Comparing H281DRAFT_05849 FitnessBrowser__Burk376:H281DRAFT_05849 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1cjxA Crystal structure of pseudomonas fluorescens hppd (see paper)
57% identity, 98% coverage: 6:361/365 of query aligns to 1:351/352 of 1cjxA
7xntA Crystal structure of pfhppd-y13161 complex
57% identity, 96% coverage: 6:355/365 of query aligns to 4:341/341 of 7xntA
7x8eA Crystal structure of pfhppd-y13287 complex
56% identity, 97% coverage: 6:359/365 of query aligns to 3:341/341 of 7x8eA
7xntC Crystal structure of pfhppd-y13161 complex
54% identity, 95% coverage: 6:350/365 of query aligns to 3:320/320 of 7xntC
5hmqD Xylose isomerase-like tim barrel/4-hydroxyphenylpyruvate dioxygenase fusion protein
36% identity, 91% coverage: 13:343/365 of query aligns to 296:611/624 of 5hmqD
Sites not aligning to the query:
Q88JU3 3-dehydroshikimate dehydratase; DSD; EC 4.2.1.118 from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see paper)
35% identity, 91% coverage: 13:343/365 of query aligns to 294:614/635 of Q88JU3
Sites not aligning to the query:
1t47A Structure of fe2-hppd bound to ntbc (see paper)
39% identity, 77% coverage: 75:355/365 of query aligns to 81:360/362 of 1t47A
O52791 4-hydroxymandelate synthase; HMS; HmaS; 4-hydroxyphenylpyruvate dioxygenase II; EC 1.13.11.46 from Amycolatopsis orientalis (Nocardia orientalis) (see paper)
30% identity, 85% coverage: 45:355/365 of query aligns to 40:346/357 of O52791
2r5vA Hydroxymandelate synthase crystal structure (see paper)
30% identity, 85% coverage: 45:355/365 of query aligns to 39:344/346 of 2r5vA
P32755 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase; F Alloantigen; F protein; EC 1.13.11.27 from Rattus norvegicus (Rat) (see 2 papers)
30% identity, 85% coverage: 52:363/365 of query aligns to 63:383/393 of P32755
Sites not aligning to the query:
7yvvA Acmp1, r-4-hydroxymandelate synthase
31% identity, 82% coverage: 55:352/365 of query aligns to 48:331/335 of 7yvvA
5ec3A Structural insight into the catalyitc mechanism of human 4- hydroxyphenylpyruvate dioxygenase
29% identity, 84% coverage: 52:359/365 of query aligns to 55:371/376 of 5ec3A
8im2A Crystal structure of human hppd complexed with ntbc (see paper)
29% identity, 84% coverage: 52:359/365 of query aligns to 57:373/374 of 8im2A
3zgjB S221m v223f y359a mutant of 4-hydroxymandelate synthase from streptomyces coelicolor (see paper)
28% identity, 91% coverage: 20:352/365 of query aligns to 12:339/343 of 3zgjB
Q02110 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase; EC 1.13.11.27 from Sus scrofa (Pig) (see paper)
31% identity, 79% coverage: 75:363/365 of query aligns to 89:383/393 of Q02110
Sites not aligning to the query:
8im3A Crystal structure of human hppd complexed with compound a10 (see paper)
29% identity, 83% coverage: 52:355/365 of query aligns to 57:369/371 of 8im3A
1sqiA Structural basis for inhibitor selectivity revealed by crystal structures of plant and mammalian 4-hydroxyphenylpyruvate dioxygenases (see paper)
29% identity, 86% coverage: 32:346/365 of query aligns to 35:343/343 of 1sqiA
1sp8D 4-hydroxyphenylpyruvate dioxygenase (see paper)
29% identity, 76% coverage: 75:352/365 of query aligns to 98:386/393 of 1sp8D
P93836 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase; EC 1.13.11.27 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
30% identity, 78% coverage: 68:352/365 of query aligns to 128:432/445 of P93836
7x5rA Crystal structure of athppd-lancotrione complex
30% identity, 78% coverage: 68:352/365 of query aligns to 94:377/386 of 7x5rA
>H281DRAFT_05849 FitnessBrowser__Burk376:H281DRAFT_05849
MQVATWENPVGTDGFEFIEYTAPDPKALGKLFEQMGFTAVARHRHKDVTLYRQGDINFIV
NGEPDSFAQRFARLHGPSICAIAFRVQDAGKAYRQAVEKGAWGFDNKTGPMELNIPAIKG
IGDSLIYFVDRWRGKNGAAPGSVGDIDIYDVDFEPIPGANPNPVGHGLTYIDHLTHNVHR
GRMQEWAEFYERLFNFREVRYFDIEGKVTGVKSKAMTSPCGKIRIPINEEGSETSGQIQE
YLDAYRGEGIQHIALGSNDIYRTVDGLRAANISLLDTIDTYYELVDRRVPNHGEPLDELR
KRKILIDGAPDDLLLQIFTENQIGPIFFEIIQRKGNQGFGEGNFKALFESIELDQIRRGV
VQDKA
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory