SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing HSERO_RS08290 FitnessBrowser__HerbieS:HSERO_RS08290 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

1ji0A Crystal structure analysis of the abc transporter from thermotoga maritima
57% identity, 99% coverage: 1:232/234 of query aligns to 6:238/240 of 1ji0A

query
sites
1ji0A

M

V

L

L

Q

E

F

V

D

Q

K

S

V

L

H

H

T

V

H

Y

Y
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Y

G

G

A

A

I

I

E

H

A

A

L

I

H

K

G

G

V

I

S

D

L

L

N

K

V

V

E

P

K

R

G

G

E

Q

I

I

V

V

T

T

L

L

I

I

G

G

A

A

N

N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

L

T

L

L

M

S

T

A

L

I

C

A

G

G

R

L

P

V

R

R

A

A

S

Q

S

K

G

G

R

K

V

I

I

I

F

F

E

N

G

G

Q

Q

D

D

I

I

T

T

Q

N

L

K

Q

P

T

A

H

H

E

V

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N

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R

M

G

G

L

I

A

A

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P

E
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E

G

G

R

R

V

I

F

F

P

P

S

E

L

L

T

T

V

V

L

Y

E

E

N

N

L

L

K

M

M

M

G

G

A

A

F

Y

F

N

A

R

S

K

N

D

-

K

E

E

A

G

I

I

E

K

Q

R

G

D

I

L

E

E

Y

W

V

I

F

F

G

S

L

L

F

F

P

P

R

R

L

L

K

K

E

E

R

R

A

L

A

K

Q

Q

R

L

A

G

G

G

T

T

M

L

S

S

G

G

E

E

Q

Q

M

M

L

L

A

A

I

I

G

G

R

R

A

A

L

L

M

M

S

S

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R

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P

R

K

L

L

L

M

D

D

E
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E

P

P

T

S

L

L

G

G

L

L

A

A

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P

L

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L

I

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A

S

Q

E

I

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F

F

D

E

I

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I

R

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K

I

I

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N

E

Q

S

E

G

G

V

T

T

T

V

I

F

L

L

L

V

V

E

E

Q

Q

N

N

A

A

N

L

K

G

A

A

L

L

G

K

V

V

A

A

D

H

R

Y

G

G

Y

Y

V

V

L

L

E

E

N

T

G

G

H

Q

V

I

V

V

M

L

S

E

D

G

T

K

G

A

A

S

N

E

L

L

A

D

N

N

S

E

D

M

V

V

R

R

K

K

A

A

Y

Y

L

L

G

G

binding adenosine-5'-triphosphate: Y16 (= Y11), G42 (= G37), G44 (= G39), K45 (= K40), T46 (= T41), T47 (= T42), E88 (= E83), E165 (= E159)

1g6hA Crystal structure of the adp conformation of mj1267, an atp-binding cassette of an abc transporter (see paper)
31% identity, 99% coverage: 1:232/234 of query aligns to 4:253/254 of 1g6hA

query
sites
1g6hA

M

I

L

L

Q

R

F

T

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E

K

N

V

I

H

V

T

K

H

Y

Y
x
F

G

G

A

E

I
x
F

E

K

A

A

L

L

H

D

G

G

V

V

S

S

L

I

N

S

V

V

E

N

K

K

G

G

E

D

I

V

V

T

T

L

L

I

I

I

G

G

A

P

N
|
N

G
|
G

A

S

G
|
G

K
|
K

T
x
S

T
|
T

L

L

L

I

M

N

T

V

L

I

C

T

G

G

R

F

P

L

R

K

A

A

S

D

S

E

G

G

R

R

V

V

I

Y

F

F

E

E

G

N

Q

K

D

D

I

I

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N

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K

Q

E

T

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H

A

E

E

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M

Y

R

H

R

Y

G

G

L

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A

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E

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P

R

Q

V

P

F

L

P

K

S

E

L

M

T

T

V

V

L

L

E

E

N

N

L

L

K

L

M

I

G

G

A

E

F

I

F

C

A

P

S

G

N

E

E

S

A

P

I

L

-

N

-

S

-

L

-

F

-

Y

-

K

-

W

-

I

-

P

-

K

-

E

E

E

Q

E

G

M

I

V

E

E

Y

K

V

A

F

F

G

K

L

I

-

L

-

E

F

F

P

L

R

K

L

L

K

S

E

H

R

L

A

Y

A

D

Q

R

R

K

A

A

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E

M

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S

G

G

E

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M

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L

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A

E

I

I

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G

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R

A

A

L

L

M

M

S

T

K

N

P

P

R

K

L

M

L

I

L

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L

M

D

D

E

E

P

P

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I

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A

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G

L

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A

A

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P

L

G

V

L

I

A

A

H

Q

D

I

I

F

F

D

N

I

H

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R

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T

E

I

L

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E

A

S

K

G

G

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I

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F

F

L

L

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I

E

E

Q

H

N

R

A

L

N

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K

I

A

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L

L

G

N

V

Y

A

I

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D

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H

G

L

Y

Y

V

V

L

M

E

F

N

N

G

G

H

Q

V

I

M

A

S

E

D

G

T

R

G

G

-

E

-

I

A

K

N

N

L

V

L

L

A

S

N

D

S

P

D

K

V

V

R

V

K

E

A

I

Y

Y

L

I

G

G

binding adenosine-5'-diphosphate: F14 (≠ Y11), F17 (≠ I14), N39 (= N36), G40 (= G37), G42 (= G39), K43 (= K40), S44 (≠ T41), T45 (= T42)

1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter (see paper)
31% identity, 99% coverage: 1:232/234 of query aligns to 4:253/253 of 1g9xB

query
sites
1g9xB

M

I

L

L

Q

R

F

T

D

E

K

N

V

I

H

V

T

K

H

Y

Y
x
F

G

G

A

E

I
x
F

E

K

A

A

L

L

H

D

G

G

V

V

S

S

L

I

N

S

V

V

E

C

K

K

G

G

E

D

I

V

V

T

T

L

L

I

I

I

G

G

A

P

N

N

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

L

L

L

I

M

N

T

V

L

I

C

T

G

G

R

F

P

L

R

K

A

A

S

D

S

E

G

G

R

R

V

V

I

Y

F

F

E

E

G

N

Q

K

D

D

I

I

T

T

Q

N

L

K

Q

E

T

P

H

A

E

E

I

L

M

Y

R

H

R

Y

G

G

L

I

A

V

I

R

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F

E

Q

G

T

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P

R

Q

V

P

F

L

P

K

S

E

L

M

T

T

V

V

L

L

E

E

N

N

L

L

K

L

M

I

G

G

A

E

F

I

F

N

A

P

S

G

N

E

E

S

A

P

I

L

-

N

-

S

-

L

-

F

-

Y

-

K

-

W

-

I

-

P

-

K

-

E

E

E

Q

E

G

M

I

V

E

E

Y

K

V

A

F

F

G

K

L

I

-

L

-

E

F

F

P

L

R

K

L

L

K

S

E

H

R

L

A

Y

A

D

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R

R

K

A

A

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T

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M

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S

G

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E

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M

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A

E

I

I

G

G

R

R

A

A

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M

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T

K

N

P

P

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K

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M

L

I

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L

M

D

D

E
|
E

P

P

T

I

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A

G

G

L

V

A

A

P

P

L

G

V

L

I

A

A

H

Q

D

I

I

F

F

D

N

I

H

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E

I

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K

E

A

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K

G

G

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I

T

T

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F

F

L

L

I

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I

E

E

Q

H

N

R

A

L

N

D

K

I

A

V

L

L

G

N

V

Y

A

I

D

D

R

H

G

L

Y

Y

V

V

L

M

E

F

N

N

G

G

H

Q

V

I

M

A

S

E

D

G

T

R

G

G

-

E

-

I

A

K

N

N

L

V

L

L

A

S

N

D

S

P

D

K

V

V

R

V

K

E

A

I

Y

Y

L

I

G

G

binding adenosine-5'-diphosphate: F14 (≠ Y11), F17 (≠ I14), G40 (= G37), S41 (≠ A38), G42 (= G39), K43 (= K40), S44 (≠ T41), T45 (= T42)
binding magnesium ion: S44 (≠ T41), E176 (= E159)

6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter (see paper)
33% identity, 95% coverage: 11:232/234 of query aligns to 12:235/235 of 6mhzA

query
sites
6mhzA

Y
|
Y

G

K

A

G

I

R

E

R

A

V

L

V

H

E

G

D

V

V

S

S

L

L

N

T

V

V

E

N

K

S

G

G

E

E

I

I

V

V

T

G

L

L

I

L

G

G

A

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

L

T

L

F

M

Y

T

M

L

V

C

V

G

G

R

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A

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S

A

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N

V

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D

G

D

Q

D

D

D

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H

E

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M

A

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G

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P

E
x
Q

G

E

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A

R

S

V

I

F

F

P

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S

R

L

L

T

S

V

V

L

Y

E

D

N

N

L

L

K

M

M

A

G

V

A

L

F

Q

F

I

A

R

S

D

N

D

E

L

A

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I

A

E

E

Q

Q

G

R

I

E

E

D

Y

R

V

A

F

N

G

E

L

L

-

M

-

E

-

F

-

H

F

I

P

E

R

H

L

L

K

R

E

D

R

S

A

M

A

G

Q

Q

R

-

A

-

G

-

T
x
S

M

L

S
|
S

G
|
G

E

E

Q

R

M

R

L

V

A

E

I

I

G

A

R

R

A

A

L

L

M

A

S

A

K

N

P

P

R

K

L

F

L

I

L

L

D

D

E
|
E

P

P

T

F

L

A

G
|
G

L

V

A

D

P

P

L

I

V

S

I

V

A

I

Q

D

I

I

F

K

D

R

I

I

R

E

T

H

I

L

R

R

E

D

S

S

G

G

V

L

T

G

V

V

F

L

L

I

V

T

E

D

Q
x
H

N

N

A

V

N

R

K

E

A

T

L

L

G

A

V

V

A

C

D

E

R

R

G

A

Y

Y

V

I

L

V

E

S

N

Q

G

G

H

H

V

L

V

I

M

A

S

H

D

G

T

T

G

P

A

T

N

E

L

I

L

L

A

Q

N

D

S

E

D

H

V

V

R

K

K

R

A

V

Y

Y

L

L

G

G

binding adp orthovanadate: Y12 (= Y11), N37 (= N36), G38 (= G37), G40 (= G39), K41 (= K40), T42 (= T41), T43 (= T42), Q84 (≠ E83), S136 (≠ T133), S138 (= S135), G139 (= G136), G140 (= G137), E162 (= E159), G166 (= G163), H194 (≠ Q191)

6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide (see paper)
33% identity, 95% coverage: 11:232/234 of query aligns to 12:235/238 of 6s8nB

query
sites
6s8nB

Y

Y

G

K

A

G

I

R

E

R

A

V

L

V

H

E

G

D

V

V

S

S

L

L

N

T

V

V

E

N

K

S

G

G

E

E

I

I

V

V

T

G

L

L

I

L

G

G

A

P

N

N

G

G

A

A

G

G

K

K

T

T

L

T

L

F

M

Y

T

M

L

V

C

V

G

G

R

I

P

V

R

P

A

R

S

D

S

A

G

G

R

N

V

I

I

I

F

I

E

D

G

D

Q

D

D

D

I

I

T

S

Q

L

L

L

Q

P

T

L

H

H

E

A

I

R

M

A

R

R

G

G

L

I

A

G

I

Y

S

L

P

P

E

Q

G

E

R

A

R

S

V

I

F

F

P
x
R

S

R

L

L

T

S

V

V

L

Y

E

D

N

N

L

L

K

M

M

A

G

V

A

L

F

Q

F

I

A

R

S

D

N

D

E

L

A

S

I

A

E

E

Q

Q

G

R

I

E

E

D

Y

R

V

A

F

N

G

E

L

L

-

M

-

E

-

F

-

H

F

I

P

E

R

H

L

L

K

R

E

D

R

S

A
x
M

A
x
G

Q
|
Q

R

-

A

-

G

-

T

S

M

L

S

S

G

G

E

E

Q

R

M

R

L

V

A

E

I

I

G

A

R

R

A

A

L

L

M

A

S

A

K

N

P

P

R

K

L

F

L

I

L

L

D

D

E

E

P

P

T

F

L

A

G

G

L

V

A

D

P

P

L

I

V

S

I

V

A

I

Q

D

I

I

F

K

D

R

I

I

R

E

T

H

I

L

R

R

E

D

S

S

G

G

V

L

T

G

V

V

F

L

L

I

V

T

E

D

Q

H

N

N

A

V

N

R

K

E

A

T

L

L

G

A

V

V

A

C

D

E

R

R

G

A

Y

Y

V

I

L

V

E

S

N

Q

G

G

H

H

V

L

V

I

M

A

S

H

D

G

T

T

G

P

A

T

N

E

L

I

L

L

A

Q

N

D

S

E

D

H

V

V

R

K

K

R

A

V

Y

Y

L

L

G

G

binding 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione: R90 (≠ P89), M133 (≠ A127), G134 (≠ A128), Q135 (= Q129)

6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp (see paper)
33% identity, 95% coverage: 11:232/234 of query aligns to 12:235/238 of 6s8gA

query
sites
6s8gA

Y
|
Y

G

K

A

G

I
x
R

E

R

A

V

L

V

H

E

G

D

V

V

S

S

L

L

N

T

V

V

E

N

K

S

G

G

E

E

I

I

V

V

T

G

L

L

I

L

G

G

A

P

N
|
N

G

G

A

A

G
|
G

K
|
K

T
|
T

L

T

L

F

M

Y

T

M

L

V

C

V

G

G

R

I

P

V

R

P

A

R

S

D

S

A

G

G

R

N

V

I

I

I

F

I

E

D

G

D

Q

D

D

D

I

I

T

S

Q

L

L

L

Q

P

T

L

H

H

E

A

I

R

M

A

R

R

G

G

L

I

A

G

I

Y

S

L

P

P

E
x
Q

G

E

R

A

R

S

V

I

F

F

P

R

S

R

L

L

T

S

V

V

L

Y

E

D

N

N

L

L

K

M

M

A

G

V

A

L

F

Q

F

I

A

R

S

D

N

D

E

L

A

S

I

A

E

E

Q

Q

G

R

I

E

E

D

Y

R

V

A

F

N

G

E

L

L

-

M

-

E

-

F

-

H

F

I

P

E

R

H

L

L

K

R

E

D

R

S

A

M

A

G

Q

Q

R

-

A

-

G

-

T
x
S

M

L

S
|
S

G

G

E
|
E

Q

R

M

R

L

V

A

E

I

I

G

A

R

R

A

A

L

L

M

A

S

A

K

N

P

P

R

K

L

F

L

I

L

L

D

D

E

E

P

P

T

F

L

A

G

G

L

V

A

D

P

P

L

I

V

S

I

V

A

I

Q

D

I

I

F

K

D

R

I

I

R

E

T

H

I

L

R

R

E

D

S

S

G

G

V

L

T

G

V

V

F

L

L

I

V

T

E

D

Q

H

N

N

A

V

N

R

K

E

A

T

L

L

G

A

V

V

A

C

D

E

R

R

G

A

Y

Y

V

I

L

V

E

S

N

Q

G

G

H

H

V

L

V

I

M

A

S

H

D

G

T

T

G

P

A

T

N

E

L

I

L

L

A

Q

N

D

S

E

D

H

V

V

R

K

K

R

A

V

Y

Y

L

L

G

G

binding phosphoaminophosphonic acid-adenylate ester: Y12 (= Y11), R15 (≠ I14), N37 (= N36), G40 (= G39), K41 (= K40), T42 (= T41), T43 (= T42), Q84 (≠ E83), S136 (≠ T133), S138 (= S135), E141 (= E138)

6mjpA Lptb(e163q)fgc from vibrio cholerae (see paper)
31% identity, 95% coverage: 11:232/234 of query aligns to 12:235/240 of 6mjpA

query
sites
6mjpA

Y

Y

G

K

A

K

I

R

E

K

A

V

L

V

H

S

G

D

V

V

S

S

L

L

N

Q

V

V

E

E

K

S

G

G

E

Q

I

I

V

V

T

G

L

L

I

L

G

G

A

P

N

N

G

G

A

A

G

G

K

K

T

T

L

S

L

F

M

Y

T

M

L

I

C

V

G

G

R

L

P

V

R

A

A

R

S

D

S

E

G

G

R

T

V

I

I

T

F

I

E

D

G

D

Q

N

D

D

I

I

T

S

Q

I

L

L

Q

P

T

M

H

H

E

S

I

R

M

S

R

R

R

M

G

G

L

I

A

G

I

Y

S

L

P

P

E

Q

G

E

R

A

R

S

V

I

F

F

P

R

S

K

L

L

T

S

V

V

L

E

E

D

N

N

L

I

K

M

M

-

G

-

A

A

F

V

F

L

A

Q

S

T

N

R

E

E

A

E

I

L

-

T

-

H

E
|
E

Q

E

G

R

I

Q

E
x
D

Y

K

V

L

F

E

G

D

L

L

F

L

P

E

R

E

L

F

K

H

E

I

R

Q

A

H

A

I

Q

R

R

K

A

S

G

A

T

G

M

M

-

A

-

L

S

S

G

G

E

E

Q

R

M

R

L

V

A

E

I

I

G

A

R

R

A

A

L

L

M

A

S

A

K

N

P

P

R

Q

L

F

L

I

L

L

D

D

E

Q

P

P

T

F

L

A

G

G

L

V

A

D

P

P

L

I

V

S

I

V

A

I

Q

D

I

I

F

K

D

K

I

I

R

E

T

H

I

L

R

R

E

D

S

R

G

G

V

L

T

G

V

V

F

L

L

I

V

T

E

D

Q

H

N

N

A

V

N

R

K

E

A

T

L

L

G

D

V

V

A

C

D

E

R

K

G

A

Y

Y

V

I

L

V

E

S

N

Q

G

G

H

R

V

L

V

I

M

A

S

E

D

G

T

T

G

P

A

Q

N

D

L

V

L

L

A

N

N

N

S

E

D

Q

V

V

R

K

K

Q

A

V

Y

Y

L

L

G

G

binding calcium ion: E111 (= E110), D115 (≠ E114)

6mbnA Lptb e163q in complex with atp (see paper)
33% identity, 95% coverage: 11:232/234 of query aligns to 13:236/241 of 6mbnA

query
sites
6mbnA

Y
|
Y

G

K

A

G

I
x
R

E

R

A
x
V

L

V

H

E

G

D

V

V

S

S

L

L

N

T

V

V

E

N

K

S

G

G

E

E

I

I

V

V

T

G

L

L

I

L

G

G

A

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

L

T

L

F

M

Y

T

M

L

V

C

V

G

G

R

I

P

V

R

P

A

R

S

D

S

A

G

G

R

N

V

I

I

I

F

I

E

D

G

D

Q

D

D

D

I

I

T

S

Q

L

L

L

Q

P

T

L

H

H

E

A

I

R

M

A

R

R

G

G

L

I

A

G

I

Y

S

L

P

P

E

Q

G

E

R

A

R

S

V

I

F

F

P

R

S

R

L

L

T

S

V

V

L

Y

E

D

N

N

L

L

K

M

M

A

G

V

A

L

F

Q

F

I

A

R

S

D

N

D

E

L

A

S

I

A

E

E

Q

Q

G

R

I

E

E

D

Y

R

V

A

F

N

G

E

L

L

F

M

P

E

-

E

-

F

-

H

-

I

-

E

R

H

L

L

K

R

E

D

R

S

A

M

A

G

Q

Q

R

-

A

-

G

-

T

S

M

L

S

S

G

G

E

E

Q

R

M

R

L

V

A

E

I

I

G

A

R

R

A

A

L

L

M

A

S

A

K

N

P

P

R

K

L

F

L

I

L

L

D

D

E

Q

P

P

T

F

L

A

G

G

L

V

A

D

P

P

L

I

V

S

I

V

A

I

Q

D

I

I

F

K

D

R

I

I

R

E

T

H

I

L

R

R

E

D

S

S

G

G

V

L

T

G

V

V

F

L

L

I

V

T

E

D

Q
x
H

N

N

A

V

N

R

K

E

A

T

L

L

G

A

V

V

A

C

D

E

R

R

G

A

Y

Y

V

I

L

V

E

S

N

Q

G

G

H

H

V

L

V

I

M

A

S

H

D

G

T

T

G

P

A

T

N

E

L

I

L

L

A

Q

N

D

S

E

D

H

V

V

R

K

K

R

A

V

Y

Y

L

L

G

G

binding adenosine-5'-triphosphate: Y13 (= Y11), R16 (≠ I14), V18 (≠ A16), N38 (= N36), G39 (= G37), G41 (= G39), K42 (= K40), T43 (= T41), T44 (= T42), H195 (≠ Q191)

6b89A E. Coli lptb in complex with adp and novobiocin (see paper)
33% identity, 94% coverage: 11:231/234 of query aligns to 12:234/234 of 6b89A

query
sites
6b89A

Y
|
Y

G

K

A

G

I
x
R

E

R

A
x
V

L

V

H

E

G

D

V

V

S

S

L

L

N

T

V

V

E

N

K

S

G

G

E

E

I

I

V

V

T

G

L

L

I

L

G

G

A

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

L

T

L

F

M

Y

T

M

L

V

C

V

G

G

R

I

P

V

R

P

A

R

S

D

S

A

G

G

R

N

V

I

I

I

F

I

E

D

G

D

Q

D

D

D

I

I

T

S

Q

L

L

L

Q

P

T
x
L

H
|
H

E

A

I

R

M

A

R

R

G

G

L

I

A

G

I

Y

S

L

P
|
P

E
x
Q

G

E

R
x
A

R
x
S

V

I

F
|
F

P
x
R

S
x
R

L
|
L

T

S

V

V

L

Y

E

D

N

N

L

L

K

M

M

A

G
x
V

A

L

F

Q

F

I

A

R

S

D

N

D

E

L

A

S

I

A

E

E

Q

Q

G

R

I

E

E

D

Y

R

V

A

F

N

G

E

L

L

F

M

P

E

-

E

-

F

-

H

-

I

-

E

R

H

L

L

K

R

E

D

R

S

A

M

A

G

Q
|
Q

R

-

A

-

G

-

T

S

M

L

S

S

G

G

E

E

Q

R

M

R

L

V

A

E

I

I

G

A

R
|
R

A

A

L

L

M

A

S

A

K

N

P

P

R

K

L

F

L

I

L

L

D

D

E

E

P

P

T

F

L

A

G

G

L

V

A

D

P

P

L

I

V

S

I

V

A

I

Q

D

I

I

F

K

D

R

I

I

R

E

T

H

I

L

R

R

E

D

S

S

G

G

V

L

T

G

V

V

F

L

L

I

V

T

E

D

Q

H

N

N

A

V

N

R

K

E

A

T

L

L

G

A

V

V

A

C

D

E

R

R

G

A

Y

Y

V

I

L

V

E

S

N

Q

G

G

H

H

V

L

V

I

M

A

S

H

D

G

T

T

G

P

A

T

N

E

L

I

L

L

A

Q

N

D

S

E

D

H

V

V

R

K

K

R

A

V

Y

Y

L

L

binding adenosine-5'-diphosphate: Y12 (= Y11), R15 (≠ I14), V17 (≠ A16), N37 (= N36), G38 (= G37), G40 (= G39), K41 (= K40), T42 (= T41), T43 (= T42)
binding magnesium ion: T42 (= T41), Q84 (≠ E83)
binding novobiocin: L71 (≠ T70), H72 (= H71), P83 (= P82), A86 (≠ R85), S87 (≠ R86), F89 (= F88), R90 (≠ P89), R91 (≠ S90), L92 (= L91), V101 (≠ G100), Q135 (= Q129), R149 (= R146)

4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium (see paper)
33% identity, 94% coverage: 11:231/234 of query aligns to 12:234/234 of 4p31A

query
sites
4p31A

Y
|
Y

G

K

A

G

I
x
R

E

R

A
x
V

L

V

H

E

G

D

V

V

S

S

L

L

N

T

V

V

E

N

K

S

G

G

E

E

I

I

V

V

T

G

L

L

I

L

G

G

A

P

N

N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

L

T

L

F

M

Y

T

M

L

V

C

V

G

G

R

I

P

V

R

P

A

R

S

D

S

A

G

G

R

N

V

I

I

I

F

I

E

D

G

D

Q

D

D

D

I

I

T

S

Q

L

L

L

Q

P

T

L

H

H

E

A

I

R

M

A

R

R

G

G

L

I

A

G

I

Y

S

L

P

P

E
x
Q

G

E

R

A

R

S

V

I

F

F

P

R

S

R

L

L

T

S

V

V

L

Y

E

D

N

N

L

L

K

M

M

A

G

V

A

L

F

Q

F

I

A

R

S

D

N

D

E

L

A

S

I

A

E

E

Q

Q

G

R

I

E

E

D

Y

R

V

A

F

N

G

E

L

L

F

M

P

E

-

E

-

F

-

H

-

I

-

E

R

H

L

L

K

R

E

D

R

S

A

M

A

G

Q

Q

R

-

A

-

G

-

T

S

M

L

S

S

G

G

E

E

Q

R

M

R

L

V

A

E

I

I

G

A

R

R

A

A

L

L

M

A

S

A

K

N

P

P

R

K

L

F

L

I

L

L

D

D

E

E

P

P

T

F

L

A

G

G

L

V

A

D

P

P

L

I

V

S

I

V

A

I

Q

D

I

I

F

K

D

R

I

I

R

E

T

H

I

L

R

R

E

D

S

S

G

G

V

L

T

G

V

V

F

L

L

I

V

T

E

D

Q

H

N

N

A

V

N

R

K

E

A

T

L

L

G

A

V

V

A

C

D

E

R

R

G

A

Y

Y

V

I

L

V

E

S

N

Q

G

G

H

H

V

L

V

I

M

A

S

H

D

G

T

T

G

P

A

T

N

E

L

I

L

L

A

Q

N

D

S

E

D

H

V

V

R

K

K

R

A

V

Y

Y

L

L

binding adenosine-5'-diphosphate: Y12 (= Y11), R15 (≠ I14), V17 (≠ A16), G38 (= G37), G40 (= G39), K41 (= K40), T42 (= T41), T43 (= T42)
binding magnesium ion: T42 (= T41), Q84 (≠ E83)

6b8bA E. Coli lptb in complex with adp and a novobiocin derivative (see paper)
32% identity, 94% coverage: 11:230/234 of query aligns to 12:233/233 of 6b8bA

query
sites
6b8bA

Y
|
Y

G

K

A

G

I
x
R

E

R

A
x
V

L

V

H

E

G

D

V

V

S

S

L

L

N

T

V

V

E

N

K

S

G

G

E

E

I

I

V

V

T

G

L

L

I

L

G

G

A

P

N

N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

L

T

L

F

M

Y

T

M

L

V

C

V

G

G

R

I

P

V

R

P

A

R

S

D

S

A

G

G

R

N

V

I

I

I

F

I

E

D

G

D

Q

D

D

D

I

I

T

S

Q

L

L

L

Q

P

T

L

H

H

E

A

I

R

M

A

R

R

G

G

L

I

A

G

I

Y

S

L

P

P

E

Q

G

E

R

A

R

S

V

I

F
|
F

P
x
R

S
x
R

L

L

T

S

V

V

L

Y

E

D

N

N

L

L

K

M

M

A

G

V

A

L

F

Q

F

I

A

R

S

D

N

D

E

L

A

S

I

A

E

E

Q

Q

G

R

I

E

E

D

Y

R

V

A

F

N

G

E

L

L

-

M

-

E

-

F

-

H

F

I

P

E

R

H

L

L

K

R

E

D

R

S

A

M

A

G

Q

Q

R

-

A

-

G

-

T

S

M

L

S

S

G

G

E

E

Q

R

M

R

L

V

A

E

I

I

G

A

R

R

A

A

L

L

M

A

S

A

K

N

P

P

R

K

L

F

L

I

L

L

D

D

E

E

P

P

T

F

L

A

G

G

L

V

A

D

P

P

L

I

V

S

I

V

A

I

Q

D

I

I

F

K

D

R

I

I

R

E

T

H

I

L

R

R

E

D

S

S

G

G

V

L

T

G

V

V

F

L

L

I

V

T

E

D

Q

H

N

N

A

V

N

R

K

E

A

T

L

L

G

A

V

V

A

C

D

E

R

R

G

A

Y

Y

V

I

L

V

E

S

N

Q

G

G

H

H

V

L

V

I

M

A

S

H

D

G

T

T

G

P

A

T

N

E

L

I

L

L

A

Q

N

D

S

E

D

H

V

V

R

K

K

R

A

V

Y

Y

binding adenosine-5'-diphosphate: Y12 (= Y11), R15 (≠ I14), V17 (≠ A16), G38 (= G37), G40 (= G39), K41 (= K40), T42 (= T41), T43 (= T42)
binding (3s,5s,7s)-N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl}tricyclo[3.3.1.1~3,7~]decane-1-carboxamide: F89 (= F88), R90 (≠ P89), R91 (≠ S90)

4u00A Crystal structure of ttha1159 in complex with adp (see paper)
29% identity, 91% coverage: 1:212/234 of query aligns to 2:215/241 of 4u00A

query
sites
4u00A

M

I

L

I

Q

R

F

I

D

R

K

N

V

L

H

H

T

K

H

W

Y
x
F

G

G

A

P

I

L

E

H

A
x
V

L

L

H

K

G

G

V

I

S

H

L

L

N

E

V

V

E

A

K

P

G

G

E

E

I

K

V

L

T

V

L

I

I

I

G

G

A

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

L

L

L

I

M

R

T

T

L

I

C

N

G

R

R

L

P

E

R

D

A

F

S

Q

S

E

G

G

R

E

V

V

I

V

F

V

E

D

G

G

Q

L

D

S

I

V

T

K

Q

D

L

D

Q

R

T

A

H

L

E

R

I

E

M

I

R

R

G

E

L

V

A

G

I

M

S

V

P

F

E

Q

G

Q

R

F

R

N

V

L

F

F

P

P

S

H

L

M

T

T

V

V

L

L

E

E

N

N

L

V

K

T

M

L

G

A

A

P

F

M

F

R

A

V

S

R

N

R

E

W

A

P

I

R

E

E

Q

K

G

A

I

E

E

K

Y

K

V

A

F

L

G

E

L

L

F

L

P

E

R

R

-

V

-

G

L

I

K

L

E

D

R

Q

A

A

A

R

Q

K

R

Y

A

P

G

A

T

Q

M

L

S

S

G

G

E

Q

Q

Q

M

R

L

V

A

A

I

I

G

A

R

R

A

A

L

L

M

A

S

M

K

E

P

P

R

K

L

I

L

M

L

L

L

F

D

D

E

E

P

P

T

T

L

S

G

A

L

L

A

D

P

P

L

E

V

M

I

V

A

G

Q

E

I

V

F

L

D

D

I

V

I

M

R

R

T

D

I

L

R

A

E

Q

S

G

G

G

V

M

T

T

V

M

F

V

L

V

V

V

E

T

Q

H

N

E

A

M

N

G

K

F

A

A

L

R

G

E

V

V

A

A

D

D

R

R

G

V

Y

V

V

F

L

M

E

D

N

G

G

G

H

Q

V

I

V

V

binding adenosine-5'-diphosphate: F12 (≠ Y11), V17 (≠ A16), S37 (≠ N36), G38 (= G37), S39 (≠ A38), G40 (= G39), K41 (= K40), S42 (≠ T41), T43 (= T42)

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
29% identity, 92% coverage: 1:216/234 of query aligns to 1:219/240 of 4ymuJ

query
sites
4ymuJ

M

M

L

I

Q

F

F

V

D

N

K

D

V

V

H

Y

T

K

H

N

Y
x
F

G

G

A

S

I

L

E

E

A
x
V

L

L

H

K

G

G

V

V

S

T

L

L

N

K

V

V

E

N

K

K

G

G

E

E

I

V

V

V

T

V

L

I

I

I

G

G

A

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

L

L

M

R

T

C

L

I

C

N

G

L

R

L

P

E

R

E

A

P

S

T

S

K

G

G

R

E

V

V

I

F

F

I

E

D

G

G

Q

V

D

K

I

I

T

N

Q

N

L

G

Q

K

T

V

H

N

-

I

E

N

I

K

M

V

R

R

R

Q

G

K

L

V

A

G

I

M

S

V

P

F

E

Q

G

H

R

F

R

N

V

L

F

F

P

P

S

H

L

L

T

T

V

A

L

I

E

E

N

N

L

I

K

T

M

L

G

A

A

P

F

V

F

K

A

V

S

K

N

K

E

M

A

N

I

K

E

K

Q

E

G

A

I

E

E

E

Y

L

V

A

F

V

G

D

L

L

F

L

P

A

R

K

-

V

-

G

L

L

K

L

E

D

R

K

A

K

A

D

Q

Q

R

Y

A

P

G

I

T

K

M

L

S

S

G

G

E

Q

Q

K

Q

Q

M

R

L

L

A

A

I

I

G

A

R

R

A

A

L

L

M

A

S

M

K

Q

P

P

R

E

L

V

L

M

L

L

L

F

D

D

E
|
E

P

P

T

T

L

S

G

A

L

L

A

D

P

P

L

E

V

M

I

V

A

K

Q

E

I

V

F

L

D

N

I

V

I

M

R

K

T

Q

I

L

R

A

E

N

S

E

G

G

V

M

T

T

V

M

F

V

L

V

V

V

E

T

Q
x
H

N

E

A

M

N

G

K

F

A

A

L

R

G

E

V

V

A

G

D

D

R

R

G

V

Y

I

V

F

L

M

E

D

N

D

G

G

H

V

V

I

V

V

M

E

S

E

D

G

T

T

binding adenosine-5'-triphosphate: F11 (≠ Y11), V16 (≠ A16), S36 (≠ N36), G37 (= G37), S38 (≠ A38), G39 (= G39), K40 (= K40), S41 (≠ T41), T42 (= T42), E162 (= E159), H194 (≠ Q191)
binding magnesium ion: S41 (≠ T41), E162 (= E159)

8w6iD Cryo-em structure of escherichia coli str k12 ftsex complex with atp- gamma-s in peptidisc
33% identity, 90% coverage: 1:211/234 of query aligns to 1:215/219 of 8w6iD

query
sites
8w6iD

M

M

L

I

Q

R

F

F

D

E

K

H

V

V

H

S

T

K

H

A

Y
|
Y

-

L

G

G

A

G

I

R

E

Q

A

A

L

L

H

Q

G

G

V

V

S

T

L

F

N

H

V

M

E

Q

K

P

G

G

E

E

I

M

V

A

T

F

L

L

I

T

G

G

A

H

N
x
S

G
|
G

A
|
A

G
|
G

K
|
K

T
x
S

T
|
T

L

L

M

K

T

L

L

I

C

C

G

G

R

I

P

E

R

R

A

P

S

S

S

A

G

G

R

K

V

I

I

W

F

F

E

S

G

G

Q

H

D

D

I

I

T

T

Q

R

L

L

Q

K

T

N

H

R

E

E

I

V

-

P

-

F

M

L

R

R

G

Q

L

I

A

G

I

M

S

I

P

F

E
x
Q

G

D

R

H

V

L

F

L

P

M

S

D

L

R

T

T

V

V

L

Y

E

D

N

N

L

V

K

A

M

I

G

P

A

L

F

I

-

A

-

G

A

A

S

S

N

G

E

D

A

D

I

I

E

R

Q

R

G

R

I

V

E

S

Y

A

V

A

F

L

-

D

-

K

-

V

G

G

L

L

F

L

P

D

R
x
K

L

A

K

K

E

N

R

F

A

P

A

I

Q
|
Q

R

-

A

-

G

-

T

-

M

L

S
|
S

G
|
G

E
|
E

Q

Q

M

R

L

V

A

G

I

I

G

A

R

R

A

A

L

V

M

V

S

N

K

K

P

P

R

A

L

V

L

L

L

A

D

D

E

E

P

P

T

T

L

G

G

N

L

L

A

D

P

D

L

A

V

L

I

S

A

E

Q

G

I

I

F

L

D

R

I

L

I

F

R

E

T

E

I

F

R

N

E

R

S

V

G

G

V

V

T

T

V

V

F

L

L

M

V

A

E

T

Q
x
H

N

D

A

I

N

N

K

L

A

I

L

S

G

R

V

R

A

S

D

Y

R

R

G

M

Y

L

V

T

L

L

E

S

N

D

G

G

H

H

V

L

binding phosphothiophosphoric acid-adenylate ester: Y11 (= Y11), S37 (≠ N36), G38 (= G37), A39 (= A38), G40 (= G39), K41 (= K40), S42 (≠ T41), T43 (= T42), Q86 (≠ E83), K130 (≠ R122), Q137 (= Q129), S139 (= S135), G140 (= G136), G141 (= G137), E142 (= E138), H195 (≠ Q191)

P0A9R7 Cell division ATP-binding protein FtsE from Escherichia coli (strain K12) (see paper)
33% identity, 90% coverage: 1:211/234 of query aligns to 1:215/222 of P0A9R7

query
sites
P0A9R7

M

M

L

I

Q

R

F

F

D

E

K

H

V

V

H

S

T

K

H

A

Y

Y

-

L

G

G

A

G

I

R

E

Q

A

A

L

L

H

Q

G

G

V

V

S

T

L

F

N

H

V

M

E

Q

K

P

G

G

E

E

I

M

V

A

T

F

L

L

I

T

G

G

A

H

N

S

G

G

A

A

G

G

K
|
K

T

S

T

T

L

L

M

K

T

L

L

I

C
|
C

G

G

R

I

P

E

R

R

A

P

S

S

S

A

G

G

R

K

V

I

I

W

F

F

E

S

G

G

Q

H

D

D

I

I

T

T

Q

R

L

L

Q

K

T

N

H

R

E

E

I

V

-

P

-

F

M

L

R

R

G

Q

L

I

A

G

I

M

S

I

P

F

E

Q

G

D

R

H

V

L

F

L

P

M

S

D

L

R

T

T

V

V

L

Y

E

D

N

N

L

V

K

A

M

I

G

P

A

L

F

I

-

A

-

G

A

A

S

S

N

G

E

D

A

D

I

I

E

R

Q

R

G

R

I

V

E

S

Y

A

V

A

F

L

-

D

-

K

-

V

G

G

L

L

F

L

P

D

R

K

L

A

K

K

E

N

R

F

A

P

A

I

Q

Q

R

-

A

-

G

-

T

-

M

L

S

S

G

G

E

E

Q

Q

M

R

L

V

A

G

I

I

G

A

R

R

A

A

L

V

M

V

S

N

K

K

P

P

R

A

L

V

L

L

L

A

D

D

E

E

P

P

T

T

L

G

G

N

L

L

A

D

P

D

L

A

V

L

I

S

A

E

Q

G

I

I

F

L

D

R

I

L

I

F

R

E

T

E

I

F

R

N

E

R

S

V

G

G

V

V

T

T

V

V

F

L

L

M

V

A

E

T

Q

H

N

D

A

I

N

N

K

L

A

I

L

S

G

R

V

R

A

S

D

Y

R

R

G

M

Y

L

V

T

L

L

E

S

N

D

G

G

H

H

V

L

K41 (= K40) mutation to R: Does not bind ATP.
C49 (= C48) mutation to A: Prevents dimer formation. Does not alter ATP-binding.

8hd0A Cell divisome spg hydrolysis machinery ftsex-envc
32% identity, 90% coverage: 1:211/234 of query aligns to 1:215/218 of 8hd0A

query
sites
8hd0A

M

M

L

I

Q

R

F

F

D

E

K

H

V

V

H

S

T

K

H

A

Y
|
Y

-

L

G

G

A

G

I
x
R

E

Q

A
|
A

L

L

H

Q

G

G

V

V

S

T

L

F

N

H

V

M

E

Q

K

P

G

G

E

E

I

M

V

A

T

F

L

L

I

T

G

G

A

H

N

S

G

G

A

A

G
|
G

K
|
K

T
x
S

T
|
T

L

L

M

K

T

L

L

I

C

C

G

G

R

I

P

E

R

R

A

P

S

S

S

A

G

G

R

K

V

I

I

W

F

F

E

S

G

G

Q

H

D

D

I

I

T

T

Q

R

L

L

Q

K

T

N

H

R

E

E

I

V

-

P

-

F

M

L

R

R

G

Q

L

I

A

G

I

M

S

I

P

F

E

Q

G

D

R

H

V

L

F

L

P

M

S

D

L

R

T

T

V

V

L

Y

E

D

N

N

L

V

K

A

M

I

G

P

A

L

F

I

-

A

-

G

A

A

S

S

N

G

E

D

A

D

I

I

E

R

Q

R

G

R

I

V

E

S

Y

A

V

A

F

L

-

D

-

K

-

V

G

G

L

L

F

L

P

D

R

K

L

A

K

K

E

N

R

F

A

P

A

I

Q

Q

R

-

A

-

G

-

T

-

M

L

S
|
S

G

G

G
|
G

E

E

Q

Q

M

R

L

V

A

G

I

I

G

A

R

R

A

A

L

V

M

V

S

N

K

K

P

P

R

A

L

V

L

L

L

A

D

D

E

Q

P

P

T

T

L

G

G

N

L

L

A

D

P

D

L

A

V

L

I

S

A

E

Q

G

I

I

F

L

D

R

I

L

I

F

R

E

T

E

I

F

R

N

E

R

S

V

G

G

V

V

T

T

V

V

F

L

L

M

V

A

E

T

Q

H

N

D

A

I

N

N

K

L

A

I

L

S

G

R

V

R

A

S

D

Y

R

R

G

M

Y

L

V

T

L

L

E

S

N

D

G

G

H

H

V

L

binding adenosine-5'-triphosphate: Y11 (= Y11), R15 (≠ I14), A17 (= A16), G40 (= G39), K41 (= K40), S42 (≠ T41), T43 (= T42), S139 (= S135), G141 (= G137)

3c4jA Abc protein artp in complex with atp-gamma-s
28% identity, 89% coverage: 1:209/234 of query aligns to 3:220/242 of 3c4jA

query
sites
3c4jA

M

M

L

I

Q

D

F

V

D

H

K

Q

V

L

H

K

T

K

H

S

Y
x
F

G

G

A

S

I

L

E

E

A
x
V

L

L

H

K

G

G

V

I

S

N

L

V

N

H

V

I

E

R

K

E

G

G

E

E

I

V

V

V

T

V

L

V

I

I

G

G

A

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

L

F

L

L

M

R

T

C

L

L

C

N

G

L

R

L

P

E

R

D

A

F

S

D

S

E

G

G

R

E

V

I

I

I

F

I

E

D

G

G

Q

I

D

N

I

L

T

K

Q

A

L

K

Q

D

T

T

H

N

-

L

E

N

I

K

M

V

R

R

R

E

G

E

L

V

A

G

I

M

S

V

P

F

E

Q

G

R

R

F

R

N

V

L

F

F

P

P

S

H

L

M

T

T

V

V

L

L

E

N

N

N

L

I

K

T

M

L

G

A

A

P

F

M

F

K

A

V

S

R

N

K

E

W

A

P

I

R

E

E

Q

K

G

A

I

E

E

A

Y

K

V

A

F

M

G

E

L

L

F

L

P

D

R

K

-

V

-

G

L

L

K

K

E

D

R

K

A

A

A

H

Q

A

R

Y

A

P

G

D

T

S

M

L

S

S

G

G

E

Q

Q

A

Q

Q

M

R

L

V

A

A

I

I

G

A

R

R

A

A

L

L

M

A

S

M

K

E

P

P

R

K

L

I

L

M

L

L

L

F

D

D

E

E

P

P

T

T

L

S

G

A

L

L

A

D

P

P

L

E

V

M

I

V

A

G

Q

E

I

V

F

L

D

S

I

V

I

M

R

K

T

Q

I

L

R

A

E

N

S

E

G

G

V

M

T

T

V

M

F

V

L

V

V

V

E

T

Q

H

N

E

A

M

N

G

K

F

A

A

L

R

G

E

V

V

A

G

D

D

R

R

-

V

-

L

-

F

-

M

-

D

-

G

G

G

Y

Y

V

I

L

I

E

E

N

E

G

G

binding phosphothiophosphoric acid-adenylate ester: F13 (≠ Y11), V18 (≠ A16), S38 (≠ N36), G39 (= G37), S40 (≠ A38), G41 (= G39), K42 (= K40), S43 (≠ T41), T44 (= T42)

3c41J Abc protein artp in complex with amp-pnp/mg2+
28% identity, 89% coverage: 1:209/234 of query aligns to 3:220/242 of 3c41J

query
sites
3c41J

M

M

L

I

Q

D

F

V

D

H

K

Q

V

L

H

K

T

K

H

S

Y
x
F

G

G

A

S

I

L

E

E

A
x
V

L

L

H

K

G

G

V

I

S

N

L

V

N

H

V

I

E

R

K

E

G

G

E

E

I

V

V

V

T

V

L

V

I

I

G

G

A

P

N
x
S

G
|
G

A

S

G
|
G

K
|
K

T
x
S

T
|
T

L

F

L

L

M

R

T

C

L

L

C

N

G

L

R

L

P

E

R

D

A

F

S

D

S

E

G

G

R

E

V

I

I

I

F

I

E

D

G

G

Q

I

D

N

I

L

T

K

Q

A

L

K

Q

D

T

T

H

N

-

L

E

N

I

K

M

V

R

R

R

E

G

E

L

V

A

G

I

M

S

V

P

F

E

Q

G

R

R

F

R

N

V

L

F

F

P

P

S

H

L

M

T

T

V

V

L

L

E

N

N

N

L

I

K

T

M

L

G

A

A

P

F

M

F

K

A

V

S

R

N

K

E

W

A

P

I

R

E

E

Q

K

G

A

I

E

E

A

Y

K

V

A

F

M

G

E

L

L

F

L

P

D

R

K

-

V

-

G

L

L

K

K

E

D

R

K

A

A

A

H

Q

A

R

Y

A

P

G

D

T

S

M

L

S

S

G

G

E

Q

Q

A

Q

Q

M

R

L

V

A

A

I

I

G

A

R

R

A

A

L

L

M

A

S

M

K

E

P

P

R

K

L

I

L

M

L

L

L

F

D
|
D

E

E

P

P

T

T

L

S

G

A

L

L

A

D

P

P

L

E

V

M

I

V

A

G

Q

E

I

V

F

L

D

S

I

V

I

M

R

K

T

Q

I

L

R

A

E

N

S

E

G

G

V

M

T

T

V

M

F

V

L

V

V

V

E

T

Q

H

N

E

A

M

N

G

K

F

A

A

L

R

G

E

V

V

A

G

D

D

R

R

-

V

-

L

-

F

-

M

-

D

-

G

G

G

Y

Y

V

I

L

I

E

E

N

E

G

G

binding phosphoaminophosphonic acid-adenylate ester: F13 (≠ Y11), V18 (≠ A16), S38 (≠ N36), G39 (= G37), G41 (= G39), K42 (= K40), S43 (≠ T41), T44 (= T42)
binding magnesium ion: S43 (≠ T41), D163 (= D158)

2olkA Abc protein artp in complex with adp-beta-s
28% identity, 89% coverage: 1:209/234 of query aligns to 3:220/242 of 2olkA

query
sites
2olkA

M

M

L

I

Q

D

F

V

D

H

K

Q

V

L

H

K

T

K

H

S

Y
x
F

G

G

A

S

I

L

E

E

A
x
V

L

L

H

K

G

G

V

I

S

N

L

V

N

H

V

I

E

R

K

E

G

G

E

E

I

V

V

V

T

V

L

V

I

I

G

G

A

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

L

F

L

L

M

R

T

C

L

L

C

N

G

L

R

L

P

E

R

D

A

F

S

D

S

E

G

G

R

E

V

I

I

I

F

I

E

D

G

G

Q

I

D

N

I

L

T

K

Q

A

L

K

Q

D

T

T

H

N

-

L

E

N

I

K

M

V

R

R

R

E

G

E

L

V

A

G

I

M

S

V

P

F

E

Q

G

R

R

F

R

N

V

L

F

F

P

P

S

H

L

M

T

T

V

V

L

L

E

N

N

N

L

I

K

T

M

L

G

A

A

P

F

M

F

K

A

V

S

R

N

K

E

W

A

P

I

R

E

E

Q

K

G

A

I

E

E

A

Y

K

V

A

F

M

G

E

L

L

F

L

P

D

R

K

-

V

-

G

L

L

K

K

E

D

R

K

A

A

A

H

Q

A

R

Y

A

P

G

D

T

S

M

L

S

S

G

G

E

Q

Q

A

Q

Q

M

R

L

V

A

A

I

I

G

A

R

R

A

A

L

L

M

A

S

M

K

E

P

P

R

K

L

I

L

M

L

L

L

F

D

D

E

E

P

P

T

T

L

S

G

A

L

L

A

D

P

P

L

E

V

M

I

V

A

G

Q

E

I

V

F

L

D

S

I

V

I

M

R

K

T

Q

I

L

R

A

E

N

S

E

G

G

V

M

T

T

V

M

F

V

L

V

V

V

E

T

Q

H

N

E

A

M

N

G

K

F

A

A

L

R

G

E

V

V

A

G

D

D

R

R

-

V

-

L

-

F

-

M

-

D

-

G

G

G

Y

Y

V

I

L

I

E

E

N

E

G

G

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: F13 (≠ Y11), V18 (≠ A16), S38 (≠ N36), G39 (= G37), S40 (≠ A38), G41 (= G39), K42 (= K40), S43 (≠ T41), T44 (= T42)

2oljA Abc protein artp in complex with adp/mg2+
28% identity, 89% coverage: 1:209/234 of query aligns to 3:220/242 of 2oljA

query
sites
2oljA

M

M

L

I

Q

D

F

V

D

H

K

Q

V

L

H

K

T

K

H

S

Y
x
F

G

G

A

S

I

L

E

E

A
x
V

L

L

H

K

G

G

V

I

S

N

L

V

N

H

V

I

E

R

K

E

G

G

E

E

I

V

V

V

T

V

L

V

I

I

G

G

A

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

L

F

L

L

M

R

T

C

L

L

C

N

G

L

R

L

P

E

R

D

A

F

S

D

S

E

G

G

R

E

V

I

I

I

F

I

E

D

G

G

Q

I

D

N

I

L

T

K

Q

A

L

K

Q

D

T

T

H

N

-

L

E

N

I

K

M

V

R

R

R

E

G

E

L

V

A

G

I

M

S

V

P

F

E

Q

G

R

R

F

R

N

V

L

F

F

P

P

S

H

L

M

T

T

V

V

L

L

E

N

N

N

L

I

K

T

M

L

G

A

A

P

F

M

F

K

A

V

S

R

N

K

E

W

A

P

I

R