Comparing H281DRAFT_05521 H281DRAFT_05521 3-hydroxyacyl-CoA dehydrogenase to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4pzeA Crystal structure of (s)-3-hydroxybutyryl-coa dehydrogenase paah1 in complex with acetoacetyl-coa (see paper)
59% identity, 100% coverage: 2:283/283 of query aligns to 1:282/283 of 4pzeA
4pzdA Crystal structure of (s)-3-hydroxybutyryl-coa dehydrogenase paah1 in complex with NAD+ (see paper)
59% identity, 100% coverage: 2:283/283 of query aligns to 1:282/283 of 4pzdA
4kugA Crystal structure of 3-hydroxybutylryl-coa dehydrogenase with NAD from clostridium butyricum
50% identity, 99% coverage: 3:283/283 of query aligns to 1:281/282 of 4kugA
4kuhA Crystal structure of 3-hydroxybutylryl-coa dehydrogenase with acetoacetyl-coa from clostridium butyricum
50% identity, 99% coverage: 3:282/283 of query aligns to 1:280/280 of 4kuhA
6aa8E Crystal structure of (s)-3-hydroxybutyryl-coenzymea dehydrogenase from clostridium acetobutylicum complexed with NAD+ (see paper)
49% identity, 99% coverage: 4:283/283 of query aligns to 1:280/281 of 6aa8E
P9WNP7 3-hydroxybutyryl-CoA dehydrogenase; Beta-hydroxybutyryl-CoA dehydrogenase; BHBD; EC 1.1.1.157 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
41% identity, 99% coverage: 3:282/283 of query aligns to 5:286/286 of P9WNP7
P00348 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; HCDH; L-3-hydroxyacyl CoA dehydrogenase; Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase; Short-chain 3-hydroxyacyl-CoA dehydrogenase; EC 1.1.1.35 from Sus scrofa (Pig) (see paper)
38% identity, 99% coverage: 3:283/283 of query aligns to 27:314/314 of P00348
Q16836 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; HCDH; Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase; Short-chain 3-hydroxyacyl-CoA dehydrogenase; EC 1.1.1.35 from Homo sapiens (Human) (see 7 papers)
38% identity, 99% coverage: 3:283/283 of query aligns to 27:314/314 of Q16836
1f0yA L-3-hydroxyacyl-coa dehydrogenase complexed with acetoacetyl-coa and NAD+ (see paper)
38% identity, 99% coverage: 3:283/283 of query aligns to 4:291/291 of 1f0yA
1f17A L-3-hydroxyacyl-coa dehydrogenase complexed with nadh (see paper)
38% identity, 99% coverage: 3:283/283 of query aligns to 4:291/293 of 1f17A
1f12A L-3-hydroxyacyl-coa dehydrogenase complexed with 3-hydroxybutyryl-coa (see paper)
38% identity, 99% coverage: 3:283/283 of query aligns to 4:291/293 of 1f12A
8oqqA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-79
36% identity, 99% coverage: 3:283/283 of query aligns to 328:611/723 of 8oqqA
Sites not aligning to the query:
8oqpA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-76
36% identity, 99% coverage: 3:283/283 of query aligns to 328:611/723 of 8oqpA
Sites not aligning to the query:
8oqvA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-109
36% identity, 99% coverage: 3:283/283 of query aligns to 332:615/726 of 8oqvA
Sites not aligning to the query:
7o4uA Structure of the alpha subunit of mycobacterium tuberculosis beta- oxidation trifunctional enzyme in complex with oxidized nicotinamide adenine dinucleotide (see paper)
36% identity, 99% coverage: 3:283/283 of query aligns to 316:599/711 of 7o4uA
8oqsB Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-83
36% identity, 99% coverage: 3:283/283 of query aligns to 340:623/735 of 8oqsB
Sites not aligning to the query:
8oqoA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-49
36% identity, 99% coverage: 3:283/283 of query aligns to 333:616/727 of 8oqoA
Sites not aligning to the query:
8oqlA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-1
36% identity, 99% coverage: 3:283/283 of query aligns to 333:616/728 of 8oqlA
Sites not aligning to the query:
8oqrA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-80
36% identity, 99% coverage: 3:283/283 of query aligns to 334:617/728 of 8oqrA
Sites not aligning to the query:
8pf8A Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-72
36% identity, 99% coverage: 3:283/283 of query aligns to 334:617/729 of 8pf8A
Sites not aligning to the query:
>H281DRAFT_05521 H281DRAFT_05521 3-hydroxyacyl-CoA dehydrogenase
MTLKRVGIIGAGTMGNGIAQTVALAGIDVVLIDVSQAALASGFATMVTSLQRLTSKGILE
PALSEAALARIERSMDYASLRDAELVIEAATENVALKRDILKKVEAVVSSGAIIASNTSS
ISITEMAATLDDPSRFVGMHFFNPVPLLPLVEVIRGLQTAEDVANSVEQFARDLNKTPIS
VNNSPGFVVNRILVPMINEAFFVLAEGVASAAEIDAGLKLGANHPIGPLGLADLIGLDVC
LSVMDVLTNDLGDQKYRASPLLREMVAAGRLGRKSKQGVYSYS
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory