Comparing HSERO_RS13795 FitnessBrowser__HerbieS:HSERO_RS13795 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 15 hits to proteins with known functional sites (download)
P22106 Asparagine synthetase B [glutamine-hydrolyzing]; AS-B; EC 6.3.5.4 from Escherichia coli (strain K12) (see 2 papers)
31% identity, 61% coverage: 1:392/647 of query aligns to 1:379/554 of P22106
1ct9A Crystal structure of asparagine synthetase b from escherichia coli (see paper)
32% identity, 60% coverage: 3:392/647 of query aligns to 2:362/497 of 1ct9A
Sites not aligning to the query:
P78753 Probable asparagine synthetase [glutamine-hydrolyzing]; Glutamine-dependent asparagine synthetase; EC 6.3.5.4 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
29% identity, 60% coverage: 1:389/647 of query aligns to 1:383/557 of P78753
Sites not aligning to the query:
P08243 Asparagine synthetase [glutamine-hydrolyzing]; Cell cycle control protein TS11; Glutamine-dependent asparagine synthetase; EC 6.3.5.4 from Homo sapiens (Human) (see 7 papers)
26% identity, 60% coverage: 1:387/647 of query aligns to 1:385/561 of P08243
Sites not aligning to the query:
6gq3A Human asparagine synthetase (asns) in complex with 6-diazo-5-oxo-l- norleucine (don) at 1.85 a resolution (see paper)
25% identity, 59% coverage: 5:387/647 of query aligns to 1:372/509 of 6gq3A
4amvA E.Coli glucosamine-6p synthase in complex with fructose-6p (see paper)
33% identity, 25% coverage: 2:162/647 of query aligns to 1:208/608 of 4amvA
Sites not aligning to the query:
1jxaA Glucosamine 6-phosphate synthase with glucose 6-phosphate (see paper)
33% identity, 25% coverage: 2:162/647 of query aligns to 1:208/608 of 1jxaA
Sites not aligning to the query:
2j6hA E. Coli glucosamine-6-p synthase in complex with glucose-6p and 5-oxo- l-norleucine (see paper)
33% identity, 25% coverage: 2:162/647 of query aligns to 1:208/608 of 2j6hA
Sites not aligning to the query:
1xfgA Glutaminase domain of glucosamine 6-phosphate synthase complexed with l-glu hydroxamate (see paper)
32% identity, 25% coverage: 2:162/647 of query aligns to 1:208/238 of 1xfgA
1xffA Glutaminase domain of glucosamine 6-phosphate synthase complexed with glutamate (see paper)
32% identity, 25% coverage: 2:162/647 of query aligns to 1:208/238 of 1xffA
Q9STG9 Amidophosphoribosyltransferase 2, chloroplastic; AtATase2; AtPURF2; PRPP2; Glutamine phosphoribosylpyrophosphate amidotransferase 2; AtGPRAT2; Protein CHLOROPLAST IMPORT APPARATUS 1; Protein DIFFERENTIAL DEVELOPMENT OF VASCULAR ASSOCIATED CELLS; EC 2.4.2.14 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
28% identity, 26% coverage: 2:166/647 of query aligns to 87:285/561 of Q9STG9
Sites not aligning to the query:
6lbpA Structure of the glutamine phosphoribosylpyrophosphate amidotransferase from arabidopsis thaliana (see paper)
28% identity, 26% coverage: 2:166/647 of query aligns to 1:199/460 of 6lbpA
Sites not aligning to the query:
1gph1 Structure of the allosteric regulatory enzyme of purine biosynthesis (see paper)
28% identity, 16% coverage: 61:166/647 of query aligns to 85:198/465 of 1gph1
Sites not aligning to the query:
P00497 Amidophosphoribosyltransferase; ATase; Glutamine phosphoribosylpyrophosphate amidotransferase; GPATase; EC 2.4.2.14 from Bacillus subtilis (strain 168) (see 5 papers)
28% identity, 16% coverage: 61:166/647 of query aligns to 96:209/476 of P00497
Sites not aligning to the query:
1ao0A Glutamine phosphoribosylpyrophosphate (prpp) amidotransferase from b. Subtilis complexed with adp and gmp (see paper)
28% identity, 16% coverage: 61:166/647 of query aligns to 81:194/455 of 1ao0A
Sites not aligning to the query:
>HSERO_RS13795 FitnessBrowser__HerbieS:HSERO_RS13795
MCGITGIFSLHGQAEIDRQLLARMNETQHHRGPDEGGLHVEAGLGLGHRRLSIVDLSSGQ
QPLFNEDGSVVVVFNGMIYNYRELMRELTALGHQFRSRCDTEVIVHAWEQWGRDCVTRLR
GMFAFALWDRQRQTLFVARDRLGIKPLFYALLPDGRFLFASELKALLADPALPRALDPCA
VEEYFAYGYVPEPRTILRGVHKLSPGHTLLLQRGATRGQPQQQRYWDIPFQLGSQRPAEE
IAAELLERLREVVGSHLVTDVSLGGFLSGGVDSSAVVAMMAQLTGESVNTCSIAFNDPAY
DESHYAAQVAQQFRTRHHMRTVDKDDYGLIDLLAKLYDEPYADSSAIPTYRVCQLAKESV
TVALSGDGGDENFAGYRRYRYAMNEEKVRARLPEGLRKPLFGFLGRHYPKADWAPRVLRA
KTTFEALARDTVEGYFHGVSIMPDRVRQRLLSPGLRRELQGYQAIEVMRGHAAQAPTEDA
LSLLQYLDLKTYLPGDILTKVDRASMAHALEVRVPLLDHQFVEWVSGLPPALKLHEGQGK
YIFKKALEGTLSEDILYRRKMGFSIPLSSWLRGPLRQVVQDSLLGPLLRQTGLFDMDFVQ
ELVEQHQSGRRDHAAPLWALLMFAAFLRNVLQAGAGAAPQQPAARAA
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory