SitesBLAST – Find functional sites

 

SitesBLAST

Comparing HSERO_RS00315 HSERO_RS00315 amino acid ABC transporter permease to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 2 hits to proteins with known functional sites (download)

4ymwC Crystal structure of an amino acid abc transporter with histidines (see paper)
37% identity, 93% coverage: 12:243/250 of query aligns to 10:213/214 of 4ymwC

query
sites
4ymwC
E
 
K
Y
 
Y
L
 
T
P
 
P
L
 
L
F
 
F
V
 
I
E
 
S
G
 
G
T
 
L
W
 
I
M
 
M
T
 
T
L
 
L
K
 
K
A
 
L
A
 
T
I
 
F
I
 
L
C
 
A
V
 
V
I
 
T
A
 
I
G
 
G
T
 
V
C
 
L
W
 
M
G
 
G
L
 
L
V
 
F
L
 
I
G
 
A
V
 
L
G
 
M
R
 
K
L
 
M
A
 
S
E
 
S
A
 
I
R
 
K
H
 
-
G
 
-
F
 
-
W
 
-
K
 
-
Y
 
-
F
 
-
L
 
-
C
 
-
Y
 
-
C
 
-
V
 
-
Q
 
-
W
 
-
P
 
P
I
 
I
R
 
K
F
 
L
-
 
V
-
 
A
-
 
S
-
 
S
Y
 
Y
V
 
I
S
 
E
F
 
V
L
 
I
R
 
R
G
 
G
T
 
T
P
 
P
L
 
L
F
 
L
V
 
V
Q
 
Q
I
 
L
L
 
L
L
 
L
I
 
I
H
 
Y
F
 
N
A
 
G
L
 
L
M
 
M
P
 
Q
M
 
F
L
 
G
I
 
M
N
 
N
P
 
-
S
 
-
G
 
-
G
 
-
L
 
-
I
 
-
L
 
-
S
 
-
G
 
-
D
 
-
L
 
-
A
 
-
R
 
-
E
 
-
I
 
-
R
 
-
S
 
-
H
 
-
Y
 
I
G
 
P
A
 
A
F
 
F
A
 
T
S
 
A
A
 
G
V
 
V
L
 
S
A
 
A
I
 
L
T
 
A
L
 
I
N
|
N
S
 
S
G
 
S
A
 
A
Y
|
Y
V
 
V
S
 
A
E
 
E
I
 
I
F
 
I
R
 
R
A
 
A
G
 
G
I
 
I
Q
 
Q
S
 
A
I
 
V
D
 
D
R
 
P
G
 
G
Q
 
Q
S
 
N
E
 
E
A
 
A
S
 
A
R
 
R
S
 
S
L
 
L
G
 
G
M
 
M
S
 
T
Y
 
H
L
 
A
A
 
M
T
 
A
L
 
M
R
 
R
R
 
Y
V
 
V
V
 
I
L
 
I
P
 
P
Q
 
Q
A
 
A
F
 
I
R
 
K
R
 
N
M
 
I
L
 
L
P
 
P
P
 
A
L
 
L
G
 
G
N
 
N
N
x
E
A
 
F
I
 
I
A
 
V
I
 
M
V
 
L
K
 
K
D
x
E
S
 
S
S
 
A
L
 
I
A
 
V
S
 
S
A
 
V
I
 
I
G
 
G
L
 
F
A
 
A
E
 
D
L
 
L
A
 
T
Y
 
R
A
 
Q
A
 
A
R
 
D
T
 
I
V
 
I
S
 
Q
G
 
S
A
 
V
Y
 
T
A
 
Y
R
 
R
Y
 
Y
W
 
F
E
 
E
P
 
P
Y
 
Y
L
 
I
T
 
I
I
 
I
S
 
A
V
 
A
I
 
I
Y
 
Y
W
 
F
L
 
V
I
 
M
T
 
T
L
 
L
A
 
T
L
 
F
S
 
S
A
 
K
L
 
L
V
 
L
R
 
S
H
 
L
L
 
F
E
 
E
A
 
R
R
 
R

4ymtC Crystal structure of an amino acid abc transporter complex with arginines (see paper)
37% identity, 93% coverage: 12:243/250 of query aligns to 10:213/215 of 4ymtC

query
sites
4ymtC
E
 
K
Y
 
Y
L
 
T
P
 
P
L
 
L
F
 
F
V
 
I
E
 
S
G
 
G
T
 
L
W
 
I
M
 
M
T
 
T
L
 
L
K
 
K
A
 
L
A
 
T
I
 
F
I
 
L
C
 
A
V
 
V
I
 
T
A
 
I
G
 
G
T
 
V
C
 
L
W
 
M
G
 
G
L
 
L
V
 
F
L
 
I
G
 
A
V
 
L
G
 
M
R
 
K
L
 
M
A
 
S
E
 
S
A
 
I
R
 
K
H
 
-
G
 
-
F
 
-
W
 
-
K
 
-
Y
 
-
F
 
-
L
 
-
C
 
-
Y
 
-
C
 
-
V
 
-
Q
 
-
W
 
-
P
 
P
I
 
I
R
 
K
F
 
L
-
 
V
-
 
A
-
 
S
-
 
S
Y
 
Y
V
 
I
S
 
E
F
 
V
L
 
I
R
 
R
G
 
G
T
 
T
P
|
P
L
|
L
F
 
L
V
 
V
Q
 
Q
I
 
L
L
 
L
L
 
L
I
 
I
H
 
Y
F
 
N
A
 
G
L
 
L
M
 
M
P
 
Q
M
 
F
L
 
G
I
 
M
N
 
N
P
 
-
S
 
-
G
 
-
G
 
-
L
 
-
I
 
-
L
 
-
S
 
-
G
 
-
D
 
-
L
 
-
A
 
-
R
 
-
E
 
-
I
 
-
R
 
-
S
 
-
H
 
-
Y
 
I
G
 
P
A
 
A
F
 
F
A
 
T
S
 
A
A
 
G
V
 
V
L
 
S
A
 
A
I
 
L
T
 
A
L
 
I
N
|
N
S
 
S
G
 
S
A
 
A
Y
|
Y
V
 
V
S
 
A
E
 
E
I
 
I
F
 
I
R
 
R
A
 
A
G
 
G
I
 
I
Q
 
Q
S
 
A
I
 
V
D
 
D
R
 
P
G
 
G
Q
 
Q
S
 
N
E
 
E
A
 
A
S
 
A
R
 
R
S
 
S
L
 
L
G
 
G
M
 
M
S
 
T
Y
 
H
L
 
A
A
 
M
T
 
A
L
 
M
R
 
R
R
 
Y
V
 
V
V
 
I
L
 
I
P
 
P
Q
 
Q
A
 
A
F
 
I
R
 
K
R
 
N
M
 
I
L
 
L
P
 
P
P
 
A
L
 
L
G
 
G
N
 
N
N
x
E
A
 
F
I
 
I
A
 
V
I
x
M
V
 
L
K
|
K
D
x
E
S
 
S
S
 
A
L
 
I
A
 
V
S
 
S
A
 
V
I
 
I
G
 
G
L
 
F
A
 
A
E
 
D
L
 
L
A
 
T
Y
 
R
A
 
Q
A
 
A
R
 
D
T
 
I
V
 
I
S
 
Q
G
 
S
A
 
V
Y
 
T
A
 
Y
R
 
R
Y
 
Y
W
 
F
E
 
E
P
 
P
Y
 
Y
L
 
I
T
 
I
I
 
I
S
 
A
V
 
A
I
 
I
Y
 
Y
W
 
F
L
 
V
I
 
M
T
 
T
L
 
L
A
 
T
L
 
F
S
 
S
A
 
K
L
 
L
V
 
L
R
 
S
H
 
L
L
 
F
E
 
E
A
 
R
R
 
R

Query Sequence

>HSERO_RS00315 HSERO_RS00315 amino acid ABC transporter permease
MNSFFQWEIIGEYLPLFVEGTWMTLKAAIICVIAGTCWGLVLGVGRLAEARHGFWKYFLC
YCVQWPIRFYVSFLRGTPLFVQILLIHFALMPMLINPSGGLILSGDLAREIRSHYGAFAS
AVLAITLNSGAYVSEIFRAGIQSIDRGQSEASRSLGMSYLATLRRVVLPQAFRRMLPPLG
NNAIAIVKDSSLASAIGLAELAYAARTVSGAYARYWEPYLTISVIYWLITLALSALVRHL
EARYGKGDAR

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory