H

H

D

D

L

F

A

H

K

E

Q

L

L

L

E

G

R

S

A

A

N

S

D

Q

Q

R

A

Q

D

T

G

G

A

A

T

S

V

V

F

F

A

A

Y

Y

H

H

V

V

H

L

D

D

P

P

E

E

R

R

Y

Y

G

G

V

V

E

E

F

F

D

D

K

Q

Q

G

F

G

R

K

A

A

L

I

S

S

I

L

E

E

K

K

P

P

A

L

R

E

P

P

R

K

S

S

N

N

Y

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

K

Q

Q

Q

V

V

C

V

D

D

I

I

A

A

A

R

E

D

I

L

R

K

P

P

S

S

P

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

S

R

H

A

Y

Y

L

L

A

E

N

R

A

G

A

Q

L

L

N

S

V

V

E

E

I

I

M

M

G

G

R

R

G

G

Y

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

I

L

E

E

A

A

A

G

T

Q

F

F

I

I

A

A

T

T

L

L

Q

E

K

N

R

R

Q

Q

G

G

L

L

V

K

V

V

A

A

C

C

P

P

E

E

E
|
E

I

I

A

A

Y

Y

R

R

Q
|
Q

Q

K

W

W

I

I

G

D

A

A

E

A

Q

Q

L

L

L

E

T

K

L

L

A

A

P

P

L

L

A

A

K

K

N

N

A

G

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

K

N

R

I

L

L

L

T

T

D

E

Q

T

V

V

binding 6-amino-1-butyl-5-(cyclopentylamino)pyrimidine-2,4(1H,3H)-dione: L54 (≠ V45), Y122 (≠ F113), E264 (= E255), Q269 (= Q260)

5fuhA Pseudomonas aeruginosa rmla in complex with allosteric inhibitor
74% identity, 98% coverage: 1:292/297 of query aligns to 6:297/298 of 5fuhA

query
sites
5fuhA

M

M

A

K

R

R

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

Y

H

P

P

I

A

T

T

H

L

V

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S

S

T
|
T

L

L

M

M

V
x
L

A

A

G

G

I

I

R

R

D

E

V

I

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

T

T

P

P

R

R

F

F

E

Q

A

Q

M

L

L

L

G

G

D

D

G

G

S

S

Q

N

W

W

G

G

M

L

N

D

I

L

Q

Q

Y

Y

A

A

V

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

I

L

I

I

G

G

R

E

E

S

F

F

V

I

G

G

N

N

D

D

P

L

S

S

A

A

L

L

I

V

L

L

G

G

D

D

N

N

I

L

F
x
Y

Y

Y

G
|
G

H

H

D

D

L
x
F

A

H

K

E

Q

L

L

L

E

G

R

S

A

A

N

S

D

Q

Q

R

A

Q

D

T

G

G

A

A

T

S

V

V

F

F

A

A

Y

Y

H

H

V

V

H

L

D

D

P

P

E

E

R

R

Y

Y

G

G

V

V

E

E

F

F

D

D

K

Q

Q

G

F

G

R

K

A

A

L

I

S

S

I

L

E

E

K

K

P

P

A

L

R

E

P

P

R

K

S

S

N

N

Y

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

K

Q

Q

Q

V

V

C

V

D

D

I

I

A

A

A

R

E

D

I

L

R

K

P

P

S

S

P

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

S

R

H

A

Y

Y

L

L

A

E

N

R

A

G

A

Q

L

L

N

S

V

V

E

E

I

I

M

M

G

G

R

R

G

G

Y

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

I

L

E

E

A

A

A

G

T

Q

F

F

I

I

A

A

T

T

L

L

Q

E

K

N

R

R

Q

Q

G

G

L

L

V

K

V

V

A
|
A

C

C

P

P

E

E

I

I

A

A

Y

Y

R
|
R

Q
|
Q

Q

K

W

W

I

I

G

D

A

A

E

A

Q

Q

L

L

L

E

T

K

L

L

A

A

P

P

L

L

A

A

K

K

N

N

A

G

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

K

N

R

I

L

L

L

T

T

D

E

Q

T

V

V

binding N-[6-amino-1-(3-bromobenzyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl]-N-methylbenzenesulfonamide: T47 (= T42), L50 (≠ V45), Y118 (≠ F113), G120 (= G115), F123 (≠ L118), A256 (= A251), R264 (= R259), Q265 (= Q260)

4b4bA Pseudomonas aeruginosa rmla in complex with allosteric inhibitor (see paper)
74% identity, 98% coverage: 1:292/297 of query aligns to 6:297/298 of 4b4bA

query
sites
4b4bA

M

M

A

K

R

R

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

Y

H

P

P

I

A

T

T

H

L

V

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S

S

T

T

L

L

M

M

V

L

A

A

G

G

I

I

R

R

D

E

V

I

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

T

T

P

P

R

R

F

F

E

Q

A

Q

M

L

L

L

G

G

D

D

G

G

S

S

Q

N

W

W

G

G

M

L

N

D

I

L

Q

Q

Y

Y

A

A

V

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

I

L

I

I

G

G

R

E

E

S

F

F

V

I

G

G

N

N

D

D

P

L

S

S

A

A

L

L

I

V

L

L

G

G

D

D

N

N

I

L

F

Y

Y

Y

G

G

H

H

D

D

L

F

A

H

K

E

Q

L

L

L

E

G

R

S

A

A

N

S

D

Q

Q

R

A

Q

D

T

G

G

A

A

T

S

V

V

F

F

A

A

Y

Y

H

H

V

V

H

L

D

D

P

P

E

E

R

R

Y

Y

G

G

V

V

E

E

F

F

D

D

K

Q

Q

G

F

G

R

K

A

A

L

I

S

S

I

L

E

E

K

K

P

P

A

L

R

E

P

P

R

K

S

S

N

N

Y

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

K

Q

Q

Q

V

V

C

V

D

D

I

I

A

A

A

R

E

D

I

L

R

K

P

P

S

S

P

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

S

R

H

A

Y

Y

L

L

A

E

N

R

A

G

A

Q

L

L

N

S

V

V

E

E

I

I

M

M

G

G

R

R

G

G

Y

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

I

L

E

E

A

A

A

G

T

Q

F

F

I

I

A

A

T

T

L

L

Q

E

K

N

R

R

Q

Q

G

G

L

L

V

K

V
|
V

A
|
A

C

C

P

P

E

E

E
|
E

I
|
I

A

A

Y

Y

R
|
R

Q

Q

Q

K

W

W

I

I

G

D

A

A

E

A

Q

Q

L

L

L

E

T

K

L

L

A

A

P

P

L

L

A

A

K

K

N

N

A

G

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

K

N

R

I

L

L

L

T

T

D

E

Q

T

V

V

binding 1-(2-phenylethyl)pyrimidine-2,4,6(1H,3H,5H)-trione: V255 (= V250), A256 (= A251), E260 (= E255), I261 (= I256), R264 (= R259)

4b4mA Pseudomonas aeruginosa rmla in complex with allosteric inhibitor (see paper)
74% identity, 98% coverage: 1:292/297 of query aligns to 4:295/296 of 4b4mA

query
sites
4b4mA

M

M

A

K

R

R

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

Y

H

P

P

I

A

T

T

H

L

V

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S
|
S

T
|
T

L

L

M

M

V
x
L

A

A

G

G

I

I

R

R

D

E

V

I

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

T

T

P

P

R

R

F

F

E

Q

A

Q

M

L

L

L

G

G

D

D

G

G

S

S

Q

N

W

W

G

G

M

L

N

D

I

L

Q

Q

Y

Y

A

A

V

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

I

L

I

I

G

G

R

E

E

S

F

F

V

I

G

G

N

N

D

D

P

L

S

S

A

A

L

L

I

V

L

L

G

G

D

D

N

N

I

L

F
x
Y

Y

Y

G
|
G

H

H

D

D

L

F

A

H

K

E

Q

L

L

L

E

G

R

S

A

A

N

S

D

Q

Q

R

A

Q

D

T

G

G

A

A

T

S

V

V

F

F

A

A

Y

Y

H

H

V

V

H

L

D

D

P

P

E

E

R

R

Y

Y

G

G

V

V

E

E

F

F

D

D

K

Q

Q

G

F

G

R

K

A

A

L

I

S

S

I

L

E

E

K

K

P

P

A

L

R

E

P

P

R

K

S

S

N

N

Y

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

K

Q

Q

Q

V

V

C

V

D

D

I

I

A

A

A

R

E

D

I

L

R

K

P

P

S

S

P

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

S

R

H

A

Y

Y

L

L

A

E

N

R

A

G

A

Q

L

L

N

S

V

V

E

E

I

I

M

M

G

G

R

R

G

G

Y

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

I

L

E

E

A

A

A

G

T

Q

F

F

I

I

A

A

T

T

L

L

Q

E

K

N

R

R

Q

Q

G

G

L

L

V

K

V
|
V

A
|
A

C

C

P

P

E

E

E
|
E

I
|
I

A

A

Y

Y

R
|
R

Q

Q

Q

K

W

W

I

I

G

D

A

A

E

A

Q

Q

L

L

L

E

T

K

L

L

A

A

P

P

L

L

A

A

K

K

N

N

A

G

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

K

N

R

I

L

L

L

T

T

D

E

Q

T

V

V

binding N-(6-amino-1-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-4-fluoro-N-methylbenzenesulfonamide: S44 (= S41), T45 (= T42), L48 (≠ V45), Y116 (≠ F113), G118 (= G115), V253 (= V250), A254 (= A251), E258 (= E255), I259 (= I256), R262 (= R259)

5fu8A Pseudomonas aeruginosa rmla in complex with allosteric inhibitor
74% identity, 98% coverage: 1:292/297 of query aligns to 5:296/297 of 5fu8A

query
sites
5fu8A

M

M

A

K

R

R

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

Y

H

P

P

I

A

T

T

H

L

V

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S
|
S

T

T

L

L

M

M

V
x
L

A

A

G

G

I

I

R

R

D

E

V

I

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

T

T

P

P

R

R

F

F

E

Q

A

Q

M

L

L

L

G

G

D

D

G

G

S

S

Q

N

W

W

G

G

M

L

N

D

I

L

Q

Q

Y

Y

A

A

V

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

I

L

I

I

G

G

R

E

E

S

F

F

V

I

G

G

N

N

D

D

P

L

S

S

A

A

L

L

I

V

L

L

G

G

D

D

N

N

I

L

F
x
Y

Y
|
Y

G
|
G

H

H

D

D

L

F

A
x
H

K

E

Q

L

L

L

E

G

R

S

A

A

N

S

D

Q

Q

R

A

Q

D

T

G

G

A

A

T

S

V

V

F

F

A

A

Y

Y

H

H

V

V

H

L

D

D

P

P

E

E

R

R

Y

Y

G

G

V

V

E

E

F

F

D

D

K

Q

Q

G

F

G

R

K

A

A

L

I

S

S

I

L

E

E

K

K

P

P

A

L

R

E

P

P

R

K

S

S

N

N

Y

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

K

Q

Q

Q

V

V

C

V

D

D

I

I

A

A

A

R

E

D

I

L

R

K

P

P

S

S

P

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

S

R

H

A

Y

Y

L

L

A

E

N

R

A

G

A

Q

L

L

N

S

V

V

E

E

I

I

M

M

G

G

R

R

G

G

Y

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

I

L

E

E

A

A

A

G

T

Q

F

F

I

I

A

A

T

T

L

L

Q

E

K

N

R

R

Q

Q

G

G

L

L

V

K

V
|
V

A

A

C

C

P

P

E

E

E
|
E

I

I

A

A

Y

Y

R
|
R

Q
|
Q

Q

K

W

W

I

I

G

D

A

A

E

A

Q

Q

L

L

L

E

T

K

L

L

A

A

P

P

L

L

A

A

K

K

N

N

A

G

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

K

N

R

I

L

L

L

T

T

D

E

Q

T

V

V

binding N-(6-amino-1-(4-bromo-3-methylbenzyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylbenzenesulfonamide: S45 (= S41), L49 (≠ V45), Y117 (≠ F113), Y118 (= Y114), G119 (= G115), H123 (≠ A119), V254 (= V250), E259 (= E255), R263 (= R259), Q264 (= Q260)

4b2wA Pseudomonas aeruginosa rmla in complex with allosteric inhibitor (see paper)
74% identity, 98% coverage: 1:292/297 of query aligns to 5:296/297 of 4b2wA

query
sites
4b2wA

M

M

A

K

R

R

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

Y

H

P

P

I

A

T

T

H

L

V

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S
|
S

T

T

L

L

M

M

V
x
L

A

A

G

G

I

I

R

R

D

E

V

I

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

T

T

P

P

R

R

F

F

E

Q

A

Q

M

L

L

L

G

G

D

D

G

G

S

S

Q

N

W

W

G

G

M

L

N

D

I

L

Q

Q

Y

Y

A

A

V

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

I

L

I

I

G

G

R

E

E

S

F

F

V

I

G

G

N

N

D

D

P

L

S

S

A

A

L

L

I

V

L

L

G

G

D

D

N

N

I

L

F

Y

Y

Y

G

G

H

H

D

D

L

F

A

H

K

E

Q

L

L

L

E

G

R

S

A

A

N

S

D

Q

Q

R

A

Q

D

T

G

G

A

A

T

S

V

V

F

F

A

A

Y

Y

H

H

V

V

H

L

D

D

P

P

E

E

R

R

Y

Y

G

G

V

V

E

E

F

F

D

D

K

Q

Q

G

F

G

R

K

A

A

L

I

S

S

I

L

E

E

K

K

P

P

A

L

R

E

P

P

R

K

S

S

N

N

Y

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

K

Q

Q

Q

V

V

C

V

D

D

I

I

A

A

A

R

E

D

I

L

R

K

P

P

S

S

P

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

S

R

H

A

Y

Y

L

L

A

E

N

R

A

G

A

Q

L

L

N

S

V

V

E

E

I

I

M

M

G

G

R

R

G

G

Y

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

I

L

E

E

A

A

A

G

T

Q

F

F

I

I

A

A

T

T

L

L

Q

E

K

N

R

R

Q

Q

G

G

L

L

V

K

V

V

A

A

C

C

P

P

E

E

E
|
E

I
|
I

A

A

Y

Y

R
|
R

Q

Q

Q

K

W

W

I

I

G

D

A

A

E

A

Q

Q

L

L

L

E

T

K

L

L

A

A

P

P

L

L

A

A

K

K

N

N

A

G

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

K

N

R

I

L

L

L

T

T

D

E

Q

T

V

V

binding N-(6-amino-1-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)benzamide: S45 (= S41), L49 (≠ V45), E259 (= E255), I260 (= I256), R263 (= R259)

4asjA Pseudomonas aeruginosa rmla in complex with allosteric inhibitor (see paper)
74% identity, 98% coverage: 3:292/297 of query aligns to 2:291/292 of 4asjA

query
sites
4asjA

R

R

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

Y

H

P

P

I

A

T

T

H

L

V

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S
|
S

T

T

L

L

M

M

V
x
L

A

A

G

G

I

I

R

R

D

E

V

I

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

T

T

P

P

R

R

F

F

E

Q

A

Q

M

L

L

L

G

G

D

D

G

G

S

S

Q

N

W

W

G

G

M

L

N

D

I

L

Q

Q

Y

Y

A

A

V

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

I

L

I

I

G

G

R

E

E

S

F

F

V

I

G

G

N

N

D

D

P

L

S

S

A

A

L

L

I

V

L

L

G

G

D

D

N

N

I

L

F
x
Y

Y

Y

G
|
G

H

H

D

D

L
x
F

A

H

K

E

Q

L

L

L

E

G

R

S

A

A

N

S

D

Q

Q

R

A

Q

D

T

G

G

A

A

T

S

V

V

F

F

A

A

Y

Y

H

H

V

V

H

L

D

D

P

P

E

E

R

R

Y

Y

G

G

V

V

E

E

F

F

D

D

K

Q

Q

G

F

G

R

K

A
|
A

L

I

S

S

I

L

E

E

K

K

P

P

A

L

R

E

P

P

R

K

S

S

N

N

Y

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

K

Q

Q

Q

V

V

C

V

D

D

I

I

A

A

A

R

E

D

I

L

R

K

P

P

S

S

P

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

S

R

H

A

Y

Y

L

L

A

E

N

R

A

G

A

Q

L

L

N

S

V
|
V

E

E

I

I

M

M

G

G

R

R

G

G

Y

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

I

L

E

E

A

A

A

G

T

Q

F

F

I

I

A

A

T

T

L

L

Q

E

K

N

R

R

Q

Q

G

G

L

L

V

K

V
|
V

A

A

C

C

P

P

E

E

E
|
E

I

I

A

A

Y

Y

R

R

Q

Q

Q

K

W

W

I

I

G

D

A

A

E

A

Q

Q

L

L

L

E

T

K

L

L

A

A

P

P

L

L

A

A

K

K

N

N

A

G

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

K

N

R

I

L

L

L

T

T

D

E

Q

T

V

V

binding N-(6-amino-1-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylbenzenesulfonamide: S40 (= S41), L44 (≠ V45), Y112 (≠ F113), G114 (= G115), F117 (≠ L118), V249 (= V250), E254 (= E255)
binding phosphate ion: A155 (= A156), V213 (= V214)

1g3lA The structural basis of the catalytic mechanism and regulation of glucose-1-phosphate thymidylyltransferase (rmla). Tdp-l-rhamnose complex. (see paper)
74% identity, 98% coverage: 3:292/297 of query aligns to 2:291/292 of 1g3lA

query
sites
1g3lA

R

R

K

K

G

G

I

I

L
|
L

A

A

G
|
G

S

S

G

G

T

T

R

R

L

L

Y

H

P

P

I

A

T

T

H

L

V

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S

S

T

T

L

L

M

M

V

L

A

A

G

G

I

I

R

R

D

E

V

I

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

T

T

P

P

R

R

F

F

E

Q

A

Q

M

L

L

L

G

G

D

D

G

G

S

S

Q

N

W

W

G

G

M

L

N

D

I

L

Q

Q

Y

Y

A

A

V

V

Q
|
Q

P

P

S

S

P
|
P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

I

L

I

I

G

G

R

E

E

S

F

F

V

I

G

G

N

N

D

D

P

L

S

S

A

A

L

L

I

V

L

L

G

G

D
|
D

N

N

I

L

F

Y

Y
|
Y

G
|
G

H
|
H

D
|
D

L
x
F

A
x
H

K

E

Q

L

L

L

E

G

R

S

A

A

N

S

D

Q

Q

R

A

Q

D

T

G

G

A

A

T

S

V

V

F

F

A

A

Y

Y

H

H

V

V

H

L

D

D

P

P

E

E

R

R

Y
|
Y

G
|
G

V

V

E

E

F

F

D

D

K

Q

Q

G

F

G

R

K

A

A

L

I

S

S

I

L

E

E

E
|
E

K
|
K

P

P

A

L

R

E

P

P

R

K

S

S

N

N

Y

Y

A

A

V
|
V

T
|
T

G
|
G

L

L

Y
|
Y

F

F

Y

Y

D

D

K

Q

Q

Q

V

V

C

V

D

D

I

I

A

A

A

R

E

D

I

L

R

K

P

P

S

S

P

P

R
|
R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

S

R

H

A

Y

Y

L

L

A

E

N

R

A

G

A

Q

L

L

N

S

V

V

E

E

I

I

M

M

G
|
G

R
|
R

G
|
G

Y

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

I

L

E

E

A

A

A

G

T

Q

F

F

I

I

A

A

T

T

L

L

Q

E

K

N

R

R

Q

Q

G

G

L

L

V

K

V

V

A

A

C

C

P

P

E

E

E
|
E

I
|
I

A

A

Y

Y

R
|
R

Q

Q

Q

K

W

W

I

I

G

D

A

A

E

A

Q

Q

L

L

L

E

T

K

L

L

A

A

P

P

L

L

A

A

K

K

N

N

A

G

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

K

N

R

I

L

L

L

T

T

D

E

Q

T

V

V

binding 2'-deoxy-thymidine-beta-l-rhamnose: L7 (= L8), G9 (= G10), G10 (= G11), Q81 (= Q82), P84 (= P85), D109 (= D110), Y113 (= Y114), G114 (= G115), H115 (= H116), D116 (= D117), F117 (≠ L118), H118 (≠ A119), Y144 (= Y145), G145 (= G146), E160 (= E161), K161 (= K162), V171 (= V172), T172 (= T173), G173 (= G174), Y175 (= Y176), R193 (= R194), G217 (= G218), R218 (= R219), G219 (= G220), E254 (= E255), I255 (= I256), R258 (= R259)

1g2vA The structural basis of the catalytic mechanism and regulation of glucose-1-phosphate thymidylyltransferase (rmla). Ttp complex. (see paper)
74% identity, 98% coverage: 3:292/297 of query aligns to 2:291/292 of 1g2vA

query
sites
1g2vA

R

R

K

K

G

G

I

I

L
|
L

A
|
A

G
|
G

S

S

G
|
G

T
|
T

R
|
R

L

L

Y

H

P

P

I

A

T

T

H

L

V

A

V

I

S

S

K

K

Q
|
Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S

S

T

T

L

L

M

M

V

L

A

A

G

G

I

I

R

R

D

E

V

I

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

T

T

P

P

R

R

F

F

E

Q

A

Q

M

L

L

L

G

G

D

D

G

G

S

S

Q

N

W

W

G

G

M

L

N

D

I

L

Q

Q

Y

Y

A

A

V

V

Q
|
Q

P

P

S

S

P
|
P

D

D

G

G

L
|
L

A

A

Q

Q

A

A

F

F

I

L

I

I

G

G

R

E

E

S

F

F

V

I

G

G

N

N

D

D

P

L

S

S

A

A

L

L

I

V

L

L

G

G

D
|
D

N

N

I

L

F

Y

Y
|
Y

G
|
G

H
|
H

D
|
D

L
x
F

A
x
H

K

E

Q

L

L

L

E

G

R

S

A

A

N

S

D

Q

Q

R

A

Q

D

T

G

G

A

A

T

S

V

V

F

F

A

A

Y

Y

H

H

V

V

H

L

D

D

P

P

E

E

R

R

Y

Y

G

G

V

V

E

E

F

F

D

D

K

Q

Q

G

F

G

R

K

A

A

L

I

S

S

I

L

E

E

K

K

P

P

A

L

R

E

P

P

R

K

S

S

N

N

Y

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

K

Q

Q

Q

V

V

C

V

D

D

I

I

A

A

A

R

E

D

I

L

R

K

P

P

S

S

P

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

S

R

H

A

Y

Y

L

L

A

E

N

R

A

G

A

Q

L

L

N

S

V

V

E

E

I

I

M

M

G
|
G

R
|
R

G
|
G

Y

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

I

L

E

E

A

A

A

G

T

Q

F

F

I

I

A

A

T

T

L

L

Q

E

K

N

R

R

Q

Q

G

G

L

L

V

K

V

V

A

A

C

C

P

P

E

E

E
|
E

I
|
I

A

A

Y

Y

R

R

Q

Q

Q

K

W

W

I

I

G

D

A

A

E

A

Q

Q

L

L

L

E

T

K

L

L

A

A

P

P

L

L

A

A

K

K

N

N

A

G

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

K

N

R

I

L

L

L

T

T

D

E

Q

T

V

V

binding thymidine-5'-triphosphate: L7 (= L8), A8 (= A9), G9 (= G10), G10 (= G11), G12 (= G13), T13 (= T14), R14 (= R15), Q25 (= Q26), Q81 (= Q82), P84 (= P85), L87 (= L88), D109 (= D110), Y113 (= Y114), G114 (= G115), H115 (= H116), D116 (= D117), F117 (≠ L118), H118 (≠ A119), G217 (= G218), R218 (= R219), G219 (= G220), E254 (= E255), I255 (= I256)

1g1lA The structural basis of the catalytic mechanism and regulation of glucose-1-phosphate thymidylyltransferase (rmla). Tdp-glucose complex. (see paper)
74% identity, 98% coverage: 3:292/297 of query aligns to 2:291/292 of 1g1lA

query
sites
1g1lA

R

R

K

K

G

G

I

I

L
|
L

A

A

G
|
G

S

S

G

G

T

T

R

R

L

L

Y

H

P

P

I

A

T

T

H

L

V

A

V

I

S

S

K

K

Q
|
Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S

S

T

T

L

L

M

M

V

L

A

A

G

G

I

I

R

R

D

E

V

I

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

T

T

P

P

R

R

F

F

E

Q

A

Q

M

L

L

L

G

G

D

D

G

G

S

S

Q

N

W

W

G

G

M

L

N

D

I

L

Q

Q

Y

Y

A

A

V

V

Q
|
Q

P

P

S

S

P
|
P

D

D

G
|
G

L
|
L

A

A

Q

Q

A

A

F

F

I

L

I

I

G

G

R

E

E

S

F

F

V

I

G

G

N

N

D

D

P

L

S

S

A

A

L

L

I

V

L
|
L

G

G

D
|
D

N

N

I

L

F

Y

Y
|
Y

G
|
G

H
|
H

D
|
D

L
x
F

A
x
H

K
x
E

Q

L

L

L

E

G

R

S

A

A

N

S

D

Q

Q

R

A

Q

D

T

G

G

A

A

T

S

V

V

F

F

A

A

Y

Y

H

H

V

V

H

L

D

D

P

P

E

E

R

R

Y
|
Y

G
|
G

V

V

E

E

F

F

D

D

K

Q

Q

G

F

G

R

K

A

A

L

I

S

S

I

L

E

E

E
|
E

K
|
K

P

P

A

L

R

E

P

P

R

K

S

S

N

N

Y

Y

A

A

V
|
V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

K

Q

Q

Q

V

V

C

V

D

D

I

I

A

A

A

R

E

D

I

L

R

K

P

P

S

S

P

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

S

R

H

A

Y

Y

L

L

A

E

N

R

A

G

A

Q

L

L

N

S

V

V

E

E

I

I

M

M

G
|
G

R
|
R

G
|
G

Y

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

I

L

E

E

A

A

A

G

T

Q

F

F

I

I

A

A

T

T

L

L

Q

E

K

N

R

R

Q

Q

G

G

L

L

V

K

V
|
V

A
|
A

C

C

P

P

E

E

E
|
E

I
|
I

A

A

Y

Y

R
|
R

Q

Q

Q

K

W

W

I

I

G

D

A

A

E

A

Q

Q

L

L

L

E

T

K

L

L

A

A

P

P

L

L

A

A

K

K

N

N

A

G

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

K

N

R

I

L

L

L

T

T

D

E

Q

T

V

V

binding 2'deoxy-thymidine-5'-diphospho-alpha-d-glucose: L7 (= L8), G9 (= G10), G10 (= G11), Q25 (= Q26), Q81 (= Q82), P84 (= P85), G86 (= G87), L87 (= L88), L107 (= L108), D109 (= D110), Y113 (= Y114), G114 (= G115), H115 (= H116), D116 (= D117), F117 (≠ L118), H118 (≠ A119), E119 (≠ K120), Y144 (= Y145), G145 (= G146), E160 (= E161), K161 (= K162), V171 (= V172), G217 (= G218), R218 (= R219), G219 (= G220), V249 (= V250), A250 (= A251), E254 (= E255), I255 (= I256), R258 (= R259)

Sites not aligning to the query:

binding 2'deoxy-thymidine-5'-diphospho-alpha-d-glucose: 292

1g0rA The structural basis of the catalytic mechanism and regulation of glucose-1-phosphate thymidylyltransferase (rmla). Thymidine/glucose- 1-phosphate complex. (see paper)
74% identity, 98% coverage: 3:292/297 of query aligns to 2:291/292 of 1g0rA

query
sites
1g0rA

R

R

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

Y

H

P

P

I

A

T

T

H

L

V

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S

S

T

T

L

L

M

M

V

L

A

A

G

G

I

I

R

R

D

E

V

I

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

T

T

P

P

R

R

F

F

E

Q

A

Q

M

L

L

L

G

G

D

D

G

G

S

S

Q

N

W

W

G

G

M

L

N

D

I

L

Q

Q

Y

Y

A

A

V

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L
|
L

A

A

Q

Q

A

A

F

F

I

L

I

I

G

G

R

E

E

S

F

F

V

I

G

G

N

N

D

D

P

L

S

S

A

A

L

L

I

V

L

L

G

G

D

D

N

N

I

L

F

Y

Y

Y

G

G

H

H

D

D

L

F

A

H

K

E

Q

L

L

L

E

G

R

S

A

A

N

S

D

Q

Q

R

A

Q

D

T

G

G

A

A

T

S

V

V

F

F

A

A

Y

Y

H

H

V

V

H

L

D

D

P

P

E

E

R

R

Y
|
Y

G
|
G

V

V

E

E

F

F

D

D

K

Q

Q

G

F

G

R

K

A

A

L

I

S

S

I

L

E

E

E
|
E

K
|
K

P

P

A

L

R

E

P

P

R

K

S

S

N

N

Y

Y

A

A

V
|
V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

K

Q

Q

Q

V

V

C

V

D

D

I

I

A

A

A

R

E

D

I

L

R

K

P

P

S

S

P

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

S

R

H

A

Y

Y

L

L

A

E

N

R

A

G

A

Q

L

L

N

S

V

V

E

E

I

I

M

M

G

G

R

R

G

G

Y

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

I

L

E

E

A

A

A

G

T

Q

F

F

I

I

A

A

T

T

L

L

Q

E

K

N

R

R

Q

Q

G

G

L

L

V

K

V

V

A

A

C

C

P

P

E

E

I

I

A

A

Y

Y

R

R

Q

Q

Q

K

W

W

I

I

G

D

A

A

E

A

Q

Q

L

L

L

E

T

K

L

L

A

A

P

P

L

L

A

A

K

K

N

N

A

G

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

K

N

R

I

L

L

L

T

T

D

E

Q

T

V

V

binding 1-O-phosphono-alpha-D-glucopyranose: L87 (= L88), Y144 (= Y145), G145 (= G146), E160 (= E161), K161 (= K162), V171 (= V172)

1fxoA The structural basis of the catalytic mechanism and regulation of glucose-1-phosphate thymidylyltransferase (rmla). Tmp complex. (see paper)
74% identity, 98% coverage: 3:292/297 of query aligns to 2:291/292 of 1fxoA

query
sites
1fxoA

R

R

K

K

G

G

I

I

L
|
L

A

A

G
|
G

S

S

G

G

T

T

R

R

L

L

Y

H

P

P

I

A

T

T

H

L

V

A

V

I

S

S

K

K

Q
|
Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S

S

T

T

L

L

M

M

V

L

A

A

G

G

I

I

R

R

D

E

V

I

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

T

T

P

P

R

R

F

F

E

Q

A

Q

M

L

L

L

G

G

D

D

G

G

S

S

Q

N

W

W

G

G

M

L

N

D

I

L

Q

Q

Y

Y

A

A

V

V

Q
|
Q

P

P

S

S

P
|
P

D

D

G
|
G

L
|
L

A

A

Q

Q

A

A

F

F

I

L

I

I

G

G

R

E

E

S

F

F

V

I

G

G

N

N

D

D

P

L

S

S

A

A

L

L

I

V

L

L

G

G

D
|
D

N

N

I

L

F

Y

Y
|
Y

G
|
G

H
|
H

D
|
D

L

F

A

H

K

E

Q

L

L

L

E

G

R

S

A

A

N

S

D

Q

Q

R

A

Q

D

T

G

G

A

A

T

S

V

V

F

F

A

A

Y

Y

H

H

V

V

H

L

D

D

P

P

E

E

R

R

Y

Y

G

G

V

V

E

E

F

F

D

D

K

Q

Q

G

F

G

R

K

A

A

L

I

S

S

I

L

E

E

K

K

P

P

A

L

R

E

P

P

R

K

S

S

N

N

Y

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

K

Q

Q

Q

V

V

C

V

D

D

I

I

A

A

A

R

E

D

I

L

R

K

P

P

S

S

P

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

S

R

H

A

Y

Y

L

L

A

E

N

R

A

G

A

Q

L

L

N

S

V

V

E

E

I

I

M

M

G
|
G

R
|
R

G
|
G

Y

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

I

L

E

E

A

A

A

G

T

Q

F

F

I

I

A

A

T

T

L

L

Q

E

K

N

R

R

Q

Q

G

G

L

L

V

K

V
|
V

A

A

C

C

P

P

E

E

E
|
E

I
|
I

A

A

Y

Y

R
|
R

Q

Q

Q

K

W

W

I

I

G

D

A

A

E

A

Q

Q

L

L

L

E

T

K

L

L

A

A

P

P

L

L

A

A

K

K

N

N

A

G

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

K

N

R

I

L

L

L

T

T

D

E

Q

T

V

V

binding thymidine-5'-phosphate: L7 (= L8), G9 (= G10), G10 (= G11), Q25 (= Q26), Q81 (= Q82), P84 (= P85), G86 (= G87), L87 (= L88), D109 (= D110), Y113 (= Y114), G114 (= G115), H115 (= H116), D116 (= D117), G217 (= G218), R218 (= R219), G219 (= G220), V249 (= V250), E254 (= E255), I255 (= I256), R258 (= R259)

5fyeA Pseudomonas aeruginosa rmla in complex with allosteric inhibitor
74% identity, 98% coverage: 3:292/297 of query aligns to 6:295/296 of 5fyeA

query
sites
5fyeA

R

R

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

Y

H

P

P

I

A

T

T

H

L

V

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

S
|
S

T

T

L

L

M

M

V
x
L

A

A

G

G

I

I

R

R

D

E

V

I

L

L

I

I

S

S

T

T

P

P

Q

Q

D

D

T

T

P

P

R

R

F

F

E

Q

A

Q

M

L

L

L

G

G

D

D

G

G

S

S

Q

N

W

W

G

G

M

L

N

D

I

L

Q

Q

Y

Y

A

A

V

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

I

L

I

I

G

G

R

E

E

S

F

F

V

I

G

G

N

N

D

D

P

L

S

S

A

A

L

L

I

V

L

L

G

G

D

D

N

N

I

L

F
x
Y

Y

Y

G
|
G

H

H

D

D

L

F

A

H

K

E

Q

L

L

L

E

G

R

S

A

A

N

S

D

Q

Q

R

A

Q

D

T

G

G

A

A

T

S

V

V

F

F

A

A

Y

Y

H

H

V

V

H

L

D

D

P

P

E

E

R

R

Y

Y

G

G

V

V

E

E

F

F

D

D

K

Q

Q

G

F

G

R

K

A

A

L

I

S

S

I

L

E

E

K

K

P

P

A

L

R

E

P

P

R

K

S

S

N

N

Y

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

K

Q

Q

Q

V

V

C

V

D

D

I

I

A

A

A

R

E

D

I

L

R

K

P

P

S

S

P

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

V

V

N

N

S

R

H

A

Y

Y

L

L

A

E

N

R

A

G

A

Q

L

L

N

S

V

V

E

E

I

I

M

M

G

G

R

R

G

G

Y

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

D

D

S

S

L

L

I

L

E

E

A

A

A

G

T

Q

F

F

I

I

A

A

T

T

L

L

Q

E

K

N

R

R

Q

Q

G

G

L

L

V

K

V
|
V

A
|
A

C

C

P

P

E

E

E
|
E

I

I

A

A

Y

Y

R
|
R

Q

Q

Q

K

W

W

I

I

G

D

A

A

E

A

Q

Q

L

L

L

E

T

K

L

L

A

A

P

P

L

L

A

A

K

K

N

N

A

G

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

K

N

R

I

L

L

L

T

T

D

E

Q

T

V

V

binding N-(6-Amino-1-(3-fluorobenzyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylbenzenesulfonamide: S44 (= S41), L48 (≠ V45), Y116 (≠ F113), G118 (= G115), V253 (= V250), A254 (= A251), E258 (= E255), R262 (= R259)

Query Sequence

>H281DRAFT_04823 FitnessBrowser__Burk376:H281DRAFT_04823
MARKGIILAGGSGTRLYPITHVVSKQLLPVYDKPMIYYPLSTLMVAGIRDVLIISTPQDT
PRFEAMLGDGSQWGMNIQYAVQPSPDGLAQAFIIGREFVGNDPSALILGDNIFYGHDLAK
QLERANDQADGATVFAYHVHDPERYGVVEFDKQFRALSIEEKPARPRSNYAVTGLYFYDK
QVCDIAAEIRPSPRGELEITDVNSHYLANAALNVEIMGRGYAWLDTGTHDSLIEAATFIA
TLQKRQGLVVACPEEIAYRQQWIGAEQLLTLAAPLAKNAYGQYLQNILTDQVAWPSK

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory