SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing HSERO_RS02995 FitnessBrowser__HerbieS:HSERO_RS02995 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 1 hits to proteins with known functional sites (download)

P68183 Maltose/maltodextrin transport system permease protein MalG from Escherichia coli (strain K12) (see 2 papers)
33% identity, 56% coverage: 103:265/291 of query aligns to 112:270/296 of P68183

query
sites
P68183

R

R

H

M

R

R

F

F

P

P

G

G

Q

K

A

A

L

T

L

L

L

L

A

K

-

G

M

M

L

L

T

I

F

F

P

Q

L

M

A

-

F

F

P

P

G

A

V

V

V

L

V

S

G

L

F

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M

A

V

L

I

Y

M

A

L

L

A

F

G

D

R

R

Q

L

G

G

-

E

-

Y

-

I

-

P

L

F

I

I

G

G

A

L

L

N

T

T

N

H

G

G

L

-

F

-

G

-

E

-

S

G

L

V

V

I

F

F

A

A

Y

Y

S

-

L

L

A

G

G

G

L

I

F

A

L

L

G

H

Y

-

L

-

Y

-

F

-

S

-

I

-

P

-

R

-

V

-

I

V

L

W

T

T

V

I

V

K

A

G

A

Y

A

F

E

E

K

T

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I

D

D

P

S

S

S

L

L

E

E

E
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E

A

A

A
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A

R

A

S

L

L

D

G
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G

A

A

R

T

P

P

W

W

Q

Q

V

A

L

F

L

R

H

L

V

V

V

L

L

L

P
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P

A

L

L

S

L

V

P

P

A

I

L

L

V

A

S

V

S

V

G

F

A

I

I

L

C

S

F

F

A

I

T

A

S

A

V

I

G

T

A

E

F

V

G

P

T

V

A

A

F

S

T

L

L

L

A

L

A

R

N

D

I

V

D

N

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S

-

Y

-

T

-

L

V

A

L

V

P

G

M

M

T

Q

I

Q

Y

Y

N

L

E

N

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P

T

Q

G

N

Y

Y

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L

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W

A

G

N

D

F

F

A

A

T

A

A

A

A

A

S

V

L

M

S

S

E190 (= E191) mutation E->A,C,K,L: Reduction of transport rate.
A192 (= A193) mutation A->D,S,L: Loss of transport and MalK dissociation from the membrane.
G196 (= G197) mutation to A: No effect.; mutation to P: Loss of transport and MalK dissociation from the membrane.
P209 (= P210) mutation to A: No effect.

Query Sequence

>HSERO_RS02995 FitnessBrowser__HerbieS:HSERO_RS02995
MKTVLPTSARPARPPASRPRRAGNQVWLCFAVPGLTLFCAFWLLPMARLVGVGASGPDGA
MAYLSVLTNRHYFASLVSTLALSAAVTAATLAISVFVGLFLQRHRFPGQALLLAMLTFPL
AFPGVVVGFMVIMLAGRQGLIGALTNGLFGESLVFAYSLAGLFLGYLYFSIPRVILTVVA
AAEKLDPSLEEAARSLGARPWQVLLHVVLPALLPALVSSGAICFATSVGAFGTAFTLAAN
IDVLPMTIYNEFTGYANFATAASLSIVLGVITWAVLALARSLTGSGVAAAA

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory