Comparing HSERO_RS12245 FitnessBrowser__HerbieS:HSERO_RS12245 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1djeA Crystal structure of the plp-bound form of 8-amino-7-oxonanoate synthase (see paper)
47% identity, 94% coverage: 17:377/385 of query aligns to 19:379/383 of 1djeA
1dj9A Crystal structure of 8-amino-7-oxonanoate synthase (or 7-keto- 8aminipelargonate or kapa synthase) complexed with plp and the product 8(s)-amino-7-oxonanonoate (or kapa). The enzyme of biotin biosynthetic pathway. (see paper)
47% identity, 94% coverage: 17:377/385 of query aligns to 19:379/383 of 1dj9A
P12998 8-amino-7-oxononanoate synthase; AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; EC 2.3.1.47 from Escherichia coli (strain K12) (see 2 papers)
47% identity, 92% coverage: 23:377/385 of query aligns to 26:380/384 of P12998
Sites not aligning to the query:
2g6wA Suicide inhibition of a-oxamine synthase: structures of the covalent adducts of 8-amino-7-oxonanoate synthase with trifluoroalanine (see paper)
47% identity, 92% coverage: 23:377/385 of query aligns to 25:379/383 of 2g6wA
7poaA An irreversible, promiscuous and highly thermostable claisen- condensation biocatalyst drives the synthesis of substituted pyrroles
40% identity, 96% coverage: 6:376/385 of query aligns to 14:386/398 of 7poaA
3tqxA Structure of the 2-amino-3-ketobutyrate coenzyme a ligase (kbl) from coxiella burnetii (see paper)
34% identity, 98% coverage: 1:379/385 of query aligns to 5:388/396 of 3tqxA
1fc4A 2-amino-3-ketobutyrate coa ligase (see paper)
36% identity, 98% coverage: 3:379/385 of query aligns to 7:392/401 of 1fc4A
P0AB77 2-amino-3-ketobutyrate coenzyme A ligase; AKB ligase; Glycine acetyltransferase; EC 2.3.1.29 from Escherichia coli (strain K12) (see paper)
36% identity, 98% coverage: 3:379/385 of query aligns to 4:389/398 of P0AB77
Q8GW43 8-amino-7-oxononanoate synthase; AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Biotin synthase 4; Biotin synthase F; AtbioF; EC 2.3.1.47 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
39% identity, 89% coverage: 36:377/385 of query aligns to 102:455/476 of Q8GW43
Sites not aligning to the query:
8h29A Serine palmitoyltransferase from sphingobacterium multivorum complexed with l-threonine (see paper)
34% identity, 97% coverage: 8:379/385 of query aligns to 15:387/394 of 8h29A
8h21A Serine palmitoyltransferase from sphingobacterium multivorum complexed with l-alanine (see paper)
34% identity, 97% coverage: 8:379/385 of query aligns to 15:387/394 of 8h21A
8h20A Serine palmitoyltransferase from sphingobacterium multivorum complexed with glycine (see paper)
34% identity, 97% coverage: 8:379/385 of query aligns to 15:387/394 of 8h20A
8h1yA Serine palmitoyltransferase from sphingobacterium multivorum complexed with l-homoserine (see paper)
34% identity, 97% coverage: 8:379/385 of query aligns to 15:387/394 of 8h1yA
8h1qA Serine palmitoyltransferase from sphingobacterium multivorum complexed with l-serine (see paper)
34% identity, 97% coverage: 8:379/385 of query aligns to 15:387/394 of 8h1qA
8guhA Serine palmitoyltransferase from sphingobacterium multivorum complexed with tris (see paper)
34% identity, 97% coverage: 8:379/385 of query aligns to 15:387/394 of 8guhA
3a2bA Crystal structure of serine palmitoyltransferase from sphingobacterium multivorum with substrate l-serine (see paper)
34% identity, 97% coverage: 8:379/385 of query aligns to 15:387/392 of 3a2bA
Q0P5L8 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial; AKB ligase; Aminoacetone synthase; Glycine acetyltransferase; EC 2.3.1.29 from Bos taurus (Bovine) (see paper)
33% identity, 98% coverage: 4:379/385 of query aligns to 31:410/419 of Q0P5L8
Sites not aligning to the query:
7bxsA 2-amino-3-ketobutyrate coa ligase from cupriavidus necator glycine binding form
35% identity, 97% coverage: 7:380/385 of query aligns to 14:392/399 of 7bxsA
7bxrA 2-amino-3-ketobutyrate coa ligase from cupriavidus necator 3- hydroxynorvaline binding form
35% identity, 97% coverage: 7:380/385 of query aligns to 14:392/399 of 7bxrA
7bxqA 2-amino-3-ketobutyrate coa ligase from cupriavidus necator l-threonine binding form
35% identity, 97% coverage: 7:380/385 of query aligns to 14:392/399 of 7bxqA
>HSERO_RS12245 FitnessBrowser__HerbieS:HSERO_RS12245
MHDFHQQLDELARQSLLRTRRTVSSAQGPLLTVEARPYLSFCSNDYLGLANHPAITAAAV
TALGQYGMGAAASALISGHSAAHETLERALAEFTGLPAALGFGSGYMANMGVIGALVGAG
DTVVVDRLSHASLIDGARLSGASLKVFPHNDTQRLDHVLARCGSGRKLVVTDAVFSMDGD
QAPLSELAEICARHGAWLLVDDAHGFGVLGPQGRGSLAHAGVRAPHVLCMGTLGKAAGVA
GAFVAGERDLLAWIMQRARTYMFSTAHPPALAAAATASLAVIAADEWRRTHLRALVAQLR
KGLAGLSWQLLPSQTPIQPLIIGDNARARALMQQLREQGIWVPAICPPTVPRMTARLRIS
LSALHTQEQVAQLIEALVQAEQVAA
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory