SitesBLAST
Comparing HSERO_RS01270 FitnessBrowser__HerbieS:HSERO_RS01270 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
7borA Structure of pseudomonas aeruginosa coa-bound odaa (see paper)
43% identity, 95% coverage: 5:247/256 of query aligns to 4:247/247 of 7borA
- active site: N63 (= N64), F68 (= F69), D77 (= D78), G81 (≠ F82), I105 (= I106), T108 (= T109), F128 (= F129), L133 (= L134), P135 (= P136), E136 (= E137), A222 (≠ V222), L232 (= L232)
- binding coenzyme a: D21 (= D22), K22 (= K23), A25 (= A26), S61 (≠ A62), I65 (≠ L66), V103 (= V104), F128 (= F129), L131 (= L132), F244 (= F244), R247 (≠ K247)
6slbAAA Enoyl-CoA hydratase/carnithine racemase (see paper)
37% identity, 96% coverage: 9:253/256 of query aligns to 9:255/257 of 6slbAAA
- active site: Q64 (≠ N64), F69 (= F69), L80 (≠ V81), N84 (vs. gap), A108 (≠ I106), S111 (≠ T109), A130 (≠ P128), F131 (= F129), L136 (= L134), P138 (= P136), D139 (≠ E137), A224 (≠ V222), G234 (≠ L232)
- binding (~{E})-6-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-6-oxidanylidene-hex-3-enoic acid: R58 (≠ K58), A62 (= A62), Q64 (≠ N64), D65 (= D65), L66 (= L66), Y76 (≠ Q77), A108 (≠ I106), F131 (= F129), D139 (≠ E137)
6slaAAA Enoyl-CoA hydratase/carnithine racemase (see paper)
37% identity, 96% coverage: 9:253/256 of query aligns to 6:243/245 of 6slaAAA
- active site: Q61 (≠ N64), L68 (= L70), N72 (≠ P74), A96 (≠ I106), S99 (≠ T109), A118 (≠ P128), F119 (= F129), L124 (= L134), P126 (= P136), N127 (≠ E137), A212 (≠ V222), G222 (≠ L232)
- binding ~{S}-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl] 2-(2,5-dihydrooxepin-7-yl)ethanethioate: L21 (≠ K24), A59 (= A62), Q61 (≠ N64), D62 (= D65), L63 (= L66), L68 (= L70), Y71 (≠ P73), A94 (≠ V104), G95 (= G105), A96 (≠ I106), F119 (= F129), I122 (≠ L132), L124 (= L134), N127 (≠ E137), F234 (= F244), K237 (= K247)
5zaiC Crystal structure of 3-hydroxypropionyl-coa dehydratase from metallosphaera sedula (see paper)
31% identity, 97% coverage: 5:253/256 of query aligns to 6:257/259 of 5zaiC
- active site: A65 (≠ N64), F70 (= F69), S82 (vs. gap), R86 (vs. gap), G110 (≠ I106), E113 (≠ T109), P132 (= P128), E133 (≠ F129), I138 (≠ L134), P140 (= P136), G141 (≠ E137), A226 (≠ V222), F236 (≠ L232)
- binding coenzyme a: K24 (= K23), L25 (≠ K24), A63 (= A62), G64 (= G63), A65 (≠ N64), D66 (= D65), I67 (≠ L66), P132 (= P128), R166 (≠ A162), F248 (= F244), K251 (= K247)
2hw5C The crystal structure of human enoyl-coenzyme a (coa) hydratase short chain 1, echs1
34% identity, 96% coverage: 8:253/256 of query aligns to 12:258/260 of 2hw5C
- active site: A68 (≠ N64), M73 (≠ L70), S83 (≠ V81), L87 (= L85), G111 (≠ I106), E114 (≠ T109), P133 (= P128), E134 (≠ F129), T139 (≠ L134), P141 (= P136), G142 (≠ E137), K227 (≠ M221), F237 (≠ L232)
- binding crotonyl coenzyme a: K26 (≠ D22), A27 (≠ K23), L28 (≠ K24), A30 (= A26), K62 (= K58), I70 (≠ L66), F109 (≠ V104)
1dubA 2-enoyl-coa hydratase, data collected at 100 k, ph 6.5 (see paper)
34% identity, 96% coverage: 8:253/256 of query aligns to 12:258/260 of 1dubA
- active site: A68 (≠ N64), M73 (≠ L70), S83 (≠ V81), L87 (= L85), G111 (≠ I106), E114 (≠ T109), P133 (= P128), E134 (≠ F129), T139 (≠ L134), P141 (= P136), G142 (≠ E137), K227 (≠ M221), F237 (≠ L232)
- binding acetoacetyl-coenzyme a: K26 (≠ D22), A27 (≠ K23), L28 (≠ K24), A30 (= A26), A66 (= A62), A68 (≠ N64), D69 (= D65), I70 (≠ L66), Y107 (≠ V102), G110 (= G105), G111 (≠ I106), E114 (≠ T109), P133 (= P128), E134 (≠ F129), L137 (= L132), G142 (≠ E137), F233 (= F228), F249 (= F244)
1ey3A Structure of enoyl-coa hydratase complexed with the substrate dac-coa (see paper)
34% identity, 96% coverage: 8:253/256 of query aligns to 10:256/258 of 1ey3A
- active site: A66 (≠ N64), M71 (≠ L70), S81 (≠ V81), L85 (= L85), G109 (≠ I106), E112 (≠ T109), P131 (= P128), E132 (≠ F129), T137 (≠ L134), P139 (= P136), G140 (≠ E137), K225 (≠ M221), F235 (≠ L232)
- binding 4-(n,n-dimethylamino)cinnamoyl-coa: K24 (≠ D22), L26 (≠ K24), A28 (= A26), A64 (= A62), G65 (= G63), A66 (≠ N64), D67 (= D65), I68 (≠ L66), L85 (= L85), W88 (= W86), G109 (≠ I106), P131 (= P128), L135 (= L132), G140 (≠ E137)
P14604 Enoyl-CoA hydratase, mitochondrial; mECH; mECH1; Enoyl-CoA hydratase 1; ECHS1; Short-chain enoyl-CoA hydratase; SCEH; EC 4.2.1.17; EC 5.3.3.8 from Rattus norvegicus (Rat) (see 3 papers)
33% identity, 96% coverage: 8:253/256 of query aligns to 42:288/290 of P14604
- E144 (≠ T109) mutation to D: Reduces activity 50-fold.; mutation to Q: Reduces activity 3300-fold.
- E164 (≠ F129) mutation to D: Reduces activity 1250-fold.; mutation to Q: Reduces activity 330000-fold.
Sites not aligning to the query:
- 1:29 modified: transit peptide, Mitochondrion
1mj3A Crystal structure analysis of rat enoyl-coa hydratase in complex with hexadienoyl-coa (see paper)
33% identity, 96% coverage: 8:253/256 of query aligns to 12:256/258 of 1mj3A
- active site: A68 (≠ N64), M73 (≠ L70), S83 (≠ V81), L85 (≠ Q83), G109 (≠ I106), E112 (≠ T109), P131 (= P128), E132 (≠ F129), T137 (≠ L134), P139 (= P136), G140 (≠ E137), K225 (≠ M221), F235 (≠ L232)
- binding hexanoyl-coenzyme a: K26 (≠ D22), A27 (≠ K23), L28 (≠ K24), A30 (= A26), A66 (= A62), G67 (= G63), A68 (≠ N64), D69 (= D65), I70 (≠ L66), G109 (≠ I106), P131 (= P128), E132 (≠ F129), L135 (= L132), G140 (≠ E137)
2dubA Enoyl-coa hydratase complexed with octanoyl-coa (see paper)
33% identity, 96% coverage: 8:253/256 of query aligns to 11:252/254 of 2dubA
- active site: A67 (≠ N64), M72 (≠ L70), S82 (≠ Q83), G105 (≠ I106), E108 (≠ T109), P127 (= P128), E128 (≠ F129), T133 (≠ L134), P135 (= P136), G136 (≠ E137), K221 (≠ M221), F231 (≠ L232)
- binding octanoyl-coenzyme a: K25 (≠ D22), A26 (≠ K23), L27 (≠ K24), A29 (= A26), A65 (= A62), A67 (≠ N64), D68 (= D65), I69 (≠ L66), K70 (≠ E67), G105 (≠ I106), E108 (≠ T109), P127 (= P128), E128 (≠ F129), G136 (≠ E137), A137 (= A138)
3q0gD Crystal structure of the mycobacterium tuberculosis crotonase bound to a reaction intermediate derived from crotonyl coa
29% identity, 94% coverage: 12:252/256 of query aligns to 14:249/250 of 3q0gD
- active site: A64 (≠ N64), M69 (≠ F69), T75 (≠ K75), F79 (= F82), G103 (≠ I106), E106 (≠ T109), P125 (= P128), E126 (≠ F129), V131 (≠ L134), P133 (= P136), G134 (≠ E137), L219 (≠ V222), F229 (≠ L232)
- binding Butyryl Coenzyme A: F225 (= F228), F241 (= F244)
5du6A Crystal structure of m. Tuberculosis echa6 bound to ligand gsk059a. (see paper)
32% identity, 97% coverage: 5:253/256 of query aligns to 3:240/242 of 5du6A
- active site: A61 (≠ N64), P71 (= P74), I75 (≠ F82), A99 (≠ I106), Q102 (≠ T109), P121 (= P128), T122 (≠ F129), L127 (= L134), L129 (≠ P136), D130 (≠ E137), P209 (≠ V222), W219 (≠ L232)
- binding (5R,7R)-5-(4-ethylphenyl)-N-(4-fluorobenzyl)-7-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide: L74 (≠ V81), D82 (≠ S89), D130 (≠ E137), W132 (≠ A139), A207 (≠ Q220), K212 (≠ I225), F215 (= F228)
Q9P4U9 Enoyl-CoA hydratase AKT3-1; AF-toxin biosynthesis protein 3-1; EC 4.2.1.17 from Alternaria alternata (Alternaria rot fungus) (Torula alternata) (see paper)
30% identity, 95% coverage: 10:253/256 of query aligns to 22:269/296 of Q9P4U9
Sites not aligning to the query:
- 294:296 Peroxisomal targeting signal type 1
3h81A Crystal structure of enoyl-coa hydratase from mycobacterium tuberculosis (see paper)
29% identity, 95% coverage: 12:254/256 of query aligns to 14:255/256 of 3h81A
- active site: A64 (≠ N64), M69 (≠ F69), T79 (≠ A79), F83 (≠ Q83), G107 (≠ I106), E110 (≠ T109), P129 (= P128), E130 (≠ F129), V135 (≠ L134), P137 (= P136), G138 (≠ E137), L223 (≠ V222), F233 (≠ L232)
- binding calcium ion: F233 (≠ L232), Q238 (≠ A237)
Q4WF54 Mevalonyl-coenzyme A hydratase sidH; Siderophore biosynthesis protein H; EC 4.2.1.- from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see paper)
29% identity, 94% coverage: 13:253/256 of query aligns to 21:266/270 of Q4WF54
Sites not aligning to the query:
- 268:270 PTS1-type peroxisomal targeting signal
3q0jC Crystal structure of the mycobacterium tuberculosis crotonase in complex with the inhibitor acetoacetylcoa
29% identity, 94% coverage: 12:252/256 of query aligns to 15:254/255 of 3q0jC
- active site: A65 (≠ N64), M70 (≠ F69), T80 (≠ A79), F84 (≠ Q83), G108 (≠ I106), E111 (≠ T109), P130 (= P128), E131 (≠ F129), V136 (≠ L134), P138 (= P136), G139 (≠ E137), L224 (≠ V222), F234 (≠ L232)
- binding acetoacetyl-coenzyme a: Q23 (≠ D22), A24 (≠ K23), L25 (≠ K24), A27 (= A26), A63 (= A62), G64 (= G63), A65 (≠ N64), D66 (= D65), I67 (≠ L66), K68 (≠ E67), M70 (≠ F69), F84 (≠ Q83), G107 (= G105), G108 (≠ I106), E111 (≠ T109), P130 (= P128), E131 (≠ F129), P138 (= P136), G139 (≠ E137), M140 (≠ A138)
3q0gC Crystal structure of the mycobacterium tuberculosis crotonase bound to a reaction intermediate derived from crotonyl coa
29% identity, 94% coverage: 12:252/256 of query aligns to 15:254/255 of 3q0gC
- active site: A65 (≠ N64), M70 (≠ F69), T80 (≠ A79), F84 (≠ Q83), G108 (≠ I106), E111 (≠ T109), P130 (= P128), E131 (≠ F129), V136 (≠ L134), P138 (= P136), G139 (≠ E137), L224 (≠ V222), F234 (≠ L232)
- binding coenzyme a: L25 (≠ K24), A63 (= A62), I67 (≠ L66), K68 (≠ E67), Y104 (≠ V102), P130 (= P128), E131 (≠ F129), L134 (= L132)
5du8A Crystal structure of m. Tuberculosis echa6 bound to gsk572a (see paper)
33% identity, 97% coverage: 5:253/256 of query aligns to 3:232/234 of 5du8A
- active site: A61 (≠ N64), P63 (≠ E67), I67 (≠ K71), A91 (≠ I106), Q94 (≠ T109), P113 (= P128), T114 (≠ F129), L119 (= L134), L121 (≠ P136), D122 (≠ E137), P201 (≠ V222), W211 (≠ L232)
- binding (5R,7S)-5-(4-ethylphenyl)-N-[(5-fluoropyridin-2-yl)methyl]-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide: L66 (= L70), I67 (≠ K71), H70 (≠ P74), Q94 (≠ T109), D122 (≠ E137), W124 (≠ A139), F207 (= F228)
5ducA Crystal structure of m. Tuberculosis echa6 bound to ligand gsk951a (see paper)
31% identity, 97% coverage: 5:253/256 of query aligns to 3:242/244 of 5ducA
- active site: A61 (≠ N64), D66 (≠ E67), P73 (= P74), I77 (≠ F82), A101 (≠ I106), Q104 (≠ T109), P123 (= P128), T124 (≠ F129), L129 (= L134), L131 (≠ P136), D132 (≠ E137), P211 (≠ V222), W221 (≠ L232)
- binding (5R,7S)-N-(1,3-benzodioxol-5-ylmethyl)-5-(4-ethylphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide: L76 (≠ V81), H80 (≠ L85), D84 (≠ S89), Q104 (≠ T109), D132 (≠ E137), W134 (≠ A139), F217 (= F228)
5du4A Crystal structure of m. Tuberculosis echa6 bound to ligand gsk366a (see paper)
31% identity, 97% coverage: 5:253/256 of query aligns to 3:242/244 of 5du4A
- active site: A61 (≠ N64), D66 (≠ E67), P73 (= P74), I77 (≠ F82), A101 (≠ I106), Q104 (≠ T109), P123 (= P128), T124 (≠ F129), L129 (= L134), L131 (≠ P136), D132 (≠ E137), P211 (≠ V222), W221 (≠ L232)
- binding (5R,7S)-5-(4-ethylphenyl)-N-(4-methoxybenzyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide: L76 (≠ V81), I77 (≠ F82), H80 (≠ L85), D84 (≠ S89), Q104 (≠ T109), D132 (≠ E137), W134 (≠ A139)
Query Sequence
>HSERO_RS01270 FitnessBrowser__HerbieS:HSERO_RS01270
VQMDIQLSKADGVLTIHFDREDKKNAITAAMYQQLADALKEAESDSAVRAILFTGKPKAF
SAGNDLEDFLKNPPKTQDAPVFQFLWQISHASKPIVAAVSGVAVGIGTTLLLHCDLVYAA
DNAKFSMPFTQLGLCPEAASSLLLPHIAGYQRAAEKLLLGEAFGADEACQMGFVNRVMAQ
EELLPYAQQQAAKLAALPAASIRVTKQLMKKNRVTATEQQMVAEIEHFSRMLTAPEAKEA
FTAFFEKRKPDFKQFA
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory