SitesBLAST – Find functional sites

 

SitesBLAST

Comparing HSERO_RS10770 HSERO_RS10770 amino acid ABC transporter permease to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 2 hits to proteins with known functional sites (download)

4ymwC Crystal structure of an amino acid abc transporter with histidines (see paper)
35% identity, 91% coverage: 14:215/221 of query aligns to 13:214/214 of 4ymwC

query
sites
4ymwC
P
 
P
T
 
L
L
 
F
A
 
I
K
 
S
G
 
G
V
 
L
G
 
I
Y
 
M
T
 
T
L
 
L
L
 
K
F
 
L
A
 
T
L
 
F
A
 
L
S
 
A
M
 
V
L
 
T
G
 
I
G
 
G
L
 
V
V
 
L
L
 
M
G
 
G
F
 
L
V
 
F
L
 
I
A
 
A
V
 
L
A
 
M
R
 
K
I
 
M
V
 
S
P
 
S
W
 
I
R
 
K
P
 
P
I
 
I
H
 
K
W
 
L
P
 
V
A
 
A
A
 
S
I
 
S
Y
 
Y
V
 
I
S
 
E
M
 
V
M
 
I
R
 
R
G
 
G
T
 
T
P
 
P
L
 
L
L
 
L
V
 
V
Q
 
Q
I
 
L
F
 
L
V
 
L
V
 
I
Y
 
Y
Y
 
N
G
 
G
L
 
L
P
 
M
G
 
Q
M
 
F
G
 
G
I
 
M
E
 
N
F
 
I
S
 
P
P
 
A
L
 
F
T
 
T
A
 
A
G
 
G
V
 
V
L
 
S
T
 
A
L
 
L
S
 
A
L
 
I
N
|
N
A
 
S
S
 
S
A
 
A
Y
|
Y
L
 
V
S
 
A
E
 
E
S
 
I
L
 
I
R
 
R
G
 
A
A
 
G
I
 
I
L
 
Q
G
 
A
V
 
V
T
 
D
R
 
P
G
 
G
Q
 
Q
W
 
N
N
 
E
A
 
A
A
 
A
F
 
R
S
 
S
V
 
L
G
 
G
L
 
M
T
 
T
Y
 
H
F
 
A
Q
 
M
T
 
A
L
 
M
R
 
R
Y
 
Y
I
 
V
I
 
I
V
 
I
P
 
P
Q
 
Q
A
 
A
V
 
I
R
 
K
I
 
N
A
 
I
V
 
L
P
 
P
S
 
A
M
 
L
S
 
G
N
 
N
T
x
E
L
 
F
I
 
I
S
 
V
L
 
M
I
 
L
K
 
K
D
x
E
T
 
S
S
 
A
L
 
I
V
 
V
S
 
S
V
 
V
I
 
I
T
 
G
V
 
F
T
 
A
E
 
D
L
 
L
M
 
T
L
 
R
A
 
Q
T
 
A
K
 
D
E
 
I
V
 
I
I
 
Q
A
 
S
V
 
V
T
 
T
F
 
Y
R
 
R
P
 
Y
L
 
F
P
 
E
L
 
P
Y
 
Y
V
 
I
A
 
I
A
 
I
A
 
A
A
 
A
I
 
I
Y
 
Y
W
 
F
M
 
V
L
 
M
S
 
T
L
 
L
C
 
T
F
 
F
E
 
S
A
 
K
L
 
L
Q
 
L
H
 
S
R
 
L
L
 
F
E
 
E
K
 
R
K
 
R
L
 
L

4ymtC Crystal structure of an amino acid abc transporter complex with arginines (see paper)
35% identity, 91% coverage: 14:215/221 of query aligns to 13:214/215 of 4ymtC

query
sites
4ymtC
P
 
P
T
 
L
L
 
F
A
 
I
K
 
S
G
 
G
V
 
L
G
 
I
Y
 
M
T
 
T
L
 
L
L
 
K
F
 
L
A
 
T
L
 
F
A
 
L
S
 
A
M
 
V
L
 
T
G
 
I
G
 
G
L
 
V
V
 
L
L
 
M
G
 
G
F
 
L
V
 
F
L
 
I
A
 
A
V
 
L
A
 
M
R
 
K
I
 
M
V
 
S
P
 
S
W
 
I
R
 
K
P
 
P
I
 
I
H
 
K
W
 
L
P
 
V
A
 
A
A
 
S
I
 
S
Y
 
Y
V
 
I
S
 
E
M
 
V
M
 
I
R
 
R
G
 
G
T
 
T
P
|
P
L
|
L
L
 
L
V
 
V
Q
 
Q
I
 
L
F
 
L
V
 
L
V
 
I
Y
 
Y
Y
 
N
G
 
G
L
 
L
P
 
M
G
 
Q
M
 
F
G
 
G
I
 
M
E
 
N
F
 
I
S
 
P
P
 
A
L
 
F
T
 
T
A
 
A
G
 
G
V
 
V
L
 
S
T
 
A
L
 
L
S
 
A
L
 
I
N
|
N
A
 
S
S
 
S
A
 
A
Y
|
Y
L
 
V
S
 
A
E
 
E
S
 
I
L
 
I
R
 
R
G
 
A
A
 
G
I
 
I
L
 
Q
G
 
A
V
 
V
T
 
D
R
 
P
G
 
G
Q
 
Q
W
 
N
N
 
E
A
 
A
A
 
A
F
 
R
S
 
S
V
 
L
G
 
G
L
 
M
T
 
T
Y
 
H
F
 
A
Q
 
M
T
 
A
L
 
M
R
 
R
Y
 
Y
I
 
V
I
 
I
V
 
I
P
 
P
Q
 
Q
A
 
A
V
 
I
R
 
K
I
 
N
A
 
I
V
 
L
P
 
P
S
 
A
M
 
L
S
 
G
N
 
N
T
x
E
L
 
F
I
 
I
S
 
V
L
x
M
I
 
L
K
|
K
D
x
E
T
 
S
S
 
A
L
 
I
V
 
V
S
 
S
V
 
V
I
 
I
T
 
G
V
 
F
T
 
A
E
 
D
L
 
L
M
 
T
L
 
R
A
 
Q
T
 
A
K
 
D
E
 
I
V
 
I
I
 
Q
A
 
S
V
 
V
T
 
T
F
 
Y
R
 
R
P
 
Y
L
 
F
P
 
E
L
 
P
Y
 
Y
V
 
I
A
 
I
A
 
I
A
 
A
A
 
A
I
 
I
Y
 
Y
W
 
F
M
 
V
L
 
M
S
 
T
L
 
L
C
 
T
F
 
F
E
 
S
A
 
K
L
 
L
Q
 
L
H
 
S
R
 
L
L
 
F
E
 
E
K
 
R
K
 
R
L
 
L

Query Sequence

>HSERO_RS10770 HSERO_RS10770 amino acid ABC transporter permease
MLMEILELLQQAAPTLAKGVGYTLLFALASMLGGLVLGFVLAVARIVPWRPIHWPAAIYV
SMMRGTPLLVQIFVVYYGLPGMGIEFSPLTAGVLTLSLNASAYLSESLRGAILGVTRGQW
NAAFSVGLTYFQTLRYIIVPQAVRIAVPSMSNTLISLIKDTSLVSVITVTELMLATKEVI
AVTFRPLPLYVAAAAIYWMLSLCFEALQHRLEKKLGKAHQI

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory