Comparing HSERO_RS05605 FitnessBrowser__HerbieS:HSERO_RS05605 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 8 hits to proteins with known functional sites (download)
4aq6D Substrate bound homogentisate 1,2-dioxygenase (see paper)
60% identity, 96% coverage: 18:442/445 of query aligns to 5:424/427 of 4aq6D
3zdsF Structure of homogentisate 1,2-dioxygenase in complex with reaction intermediates of homogentisate with oxygen. (see paper)
60% identity, 96% coverage: 18:442/445 of query aligns to 4:423/426 of 3zdsF
3zdsC Structure of homogentisate 1,2-dioxygenase in complex with reaction intermediates of homogentisate with oxygen. (see paper)
60% identity, 96% coverage: 18:442/445 of query aligns to 4:423/426 of 3zdsC
Q88E47 Homogentisate 1,2-dioxygenase; HGDO; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase; EC 1.13.11.5 from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see paper)
60% identity, 96% coverage: 18:442/445 of query aligns to 11:430/433 of Q88E47
3zdsA Structure of homogentisate 1,2-dioxygenase in complex with reaction intermediates of homogentisate with oxygen. (see paper)
60% identity, 96% coverage: 18:442/445 of query aligns to 3:422/425 of 3zdsA
Q93099 Homogentisate 1,2-dioxygenase; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase; EC 1.13.11.5 from Homo sapiens (Human) (see 13 papers)
52% identity, 96% coverage: 18:442/445 of query aligns to 6:436/445 of Q93099
Q9Y041 Homogentisate 1,2-dioxygenase; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase; EC 1.13.11.5 from Caenorhabditis elegans (see paper)
53% identity, 95% coverage: 18:440/445 of query aligns to 9:433/437 of Q9Y041
1ey2A Human homogentisate dioxygenase with fe(ii) (see paper)
51% identity, 93% coverage: 18:429/445 of query aligns to 5:413/419 of 1ey2A
>HSERO_RS05605 FitnessBrowser__HerbieS:HSERO_RS05605
MNTATDFSVSHHVHTRGYQSGFGNEFATEALPSALPAHQNSPQRVAYGLYAEQISGTAFT
APRGHNRRSWLYRIRPAAMHHPFEAMSQGLLVSRFDDVAPPPNQLRWDPLPMPTTPTDFI
DGLVTMAGNGSPQAQSGCAIHLYAANCSMTDRFFYSADGELLIVPQMGRLQLRTEMGVID
IEPQEIAVIPRGVRFQVRLPGGEARGYICENFGALLRLPDLGPLGSNGLANPRDFATPHA
WYEDREGDFQLIAKFGGQLWQARIGHSPLDVVAWHGNYAPYKYDLRHFNTIGSISYDHPD
PSIFLVLQSQSDTPGVDTIDFVIFPPRWLAAENTFRPPWFHRNVASEYMGLITGQYDAKE
GGGFVPGGGSLHNCMSGHGPDAATFEKASRIDTSTPNKVDHTMAFMFETRNILCPTRHAL
ASPALQRDYQDCWLGIQKNFNPEHP
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory