SitesBLAST
Comparing H281DRAFT_05174 FitnessBrowser__Burk376:H281DRAFT_05174 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 9 hits to proteins with known functional sites (download)
7e1sC Crystal structure of dehydrogenase/isomerase fabx from helicobacter pylori in complex with octanoyl-acp (see paper)
34% identity, 95% coverage: 6:381/396 of query aligns to 7:366/366 of 7e1sC
- binding S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] octanethioate: L104 (≠ M102), A129 (= A127), G130 (= G128), L131 (= L129), I150 (= I147), I151 (≠ L148), S152 (= S149), E178 (= E174), H185 (= H182), Y280 (≠ L283), I324 (= I338), L328 (= L342)
- binding flavin mononucleotide: G25 (= G23), G26 (= G24), M27 (= M25), G28 (= G26), N102 (= N100), E178 (= E174), S182 (≠ A179), G183 (= G180), G223 (= G225), G224 (= G226), M244 (≠ L246), A245 (≠ G247), T246 (= T248), L249 (≠ A251), F342 (= F356), T343 (≠ R357)
- binding iron/sulfur cluster: C303 (= C314), N306 (≠ E319), C307 (= C320), V308 (≠ L321), C311 (= C324), G314 (≠ R327), A317 (≠ V330), C323 (= C337), I324 (= I338)
- binding : L131 (= L129), T133 (≠ L131), N134 (≠ D132), K155 (≠ R152), I159 (≠ L156), K162 (= K159), R163 (= R160), R167 (≠ K164)
7e1sA Crystal structure of dehydrogenase/isomerase fabx from helicobacter pylori in complex with octanoyl-acp (see paper)
34% identity, 95% coverage: 6:381/396 of query aligns to 7:366/366 of 7e1sA
- binding S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] octanethioate: L104 (≠ M102), A129 (= A127), G130 (= G128), I150 (= I147), I151 (≠ L148), S152 (= S149), E178 (= E174), H185 (= H182), G187 (= G184), Y280 (≠ L283), L328 (= L342)
- binding flavin mononucleotide: G25 (= G23), G26 (= G24), M27 (= M25), G28 (= G26), N102 (= N100), L104 (≠ M102), E178 (= E174), G183 (= G180), G223 (= G225), G224 (= G226), Q243 (= Q245), M244 (≠ L246), A245 (≠ G247), T246 (= T248)
- binding iron/sulfur cluster: C303 (= C314), N306 (≠ E319), C307 (= C320), V308 (≠ L321), C311 (= C324), G314 (≠ R327), A317 (≠ V330), C323 (= C337), I324 (= I338)
7e1rA Crystal structure of dehydrogenase/isomerase fabx from helicobacter pylori in complex with holo-acp (see paper)
34% identity, 95% coverage: 6:381/396 of query aligns to 7:366/366 of 7e1rA
- binding flavin mononucleotide: G25 (= G23), G26 (= G24), M27 (= M25), G28 (= G26), N102 (= N100), L104 (≠ M102), E178 (= E174), G183 (= G180), G224 (= G226), Q243 (= Q245), M244 (≠ L246), A245 (≠ G247), T246 (= T248), F342 (= F356)
- binding N~3~-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-(2-sulfanylethyl)-beta-alaninamide: G128 (= G126), A129 (= A127), G130 (= G128), E178 (= E174), H185 (= H182), G187 (= G184)
- binding iron/sulfur cluster: C303 (= C314), N306 (≠ E319), C307 (= C320), V308 (≠ L321), C311 (= C324), G314 (≠ R327), A317 (≠ V330), C323 (= C337), I324 (= I338)
7e1qA Crystal structure of dehydrogenase/isomerase fabx from helicobacter pylori (see paper)
34% identity, 95% coverage: 6:381/396 of query aligns to 7:366/366 of 7e1qA
- binding flavin mononucleotide: G25 (= G23), G26 (= G24), M27 (= M25), G28 (= G26), N102 (= N100), L104 (≠ M102), E178 (= E174), S182 (≠ A179), G183 (= G180), G223 (= G225), G224 (= G226), M244 (≠ L246), A245 (≠ G247), T246 (= T248), F342 (= F356)
- binding iron/sulfur cluster: P277 (≠ V280), C303 (= C314), N306 (≠ E319), C307 (= C320), V308 (≠ L321), C311 (= C324), G314 (≠ R327), A317 (≠ V330), C323 (= C337), I324 (= I338)
7l00C Crystal structure of c. Difficile enoyl-acyl carrier protein reductase (fabk) in complex with an inhibitor
27% identity, 72% coverage: 19:302/396 of query aligns to 19:251/315 of 7l00C
- binding flavin mononucleotide: G23 (= G23), G24 (= G24), M25 (= M25), A26 (≠ G26), N74 (= N100), E142 (≠ H175), G146 (≠ A179), G147 (= G180), G174 (= G225), G175 (= G226), Q194 (= Q245), G196 (= G247), T197 (= T248)
- binding N-[6-(methylsulfonyl)-1,3-benzothiazol-2-yl]-2-[2-(1H-pyrrol-1-yl)-1,3-thiazol-4-yl]acetamide: A26 (≠ G26), M76 (= M102), G100 (= G126), A101 (= A127), G102 (= G128), V121 (≠ I147), P123 (≠ S149), H149 (= H182)
Sites not aligning to the query:
2z6iB Crystal structure of s. Pneumoniae enoyl-acyl carrier protein reductase (fabk) (see paper)
32% identity, 50% coverage: 99:295/396 of query aligns to 68:238/321 of 2z6iB
- binding calcium ion: E137 (= E174), H144 (= H182), A158 (= A207), I161 (≠ V210)
- binding flavin mononucleotide: N69 (= N100), E137 (= E174), A141 (= A179), G142 (= G180), G169 (= G225), G170 (= G226), G191 (= G247), T192 (= T248)
Sites not aligning to the query:
2z6jA Crystal structure of s. Pneumoniae enoyl-acyl carrier protein reductase (fabk) in complex with an inhibitor (see paper)
33% identity, 43% coverage: 99:269/396 of query aligns to 68:213/307 of 2z6jA
- binding calcium ion: A158 (= A207), I161 (≠ V210)
- binding flavin mononucleotide: N69 (= N100), E137 (= E174), A141 (= A179), G142 (= G180), G169 (= G225), G170 (= G226), G191 (= G247), T192 (= T248)
- binding 2-(4-(2-((3-(5-(pyridin-2-ylthio)thiazol-2-yl)ureido)methyl)-1h-imidazol-4-yl)phenoxy)acetic acid: M71 (= M102), L73 (≠ A104), A96 (= A127), G97 (= G128), V116 (≠ I147), P118 (≠ S149), L122 (= L156), E137 (= E174), H144 (= H182)
Sites not aligning to the query:
5gvhA Structure of fabk from thermotoga maritima (see paper)
26% identity, 71% coverage: 19:300/396 of query aligns to 15:245/311 of 5gvhA
- binding flavin mononucleotide: G19 (= G23), G20 (= G24), M21 (= M25), A22 (≠ G26), N70 (= N100), I72 (≠ M102), E138 (= E174), S142 (≠ A179), G143 (= G180), G170 (= G225), G171 (= G226), Q190 (= Q245), G192 (= G247), T193 (= T248)
Sites not aligning to the query:
5lsmA Crystal structure of nitronate monooxygenase (so_0471) from shewanella oneidensis mr-1
27% identity, 44% coverage: 161:336/396 of query aligns to 154:308/339 of 5lsmA
Sites not aligning to the query:
Query Sequence
>H281DRAFT_05174 FitnessBrowser__Burk376:H281DRAFT_05174
MLQSHSFSPLVIRGRSLLPIVQGGMGVGISAHRLAGSVAREGALGTIASIDLRHHHPDLV
ERCSRPADHATLEQANLTALAREIHAAKALSEGRGMIAVNVMKAVSAQADYVRVACESGA
DAIVMGAGLPLDLPEMTQGCDIALIPILSDSRGVALVLKRWMKKGRLPDAVVIEHPAHAG
GHLGVANIADMNDQRFDFVRILQELDAVFVSLGLDRKQVPLILAGGINSHEAVRALLNAG
ANGVQLGTPFAVTEEGDAHPNFKRVLADAAPEDIVEFVSVTGLPARAVKTPWLTRYLRHE
SRIRDKVGALKHACPTALECLSVCGWRDGVEKFGHFCIDTRLAAALRGDVANGLFFRGKE
ALPFGPAIRSVHDLLELLLTGVTRPAVAGRCAFSPG
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory