SitesBLAST
Comparing HSERO_RS07235 FitnessBrowser__HerbieS:HSERO_RS07235 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
5x5uA Crystal structure of alpha-ketoglutarate-semialdehyde dehydrogenase (kgsadh) complexed with NAD (see paper)
65% identity, 99% coverage: 2:475/477 of query aligns to 2:475/476 of 5x5uA
- active site: N151 (= N151), K174 (= K174), E249 (= E249), C283 (= C283), E380 (= E380), E457 (= E457)
- binding glycerol: D15 (≠ A15), A16 (≠ S16), A17 (= A17), G19 (= G19)
- binding nicotinamide-adenine-dinucleotide: P149 (= P149), P207 (= P207), A208 (= A208), S211 (= S211), G227 (= G227), S228 (= S228), V231 (= V231), R329 (= R329), R330 (= R330), E380 (= E380), F382 (= F382)
5x5tA Crystal structure of alpha-ketoglutarate semialdehyde dehydrogenase (kgsadh) from azospirillum brasilense (see paper)
65% identity, 99% coverage: 2:475/477 of query aligns to 2:475/476 of 5x5tA
P25526 Succinate-semialdehyde dehydrogenase [NADP(+)] GabD; SSDH; Glutarate-semialdehyde dehydrogenase; EC 1.2.1.79; EC 1.2.1.- from Escherichia coli (strain K12) (see paper)
42% identity, 98% coverage: 6:473/477 of query aligns to 12:479/482 of P25526
3jz4A Crystal structure of e. Coli NADP dependent enzyme (see paper)
42% identity, 98% coverage: 6:473/477 of query aligns to 11:478/481 of 3jz4A
- active site: N156 (= N151), K179 (= K174), E254 (= E249), C288 (= C283), E385 (= E380), E462 (= E457)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: P154 (= P149), W155 (= W150), K179 (= K174), A181 (≠ P176), S182 (≠ E177), A212 (≠ P207), G216 (≠ S211), G232 (= G227), S233 (= S228), I236 (≠ V231), C288 (= C283), K338 (≠ A333), E385 (= E380), F387 (= F382)
P51649 Succinate-semialdehyde dehydrogenase, mitochondrial; Aldehyde dehydrogenase family 5 member A1; NAD(+)-dependent succinic semialdehyde dehydrogenase; EC 1.2.1.24 from Homo sapiens (Human) (see 5 papers)
41% identity, 98% coverage: 8:473/477 of query aligns to 64:531/535 of P51649
- C93 (≠ A39) to F: in SSADHD; 3% of activity; dbSNP:rs765561257
- G176 (= G122) to R: in SSADHD; <1% of activity; dbSNP:rs72552281
- H180 (≠ P126) to Y: 83% of activity; dbSNP:rs2760118
- P182 (≠ R128) to L: 48% of activity; dbSNP:rs3765310
- R213 (= R159) binding ; mutation to A: Reduces catalytic activity to less than 15% of wild-type.
- C223 (= C169) to Y: in SSADHD; 5% of activity; dbSNP:rs72552282
- KPAE 228:231 (≠ KAPE 174:177) binding
- T233 (= T179) to M: in SSADHD; 4% of activity; dbSNP:rs1326526453
- A237 (≠ P183) to S: 65% of activity; dbSNP:rs62621664
- N255 (= N201) to S: in SSADHD; 17% of activity; dbSNP:rs145087265
- G268 (≠ S211) to E: in SSADHD; <1% of activity; dbSNP:rs375628463
- GSTTTG 284:289 (≠ GSTPVG 227:232) binding
- R334 (= R277) binding ; mutation to A: Reduces catalytic activity to less than 15% of wild-type.
- N335 (= N278) to K: in SSADHD; 1% of activity; dbSNP:rs72552283
- C340 (= C283) modified: Disulfide link with 342, In inhibited form
- C342 (≠ S285) modified: Disulfide link with 340, In inhibited form; mutation to A: Loss of regulation by redox state.
- N372 (= N314) natural variant: N -> S
- P382 (= P324) to L: in SSADHD; 2% of activity
- V406 (≠ L348) to I: in dbSNP:rs143741652
- G409 (= G351) to D: in SSADHD; <1% of activity; dbSNP:rs118203984
- S498 (≠ A440) binding ; mutation to A: Reduces catalytic activity to less than 15% of wild-type.
Sites not aligning to the query:
- 36 G → R: no effect on succinate-semialdehyde dehydrogenase activity; dbSNP:rs4646832
- 533 G → R: in SSADHD; <1% of activity; dbSNP:rs72552284
8c54A Cryo-em structure of nadh bound sla dehydrogenase rlgabd from rhizobium leguminosarum bv. Trifolii srd1565
41% identity, 97% coverage: 8:472/477 of query aligns to 13:477/482 of 8c54A
- binding 1,4-dihydronicotinamide adenine dinucleotide: I152 (≠ F147), T153 (= T148), P154 (= P149), K179 (= K174), A212 (≠ P207), K213 (≠ A208), F230 (= F225), T231 (= T226), G232 (= G227), S233 (= S228), V236 (= V231), W239 (≠ Q234), G256 (= G251)
2w8rA The crystal structure of human ssadh in complex with NAD+ (see paper)
41% identity, 98% coverage: 8:473/477 of query aligns to 14:481/485 of 2w8rA
2w8qA The crystal structure of human ssadh in complex with ssa. (see paper)
41% identity, 98% coverage: 8:473/477 of query aligns to 14:481/485 of 2w8qA
4pxlA Structure of zm aldh2-3 (rf2c) in complex with NAD (see paper)
38% identity, 98% coverage: 6:472/477 of query aligns to 7:476/486 of 4pxlA
- active site: N154 (= N151), K177 (= K174), E253 (= E249), C287 (= C283), E384 (= E380), D461 (≠ E457)
- binding nicotinamide-adenine-dinucleotide: I150 (≠ F147), V151 (≠ T148), P152 (= P149), W153 (= W150), K177 (= K174), E180 (= E177), G210 (≠ P207), G214 (≠ S211), A215 (≠ E212), F228 (= F225), G230 (= G227), S231 (= S228), V234 (= V231), E253 (= E249), G255 (= G251), C287 (= C283), Q334 (≠ R330), K337 (≠ A333), E384 (= E380), F386 (= F382)
5izdA Wild-type glyceraldehyde dehydrogenase from thermoplasma acidophilum in complex with NADP
36% identity, 98% coverage: 4:470/477 of query aligns to 2:471/494 of 5izdA
- active site: N149 (= N151), K172 (= K174), E247 (= E249), C281 (= C283), E381 (= E380), E458 (= E457)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: L145 (≠ F147), T146 (= T148), W148 (= W150), K172 (= K174), P173 (≠ A175), S174 (≠ P176), S175 (≠ E177), R204 (≠ V206), G205 (≠ P207), G209 (≠ S211), D210 (≠ E212), G225 (= G227), S226 (= S228), T229 (≠ V231)
P15437 Aldehyde dehydrogenase 1A1; 3-deoxyglucosone dehydrogenase; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic; Retinal dehydrogenase 1; RALDH 1; RalDH1; EC 1.2.1.19; EC 1.2.1.28; EC 1.2.1.3; EC 1.2.1.36 from Equus caballus (Horse) (see paper)
36% identity, 99% coverage: 2:473/477 of query aligns to 18:493/501 of P15437
Sites not aligning to the query:
- 2 modified: N-acetylserine
7um9A Human aldh1a1 with bound compound cm38 (see paper)
36% identity, 98% coverage: 6:473/477 of query aligns to 15:486/494 of 7um9A
- binding nicotinamide-adenine-dinucleotide: I159 (≠ F147), I160 (≠ T148), P161 (= P149), W162 (= W150), N163 (= N151), K186 (= K174), E189 (= E177), G219 (≠ P207), G223 (≠ S211), F237 (= F225), T238 (= T226), G239 (= G227), S240 (= S228), V243 (= V231), E262 (= E249), G264 (= G251), Q343 (≠ R330), K346 (≠ A333), E393 (= E380), F395 (= F382)
- binding (4-methylfuro[3,2-c]quinolin-2-yl)(piperidin-1-yl)methanone: W171 (≠ R159), H286 (≠ T273), Y290 (≠ R277), I297 (≠ V284), G451 (= G438)
5l2oA Crystal structure of aldh1a1 in complex with buc22 (see paper)
36% identity, 98% coverage: 6:473/477 of query aligns to 15:486/494 of 5l2oA
5l2nA Structure of aldh1a1 in complex with buc25 (see paper)
36% identity, 98% coverage: 6:473/477 of query aligns to 15:486/494 of 5l2nA
- active site: N163 (= N151), K186 (= K174), E262 (= E249), C296 (= C283), E393 (= E380), E470 (= E457)
- binding 3-benzyl-4-methyl-2-oxo-2H-1-benzopyran-7-yl methanesulfonate: F164 (= F152), M168 (≠ Q156), W171 (≠ R159), H286 (≠ T273), G287 (≠ A274), Y290 (≠ R277), C295 (≠ V282), C296 (= C283), I297 (≠ V284), Y450 (≠ L437), G451 (= G438), V453 (≠ A440), F459 (= F446)
5l2mA Structure of aldh1a1 in complex with buc11 (see paper)
36% identity, 98% coverage: 6:473/477 of query aligns to 15:486/494 of 5l2mA
- active site: N163 (= N151), K186 (= K174), E262 (= E249), C296 (= C283), E393 (= E380), E470 (= E457)
- binding 2,3,5-trimethyl-6-[3-oxo-3-(piperidin-1-yl)propyl]-7H-furo[3,2-g][1]benzopyran-7-one: F164 (= F152), F283 (≠ M270), H286 (≠ T273), Y290 (≠ R277)
4wpnA Structure of human aldh1a1 with inhibitor cm053 (see paper)
36% identity, 98% coverage: 6:473/477 of query aligns to 15:486/494 of 4wpnA
- active site: N163 (= N151), K186 (= K174), E262 (= E249), C296 (= C283), E393 (= E380), E470 (= E457)
- binding 1-{[1,3-dimethyl-7-(3-methylbutyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]methyl}piperidine-4-carboxamide: F164 (= F152), H286 (≠ T273), G287 (≠ A274), Y290 (≠ R277), C295 (≠ V282), I297 (≠ V284), G451 (= G438), V453 (≠ A440)
5teiA Structure of human aldh1a1 with inhibitor cm039
36% identity, 98% coverage: 6:473/477 of query aligns to 14:485/493 of 5teiA
- active site: N162 (= N151), K185 (= K174), E261 (= E249), C295 (= C283), E392 (= E380), E469 (= E457)
- binding 6-{[(3-fluorophenyl)methyl]sulfanyl}-5-(2-methylphenyl)-2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one: S113 (≠ E102), F163 (= F152), H285 (≠ T273), G286 (≠ A274), Y289 (≠ R277), C295 (= C283), G450 (= G438), V452 (≠ A440), F458 (= F446)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I158 (≠ F147), I159 (≠ T148), P160 (= P149), W161 (= W150), N162 (= N151), K185 (= K174), E188 (= E177), G218 (≠ P207), G222 (≠ S211), A223 (≠ E212), F236 (= F225), T237 (= T226), G238 (= G227), S239 (= S228), V242 (= V231), C295 (= C283), Q342 (≠ R330), K345 (≠ A333), E392 (= E380), F394 (= F382)
4x4lA Structure of human aldh1a1 with inhibitor cm037 (see paper)
36% identity, 98% coverage: 6:473/477 of query aligns to 14:485/493 of 4x4lA
- active site: N162 (= N151), K185 (= K174), E261 (= E249), C295 (= C283), E392 (= E380), E469 (= E457)
- binding ethyl ({4-oxo-3-[3-(pyrrolidin-1-yl)propyl]-3,4-dihydro[1]benzothieno[3,2-d]pyrimidin-2-yl}sulfanyl)acetate: S113 (≠ E102), M167 (≠ Q156), W170 (≠ R159), Y289 (≠ R277), G450 (= G438), F458 (= F446)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I158 (≠ F147), I159 (≠ T148), P160 (= P149), W161 (= W150), K185 (= K174), E188 (= E177), G218 (≠ P207), G222 (≠ S211), F236 (= F225), T237 (= T226), G238 (= G227), S239 (= S228), V242 (= V231), C295 (= C283), Q342 (≠ R330), K345 (≠ A333), E392 (= E380), F394 (= F382)
4wb9A Human aldh1a1 complexed with nadh (see paper)
36% identity, 98% coverage: 6:473/477 of query aligns to 14:485/493 of 4wb9A
- active site: N162 (= N151), K185 (= K174), E261 (= E249), C295 (= C283), E392 (= E380), E469 (= E457)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I158 (≠ F147), I159 (≠ T148), P160 (= P149), W161 (= W150), N162 (= N151), K185 (= K174), E188 (= E177), G218 (≠ P207), G222 (≠ S211), F236 (= F225), T237 (= T226), G238 (= G227), S239 (= S228), V242 (= V231), G263 (= G251), C295 (= C283), Q342 (≠ R330), K345 (≠ A333), E392 (= E380), F394 (= F382)
7jwwA Crystal structure of human aldh1a1 bound to compound (r)-28 (see paper)
36% identity, 98% coverage: 6:473/477 of query aligns to 15:486/494 of 7jwwA
- active site: N163 (= N151), K186 (= K174), E262 (= E249), C296 (= C283), E393 (= E380), E470 (= E457)
- binding 5-{4-[(Z)-2-hydroxyethenyl]phenyl}-1-methyl-6-{[(1R)-1-phenylethyl]sulfanyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one: G118 (= G105), T122 (= T109), F164 (= F152), M168 (≠ Q156), Y290 (≠ R277), C295 (≠ V282), C296 (= C283), I297 (≠ V284), V453 (≠ A440), F459 (= F446)
Query Sequence
>HSERO_RS07235 FitnessBrowser__HerbieS:HSERO_RS07235
MYKDVQLFINGEWTASASGRTIDVINPATEEVIGKIAHADRADLDRALEAASKGFETWRN
MSAFERSKIMRRAADLLRERAEEVARLMTMEQGKPLAEAKMETLGAADTIDWFAEEARRT
YGRLVPARVPGAYQMVIKEPVGPVAAFTPWNFPLNQVVRKLSAALAAGCSIIVKAPEETP
ASPAELIRAYADAGVPAGVINLVYGVPAEISEYLIPHPVIKKISFTGSTPVGKQLAALAG
QHMKRATMELGGHAPAMVFDDADVDVAAKMLATAKFRNAGQVCVSPTRFLVQKGVFNAFV
DKFVTYAEQLKVGNGLEAGITMGPVANKRRIPALEALIDDAVSQGAQLRTGGKRIGNKGY
FFQPTVLTNLPLQARAMNEEPFGPLALINSFETLDEVITEANRLPYGLAAYAFAKSAHTK
HALAARVESGMLTINHLGLALPELPFGGIKDSGYGSEGGTEAIEAYINTKLVTQLDV
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory