SitesBLAST – Find functional sites

 

SitesBLAST

Comparing HSERO_RS02155 FitnessBrowser__HerbieS:HSERO_RS02155 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 5 hits to proteins with known functional sites (download)

P9WIB9 Secreted chorismate mutase; CM; *MtCM; EC 5.4.99.5 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 4 papers)
29% identity, 79% coverage: 5:153/189 of query aligns to 5:153/199 of P9WIB9

query
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P9WIB9
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Sites not aligning to the query:

2fp2B Secreted chorismate mutase from mycobacterium tuberculosis (see paper)
28% identity, 64% coverage: 33:153/189 of query aligns to 1:117/163 of 2fp2B

query
sites
2fp2B
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2ao2B The 2.07 angstrom crystal structure of mycobacterium tuberculosis chorismate mutase reveals unexpected gene duplication and suggests a role in host-pathogen interactions (see paper)
28% identity, 64% coverage: 33:153/189 of query aligns to 3:119/165 of 2ao2B

query
sites
2ao2B
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2ao2A The 2.07 angstrom crystal structure of mycobacterium tuberculosis chorismate mutase reveals unexpected gene duplication and suggests a role in host-pathogen interactions (see paper)
28% identity, 64% coverage: 33:153/189 of query aligns to 3:119/165 of 2ao2A

query
sites
2ao2A
S
 
S
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Q7CHH5 Secreted chorismate mutase; CM; *YpCM; EC 5.4.99.5 from Yersinia pestis (see paper)
25% identity, 85% coverage: 5:164/189 of query aligns to 3:159/186 of Q7CHH5

query
sites
Q7CHH5
P
 
P
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H
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F

Query Sequence

>HSERO_RS02155 FitnessBrowser__HerbieS:HSERO_RS02155
MRRLPSSCLPALALIATLLLSACATSTPPAVRSDVEQLLSLQKTRLDVAAPVARSKWNSH
APIDDPAREAVILDDVAARAQKLGLDAAWTRRFFQDQFEAGKIVQRDLHRQWRVEQRPPF
ANPPDLALQVRPVLDRLTPDLLAALARLNGHWCEPAVQRDLAELDAEILGADYPPAVRER
ATEALRCQR

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory