SitesBLAST
Comparing HSERO_RS04810 FitnessBrowser__HerbieS:HSERO_RS04810 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4o6rA Crystal structure of a putative aldehyde dehydrogenase from burkholderia cenocepacia
43% identity, 93% coverage: 26:495/504 of query aligns to 7:482/489 of 4o6rA
- active site: N150 (= N167), K173 (= K190), E248 (= E265), C282 (= C299), E383 (= E396), E460 (≠ S473)
- binding adenosine monophosphate: I146 (≠ M163), V147 (≠ T164), K173 (= K190), G206 (= G223), G210 (≠ V227), Q211 (≠ P228), F224 (= F241), G226 (= G243), S227 (= S244), T230 (= T247), R233 (≠ L250)
5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
42% identity, 93% coverage: 21:490/504 of query aligns to 15:488/491 of 5gtlA
- active site: N165 (= N167), K188 (= K190), E263 (= E265), C297 (= C299), E394 (= E396), E471 (≠ S473)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I161 (≠ M163), P163 (= P165), K188 (= K190), A190 (≠ S192), E191 (= E193), Q192 (≠ L194), G221 (= G223), G225 (≠ V227), G241 (= G243), S242 (= S244), T245 (= T247), L264 (= L266), C297 (= C299), E394 (= E396), F396 (= F398)
5gtkA NAD+ complex structure of aldehyde dehydrogenase from bacillus cereus
42% identity, 93% coverage: 21:490/504 of query aligns to 15:488/491 of 5gtkA
- active site: N165 (= N167), K188 (= K190), E263 (= E265), C297 (= C299), E394 (= E396), E471 (≠ S473)
- binding nicotinamide-adenine-dinucleotide: I161 (≠ M163), I162 (≠ T164), P163 (= P165), W164 (= W166), K188 (= K190), E191 (= E193), G221 (= G223), G225 (≠ V227), A226 (≠ P228), F239 (= F241), G241 (= G243), S242 (= S244), T245 (= T247), Y248 (≠ L250), L264 (= L266), C297 (= C299), Q344 (= Q346), R347 (≠ H349), E394 (= E396), F396 (= F398)
4go4A Crystal structure of pnpe in complex with nicotinamide adenine dinucleotide
42% identity, 94% coverage: 26:500/504 of query aligns to 6:485/487 of 4go4A
- active site: N149 (= N167), K172 (= K190), E247 (= E265), C281 (= C299), E381 (= E396), E458 (≠ S473)
- binding nicotinamide-adenine-dinucleotide: I145 (≠ M163), V146 (≠ T164), W148 (= W166), N149 (= N167), F154 (≠ T172), K172 (= K190), G205 (= G223), G209 (≠ V227), Q210 (≠ P228), F223 (= F241), T224 (≠ V242), G225 (= G243), S226 (= S244), T229 (= T247), E247 (= E265), G249 (= G267), C281 (= C299), E381 (= E396), F383 (= F398)
O14293 Putative aldehyde dehydrogenase-like protein C9E9.09c; EC 1.2.1.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
40% identity, 93% coverage: 23:491/504 of query aligns to 23:496/503 of O14293
- S248 (= S244) modified: Phosphoserine
Sites not aligning to the query:
- 501 modified: Phosphoserine
O94788 Retinal dehydrogenase 2; RALDH 2; RalDH2; Aldehyde dehydrogenase family 1 member A2; ALDH1A2; Retinaldehyde-specific dehydrogenase type 2; RALDH(II); EC 1.2.1.36 from Homo sapiens (Human) (see 6 papers)
38% identity, 96% coverage: 8:491/504 of query aligns to 32:512/518 of O94788
- E50 (= E30) to G: in dbSNP:rs34266719
- A110 (≠ G91) to V: in dbSNP:rs35365164
- Q182 (= Q162) to K: in DIH4; decreased retinoic acid biosynthetic process
- IPW 184:186 (≠ TPW 164:166) binding
- KPAE 210:213 (≠ KPSE 190:193) binding
- STE 264:266 (≠ SPA 244:246) binding
- C320 (= C299) active site, Nucleophile
- R347 (≠ I326) to H: in DIH4; decreased expression; dbSNP:rs141245344
- V348 (≠ R327) to I: in dbSNP:rs4646626
- KQYNK 366:370 (≠ KQYEH 345:349) binding
- A383 (= A362) to T: in DIH4; uncertain significance; dbSNP:rs749124508
- E417 (= E396) binding
- E436 (≠ A415) to K: in dbSNP:rs34744827
- S461 (≠ A440) to Y: in DIH4; decreased retinoic acid biosynthetic process
6b5hA Aldh1a2 liganded with NAD and 1-(4-cyanophenyl)-n-(3-fluorophenyl)-3- [4-(methylsulfonyl)phenyl]-1h-pyrazole-4-carboxamide (compound cm121) (see paper)
38% identity, 96% coverage: 8:491/504 of query aligns to 6:486/492 of 6b5hA
- active site: N161 (= N167), E260 (= E265), C294 (= C299), E468 (≠ S473)
- binding 1-(4-cyanophenyl)-N-(3-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-1H-pyrazole-4-carboxamide: V112 (≠ A118), G116 (≠ K122), F162 (≠ A168), W169 (= W175), Q284 (≠ A289), F288 (≠ S293), T295 (≠ V300), N449 (≠ K454), L451 (≠ I456), N452 (= N457), F457 (= F462)
- binding nicotinamide-adenine-dinucleotide: I157 (≠ M163), I158 (≠ T164), W160 (= W166), N161 (= N167), K184 (= K190), G217 (= G223), G221 (≠ V227), F235 (= F241), T236 (≠ V242), G237 (= G243), S238 (= S244), V241 (≠ T247), E260 (= E265), L261 (= L266), C294 (= C299), F393 (= F398)
6b5gA Aldh1a2 liganded with NAD and (3-ethoxythiophen-2-yl){4-[4-nitro-3- (pyrrolidin-1-yl)phenyl]piperazin-1-yl}methanone (compound 6-118) (see paper)
38% identity, 96% coverage: 8:491/504 of query aligns to 6:486/492 of 6b5gA
- active site: N161 (= N167), E260 (= E265), C294 (= C299), E468 (≠ S473)
- binding (3-ethoxythiophen-2-yl){4-[4-nitro-3-(pyrrolidin-1-yl)phenyl]piperazin-1-yl}methanone: F162 (≠ A168), L165 (≠ F171), W169 (= W175), F288 (≠ S293), C293 (≠ S298), C294 (= C299), T295 (≠ V300), N449 (≠ K454), L451 (≠ I456)
- binding nicotinamide-adenine-dinucleotide: I157 (≠ M163), I158 (≠ T164), P159 (= P165), W160 (= W166), N161 (= N167), M166 (≠ T172), K184 (= K190), E187 (= E193), G217 (= G223), G221 (≠ V227), F235 (= F241), T236 (≠ V242), G237 (= G243), S238 (= S244), V241 (≠ T247), E260 (= E265), L261 (= L266), C294 (= C299), E391 (= E396), F393 (= F398)
6aljA Aldh1a2 liganded with NAD and compound win18,446 (see paper)
38% identity, 96% coverage: 8:491/504 of query aligns to 6:486/492 of 6aljA
- active site: N161 (= N167), E260 (= E265), C294 (= C299), E468 (≠ S473)
- binding N,N'-(octane-1,8-diyl)bis(2,2-dichloroacetamide): G116 (≠ K122), F162 (≠ A168), L165 (≠ F171), M166 (≠ T172), W169 (= W175), E260 (= E265), C293 (≠ S298), C294 (= C299), L451 (≠ I456), N452 (= N457), A453 (≠ V458)
- binding nicotinamide-adenine-dinucleotide: I157 (≠ M163), I158 (≠ T164), P159 (= P165), W160 (= W166), N161 (= N167), K184 (= K190), E187 (= E193), G217 (= G223), G221 (≠ V227), F235 (= F241), G237 (= G243), S238 (= S244), V241 (≠ T247), Q341 (= Q346), K344 (≠ H349), E391 (= E396), F393 (= F398)
Q63639 Retinal dehydrogenase 2; RALDH 2; RalDH2; Aldehyde dehydrogenase family 1 member A2; ALDH1A2; Retinaldehyde-specific dehydrogenase type 2; RALDH(II); EC 1.2.1.36 from Rattus norvegicus (Rat) (see paper)
37% identity, 96% coverage: 8:491/504 of query aligns to 32:512/518 of Q63639
7radA Crystal structure analysis of aldh1b1
39% identity, 89% coverage: 43:491/504 of query aligns to 34:487/493 of 7radA
- binding nicotinamide-adenine-dinucleotide: I158 (≠ M163), I159 (≠ T164), P160 (= P165), W161 (= W166), N162 (= N167), M167 (≠ T172), K185 (= K190), E188 (= E193), G218 (= G223), G222 (≠ V227), A223 (≠ P228), T237 (≠ V242), G238 (= G243), S239 (= S244), V242 (≠ T247), E261 (= E265), L262 (= L266), C295 (= C299), E392 (= E396), F394 (= F398)
- binding 3-(2-methoxyphenyl)-1-(4-phenylphenyl)-6,7,8,9-tetrahydro-5~{H}-imidazo[1,2-a][1,3]diazepine: L113 (vs. gap), E117 (≠ K122), F163 (≠ A168), E285 (≠ A289), F289 (≠ S293), N450 (≠ K454), V452 (≠ I456)
7mjdA Crystal structure analysis of aldh1b1
39% identity, 89% coverage: 43:491/504 of query aligns to 34:487/493 of 7mjdA
- binding nicotinamide-adenine-dinucleotide: I158 (≠ M163), I159 (≠ T164), P160 (= P165), W161 (= W166), N162 (= N167), M167 (≠ T172), K185 (= K190), E188 (= E193), G218 (= G223), G222 (≠ V227), F236 (= F241), T237 (≠ V242), G238 (= G243), S239 (= S244), V242 (≠ T247), E261 (= E265), L262 (= L266), C295 (= C299), E392 (= E396), F394 (= F398)
- binding 8-(2-methoxyphenyl)-10-(4-phenylphenyl)-1$l^{4},8-diazabicyclo[5.3.0]deca-1(7),9-diene: E117 (≠ K122), E285 (≠ A289), F289 (≠ S293), N450 (≠ K454), V452 (≠ I456)
7mjcA Crystal structure analysis of aldh1b1
39% identity, 89% coverage: 43:491/504 of query aligns to 34:487/493 of 7mjcA
- binding nicotinamide-adenine-dinucleotide: I158 (≠ M163), I159 (≠ T164), P160 (= P165), W161 (= W166), N162 (= N167), K185 (= K190), E188 (= E193), G218 (= G223), G222 (≠ V227), T237 (≠ V242), G238 (= G243), S239 (= S244), V242 (≠ T247), E261 (= E265), L262 (= L266), C295 (= C299), E392 (= E396), F394 (= F398)
P20000 Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI; EC 1.2.1.3 from Bos taurus (Bovine) (see 2 papers)
41% identity, 89% coverage: 43:490/504 of query aligns to 61:513/520 of P20000
Sites not aligning to the query:
- 1:21 modified: transit peptide, Mitochondrion
5l13A Structure of aldh2 in complex with 2p3 (see paper)
40% identity, 89% coverage: 43:491/504 of query aligns to 35:488/494 of 5l13A
- active site: N163 (= N167), K186 (= K190), E262 (= E265), C296 (= C299), E393 (= E396), E470 (≠ S473)
- binding 2,3,5-trimethyl-6-propyl-7H-furo[3,2-g][1]benzopyran-7-one: F164 (≠ A168), M168 (≠ T172), W171 (= W175), F290 (≠ S293), C295 (≠ S298), C296 (= C299), C297 (≠ V300), D451 (≠ K454), F453 (≠ I456)
4kwgA Crystal structure analysis of aldh2+aldib13 (see paper)
40% identity, 89% coverage: 43:491/504 of query aligns to 35:488/494 of 4kwgA
- active site: N163 (= N167), K186 (= K190), E262 (= E265), C296 (= C299), E393 (= E396), E470 (≠ S473)
- binding 7-bromo-5-methyl-1H-indole-2,3-dione: F164 (≠ A168), M168 (≠ T172), C295 (≠ S298), C296 (= C299), C297 (≠ V300), D451 (≠ K454), F453 (≠ I456)
4kwfA Crystal structure analysis of aldh2+aldib33 (see paper)
40% identity, 89% coverage: 43:491/504 of query aligns to 35:488/494 of 4kwfA
- active site: N163 (= N167), K186 (= K190), E262 (= E265), C296 (= C299), E393 (= E396), E470 (≠ S473)
- binding 1-benzyl-1H-indole-2,3-dione: F164 (≠ A168), M168 (≠ T172), W171 (= W175), E262 (= E265), C295 (≠ S298), C296 (= C299), C297 (≠ V300), D451 (≠ K454), F453 (≠ I456), F459 (= F462)
3sz9A Crystal structure of human aldh2 modified with the beta-elimination product of aldi-3; 1-(4-ethylbenzene)prop-2-en-1-one (see paper)
40% identity, 89% coverage: 43:491/504 of query aligns to 35:488/494 of 3sz9A
- active site: N163 (= N167), K186 (= K190), E262 (= E265), C296 (= C299), E393 (= E396), E470 (≠ S473)
- binding 1-(4-ethylphenyl)propan-1-one: F164 (≠ A168), C295 (≠ S298), C296 (= C299), D451 (≠ K454), F453 (≠ I456), F459 (= F462)
3injA Human mitochondrial aldehyde dehydrogenase complexed with agonist alda-1 (see paper)
40% identity, 89% coverage: 43:491/504 of query aligns to 35:488/494 of 3injA
- active site: N163 (= N167), K186 (= K190), E262 (= E265), C296 (= C299), E393 (= E396), E470 (≠ S473)
- binding N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide: M118 (≠ K122), F164 (≠ A168), L167 (≠ F171), F286 (≠ A289), F290 (≠ S293), D451 (≠ K454), F453 (≠ I456)
2vleA The structure of daidzin, a naturally occurring anti alcohol- addiction agent, in complex with human mitochondrial aldehyde dehydrogenase (see paper)
40% identity, 89% coverage: 43:491/504 of query aligns to 35:488/494 of 2vleA
- active site: N163 (= N167), K186 (= K190), E262 (= E265), C296 (= C299), E393 (= E396), E470 (≠ S473)
- binding daidzin: M118 (≠ K122), F164 (≠ A168), M168 (≠ T172), W171 (= W175), F286 (≠ A289), F290 (≠ S293), C295 (≠ S298), C296 (= C299), D451 (≠ K454), V452 (≠ T455), F453 (≠ I456)
Query Sequence
>HSERO_RS04810 FitnessBrowser__HerbieS:HSERO_RS04810
MQSNDAENLMLAFGHFFPGAKEIGSWINGELVAGQGEIIQLYNPATGRASLSYRDGGAAA
VEAAAVAAQRAQRQWWALSHAARGRALYAVGAVIRAEAEPLARLEAISSGKPIRDCRAEM
QKVAEMFEYYAGWADKFYGEVIPVPSSHLNYTRREPYGTVLQMTPWNAPAFTCGWQLGPA
LATGNAVLLKPSELTPFSSLAIARLGEQAGLPAGLVNVLAGLGQTMVPQAMATWTVKKVI
FVGSPATGALIAKAAAARVMPCVLELGGKSANIIFEDADLRLAAFGAQAAIFSGAGQSCV
AGSRLLVQRKVYDRFVETVAAGAEKIRLGAPLDDSTEVGPINNRKQYEHIQRMVARGLEA
GATLAAGHTRYGEEGYFVRPTLLAHASNAMEVARSEIFGPVAVAIPFEDEEEAIAIANDS
EFGLAGAVWTRDVARAHRVAASVNAGTFWVNSYKTINVASPFGGFNRSGYGRSSGMEALY
DYTQTKSVWVETSASPATPFGYAG
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory