Comparing H281DRAFT_06606 H281DRAFT_06606 aconitase to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
Q9SIB9 Aconitate hydratase 3, mitochondrial; Aconitase 3; mACO1; Citrate hydro-lyase 3; EC 4.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
55% identity, 98% coverage: 19:902/905 of query aligns to 115:987/990 of Q9SIB9
Sites not aligning to the query:
P09339 Aconitate hydratase A; ACN; Aconitase; Aconitate/2-methylaconitate hydratase; Iron-responsive protein-like; IRP-like; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.- from Bacillus subtilis (strain 168) (see 2 papers)
53% identity, 99% coverage: 2:900/905 of query aligns to 9:903/909 of P09339
Sites not aligning to the query:
A0QX20 Aconitate hydratase A; ACN; Aconitase; (2R,3S)-2-methylisocitrate dehydratase; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase; Iron-responsive protein-like; IRP-like; Probable 2-methyl-cis-aconitate hydratase; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.99 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
50% identity, 96% coverage: 36:905/905 of query aligns to 39:941/943 of A0QX20
P21399 Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1; EC 4.2.1.3 from Homo sapiens (Human) (see 2 papers)
50% identity, 98% coverage: 20:902/905 of query aligns to 20:887/889 of P21399
2b3xA Structure of an orthorhombic crystal form of human cytosolic aconitase (irp1) (see paper)
50% identity, 98% coverage: 20:902/905 of query aligns to 19:886/888 of 2b3xA
3snpA Crystal structure analysis of iron regulatory protein 1 in complex with ferritin h ire RNA (see paper)
48% identity, 98% coverage: 12:902/905 of query aligns to 11:848/850 of 3snpA
P19414 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
28% identity, 86% coverage: 122:895/905 of query aligns to 117:769/778 of P19414
Sites not aligning to the query:
P39533 Homocitrate dehydratase, mitochondrial; Aconitase 2; EC 4.2.1.- from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
28% identity, 78% coverage: 127:828/905 of query aligns to 117:711/789 of P39533
8acnA Crystal structures of aconitase with isocitrate and nitroisocitrate bound (see paper)
27% identity, 95% coverage: 33:895/905 of query aligns to 15:744/753 of 8acnA
1fghA Complex with 4-hydroxy-trans-aconitate (see paper)
27% identity, 95% coverage: 33:895/905 of query aligns to 15:744/753 of 1fghA
1amjA Steric and conformational features of the aconitase mechanism (see paper)
27% identity, 95% coverage: 33:895/905 of query aligns to 15:744/753 of 1amjA
1amiA Steric and conformational features of the aconitase mechanism (see paper)
27% identity, 95% coverage: 33:895/905 of query aligns to 15:744/753 of 1amiA
1acoA Crystal structure of aconitase with transaconitate bound (see paper)
27% identity, 95% coverage: 33:895/905 of query aligns to 15:744/753 of 1acoA
1nisA Crystal structure of aconitase with trans-aconitate and nitrocitrate bound (see paper)
27% identity, 95% coverage: 33:895/905 of query aligns to 15:744/753 of 1nisA
P20004 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Bos taurus (Bovine) (see 2 papers)
28% identity, 95% coverage: 33:895/905 of query aligns to 43:772/780 of P20004
5acnA Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal (see paper)
27% identity, 95% coverage: 33:895/905 of query aligns to 16:745/754 of 5acnA
P16276 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Sus scrofa (Pig) (see 3 papers)
27% identity, 95% coverage: 33:895/905 of query aligns to 43:772/781 of P16276
Sites not aligning to the query:
1b0kA S642a:fluorocitrate complex of aconitase (see paper)
27% identity, 95% coverage: 33:895/905 of query aligns to 15:744/753 of 1b0kA
4kp1A Crystal structure of ipm isomerase large subunit from methanococcus jannaschii (mj0499) (see paper)
25% identity, 41% coverage: 206:572/905 of query aligns to 115:423/423 of 4kp1A
Sites not aligning to the query:
O14289 3-isopropylmalate dehydratase; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase; EC 4.2.1.33 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
28% identity, 40% coverage: 207:569/905 of query aligns to 135:473/758 of O14289
Sites not aligning to the query:
>H281DRAFT_06606 H281DRAFT_06606 aconitase
MAHNLHKTLKEFDSGSGKGKFYSLPQLGKALNIKIDRLPVSIRIVLESVLRNYDGKKIAE
EHITQLANWKPTAPRVDEIPFVVSRVVLQDFTGVPLLADIAAMRGVAQRVGKNPKSIEPL
VPVDLVVDHSVQIDHFREKNALDLNMKLEFQRNNERYQFMKWGMQAFDTFKVVPPGVGIV
HQVNLEYLARGVHKKAEGADTVYYPDSLVGTDSHTTMINGIGVVGWGVGGIEAEAGMLGQ
PVYFLTPDVVGVNLKGKLREGVTATDLVLTITELLRKEKVVGKFVEFFGEGTRSLSLPDR
ATIGNMAPEYGATMGFFPVDEKTIDYFKGTGRTDAEISAFQNYFKAQNLFGIPKEGDIDF
TKVVTLDLGTVAPSLAGPKRPQDRIEIGNVKSTFSDLFSKPVAENGFAKKEADLDAQYTT
SNGVNVKNGDVLIAAITSCTNTSNPSVLLAAGLLAKKAVEAGLTVAPHIKTSLAPGSRIV
TEYLTKTGLLPYLDKLGFTLAAYGCTTCIGNAGDLTPELNEAITKNDIVAAAVLSGNRNF
EARIHPNIRANFLASPPLVVAYAIAGNITRDLMTEPVGKGKGGKDVYLGDIWPTSDEVND
LLKFALDADAFRKNYASLTKKGDLWSKIEGEEGQVYDWPKSTYIAEPPFFGNDFSMTPAD
SIAAVKNARALGIFGDSVTTDHISPAGSIKEDSPAGKWLKENGVQKADFNSYGSRRGNHD
VMMRGTFANVRIKNLMIPAKADGSRVEGGLTIHQPSGEQLSIYDAAMKYIDAGTPTIVFA
GEEYGTGSSRDWAAKGTQLLGVKAVVARSFERIHRSNLVGMGVLPLQFKGSDSVQSLGIT
GEETYDIEGLGADFKPQQEVTLVIRGKDGSEKRVPVLLRIDTPIEVDYYKHGGILPFVLR
SLLAA
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory