Comparing HSERO_RS07760 FitnessBrowser__HerbieS:HSERO_RS07760 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 8 hits to proteins with known functional sites (download)
E9AE57 Fumarate hydratase 2; Fumarase 2; LmFH-2; EC 4.2.1.2 from Leishmania major (see paper)
30% identity, 92% coverage: 16:489/513 of query aligns to 82:564/568 of E9AE57
P14407 Fumarate hydratase class I, anaerobic; D-tartrate dehydratase; Fumarase B; EC 4.2.1.2; EC 4.2.1.81 from Escherichia coli (strain K12) (see paper)
31% identity, 90% coverage: 25:484/513 of query aligns to 64:531/548 of P14407
6uoiA Crystal structure of cytosolic fumarate hydratase from leishmania major in a complex with malonate (see paper)
30% identity, 92% coverage: 16:489/513 of query aligns to 57:531/535 of 6uoiA
6msnA Crystal structure of cytosolic fumarate hydratase from leishmania major in a complex with inhibitor thiomalate (see paper)
29% identity, 92% coverage: 16:489/513 of query aligns to 55:528/532 of 6msnA
6unzA Crystal structure of cytosolic fumarate hydratase from leishmania major (see paper)
29% identity, 92% coverage: 16:489/513 of query aligns to 62:535/539 of 6unzA
6uqnB Crystal structure of r173a variant of cytosolic fumarate hydratase from leishmania major in a complex with fumarate and s-malate (see paper)
29% identity, 92% coverage: 16:489/513 of query aligns to 55:528/532 of 6uqnB
6msoA Crystal structure of mitochondrial fumarate hydratase from leishmania major in a complex with inhibitor thiomalate (see paper)
30% identity, 89% coverage: 27:484/513 of query aligns to 56:533/540 of 6msoA
Q4QAU9 Fumarate hydratase 1, mitochondrial; Fumarase 1; LmFH-1; EC 4.2.1.2 from Leishmania major (see paper)
30% identity, 89% coverage: 27:484/513 of query aligns to 65:542/549 of Q4QAU9
>HSERO_RS07760 FitnessBrowser__HerbieS:HSERO_RS07760
MTIIKQDDLIESVAAALQYISYYHPADYIQHLARAYETEQSPAAKDAIAQILTNSRMCAE
GKRPICQDTGIVNVFLKIGMGVRFEGFSGSIADAVNEGVRRGYSHPDNVLRASIVADPQF
ERKNTKDNTPAVIHMELVPGNTVDVQIAAKGGGSENKTKFVMLNPSDNLVDWVLKTVPTM
GAGWCPPGMLGIGIGGTAEKAMLMAKEVLMEDIDMYELLKRGPQNKTEELRIELYEKVNA
LGIGAQGLGGLTTVLDVKIMMHPTHAASKPVAMIPNCAATRHGHFVLDGSGPAYMEPPSL
SDWPEVHWVADTEKSKRVNLDTLTKEEVASWKPGQTLLLNGKMLTGRDAAHKRIQDMLAK
GEKLPVDFTNRVIYYVGPVDPVRDEVVGPAGPTTATRMDKFTDMMLEQTGLISMIGKSER
GPAAIEAIKKHKSAYLMAVGGSAYLVSKAIKSAKVLGFADLGMEAIYEFDVKDMPVTVAV
DANGVSVHNTGPAEWKEKIAQSVSLSKIPVTTA
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory