SitesBLAST
Comparing HSERO_RS08650 FitnessBrowser__HerbieS:HSERO_RS08650 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6deqA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
44% identity, 98% coverage: 6:567/572 of query aligns to 14:580/601 of 6deqA
- active site: Y35 (= Y27), G37 (= G29), G38 (= G30), A39 (= A31), I40 (≠ V32), E61 (= E53), T84 (= T76), F123 (= F115), Q124 (= Q116), E125 (= E117), K173 (= K165), K232 (≠ E225), M268 (= M260), V295 (= V287), V411 (= V396), L436 (= L421), G437 (= G422), M439 (= M424), D464 (≠ E449), N491 (= N476), E493 (≠ F478), Q494 (≠ L479), M496 (= M481), V497 (= V482), W500 (= W485), L522 (= L508), N527 (≠ G513), V528 (≠ H514)
- binding flavin-adenine dinucleotide: R163 (= R155), G221 (= G214), A222 (≠ G215), G223 (= G216), N226 (≠ L219), T248 (= T240), L249 (= L241), Q250 (≠ M242), L266 (≠ P258), G288 (= G280), A289 (= A281), R290 (= R282), D292 (= D284), R294 (= R286), V295 (= V287), E321 (≠ D305), I322 (= I306), D340 (≠ N324), V341 (= V325), M416 (= M401), G434 (= G419)
- binding magnesium ion: D464 (≠ E449), N491 (= N476), E493 (≠ F478)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M268 (= M260), R294 (= R286), M496 (= M481), V497 (= V482), W500 (= W485), A571 (= A558)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V411 (= V396), G412 (= G397), Q413 (= Q398), H414 (= H399), M439 (= M424), G463 (= G448), D464 (≠ E449), A465 (= A450), S466 (= S451), N491 (= N476), E493 (≠ F478), Q494 (≠ L479), G495 (= G480), M496 (= M481), V497 (= V482)
6demA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide bensulfuron methyl (see paper)
44% identity, 98% coverage: 6:567/572 of query aligns to 12:576/597 of 6demA
- active site: Y33 (= Y27), G35 (= G29), G36 (= G30), A37 (= A31), I38 (≠ V32), E59 (= E53), T82 (= T76), F121 (= F115), Q122 (= Q116), E123 (= E117), K171 (= K165), K228 (≠ E225), M264 (= M260), V291 (= V287), V407 (= V396), L432 (= L421), G433 (= G422), M435 (= M424), D460 (≠ E449), N487 (= N476), E489 (≠ F478), Q490 (≠ L479), M492 (= M481), V493 (= V482), W496 (= W485), L518 (= L508), N523 (≠ G513), V524 (≠ H514)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: M264 (= M260), D289 (= D285), R290 (= R286), M492 (= M481), W496 (= W485), A567 (= A558)
- binding flavin-adenine dinucleotide: R161 (= R155), G217 (= G214), A218 (≠ G215), G219 (= G216), N222 (≠ L219), T244 (= T240), L245 (= L241), Q246 (≠ M242), L262 (≠ P258), G284 (= G280), A285 (= A281), R286 (= R282), D288 (= D284), R290 (= R286), V291 (= V287), E317 (≠ D305), I318 (= I306), N322 (≠ S310), D336 (≠ N324), V337 (= V325), M412 (= M401), G430 (= G419)
- binding magnesium ion: D460 (≠ E449), N487 (= N476), E489 (≠ F478)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (= V396), G408 (= G397), Q409 (= Q398), H410 (= H399), M435 (= M424), G459 (= G448), D460 (≠ E449), A461 (= A450), S462 (= S451), M465 (= M454), N487 (= N476), E489 (≠ F478), Q490 (≠ L479), G491 (= G480), M492 (= M481), V493 (= V482)
6delA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide chlorimuron ethyl (see paper)
44% identity, 98% coverage: 6:567/572 of query aligns to 12:576/597 of 6delA
- active site: Y33 (= Y27), G35 (= G29), G36 (= G30), A37 (= A31), I38 (≠ V32), E59 (= E53), T82 (= T76), F121 (= F115), Q122 (= Q116), E123 (= E117), K171 (= K165), K228 (≠ E225), M264 (= M260), V291 (= V287), V407 (= V396), L432 (= L421), G433 (= G422), M435 (= M424), D460 (≠ E449), N487 (= N476), E489 (≠ F478), Q490 (≠ L479), M492 (= M481), V493 (= V482), W496 (= W485), L518 (= L508), N523 (≠ G513), V524 (≠ H514)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: D289 (= D285), R290 (= R286), W496 (= W485)
- binding flavin-adenine dinucleotide: R161 (= R155), G217 (= G214), A218 (≠ G215), G219 (= G216), N222 (≠ L219), T244 (= T240), L245 (= L241), Q246 (≠ M242), L262 (≠ P258), G284 (= G280), A285 (= A281), R286 (= R282), D288 (= D284), R290 (= R286), V291 (= V287), E317 (≠ D305), I318 (= I306), N322 (≠ S310), D336 (≠ N324), V337 (= V325), M412 (= M401), G430 (= G419)
- binding (3Z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}-3-sulfanylpent-3-en-1-yl trihydrogen diphosphate: V407 (= V396), G408 (= G397), Q409 (= Q398), H410 (= H399), G433 (= G422), M435 (= M424), G459 (= G448), D460 (≠ E449), A461 (= A450), S462 (= S451), M465 (= M454), N487 (= N476), E489 (≠ F478), Q490 (≠ L479), G491 (= G480), M492 (= M481), V493 (= V482)
- binding magnesium ion: D460 (≠ E449), N487 (= N476), E489 (≠ F478)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (= V396), G408 (= G397), Q409 (= Q398), H410 (= H399), G433 (= G422), M435 (= M424), G459 (= G448), D460 (≠ E449), A461 (= A450), S462 (= S451), M465 (= M454), N487 (= N476), E489 (≠ F478), Q490 (≠ L479), G491 (= G480), M492 (= M481), V493 (= V482)
6derA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide metosulam (see paper)
44% identity, 98% coverage: 6:567/572 of query aligns to 14:579/600 of 6derA
- active site: Y35 (= Y27), G37 (= G29), G38 (= G30), A39 (= A31), I40 (≠ V32), E61 (= E53), T84 (= T76), F123 (= F115), Q124 (= Q116), E125 (= E117), K173 (= K165), K231 (≠ E225), M267 (= M260), V294 (= V287), V410 (= V396), L435 (= L421), G436 (= G422), M438 (= M424), D463 (≠ E449), N490 (= N476), E492 (≠ F478), Q493 (≠ L479), M495 (= M481), V496 (= V482), W499 (= W485), L521 (= L508), N526 (≠ G513), V527 (≠ H514)
- binding flavin-adenine dinucleotide: R163 (= R155), G220 (= G214), A221 (≠ G215), G222 (= G216), N225 (≠ L219), T247 (= T240), L248 (= L241), Q249 (≠ M242), L265 (≠ P258), H268 (= H261), G287 (= G280), A288 (= A281), R289 (= R282), D291 (= D284), R293 (= R286), V294 (= V287), E320 (≠ D305), I321 (= I306), N325 (≠ S310), G338 (= G323), D339 (≠ N324), V340 (= V325), Q414 (= Q400), M415 (= M401), G433 (= G419)
- binding Metosulam: R293 (= R286), M495 (= M481), W499 (= W485), A570 (= A558)
- binding magnesium ion: D463 (≠ E449), N490 (= N476), E492 (≠ F478)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V410 (= V396), G411 (= G397), Q412 (= Q398), H413 (= H399), G436 (= G422), M438 (= M424), G462 (= G448), D463 (≠ E449), A464 (= A450), S465 (= S451), N490 (= N476), E492 (≠ F478), Q493 (≠ L479), G494 (= G480), M495 (= M481), V496 (= V482)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V410 (= V396), G411 (= G397), Q412 (= Q398), H413 (= H399), G436 (= G422), M438 (= M424), G462 (= G448), D463 (≠ E449), A464 (= A450), S465 (= S451), M468 (= M454), N490 (= N476), E492 (≠ F478), Q493 (≠ L479), G494 (= G480), V496 (= V482)
6desA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide propoxycarbazone (see paper)
44% identity, 98% coverage: 6:567/572 of query aligns to 12:577/598 of 6desA
- active site: Y33 (= Y27), G35 (= G29), G36 (= G30), A37 (= A31), I38 (≠ V32), E59 (= E53), T82 (= T76), F121 (= F115), Q122 (= Q116), E123 (= E117), K171 (= K165), K229 (≠ E225), M265 (= M260), V292 (= V287), V408 (= V396), L433 (= L421), G434 (= G422), M436 (= M424), D461 (≠ E449), N488 (= N476), E490 (≠ F478), Q491 (≠ L479), M493 (= M481), V494 (= V482), W497 (= W485), L519 (= L508), N524 (≠ G513), V525 (≠ H514)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: M265 (= M260), D290 (= D285), R291 (= R286), W497 (= W485)
- binding flavin-adenine dinucleotide: R161 (= R155), G218 (= G214), A219 (≠ G215), G220 (= G216), N223 (≠ L219), T245 (= T240), L246 (= L241), Q247 (≠ M242), L263 (≠ P258), G285 (= G280), A286 (= A281), R287 (= R282), D289 (= D284), R291 (= R286), V292 (= V287), E318 (≠ D305), I319 (= I306), N323 (≠ S310), D337 (≠ N324), V338 (= V325), Q412 (= Q400), M413 (= M401), G431 (= G419)
- binding magnesium ion: D461 (≠ E449), N488 (= N476), E490 (≠ F478)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (= V396), G409 (= G397), Q410 (= Q398), H411 (= H399), G434 (= G422), M436 (= M424), G460 (= G448), D461 (≠ E449), A462 (= A450), S463 (= S451), N488 (= N476), E490 (≠ F478), Q491 (≠ L479), G492 (= G480), M493 (= M481), V494 (= V482)
6depA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide sulfometuron methyl (see paper)
44% identity, 98% coverage: 6:567/572 of query aligns to 12:577/598 of 6depA
- active site: Y33 (= Y27), G35 (= G29), G36 (= G30), A37 (= A31), I38 (≠ V32), E59 (= E53), T82 (= T76), F121 (= F115), Q122 (= Q116), E123 (= E117), K171 (= K165), K229 (≠ E225), M265 (= M260), V292 (= V287), V408 (= V396), L433 (= L421), G434 (= G422), M436 (= M424), D461 (≠ E449), N488 (= N476), E490 (≠ F478), Q491 (≠ L479), M493 (= M481), V494 (= V482), W497 (= W485), L519 (= L508), N524 (≠ G513), V525 (≠ H514)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D290 (= D285), R291 (= R286), M493 (= M481), W497 (= W485)
- binding flavin-adenine dinucleotide: R161 (= R155), G218 (= G214), A219 (≠ G215), G220 (= G216), N223 (≠ L219), T245 (= T240), L246 (= L241), Q247 (≠ M242), L263 (≠ P258), G264 (= G259), G285 (= G280), A286 (= A281), R287 (= R282), D289 (= D284), R291 (= R286), V292 (= V287), E318 (≠ D305), I319 (= I306), N323 (≠ S310), D337 (≠ N324), V338 (= V325), M413 (= M401), G431 (= G419)
- binding magnesium ion: D461 (≠ E449), N488 (= N476), E490 (≠ F478)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V408 (= V396), G409 (= G397), Q410 (= Q398), H411 (= H399), G434 (= G422), M436 (= M424), G460 (= G448), D461 (≠ E449), A462 (= A450), S463 (= S451), M466 (= M454), N488 (= N476), E490 (≠ F478), Q491 (≠ L479), G492 (= G480), M493 (= M481), V494 (= V482)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (= V396), G409 (= G397), Q410 (= Q398), H411 (= H399), G434 (= G422), M436 (= M424), G460 (= G448), D461 (≠ E449), A462 (= A450), S463 (= S451), M466 (= M454), N488 (= N476), E490 (≠ F478), Q491 (≠ L479), G492 (= G480), M493 (= M481), V494 (= V482)
6denA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron ethyl (see paper)
44% identity, 98% coverage: 6:567/572 of query aligns to 14:578/599 of 6denA
- active site: Y35 (= Y27), G37 (= G29), G38 (= G30), A39 (= A31), I40 (≠ V32), E61 (= E53), T84 (= T76), F123 (= F115), Q124 (= Q116), E125 (= E117), K173 (= K165), K230 (≠ E225), M266 (= M260), V293 (= V287), V409 (= V396), L434 (= L421), G435 (= G422), M437 (= M424), D462 (≠ E449), N489 (= N476), E491 (≠ F478), Q492 (≠ L479), M494 (= M481), V495 (= V482), W498 (= W485), L520 (= L508), N525 (≠ G513), V526 (≠ H514)
- binding flavin-adenine dinucleotide: R163 (= R155), G219 (= G214), A220 (≠ G215), G221 (= G216), N224 (≠ L219), T246 (= T240), L247 (= L241), Q248 (≠ M242), L264 (≠ P258), G286 (= G280), A287 (= A281), R288 (= R282), D290 (= D284), R292 (= R286), V293 (= V287), E319 (≠ D305), I320 (= I306), N324 (≠ S310), D338 (≠ N324), V339 (= V325), M414 (= M401), G432 (= G419)
- binding ethyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M266 (= M260), D291 (= D285), R292 (= R286), W498 (= W485)
- binding magnesium ion: D462 (≠ E449), N489 (= N476), E491 (≠ F478)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V409 (= V396), G410 (= G397), Q411 (= Q398), H412 (= H399), G435 (= G422), M437 (= M424), G461 (= G448), D462 (≠ E449), A463 (= A450), S464 (= S451), N489 (= N476), E491 (≠ F478), Q492 (≠ L479), G493 (= G480), M494 (= M481), V495 (= V482)
6deoA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron methyl (see paper)
44% identity, 98% coverage: 6:567/572 of query aligns to 10:572/593 of 6deoA
- active site: Y31 (= Y27), G33 (= G29), G34 (= G30), A35 (= A31), I36 (≠ V32), E57 (= E53), T80 (= T76), F119 (= F115), Q120 (= Q116), E121 (= E117), K169 (= K165), K224 (≠ E225), M260 (= M260), V287 (= V287), V403 (= V396), L428 (= L421), G429 (= G422), M431 (= M424), D456 (≠ E449), N483 (= N476), E485 (≠ F478), Q486 (≠ L479), M488 (= M481), V489 (= V482), W492 (= W485), L514 (= L508), N519 (≠ G513), V520 (≠ H514)
- binding flavin-adenine dinucleotide: R159 (= R155), G213 (= G214), A214 (≠ G215), G215 (= G216), N218 (≠ L219), T240 (= T240), L241 (= L241), Q242 (≠ M242), L258 (≠ P258), G280 (= G280), A281 (= A281), R282 (= R282), D284 (= D284), R286 (= R286), V287 (= V287), E313 (≠ D305), I314 (= I306), N318 (≠ S310), D332 (≠ N324), V333 (= V325), M408 (= M401), G426 (= G419)
- binding methyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M260 (= M260), D285 (= D285), R286 (= R286), M488 (= M481), W492 (= W485)
- binding magnesium ion: D456 (≠ E449), N483 (= N476), E485 (≠ F478)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V403 (= V396), G404 (= G397), Q405 (= Q398), H406 (= H399), G429 (= G422), M431 (= M424), G455 (= G448), D456 (≠ E449), A457 (= A450), S458 (= S451), M461 (= M454), N483 (= N476), E485 (≠ F478), Q486 (≠ L479), G487 (= G480), M488 (= M481), V489 (= V482)
1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
44% identity, 98% coverage: 6:566/572 of query aligns to 8:574/596 of 1t9cA
- active site: Y29 (= Y27), G31 (= G29), G32 (= G30), A33 (= A31), I34 (≠ V32), E55 (= E53), T78 (= T76), F117 (= F115), Q118 (= Q116), E119 (= E117), K167 (= K165), R227 (≠ E225), M263 (= M260), V290 (= V287), V406 (= V396), L431 (= L421), G432 (= G422), M434 (= M424), D459 (≠ E449), N486 (= N476), E488 (≠ F478), Q489 (≠ L479), M491 (= M481), V492 (= V482), W495 (= W485), L517 (= L508), G522 (= G513), L523 (≠ H514), K556 (≠ Q548)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G30), V107 (= V105), P108 (= P106), F117 (= F115), K167 (= K165), D288 (= D285), R289 (= R286), W495 (= W485)
- binding flavin-adenine dinucleotide: R157 (= R155), G216 (= G214), A217 (≠ G215), G218 (= G216), N221 (≠ L219), T243 (= T240), L244 (= L241), Q245 (≠ M242), L261 (≠ P258), M263 (= M260), H264 (= H261), G283 (= G280), A284 (= A281), R285 (= R282), D287 (= D284), R289 (= R286), V290 (= V287), E316 (≠ D305), V317 (≠ I306), N321 (≠ S310), G334 (= G323), D335 (≠ N324), A336 (≠ V325), M411 (= M401), G429 (= G419), G430 (= G420)
- binding magnesium ion: D459 (≠ E449), N486 (= N476), E488 (≠ F478)
1t9dA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
44% identity, 98% coverage: 6:566/572 of query aligns to 8:574/596 of 1t9dA
- active site: Y29 (= Y27), G31 (= G29), G32 (= G30), A33 (= A31), I34 (≠ V32), E55 (= E53), T78 (= T76), F117 (= F115), Q118 (= Q116), E119 (= E117), K167 (= K165), R227 (≠ E225), M263 (= M260), V290 (= V287), V406 (= V396), L431 (= L421), G432 (= G422), M434 (= M424), D459 (≠ E449), N486 (= N476), E488 (≠ F478), Q489 (≠ L479), M491 (= M481), V492 (= V482), W495 (= W485), L517 (= L508), G522 (= G513), L523 (≠ H514), K556 (≠ Q548)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G30), A33 (= A31), V107 (= V105), P108 (= P106), F117 (= F115), K167 (= K165), M263 (= M260), D288 (= D285), R289 (= R286), W495 (= W485)
- binding flavin-adenine dinucleotide: R157 (= R155), G216 (= G214), A217 (≠ G215), G218 (= G216), N221 (≠ L219), T243 (= T240), L244 (= L241), Q245 (≠ M242), M260 (= M257), L261 (≠ P258), H264 (= H261), G283 (= G280), A284 (= A281), R285 (= R282), D287 (= D284), R289 (= R286), V290 (= V287), E316 (≠ D305), V317 (≠ I306), N321 (≠ S310), G334 (= G323), D335 (≠ N324), A336 (≠ V325), Q410 (= Q400), M411 (= M401), G429 (= G419), G430 (= G420)
- binding magnesium ion: D459 (≠ E449), N486 (= N476), E488 (≠ F478)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E55 (= E53), P81 (= P79), Q118 (= Q116), G432 (= G422), M434 (= M424), M464 (= M454)
1t9aA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
44% identity, 98% coverage: 6:566/572 of query aligns to 9:575/597 of 1t9aA
- active site: Y30 (= Y27), G32 (= G29), G33 (= G30), A34 (= A31), I35 (≠ V32), E56 (= E53), T79 (= T76), F118 (= F115), Q119 (= Q116), E120 (= E117), K168 (= K165), R228 (≠ E225), M264 (= M260), V291 (= V287), V407 (= V396), L432 (= L421), G433 (= G422), M435 (= M424), D460 (≠ E449), N487 (= N476), E489 (≠ F478), Q490 (≠ L479), M492 (= M481), V493 (= V482), W496 (= W485), L518 (= L508), G523 (= G513), L524 (≠ H514), K557 (≠ Q548)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: G33 (= G30), V108 (= V105), P109 (= P106), F118 (= F115), K168 (= K165), M264 (= M260), D289 (= D285), R290 (= R286), M492 (= M481), V493 (= V482), W496 (= W485)
- binding flavin-adenine dinucleotide: R158 (= R155), G217 (= G214), A218 (≠ G215), G219 (= G216), N222 (≠ L219), T244 (= T240), L245 (= L241), Q246 (≠ M242), L262 (≠ P258), M264 (= M260), H265 (= H261), G284 (= G280), A285 (= A281), R286 (= R282), D288 (= D284), R290 (= R286), V291 (= V287), E317 (≠ D305), V318 (≠ I306), N322 (≠ S310), G335 (= G323), D336 (≠ N324), A337 (≠ V325), Q411 (= Q400), M412 (= M401), G430 (= G419), G431 (= G420)
- binding magnesium ion: D460 (≠ E449), N487 (= N476), E489 (≠ F478)
- binding propyl trihydrogen diphosphate: V407 (= V396), G408 (= G397), Q409 (= Q398), H410 (= H399), M435 (= M424), G459 (= G448), D460 (≠ E449), A461 (= A450), S462 (= S451), N487 (= N476), E489 (≠ F478), Q490 (≠ L479), G491 (= G480), M492 (= M481)
- binding 5-{[ethyl(methyl)amino]methyl}-2-methyl-5,6-dihydropyrimidin-4-amine: G433 (= G422), M435 (= M424), M465 (= M454)
1t9bB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
44% identity, 98% coverage: 6:566/572 of query aligns to 8:573/595 of 1t9bB
- active site: Y29 (= Y27), G31 (= G29), G32 (= G30), A33 (= A31), I34 (≠ V32), E55 (= E53), T78 (= T76), F117 (= F115), Q118 (= Q116), E119 (= E117), K167 (= K165), R226 (≠ E225), M262 (= M260), V289 (= V287), V405 (= V396), L430 (= L421), G431 (= G422), M433 (= M424), D458 (≠ E449), N485 (= N476), E487 (≠ F478), Q488 (≠ L479), M490 (= M481), V491 (= V482), W494 (= W485), L516 (= L508), G521 (= G513), L522 (≠ H514), K555 (≠ Q548)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (= V105), P108 (= P106), D287 (= D285), R288 (= R286), M490 (= M481), W494 (= W485)
- binding flavin-adenine dinucleotide: R157 (= R155), G215 (= G214), A216 (≠ G215), G217 (= G216), N220 (≠ L219), T242 (= T240), L243 (= L241), Q244 (≠ M242), M259 (= M257), L260 (≠ P258), M262 (= M260), H263 (= H261), G282 (= G280), A283 (= A281), R284 (= R282), D286 (= D284), R288 (= R286), V289 (= V287), E315 (≠ D305), V316 (≠ I306), N320 (≠ S310), G333 (= G323), D334 (≠ N324), A335 (≠ V325), Q409 (= Q400), M410 (= M401), G428 (= G419), G429 (= G420)
- binding magnesium ion: D458 (≠ E449), N485 (= N476), E487 (≠ F478)
1n0hA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorimuron ethyl (see paper)
44% identity, 98% coverage: 6:566/572 of query aligns to 10:577/599 of 1n0hA
- active site: Y31 (= Y27), G33 (= G29), G34 (= G30), A35 (= A31), I36 (≠ V32), E57 (= E53), T80 (= T76), F119 (= F115), Q120 (= Q116), E121 (= E117), K169 (= K165), R230 (≠ E225), M266 (= M260), V293 (= V287), V409 (= V396), L434 (= L421), G435 (= G422), M437 (= M424), D462 (≠ E449), N489 (= N476), E491 (≠ F478), Q492 (≠ L479), M494 (= M481), V495 (= V482), W498 (= W485), L520 (= L508), G525 (= G513), L526 (≠ H514), K559 (≠ Q548)
- binding 4-{[(4'-amino-2'-methylpyrimidin-5'-yl)methyl]amino}pent-3-enyl diphosphate: V409 (= V396), G410 (= G397), Q411 (= Q398), H412 (= H399), G435 (= G422), M437 (= M424), G461 (= G448), D462 (≠ E449), A463 (= A450), S464 (= S451), M467 (= M454), N489 (= N476), E491 (≠ F478), Q492 (≠ L479), G493 (= G480), V495 (= V482)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: G34 (= G30), A35 (= A31), V109 (= V105), P110 (= P106), F119 (= F115), K169 (= K165), M266 (= M260), D291 (= D285), R292 (= R286), V495 (= V482), W498 (= W485)
- binding flavin-adenine dinucleotide: R159 (= R155), G219 (= G214), A220 (≠ G215), G221 (= G216), N224 (≠ L219), T246 (= T240), L247 (= L241), Q248 (≠ M242), L264 (≠ P258), G265 (= G259), M266 (= M260), H267 (= H261), G286 (= G280), A287 (= A281), R288 (= R282), D290 (= D284), R292 (= R286), V293 (= V287), E319 (≠ D305), V320 (≠ I306), N324 (≠ S310), G337 (= G323), D338 (≠ N324), A339 (≠ V325), M414 (= M401), G432 (= G419), G433 (= G420)
- binding magnesium ion: D462 (≠ E449), N489 (= N476), E491 (≠ F478)
- binding thiamine diphosphate: Y31 (= Y27), E57 (= E53), P83 (= P79)
P17597 Acetolactate synthase, chloroplastic; AtALS; Acetohydroxy-acid synthase; Protein CHLORSULFURON RESISTANT 1; EC 2.2.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
43% identity, 98% coverage: 8:566/572 of query aligns to 99:661/670 of P17597
- A122 (= A31) mutation to V: Reduced catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- M124 (≠ L33) mutation to E: Reduced catalytic activity. Resistant to imidazolinone herbicides and reduced sensitivity to sulfonylurea herbicides.; mutation to I: No effect on catalytic activity. Increased resistance to imidazolinone herbicides.
- E144 (= E53) binding
- S186 (= S95) binding
- P197 (= P106) mutation to S: In csr1-1/GH50; resistant to sulfonylurea but not to imidazolinone herbicides.
- R199 (≠ T108) mutation R->A,E: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- Q207 (= Q116) binding
- K220 (= K129) binding
- R246 (= R155) binding ; binding
- K256 (= K165) binding
- G308 (= G215) binding
- TL 331:332 (= TL 240:241) binding
- C340 (≠ S249) modified: Cysteine sulfinic acid (-SO2H)
- LGMH 349:352 (≠ PGMH 258:261) binding
- GVRFD 371:375 (≠ GARFD 280:284) binding
- DR 376:377 (= DR 285:286) binding
- DI 395:396 (= DI 305:306) binding
- DV 414:415 (≠ NV 324:325) binding
- QH 487:488 (= QH 398:399) binding
- GG 508:509 (= GG 419:420) binding
- GAM 511:513 (≠ GTM 422:424) binding
- D538 (≠ E449) binding
- DGS 538:540 (≠ EAS 449:451) binding
- N565 (= N476) binding
- NQHLGM 565:570 (≠ NRFLGM 476:481) binding
- H567 (≠ F478) binding
- W574 (= W485) binding ; mutation to L: Increased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.; mutation to S: Slightly decreased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.
- S653 (≠ A558) binding ; mutation to A: No effect on catalytic activity or sensitivity to herbicides.; mutation to F: No effect on catalytic activity. Resistant to imidazolinone herbicides and also slightly sulfonylurea-resistant.; mutation to N: In csr1-2/GH90; no effect on catalytic activity. Resistant to imidazolinone but not to sulfonylurea herbicides.; mutation to T: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
6u9dB Saccharomyces cerevisiae acetohydroxyacid synthase (see paper)
43% identity, 98% coverage: 6:566/572 of query aligns to 12:585/607 of 6u9dB
- active site: Y33 (= Y27), G35 (= G29), G36 (= G30), A37 (= A31), I38 (≠ V32), E59 (= E53), T82 (= T76), F121 (= F115), Q122 (= Q116), E123 (= E117), K171 (= K165), M274 (= M260), V301 (= V287), V417 (= V396), G443 (= G422), M445 (= M424), D470 (≠ E449), N497 (= N476), E499 (≠ F478), Q500 (≠ L479), M502 (= M481), V503 (= V482), W506 (= W485)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: G36 (= G30), V111 (= V105), P112 (= P106), F121 (= F115), K171 (= K165), D299 (= D285), R300 (= R286), M502 (= M481), W506 (= W485)
- binding flavin-adenine dinucleotide: R161 (= R155), A228 (≠ G215), G229 (= G216), N232 (≠ L219), T254 (= T240), L255 (= L241), Q256 (≠ M242), L272 (≠ P258), M274 (= M260), G294 (= G280), R296 (= R282), D298 (= D284), R300 (= R286), V301 (= V287), E327 (≠ D305), V328 (≠ I306), N332 (≠ S310), D346 (≠ N324), A347 (≠ V325), M422 (= M401), G440 (= G419), G441 (= G420)
- binding magnesium ion: D470 (≠ E449), N497 (= N476)
- binding thiamine diphosphate: E59 (= E53), P85 (= P79), V417 (= V396), G418 (= G397), Q419 (= Q398), H420 (= H399), G443 (= G422), M445 (= M424), A471 (= A450), S472 (= S451), N497 (= N476), E499 (≠ F478), Q500 (≠ L479), G501 (= G480), M502 (= M481), V503 (= V482)
P07342 Acetolactate synthase catalytic subunit, mitochondrial; Acetohydroxy-acid synthase catalytic subunit; AHAS; ALS; EC 2.2.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
43% identity, 98% coverage: 6:566/572 of query aligns to 92:665/687 of P07342
- R241 (= R155) binding
- 355:376 (vs. 261:282, 55% identical) binding
- 407:426 (vs. 305:324, 30% identical) binding
5k2oA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, pyrithiobac (see paper)
43% identity, 98% coverage: 8:566/572 of query aligns to 14:576/585 of 5k2oA
- active site: Y33 (= Y27), G35 (= G29), G36 (= G30), A37 (= A31), S38 (≠ V32), E59 (= E53), T82 (= T76), F121 (= F115), Q122 (= Q116), E123 (= E117), K171 (= K165), M266 (= M260), V293 (= V287), V400 (= V396), G426 (= G422), M428 (= M424), D453 (≠ E449), N480 (= N476), H482 (≠ F478), L483 (= L479), M485 (= M481), V486 (= V482), W489 (= W485), H558 (≠ Q548)
- binding 2-chloranyl-6-(4,6-dimethoxypyrimidin-2-yl)sulfanyl-benzoic acid: M266 (= M260), R292 (= R286), W489 (= W485), S568 (≠ A558)
- binding flavin-adenine dinucleotide: R161 (= R155), G222 (= G214), G223 (= G215), G224 (= G216), T246 (= T240), L247 (= L241), M248 (= M242), L264 (≠ P258), G286 (= G280), R288 (= R282), D290 (= D284), V293 (= V287), D310 (= D305), I311 (= I306), D329 (≠ N324), V330 (= V325), Q404 (= Q400), M405 (= M401), G423 (= G419)
- binding magnesium ion: D453 (≠ E449), N480 (= N476), H482 (≠ F478)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V396), G401 (= G397), Q402 (= Q398), H403 (= H399), M428 (= M424), D453 (≠ E449), G454 (≠ A450), S455 (= S451), N480 (= N476), H482 (≠ F478), L483 (= L479), G484 (= G480), M485 (= M481), V486 (= V482)
6dekA Crystal structure of candida albicans acetohydroxyacid synthase catalytic subunit (see paper)
43% identity, 98% coverage: 6:567/572 of query aligns to 13:574/595 of 6dekA
- active site: Y34 (= Y27), G36 (= G29), G37 (= G30), A38 (= A31), I39 (≠ V32), E60 (= E53), T83 (= T76), Q118 (= Q116), E119 (= E117), K167 (= K165), K226 (≠ E225), M262 (= M260), V289 (= V287), V405 (= V396), L430 (= L421), G431 (= G422), M433 (= M424), D458 (≠ E449), N485 (= N476), E487 (≠ F478), Q488 (≠ L479), M490 (= M481), V491 (= V482), W494 (= W485), L516 (= L508), N521 (≠ G513), V522 (≠ H514)
- binding flavin-adenine dinucleotide: R157 (= R155), G215 (= G214), A216 (≠ G215), G217 (= G216), N220 (≠ L219), T242 (= T240), L243 (= L241), Q244 (≠ M242), L260 (≠ P258), M262 (= M260), G282 (= G280), A283 (= A281), R284 (= R282), D286 (= D284), R288 (= R286), V289 (= V287), E315 (≠ D305), I316 (= I306), N320 (≠ S310), D334 (≠ N324), V335 (= V325), M410 (= M401), G428 (= G419)
- binding magnesium ion: D458 (≠ E449), N485 (= N476), E487 (≠ F478)
- binding thiamine diphosphate: V405 (= V396), G406 (= G397), Q407 (= Q398), H408 (= H399), M433 (= M424), G457 (= G448), D458 (≠ E449), A459 (= A450), S460 (= S451), N485 (= N476), E487 (≠ F478), Q488 (≠ L479), G489 (= G480), M490 (= M481), V491 (= V482)
5k3sA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, bispyribac-sodium (see paper)
43% identity, 98% coverage: 8:566/572 of query aligns to 14:576/583 of 5k3sA
- active site: Y33 (= Y27), G35 (= G29), G36 (= G30), A37 (= A31), S38 (≠ V32), E59 (= E53), T82 (= T76), F121 (= F115), Q122 (= Q116), E123 (= E117), K171 (= K165), M266 (= M260), V293 (= V287), V400 (= V396), G426 (= G422), M428 (= M424), D453 (≠ E449), N480 (= N476), H482 (≠ F478), L483 (= L479), M485 (= M481), V486 (= V482), W489 (= W485), H558 (≠ Q548)
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: R292 (= R286), M485 (= M481), W489 (= W485), G569 (= G559)
- binding flavin-adenine dinucleotide: R161 (= R155), G222 (= G214), G223 (= G215), G224 (= G216), T246 (= T240), L247 (= L241), M248 (= M242), L264 (≠ P258), M266 (= M260), G286 (= G280), R288 (= R282), D290 (= D284), V293 (= V287), D310 (= D305), I311 (= I306), D329 (≠ N324), V330 (= V325), M405 (= M401), G423 (= G419)
- binding magnesium ion: D453 (≠ E449), N480 (= N476), H482 (≠ F478)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V396), G401 (= G397), Q402 (= Q398), H403 (= H399), G426 (= G422), M428 (= M424), D453 (≠ E449), G454 (≠ A450), S455 (= S451), N480 (= N476), H482 (≠ F478), L483 (= L479), G484 (= G480), M485 (= M481), V486 (= V482)
8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron (see paper)
43% identity, 98% coverage: 8:566/572 of query aligns to 14:576/582 of 8et4A
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (= V396), G401 (= G397), Q402 (= Q398), H403 (= H399), G426 (= G422), M428 (= M424), G452 (= G448), D453 (≠ E449), G454 (≠ A450), S455 (= S451), M458 (= M454), N480 (= N476), H482 (≠ F478), L483 (= L479), G484 (= G480), M485 (= M481), V486 (= V482)
- binding flavin-adenine dinucleotide: R161 (= R155), G222 (= G214), G223 (= G215), G224 (= G216), T246 (= T240), L247 (= L241), M248 (= M242), L264 (≠ P258), M266 (= M260), H267 (= H261), G286 (= G280), V287 (≠ A281), R288 (= R282), D290 (= D284), R292 (= R286), V293 (= V287), D310 (= D305), I311 (= I306), D329 (≠ N324), V330 (= V325), M405 (= M401), G423 (= G419)
- binding magnesium ion: F370 (= F366), D453 (≠ E449), M458 (= M454), Q461 (= Q457), N480 (= N476), H482 (≠ F478), K533 (≠ P522)
- binding N-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N-methylmethanesulfonamide: M266 (= M260), R292 (= R286), M485 (= M481), W489 (= W485), S568 (≠ A558)
Query Sequence
>HSERO_RS08650 FitnessBrowser__HerbieS:HSERO_RS08650
MSAEQLTGADILVRCLAEEGVEHVFGYPGGAVLYIYDAIFKQDKFQHILVRHEQAAVHAA
DAYSRSSQKVGVAIVTSGPGVTNAVTGLATAYMDSIPMVVISGQVPSTAIGQDAFQECDT
VGITRPCVKHNFLVKDVKDLAETVKKAFYIATTGRPGPVLVDIPKDITMHTCAYAYPKAV
EMRSYKPVDKGHSGQIRKALQLLLSAERPMIYTGGGIILANAAPELNKLVDRLGYPCTNT
LMGLGAYRSSSDKFVGMPGMHGTYEANMAMQHCDVLIAIGARFDDRVIGNPKHFASHARK
IIHIDIDPSSISKRVKVDIPIVGNVKDVLQELLSQLDAAETRQNGAALDAWWKQINEWRK
RDCLKFATSEEFIKPQSVVQKVWEVTKGDAFITSDVGQHQMWAAQYYGFDKPRRWINSGG
LGTMGVGLPYAMGVQMANPDATVACITGEASIQMCIQELATCKQYHLTPKIILLNNRFLG
MVRQWQQIDYGSRYSESYMDSLPDFNKLAESYGHVGMKIEKPGDVDGALREAFAMKDRLV
FMNFITDQTENVWPMVKAGKGLTEMLLGSEDL
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory