SitesBLAST
Comparing HSERO_RS12130 FitnessBrowser__HerbieS:HSERO_RS12130 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1n0hA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorimuron ethyl (see paper)
25% identity, 84% coverage: 58:584/625 of query aligns to 31:558/599 of 1n0hA
- active site: Y31 (= Y58), G33 (≠ Y60), G34 (≠ R61), A35 (= A62), I36 (≠ T63), E57 (= E72), T80 (= T95), F119 (≠ L136), Q120 (= Q137), E121 (≠ Q138), K169 (≠ Q195), R230 (≠ E254), M266 (≠ V290), V293 (≠ T317), V409 (≠ A426), L434 (≠ Y451), G435 (≠ S452), M437 (= M454), D462 (= D479), N489 (= N506), E491 (≠ G508), Q492 (≠ Y509), M494 (≠ C511), V495 (≠ I512), W498 (≠ L515), L520 (≠ H546), G525 (= G551), L526 (≠ A552)
- binding 4-{[(4'-amino-2'-methylpyrimidin-5'-yl)methyl]amino}pent-3-enyl diphosphate: V409 (≠ A426), G410 (= G427), Q411 (≠ T428), H412 (vs. gap), G435 (≠ S452), M437 (= M454), G461 (= G478), D462 (= D479), A463 (≠ G480), S464 (= S481), M467 (= M484), N489 (= N506), E491 (≠ G508), Q492 (≠ Y509), G493 (= G510), V495 (≠ I512)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: G34 (≠ R61), A35 (= A62), V109 (= V126), P110 (≠ F127), F119 (≠ L136), K169 (≠ Q195), M266 (≠ V290), D291 (= D315), R292 (≠ F316), V495 (≠ I512), W498 (≠ L515)
- binding flavin-adenine dinucleotide: R159 (≠ Q185), G219 (= G244), A220 (≠ G245), G221 (= G246), N224 (vs. gap), T246 (= T270), L247 (≠ Q271), Q248 (≠ A272), L264 (≠ I288), G265 (= G289), M266 (≠ V290), H267 (≠ T291), G286 (= G310), A287 (≠ T311), R288 (= R312), D290 (≠ Q314), R292 (≠ F316), V293 (≠ T317), E319 (≠ N333), V320 (= V334), N324 (≠ D338), G337 (≠ A349), D338 (= D350), A339 (= A351), M414 (≠ L429), G432 (≠ Y449), G433 (= G450)
- binding magnesium ion: D462 (= D479), N489 (= N506), E491 (≠ G508)
- binding thiamine diphosphate: Y31 (= Y58), E57 (= E72), P83 (= P100)
Sites not aligning to the query:
6demA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide bensulfuron methyl (see paper)
25% identity, 87% coverage: 41:581/625 of query aligns to 27:553/597 of 6demA
- active site: Y33 (≠ H47), G35 (vs. gap), G36 (= G48), A37 (≠ N49), I38 (≠ V50), E59 (= E72), T82 (= T95), F121 (= F153), Q122 (≠ R154), E123 (≠ P155), K171 (≠ Q195), K228 (≠ E254), M264 (≠ V290), V291 (≠ T317), V407 (≠ A426), L432 (≠ Y451), G433 (≠ S452), M435 (= M454), D460 (= D479), N487 (= N506), E489 (≠ G508), Q490 (≠ Y509), M492 (≠ C511), V493 (≠ I512), W496 (≠ L515), L518 (≠ H546), N523 (≠ G551), V524 (≠ A552)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: M264 (≠ V290), D289 (= D315), R290 (≠ F316), M492 (≠ C511), W496 (≠ L515)
- binding flavin-adenine dinucleotide: R161 (vs. gap), G217 (= G244), A218 (≠ G245), G219 (= G246), N222 (≠ Y249), T244 (= T270), L245 (≠ Q271), Q246 (≠ A272), L262 (≠ I288), G284 (= G310), A285 (≠ T311), R286 (= R312), D288 (≠ Q314), R290 (≠ F316), V291 (≠ T317), E317 (≠ N333), I318 (≠ V334), N322 (≠ D338), D336 (= D350), V337 (≠ A351), M412 (≠ L436), G430 (≠ Y449)
- binding magnesium ion: D460 (= D479), N487 (= N506), E489 (≠ G508)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (≠ A426), G408 (= G427), Q409 (≠ T428), H410 (= H434), M435 (= M454), G459 (= G478), D460 (= D479), A461 (≠ G480), S462 (= S481), M465 (= M484), N487 (= N506), E489 (≠ G508), Q490 (≠ Y509), G491 (= G510), M492 (≠ C511), V493 (≠ I512)
Sites not aligning to the query:
6delA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide chlorimuron ethyl (see paper)
25% identity, 87% coverage: 41:581/625 of query aligns to 27:553/597 of 6delA
- active site: Y33 (≠ H47), G35 (vs. gap), G36 (= G48), A37 (≠ N49), I38 (≠ V50), E59 (= E72), T82 (= T95), F121 (= F153), Q122 (≠ R154), E123 (≠ P155), K171 (≠ Q195), K228 (≠ E254), M264 (≠ V290), V291 (≠ T317), V407 (≠ A426), L432 (≠ Y451), G433 (≠ S452), M435 (= M454), D460 (= D479), N487 (= N506), E489 (≠ G508), Q490 (≠ Y509), M492 (≠ C511), V493 (≠ I512), W496 (≠ L515), L518 (≠ H546), N523 (≠ G551), V524 (≠ A552)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: D289 (= D315), R290 (≠ F316), W496 (≠ L515)
- binding flavin-adenine dinucleotide: R161 (vs. gap), G217 (= G244), A218 (≠ G245), G219 (= G246), N222 (≠ Y249), T244 (= T270), L245 (≠ Q271), Q246 (≠ A272), L262 (≠ I288), G284 (= G310), A285 (≠ T311), R286 (= R312), D288 (≠ Q314), R290 (≠ F316), V291 (≠ T317), E317 (≠ N333), I318 (≠ V334), N322 (≠ D338), D336 (= D350), V337 (≠ A351), M412 (≠ L436), G430 (≠ Y449)
- binding (3Z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}-3-sulfanylpent-3-en-1-yl trihydrogen diphosphate: V407 (≠ A426), G408 (= G427), Q409 (≠ T428), H410 (= H434), G433 (≠ S452), M435 (= M454), G459 (= G478), D460 (= D479), A461 (≠ G480), S462 (= S481), M465 (= M484), N487 (= N506), E489 (≠ G508), Q490 (≠ Y509), G491 (= G510), M492 (≠ C511), V493 (≠ I512)
- binding magnesium ion: D460 (= D479), N487 (= N506), E489 (≠ G508)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (≠ A426), G408 (= G427), Q409 (≠ T428), H410 (= H434), G433 (≠ S452), M435 (= M454), G459 (= G478), D460 (= D479), A461 (≠ G480), S462 (= S481), M465 (= M484), N487 (= N506), E489 (≠ G508), Q490 (≠ Y509), G491 (= G510), M492 (≠ C511), V493 (≠ I512)
6dekA Crystal structure of candida albicans acetohydroxyacid synthase catalytic subunit (see paper)
25% identity, 87% coverage: 41:581/625 of query aligns to 28:551/595 of 6dekA
- active site: Y34 (≠ H47), G36 (vs. gap), G37 (= G48), A38 (≠ N49), I39 (≠ V50), E60 (= E72), T83 (= T95), Q118 (= Q137), E119 (≠ Q138), K167 (≠ Q195), K226 (≠ E254), M262 (≠ V290), V289 (≠ T317), V405 (≠ A426), L430 (≠ Y451), G431 (≠ S452), M433 (= M454), D458 (= D479), N485 (= N506), E487 (≠ G508), Q488 (≠ Y509), M490 (≠ C511), V491 (≠ I512), W494 (≠ L515), L516 (≠ H546), N521 (≠ G551), V522 (≠ A552)
- binding flavin-adenine dinucleotide: R157 (vs. gap), G215 (= G244), A216 (≠ G245), G217 (= G246), N220 (≠ Y249), T242 (= T270), L243 (≠ Q271), Q244 (≠ A272), L260 (≠ I288), M262 (≠ V290), G282 (= G310), A283 (≠ T311), R284 (= R312), D286 (≠ Q314), R288 (≠ F316), V289 (≠ T317), E315 (≠ N333), I316 (≠ V334), N320 (≠ D338), D334 (= D350), V335 (≠ A351), M410 (≠ L436), G428 (≠ Y449)
- binding magnesium ion: D458 (= D479), N485 (= N506), E487 (≠ G508)
- binding thiamine diphosphate: V405 (≠ A426), G406 (= G427), Q407 (≠ T428), H408 (= H434), M433 (= M454), G457 (= G478), D458 (= D479), A459 (≠ G480), S460 (= S481), N485 (= N506), E487 (≠ G508), Q488 (≠ Y509), G489 (= G510), M490 (≠ C511), V491 (≠ I512)
6denA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron ethyl (see paper)
25% identity, 87% coverage: 41:581/625 of query aligns to 29:555/599 of 6denA
- active site: Y35 (≠ H47), G37 (vs. gap), G38 (= G48), A39 (≠ N49), I40 (≠ V50), E61 (= E72), T84 (= T95), F123 (= F153), Q124 (≠ R154), E125 (≠ P155), K173 (≠ Q195), K230 (≠ E254), M266 (≠ V290), V293 (≠ T317), V409 (≠ A426), L434 (≠ Y451), G435 (≠ S452), M437 (= M454), D462 (= D479), N489 (= N506), E491 (≠ G508), Q492 (≠ Y509), M494 (≠ C511), V495 (≠ I512), W498 (≠ L515), L520 (≠ H546), N525 (≠ G551), V526 (≠ A552)
- binding flavin-adenine dinucleotide: R163 (vs. gap), G219 (= G244), A220 (≠ G245), G221 (= G246), N224 (≠ Y249), T246 (= T270), L247 (≠ Q271), Q248 (≠ A272), L264 (≠ I288), G286 (= G310), A287 (≠ T311), R288 (= R312), D290 (≠ Q314), R292 (≠ F316), V293 (≠ T317), E319 (≠ N333), I320 (≠ V334), N324 (≠ D338), D338 (= D350), V339 (≠ A351), M414 (≠ L436), G432 (≠ Y449)
- binding ethyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M266 (≠ V290), D291 (= D315), R292 (≠ F316), W498 (≠ L515)
- binding magnesium ion: D462 (= D479), N489 (= N506), E491 (≠ G508)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V409 (≠ A426), G410 (= G427), Q411 (≠ T428), H412 (= H434), G435 (≠ S452), M437 (= M454), G461 (= G478), D462 (= D479), A463 (≠ G480), S464 (= S481), N489 (= N506), E491 (≠ G508), Q492 (≠ Y509), G493 (= G510), M494 (≠ C511), V495 (≠ I512)
1t9aA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
25% identity, 84% coverage: 58:584/625 of query aligns to 30:556/597 of 1t9aA
- active site: Y30 (= Y58), G32 (≠ Y60), G33 (≠ R61), A34 (= A62), I35 (≠ T63), E56 (= E72), T79 (= T95), F118 (≠ L136), Q119 (= Q137), E120 (≠ Q138), K168 (≠ Q195), R228 (≠ E254), M264 (≠ V290), V291 (≠ T317), V407 (≠ A426), L432 (≠ Y451), G433 (≠ S452), M435 (= M454), D460 (= D479), N487 (= N506), E489 (≠ G508), Q490 (≠ Y509), M492 (≠ C511), V493 (≠ I512), W496 (≠ L515), L518 (≠ H546), G523 (= G551), L524 (≠ A552)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: G33 (≠ R61), V108 (= V126), P109 (≠ F127), F118 (≠ L136), K168 (≠ Q195), M264 (≠ V290), D289 (= D315), R290 (≠ F316), M492 (≠ C511), V493 (≠ I512), W496 (≠ L515)
- binding flavin-adenine dinucleotide: R158 (≠ Q185), G217 (= G244), A218 (≠ G245), G219 (= G246), N222 (vs. gap), T244 (= T270), L245 (≠ Q271), Q246 (≠ A272), L262 (≠ I288), M264 (≠ V290), H265 (≠ T291), G284 (= G310), A285 (≠ T311), R286 (= R312), D288 (≠ Q314), R290 (≠ F316), V291 (≠ T317), E317 (≠ N333), V318 (= V334), N322 (≠ D338), G335 (≠ A349), D336 (= D350), A337 (= A351), Q411 (vs. gap), M412 (≠ L429), G430 (≠ Y449), G431 (= G450)
- binding magnesium ion: D460 (= D479), N487 (= N506), E489 (≠ G508)
- binding propyl trihydrogen diphosphate: V407 (≠ A426), G408 (= G427), Q409 (≠ T428), H410 (vs. gap), M435 (= M454), G459 (= G478), D460 (= D479), A461 (≠ G480), S462 (= S481), N487 (= N506), E489 (≠ G508), Q490 (≠ Y509), G491 (= G510), M492 (≠ C511)
- binding 5-{[ethyl(methyl)amino]methyl}-2-methyl-5,6-dihydropyrimidin-4-amine: G433 (≠ S452), M435 (= M454), M465 (= M484)
Sites not aligning to the query:
1t9dA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
25% identity, 84% coverage: 58:584/625 of query aligns to 29:555/596 of 1t9dA
- active site: Y29 (= Y58), G31 (≠ Y60), G32 (≠ R61), A33 (= A62), I34 (≠ T63), E55 (= E72), T78 (= T95), F117 (≠ L136), Q118 (= Q137), E119 (≠ Q138), K167 (≠ Q195), R227 (≠ E254), M263 (≠ V290), V290 (≠ T317), V406 (≠ A426), L431 (≠ Y451), G432 (≠ S452), M434 (= M454), D459 (= D479), N486 (= N506), E488 (≠ G508), Q489 (≠ Y509), M491 (≠ C511), V492 (≠ I512), W495 (≠ L515), L517 (≠ H546), G522 (= G551), L523 (≠ A552)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (≠ R61), A33 (= A62), V107 (= V126), P108 (≠ F127), F117 (≠ L136), K167 (≠ Q195), M263 (≠ V290), D288 (= D315), R289 (≠ F316), W495 (≠ L515)
- binding flavin-adenine dinucleotide: R157 (≠ Q185), G216 (= G244), A217 (≠ G245), G218 (= G246), N221 (vs. gap), T243 (= T270), L244 (≠ Q271), Q245 (≠ A272), M260 (≠ A287), L261 (≠ I288), H264 (≠ T291), G283 (= G310), A284 (≠ T311), R285 (= R312), D287 (≠ Q314), R289 (≠ F316), V290 (≠ T317), E316 (≠ N333), V317 (= V334), N321 (≠ D338), G334 (≠ A349), D335 (= D350), A336 (= A351), Q410 (vs. gap), M411 (≠ L429), G429 (≠ Y449), G430 (= G450)
- binding magnesium ion: D459 (= D479), N486 (= N506), E488 (≠ G508)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E55 (= E72), P81 (= P100), Q118 (= Q137), G432 (≠ S452), M434 (= M454), M464 (= M484)
Sites not aligning to the query:
1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
25% identity, 84% coverage: 58:584/625 of query aligns to 29:555/596 of 1t9cA
- active site: Y29 (= Y58), G31 (≠ Y60), G32 (≠ R61), A33 (= A62), I34 (≠ T63), E55 (= E72), T78 (= T95), F117 (≠ L136), Q118 (= Q137), E119 (≠ Q138), K167 (≠ Q195), R227 (≠ E254), M263 (≠ V290), V290 (≠ T317), V406 (≠ A426), L431 (≠ Y451), G432 (≠ S452), M434 (= M454), D459 (= D479), N486 (= N506), E488 (≠ G508), Q489 (≠ Y509), M491 (≠ C511), V492 (≠ I512), W495 (≠ L515), L517 (≠ H546), G522 (= G551), L523 (≠ A552)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (≠ R61), V107 (= V126), P108 (≠ F127), F117 (≠ L136), K167 (≠ Q195), D288 (= D315), R289 (≠ F316), W495 (≠ L515)
- binding flavin-adenine dinucleotide: R157 (≠ Q185), G216 (= G244), A217 (≠ G245), G218 (= G246), N221 (vs. gap), T243 (= T270), L244 (≠ Q271), Q245 (≠ A272), L261 (≠ I288), M263 (≠ V290), H264 (≠ T291), G283 (= G310), A284 (≠ T311), R285 (= R312), D287 (≠ Q314), R289 (≠ F316), V290 (≠ T317), E316 (≠ N333), V317 (= V334), N321 (≠ D338), G334 (≠ A349), D335 (= D350), A336 (= A351), M411 (≠ L429), G429 (≠ Y449), G430 (= G450)
- binding magnesium ion: D459 (= D479), N486 (= N506), E488 (≠ G508)
Sites not aligning to the query:
6deqA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
25% identity, 87% coverage: 41:581/625 of query aligns to 29:557/601 of 6deqA
- active site: Y35 (≠ H47), G37 (vs. gap), G38 (= G48), A39 (≠ N49), I40 (≠ V50), E61 (= E72), T84 (= T95), F123 (= F153), Q124 (≠ R154), E125 (≠ P155), K173 (≠ Q195), K232 (≠ E254), M268 (≠ V290), V295 (≠ T317), V411 (≠ A426), L436 (≠ Y451), G437 (≠ S452), M439 (= M454), D464 (= D479), N491 (= N506), E493 (≠ G508), Q494 (≠ Y509), M496 (≠ C511), V497 (≠ I512), W500 (≠ L515), L522 (≠ H546), N527 (≠ G551), V528 (≠ A552)
- binding flavin-adenine dinucleotide: R163 (vs. gap), G221 (= G244), A222 (≠ G245), G223 (= G246), N226 (≠ Y249), T248 (= T270), L249 (≠ Q271), Q250 (≠ A272), L266 (≠ I288), G288 (= G310), A289 (≠ T311), R290 (= R312), D292 (≠ Q314), R294 (≠ F316), V295 (≠ T317), E321 (≠ N333), I322 (≠ V334), D340 (= D350), V341 (≠ A351), M416 (≠ L436), G434 (≠ Y449)
- binding magnesium ion: D464 (= D479), N491 (= N506), E493 (≠ G508)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M268 (≠ V290), R294 (≠ F316), M496 (≠ C511), V497 (≠ I512), W500 (≠ L515)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V411 (≠ A426), G412 (= G427), Q413 (≠ T428), H414 (= H434), M439 (= M454), G463 (= G478), D464 (= D479), A465 (≠ G480), S466 (= S481), N491 (= N506), E493 (≠ G508), Q494 (≠ Y509), G495 (= G510), M496 (≠ C511), V497 (≠ I512)
Sites not aligning to the query:
1t9bB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
25% identity, 84% coverage: 58:584/625 of query aligns to 29:554/595 of 1t9bB
- active site: Y29 (= Y58), G31 (≠ Y60), G32 (≠ R61), A33 (= A62), I34 (≠ T63), E55 (= E72), T78 (= T95), F117 (≠ L136), Q118 (= Q137), E119 (≠ Q138), K167 (≠ Q195), R226 (≠ E254), M262 (≠ V290), V289 (≠ T317), V405 (≠ A426), L430 (≠ Y451), G431 (≠ S452), M433 (= M454), D458 (= D479), N485 (= N506), E487 (≠ G508), Q488 (≠ Y509), M490 (≠ C511), V491 (≠ I512), W494 (≠ L515), L516 (≠ H546), G521 (= G551), L522 (≠ A552)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (= V126), P108 (≠ F127), D287 (= D315), R288 (≠ F316), M490 (≠ C511), W494 (≠ L515)
- binding flavin-adenine dinucleotide: R157 (≠ Q185), G215 (= G244), A216 (≠ G245), G217 (= G246), N220 (vs. gap), T242 (= T270), L243 (≠ Q271), Q244 (≠ A272), M259 (≠ A287), L260 (≠ I288), M262 (≠ V290), H263 (≠ T291), G282 (= G310), A283 (≠ T311), R284 (= R312), D286 (≠ Q314), R288 (≠ F316), V289 (≠ T317), E315 (≠ N333), V316 (= V334), N320 (≠ D338), G333 (≠ A349), D334 (= D350), A335 (= A351), Q409 (vs. gap), M410 (≠ L429), G428 (≠ Y449), G429 (= G450)
- binding magnesium ion: D458 (= D479), N485 (= N506), E487 (≠ G508)
Sites not aligning to the query:
1t9bA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
25% identity, 84% coverage: 58:584/625 of query aligns to 29:542/583 of 1t9bA
- active site: Y29 (= Y58), G31 (≠ Y60), G32 (≠ R61), A33 (= A62), I34 (≠ T63), E55 (= E72), T78 (= T95), F117 (≠ L136), Q118 (= Q137), E119 (≠ Q138), K167 (≠ Q195), R214 (≠ E254), M250 (≠ V290), V277 (≠ T317), V393 (≠ A426), L418 (≠ Y451), G419 (≠ S452), M421 (= M454), D446 (= D479), N473 (= N506), E475 (≠ G508), Q476 (≠ Y509), M478 (≠ C511), V479 (≠ I512), W482 (≠ L515), L504 (≠ H546), G509 (= G551), L510 (≠ A552)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (= V126), P108 (≠ F127), F117 (≠ L136), D275 (= D315), R276 (≠ F316), M478 (≠ C511), W482 (≠ L515)
- binding flavin-adenine dinucleotide: R157 (≠ Q185), G203 (= G244), A204 (≠ G245), G205 (= G246), N208 (vs. gap), T230 (= T270), L231 (≠ Q271), Q232 (≠ A272), M247 (≠ A287), L248 (≠ I288), M250 (≠ V290), H251 (≠ T291), G270 (= G310), A271 (≠ T311), R272 (= R312), D274 (≠ Q314), R276 (≠ F316), V277 (≠ T317), E303 (≠ N333), V304 (= V334), N308 (≠ D338), D322 (= D350), A323 (= A351), Q397 (vs. gap), M398 (≠ L429), G416 (≠ Y449), G417 (= G450)
- binding magnesium ion: D446 (= D479), N473 (= N506), E475 (≠ G508)
Sites not aligning to the query:
1t9dB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
25% identity, 84% coverage: 58:584/625 of query aligns to 28:541/582 of 1t9dB
- active site: Y28 (= Y58), G30 (≠ Y60), G31 (≠ R61), A32 (= A62), I33 (≠ T63), E54 (= E72), T77 (= T95), F116 (≠ L136), Q117 (= Q137), E118 (≠ Q138), K166 (≠ Q195), R213 (≠ E254), M249 (≠ V290), V276 (≠ T317), V392 (≠ A426), L417 (≠ Y451), G418 (≠ S452), M420 (= M454), D445 (= D479), N472 (= N506), E474 (≠ G508), Q475 (≠ Y509), M477 (≠ C511), V478 (≠ I512), W481 (≠ L515), L503 (≠ H546), G508 (= G551), L509 (≠ A552)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G31 (≠ R61), A32 (= A62), V106 (= V126), P107 (≠ F127), F116 (≠ L136), K166 (≠ Q195), M249 (≠ V290), D274 (= D315), R275 (≠ F316), W481 (≠ L515)
- binding flavin-adenine dinucleotide: R156 (≠ Q185), G202 (= G244), A203 (≠ G245), G204 (= G246), N207 (vs. gap), T229 (= T270), L230 (≠ Q271), Q231 (≠ A272), L247 (≠ I288), M249 (≠ V290), H250 (≠ T291), G269 (= G310), A270 (≠ T311), R271 (= R312), D273 (≠ Q314), R275 (≠ F316), V276 (≠ T317), E302 (≠ N333), V303 (= V334), N307 (≠ D338), G320 (≠ A349), D321 (= D350), A322 (= A351), Q396 (vs. gap), M397 (≠ L429), G415 (≠ Y449), G416 (= G450)
- binding magnesium ion: D445 (= D479), N472 (= N506), E474 (≠ G508)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E54 (= E72), P80 (= P100), G418 (≠ S452), M420 (= M454), M450 (= M484)
Sites not aligning to the query:
6derA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide metosulam (see paper)
25% identity, 87% coverage: 41:581/625 of query aligns to 29:556/600 of 6derA
- active site: Y35 (≠ H47), G37 (vs. gap), G38 (= G48), A39 (≠ N49), I40 (≠ V50), E61 (= E72), T84 (= T95), F123 (= F153), Q124 (≠ R154), E125 (≠ P155), K173 (≠ Q195), K231 (≠ E254), M267 (≠ V290), V294 (≠ T317), V410 (≠ A426), L435 (≠ Y451), G436 (≠ S452), M438 (= M454), D463 (= D479), N490 (= N506), E492 (≠ G508), Q493 (≠ Y509), M495 (≠ C511), V496 (≠ I512), W499 (≠ L515), L521 (≠ H546), N526 (≠ G551), V527 (≠ A552)
- binding flavin-adenine dinucleotide: R163 (vs. gap), G220 (= G244), A221 (≠ G245), G222 (= G246), N225 (≠ Y249), T247 (= T270), L248 (≠ Q271), Q249 (≠ A272), L265 (≠ I288), H268 (≠ T291), G287 (= G310), A288 (≠ T311), R289 (= R312), D291 (≠ Q314), R293 (≠ F316), V294 (≠ T317), E320 (≠ N333), I321 (≠ V334), N325 (≠ D338), G338 (≠ A349), D339 (= D350), V340 (≠ A351), Q414 (≠ K435), M415 (≠ L436), G433 (≠ Y449)
- binding Metosulam: R293 (≠ F316), M495 (≠ C511), W499 (≠ L515)
- binding magnesium ion: D463 (= D479), N490 (= N506), E492 (≠ G508)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V410 (≠ A426), G411 (= G427), Q412 (≠ T428), H413 (= H434), G436 (≠ S452), M438 (= M454), G462 (= G478), D463 (= D479), A464 (≠ G480), S465 (= S481), N490 (= N506), E492 (≠ G508), Q493 (≠ Y509), G494 (= G510), M495 (≠ C511), V496 (≠ I512)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V410 (≠ A426), G411 (= G427), Q412 (≠ T428), H413 (= H434), G436 (≠ S452), M438 (= M454), G462 (= G478), D463 (= D479), A464 (≠ G480), S465 (= S481), M468 (= M484), N490 (= N506), E492 (≠ G508), Q493 (≠ Y509), G494 (= G510), V496 (≠ I512)
Sites not aligning to the query:
6desA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide propoxycarbazone (see paper)
25% identity, 87% coverage: 41:581/625 of query aligns to 27:554/598 of 6desA
- active site: Y33 (≠ H47), G35 (vs. gap), G36 (= G48), A37 (≠ N49), I38 (≠ V50), E59 (= E72), T82 (= T95), F121 (= F153), Q122 (≠ R154), E123 (≠ P155), K171 (≠ Q195), K229 (≠ E254), M265 (≠ V290), V292 (≠ T317), V408 (≠ A426), L433 (≠ Y451), G434 (≠ S452), M436 (= M454), D461 (= D479), N488 (= N506), E490 (≠ G508), Q491 (≠ Y509), M493 (≠ C511), V494 (≠ I512), W497 (≠ L515), L519 (≠ H546), N524 (≠ G551), V525 (≠ A552)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: M265 (≠ V290), D290 (= D315), R291 (≠ F316), W497 (≠ L515)
- binding flavin-adenine dinucleotide: R161 (vs. gap), G218 (= G244), A219 (≠ G245), G220 (= G246), N223 (≠ Y249), T245 (= T270), L246 (≠ Q271), Q247 (≠ A272), L263 (≠ I288), G285 (= G310), A286 (≠ T311), R287 (= R312), D289 (≠ Q314), R291 (≠ F316), V292 (≠ T317), E318 (≠ N333), I319 (≠ V334), N323 (≠ D338), D337 (= D350), V338 (≠ A351), Q412 (≠ K435), M413 (≠ L436), G431 (≠ Y449)
- binding magnesium ion: D461 (= D479), N488 (= N506), E490 (≠ G508)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (≠ A426), G409 (= G427), Q410 (≠ T428), H411 (= H434), G434 (≠ S452), M436 (= M454), G460 (= G478), D461 (= D479), A462 (≠ G480), S463 (= S481), N488 (= N506), E490 (≠ G508), Q491 (≠ Y509), G492 (= G510), M493 (≠ C511), V494 (≠ I512)
6depA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide sulfometuron methyl (see paper)
25% identity, 87% coverage: 41:581/625 of query aligns to 27:554/598 of 6depA
- active site: Y33 (≠ H47), G35 (vs. gap), G36 (= G48), A37 (≠ N49), I38 (≠ V50), E59 (= E72), T82 (= T95), F121 (= F153), Q122 (≠ R154), E123 (≠ P155), K171 (≠ Q195), K229 (≠ E254), M265 (≠ V290), V292 (≠ T317), V408 (≠ A426), L433 (≠ Y451), G434 (≠ S452), M436 (= M454), D461 (= D479), N488 (= N506), E490 (≠ G508), Q491 (≠ Y509), M493 (≠ C511), V494 (≠ I512), W497 (≠ L515), L519 (≠ H546), N524 (≠ G551), V525 (≠ A552)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D290 (= D315), R291 (≠ F316), M493 (≠ C511), W497 (≠ L515)
- binding flavin-adenine dinucleotide: R161 (vs. gap), G218 (= G244), A219 (≠ G245), G220 (= G246), N223 (≠ Y249), T245 (= T270), L246 (≠ Q271), Q247 (≠ A272), L263 (≠ I288), G264 (= G289), G285 (= G310), A286 (≠ T311), R287 (= R312), D289 (≠ Q314), R291 (≠ F316), V292 (≠ T317), E318 (≠ N333), I319 (≠ V334), N323 (≠ D338), D337 (= D350), V338 (≠ A351), M413 (≠ L436), G431 (≠ Y449)
- binding magnesium ion: D461 (= D479), N488 (= N506), E490 (≠ G508)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V408 (≠ A426), G409 (= G427), Q410 (≠ T428), H411 (= H434), G434 (≠ S452), M436 (= M454), G460 (= G478), D461 (= D479), A462 (≠ G480), S463 (= S481), M466 (= M484), N488 (= N506), E490 (≠ G508), Q491 (≠ Y509), G492 (= G510), M493 (≠ C511), V494 (≠ I512)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (≠ A426), G409 (= G427), Q410 (≠ T428), H411 (= H434), G434 (≠ S452), M436 (= M454), G460 (= G478), D461 (= D479), A462 (≠ G480), S463 (= S481), M466 (= M484), N488 (= N506), E490 (≠ G508), Q491 (≠ Y509), G492 (= G510), M493 (≠ C511), V494 (≠ I512)
6deoA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron methyl (see paper)
25% identity, 87% coverage: 41:581/625 of query aligns to 25:549/593 of 6deoA
- active site: Y31 (≠ H47), G33 (vs. gap), G34 (= G48), A35 (≠ N49), I36 (≠ V50), E57 (= E72), T80 (= T95), F119 (= F153), Q120 (≠ R154), E121 (≠ P155), K169 (≠ Q195), K224 (≠ E254), M260 (≠ V290), V287 (≠ T317), V403 (≠ A426), L428 (≠ Y451), G429 (≠ S452), M431 (= M454), D456 (= D479), N483 (= N506), E485 (≠ G508), Q486 (≠ Y509), M488 (≠ C511), V489 (≠ I512), W492 (≠ L515), L514 (≠ H546), N519 (≠ G551), V520 (≠ A552)
- binding flavin-adenine dinucleotide: R159 (vs. gap), G213 (= G244), A214 (≠ G245), G215 (= G246), N218 (≠ Y249), T240 (= T270), L241 (≠ Q271), Q242 (≠ A272), L258 (≠ I288), G280 (= G310), A281 (≠ T311), R282 (= R312), D284 (≠ Q314), R286 (≠ F316), V287 (≠ T317), E313 (≠ N333), I314 (≠ V334), N318 (≠ D338), D332 (= D350), V333 (≠ A351), M408 (≠ L436), G426 (≠ Y449)
- binding methyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M260 (≠ V290), D285 (= D315), R286 (≠ F316), M488 (≠ C511), W492 (≠ L515)
- binding magnesium ion: D456 (= D479), N483 (= N506), E485 (≠ G508)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V403 (≠ A426), G404 (= G427), Q405 (≠ T428), H406 (= H434), G429 (≠ S452), M431 (= M454), G455 (= G478), D456 (= D479), A457 (≠ G480), S458 (= S481), M461 (= M484), N483 (= N506), E485 (≠ G508), Q486 (≠ Y509), G487 (= G510), M488 (≠ C511), V489 (≠ I512)
5wkcA Saccharomyces cerevisiae acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
25% identity, 84% coverage: 58:584/625 of query aligns to 29:550/591 of 5wkcA
- active site: Y29 (= Y58), G31 (≠ Y60), G32 (≠ R61), A33 (= A62), I34 (≠ T63), E55 (= E72), T78 (= T95), F117 (≠ L136), Q118 (= Q137), E119 (≠ Q138), K167 (≠ Q195), R222 (≠ E254), M258 (≠ V290), V285 (≠ T317), V401 (≠ A426), L426 (≠ Y451), G427 (≠ S452), M429 (= M454), D454 (= D479), N481 (= N506), E483 (≠ G508), Q484 (≠ Y509), M486 (≠ C511), V487 (≠ I512), W490 (≠ L515), L512 (≠ H546), G517 (= G551), L518 (≠ A552)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V401 (≠ A426), G402 (= G427), Q403 (≠ T428), H404 (vs. gap), G427 (≠ S452), M429 (= M454), G453 (= G478), D454 (= D479), A455 (≠ G480), S456 (= S481), M459 (= M484), N481 (= N506), E483 (≠ G508), Q484 (≠ Y509), G485 (= G510), M486 (≠ C511), V487 (≠ I512)
- binding ethaneperoxoic acid: G32 (≠ R61), Q118 (= Q137)
- binding flavin-adenine dinucleotide: R157 (≠ Q185), G211 (= G244), A212 (≠ G245), G213 (= G246), N216 (vs. gap), T238 (= T270), L239 (≠ Q271), Q240 (≠ A272), L256 (≠ I288), M258 (≠ V290), G278 (= G310), A279 (≠ T311), R280 (= R312), R284 (≠ F316), V285 (≠ T317), E311 (≠ N333), V312 (= V334), N316 (≠ D338), D330 (= D350), A331 (= A351), M406 (≠ L429), G424 (≠ Y449)
- binding magnesium ion: D454 (= D479), N481 (= N506), E483 (≠ G508)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: G32 (≠ R61), A33 (= A62), V107 (= V126), F117 (≠ L136), K167 (≠ Q195), M258 (≠ V290), R284 (≠ F316), M486 (≠ C511), W490 (≠ L515)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: P30 (≠ Q59), E55 (= E72)
Sites not aligning to the query:
6u9dB Saccharomyces cerevisiae acetohydroxyacid synthase (see paper)
25% identity, 84% coverage: 58:584/625 of query aligns to 33:566/607 of 6u9dB
- active site: Y33 (= Y58), G35 (≠ Y60), G36 (≠ R61), A37 (= A62), I38 (≠ T63), E59 (= E72), T82 (= T95), F121 (≠ L136), Q122 (= Q137), E123 (≠ Q138), K171 (≠ Q195), M274 (≠ V290), V301 (≠ T317), V417 (≠ A426), G443 (≠ S452), M445 (= M454), D470 (= D479), N497 (= N506), E499 (≠ G508), Q500 (≠ Y509), M502 (≠ C511), V503 (≠ I512), W506 (≠ L515)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: G36 (≠ R61), V111 (= V126), P112 (≠ F127), F121 (≠ L136), K171 (≠ Q195), D299 (= D315), R300 (≠ F316), M502 (≠ C511), W506 (≠ L515)
- binding flavin-adenine dinucleotide: R161 (≠ Q185), A228 (≠ G245), G229 (= G246), N232 (vs. gap), T254 (= T270), L255 (≠ Q271), Q256 (≠ A272), L272 (≠ I288), M274 (≠ V290), G294 (= G310), R296 (= R312), D298 (≠ Q314), R300 (≠ F316), V301 (≠ T317), E327 (≠ N333), V328 (= V334), N332 (≠ D338), D346 (= D350), A347 (= A351), M422 (≠ L429), G440 (≠ Y449), G441 (= G450)
- binding magnesium ion: D470 (= D479), N497 (= N506)
- binding thiamine diphosphate: E59 (= E72), P85 (= P100), V417 (≠ A426), G418 (= G427), Q419 (≠ T428), H420 (vs. gap), G443 (≠ S452), M445 (= M454), A471 (≠ G480), S472 (= S481), N497 (= N506), E499 (≠ G508), Q500 (≠ Y509), G501 (= G510), M502 (≠ C511), V503 (≠ I512)
P07342 Acetolactate synthase catalytic subunit, mitochondrial; Acetohydroxy-acid synthase catalytic subunit; AHAS; ALS; EC 2.2.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
25% identity, 84% coverage: 58:584/625 of query aligns to 113:646/687 of P07342
- R241 (≠ Q185) binding
- 355:376 (vs. 291:312, 50% identical) binding
- 407:426 (vs. 333:350, 20% identical) binding
6lpiB Crystal structure of ahas holo-enzyme (see paper)
27% identity, 67% coverage: 99:516/625 of query aligns to 78:465/539 of 6lpiB
- active site: F115 (≠ L136), Q116 (= Q137), E117 (≠ Q138), K165 (≠ Q195), M256 (≠ V290), A283 (≠ T317), V375 (≠ A426), G401 (≠ S452), M403 (= M454), D428 (= D479), N455 (= N506), A457 (≠ G508), L458 (≠ Y509), L460 (≠ C511), V461 (≠ I512), Q464 (≠ L515)
- binding flavin-adenine dinucleotide: R155 (≠ Q185), G212 (= G244), G213 (= G245), G214 (= G246), T236 (= T270), L237 (≠ Q271), M238 (≠ A272), L254 (≠ I288), M256 (≠ V290), H257 (≠ T291), G276 (= G310), A277 (≠ T311), R278 (= R312), D280 (≠ Q314), R282 (≠ F316), A283 (≠ T317), D300 (≠ N333), I301 (≠ V334), D319 (= D350), V320 (≠ A351), M380 (≠ L436), G398 (≠ Y449)
- binding magnesium ion: D428 (= D479), N455 (= N506)
- binding thiamine diphosphate: P79 (= P100), G376 (= G427), Q377 (≠ T428), H378 (= H434), G401 (≠ S452), M403 (= M454), G427 (= G478), D428 (= D479), G429 (= G480), S430 (= S481), M433 (= M484), N455 (= N506), A457 (≠ G508), L458 (≠ Y509), G459 (= G510), L460 (≠ C511), V461 (≠ I512)
Sites not aligning to the query:
Query Sequence
>HSERO_RS12130 FitnessBrowser__HerbieS:HSERO_RS12130
MNAQVNVRPTLRLTMAQALVRYLDALRIQTPQGVLPLFGGVFSIFGHGNVAGMGEALYQY
RATLPTYRAHNEQAMAHSAIAYAKAHLRQRMMAVTTSIGPGATNLLTAAALAHVNRLPVL
LLPGDVFVSRRPDPVLQQLEDFNDPGLSVNDAFRPLSRMFDRICYPEQLLTALPRAIQVL
TDPAQCGPVTLALPQDVQTMAYDYPLDFFSPRVIVPRAQAPAAQELEDAVALLRQARQPL
LIAGGGVLYGNACEHLRRFAEQHGVPVAETQAGKSALPWSHALQMGAIGVTGSPAANALA
QEADVVIAVGTRLQDFTTGSHTLFAQARLLNLNVNAMDAHKWRGLALQADAGLGLEALSH
ALEGWRSAPEWHARAHTLAQDWRERVAQITGQTDTGGRLPYDGEVIGAIQRSVADSPSQD
IVVCAAGTLPAELHKLWRAGRPGAYHVEYGYSCMGYEVAGGLGVKLAQPQREVIVIVGDG
SYLMMNSELATSVMLGAKLIVVVLDNRGYGCINRLQQACGGAPFNNMLADCLQAGPGAPA
IDFAAHARSLGALGENVKTITELEAALQRARAADRSYLVCIDTDASRTTDDGGCWWEVAV
PEVSPRSQVQQARSQYEQARQAQSV
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory