Comparing HSERO_RS00875 FitnessBrowser__HerbieS:HSERO_RS00875 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 19 hits to proteins with known functional sites (download)
6r77A Crystal structure of trans-3-hydroxy-l-proline dehydratase in complex with substrate - closed conformation (see paper)
48% identity, 98% coverage: 7:336/336 of query aligns to 19:348/348 of 6r77A
Q96EM0 Trans-3-hydroxy-L-proline dehydratase; Trans-L-3-hydroxyproline dehydratase; EC 4.2.1.77 from Homo sapiens (Human) (see paper)
41% identity, 99% coverage: 5:336/336 of query aligns to 17:354/354 of Q96EM0
8a3fAAA Proline racemase A (AsProR)
40% identity, 99% coverage: 2:333/336 of query aligns to 1:333/335 of 8a3fAAA
6j7cA Crystal structure of proline racemase-like protein from thermococcus litoralis in complex with proline (see paper)
36% identity, 98% coverage: 9:336/336 of query aligns to 8:331/331 of 6j7cA
6hjeA Trypanosoma cruzi proline racemase in complex with inhibitor ng-p27 (see paper)
37% identity, 100% coverage: 1:336/336 of query aligns to 2:355/357 of 6hjeA
6hjgB Trypanosoma cruzi proline racemase in complex with inhibitor oxopa (see paper)
37% identity, 100% coverage: 1:336/336 of query aligns to 19:372/376 of 6hjgB
Q4DA80 Proline racemase A; TcPA45-A; TcPRACA; rTcPA45; EC 5.1.1.4 from Trypanosoma cruzi (strain CL Brener) (see 2 papers)
37% identity, 100% coverage: 1:336/336 of query aligns to 69:422/423 of Q4DA80
1w61A Proline racemase in complex with 2 molecules of pyrrole-2- carboxylic acid (holo form) (see paper)
37% identity, 99% coverage: 4:336/336 of query aligns to 1:351/353 of 1w61A
Q2YLF3 4-hydroxyproline epimerase; Hydroxyproline-2-epimerase; HyPRE; EC 5.1.1.8 from Brucella abortus (strain 2308) (see paper)
34% identity, 97% coverage: 10:335/336 of query aligns to 8:332/333 of Q2YLF3
4q2hA Crystal structure of probable proline racemase from agrobacterium radiobacter k84, target efi-506561, with bound carbonate
32% identity, 99% coverage: 2:335/336 of query aligns to 2:335/346 of 4q2hA
Q9I476 4-hydroxyproline 2-epimerase; 4Hyp 2-epimerase; 4HypE; Hydroxyproline-2-epimerase; PaHyPRE; EC 5.1.1.8 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
35% identity, 98% coverage: 6:333/336 of query aligns to 2:312/314 of Q9I476
4j9xA Crystal structure of the complex of a hydroxyproline epimerase (target efi-506499, pseudomonas fluorescens pf-5) with trans-4-hydroxy-l- proline
34% identity, 98% coverage: 6:333/336 of query aligns to 2:308/310 of 4j9xA
4j9wA Crystal structure of the complex of a hydroxyproline epimerase (target efi-506499, pseudomonas fluorescens pf-5) with the inhibitor pyrrole- 2-carboxylate
34% identity, 98% coverage: 6:333/336 of query aligns to 2:308/310 of 4j9wA
Q4KGU2 4-hydroxyproline 2-epimerase; 4Hyp 2-epimerase; 4HypE; EC 5.1.1.8 from Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) (see paper)
34% identity, 98% coverage: 6:333/336 of query aligns to 2:308/310 of Q4KGU2
4lb0B Crystal structure of a hydroxyproline epimerase from agrobacterium vitis, target efi-506420, with bound trans-4-oh-l-proline
30% identity, 99% coverage: 2:335/336 of query aligns to 2:335/347 of 4lb0B
B9JQV3 4-hydroxyproline 2-epimerase; 4Hyp 2-epimerase; 4HypE; EC 5.1.1.8 from Allorhizobium ampelinum (strain ATCC BAA-846 / DSM 112012 / S4) (Agrobacterium vitis (strain S4)) (see paper)
30% identity, 99% coverage: 2:335/336 of query aligns to 1:334/347 of B9JQV3
4k7gD Crystal structure of a 3-hydroxyproline dehydratse from agrobacterium vitis, target efi-506470, with bound pyrrole 2-carboxylate, ordered active site
28% identity, 99% coverage: 2:335/336 of query aligns to 11:345/352 of 4k7gD
B9K4G4 Trans-3-hydroxy-L-proline dehydratase; T3LHyp dehydratase; t3HypD; Trans-L-3-hydroxyproline dehydratase; EC 4.2.1.77 from Allorhizobium ampelinum (strain ATCC BAA-846 / DSM 112012 / S4) (Agrobacterium vitis (strain S4)) (see paper)
28% identity, 99% coverage: 2:335/336 of query aligns to 1:335/342 of B9K4G4
4q60A Crystal structure of a 4-hydroxyproline epimerase from burkholderia multivorans atcc 17616, target efi-506586, open form, with bound pyrrole-2-carboxylate
34% identity, 98% coverage: 6:333/336 of query aligns to 7:310/311 of 4q60A
>HSERO_RS00875 FitnessBrowser__HerbieS:HSERO_RS00875
MLSYTRTVQTIDAHTGGEPLRIVVSGLPKIPAGTILEQRAWLREHRDDLRCFLMNEPRGH
ADMYGAYLLPPVTAGADFGVIFIHNEGYSDMCGHGIIALGKVLVEMGYVERTSPQTRICF
DAPAGFIEAFVEWDGERAGKVSFNNVPAFIYRRDVEVDTPGFGKITGDIVFGGAFYYYIN
ATQAGLTVKPELVRQLIQLGAETKAAVMAKVAIAHPLEPGLNTLYGTIIDSAPNFPGADQ
SNVCIFADREVDRSPTGTGTSGRAAQLFLRGQLALNQPYVNGSIVGSNFGVRVTAATQVG
PFEGALTEVSGYAHIMSTNQWVLEQSDPFPTGFFLR
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory