SitesBLAST
Comparing HSERO_RS14055 FitnessBrowser__HerbieS:HSERO_RS14055 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
5lnxD Crystal structure of mmgc, an acyl-coa dehydrogenase from bacillus subtilis.
34% identity, 96% coverage: 13:383/388 of query aligns to 9:374/374 of 5lnxD
- active site: L122 (≠ V125), T123 (= T126), G239 (≠ E246), E358 (≠ P367), K370 (≠ E379)
- binding flavin-adenine dinucleotide: L122 (≠ V125), T123 (= T126), G128 (= G131), S129 (≠ T132), F153 (≠ W156), T155 (≠ S158), R265 (= R272), Q267 (≠ V274), F268 (= F275), I272 (= I279), N275 (= N282), I278 (≠ V285), Q331 (= Q340), I332 (≠ T341), G335 (= G344), Y357 (≠ A366), T360 (≠ S369), E362 (≠ N371)
4iv6B X-ray crystal structure of an isovaleryl-coa dehydrogenase from mycobacterium smegmatis (see paper)
35% identity, 94% coverage: 17:382/388 of query aligns to 13:376/383 of 4iv6B
- active site: L121 (≠ V125), T122 (= T126), G240 (≠ E246), E361 (≠ P367), K373 (≠ E379)
- binding dihydroflavine-adenine dinucleotide: L121 (≠ V125), T122 (= T126), G126 (≠ T130), G127 (= G131), S128 (≠ T132), W152 (= W156), I153 (= I157), S154 (= S158), R266 (= R272), S268 (≠ V274), F269 (= F275), I273 (= I279), H276 (≠ N282), V279 (= V285), R334 (≠ Q340), V335 (≠ T341), G338 (= G344), L356 (= L362), G360 (≠ A366), T363 (≠ S369), E365 (≠ N371), I366 (≠ L372)
5ol2F The electron transferring flavoprotein/butyryl-coa dehydrogenase complex from clostridium difficile (see paper)
34% identity, 86% coverage: 31:365/388 of query aligns to 29:360/378 of 5ol2F
- active site: L124 (≠ V125), T125 (= T126), G241 (≠ E246)
- binding calcium ion: E29 (≠ K31), E33 (≠ A35), R35 (≠ G37)
- binding coenzyme a persulfide: L238 (= L243), R242 (= R247)
- binding flavin-adenine dinucleotide: F122 (≠ M123), L124 (≠ V125), T125 (= T126), P127 (= P128), T131 (= T132), F155 (≠ W156), I156 (= I157), T157 (≠ S158), E198 (vs. gap), R267 (= R272), F270 (= F275), L274 (≠ I279), F277 (≠ N282), Q335 (= Q340), L336 (≠ T341), G338 (= G343), G339 (= G344)
Sites not aligning to the query:
7p9xA Structure of cyclohex-1-ene-1-carboxyl-coa dehydrogenase complexed with cyclohex-1-ene-1-carboxyl-coa (see paper)
34% identity, 96% coverage: 15:385/388 of query aligns to 11:378/378 of 7p9xA
- binding 1-monoenoyl-CoA: L82 (≠ A86), D89 (≠ Y92), S129 (≠ T132), L131 (≠ T134), K176 (≠ E183), F229 (= F236), M233 (≠ L240), L236 (= L243), R240 (= R247), Y360 (≠ A366), T361 (≠ I368), G362 (≠ S369), R373 (≠ H380)
- binding flavin-adenine dinucleotide: A122 (≠ V125), T123 (= T126), G128 (= G131), S129 (≠ T132), F153 (≠ W156), I154 (= I157), T155 (≠ S158), N206 (≠ T213), L356 (= L362), Y360 (≠ A366), T363 (= T370), Q365 (≠ L372), I366 (= I373)
7p9aA Structure of cyclohex-1-ene-1-carboxyl-coa dehydrogenase complexed with cyclohex-1,5-diene-1-carboxyl-coa (see paper)
34% identity, 96% coverage: 15:385/388 of query aligns to 13:380/380 of 7p9aA
- binding 1,5 Dienoyl-CoA: S131 (≠ T132), L133 (≠ T134), K178 (≠ E183), F231 (= F236), M235 (≠ L240), L238 (= L243), N241 (≠ E246), R242 (= R247), Y362 (≠ A366), T363 (≠ I368), G364 (≠ S369), R375 (≠ H380)
- binding flavin-adenine dinucleotide: L122 (≠ M123), A124 (≠ V125), T125 (= T126), G130 (= G131), S131 (≠ T132), F155 (≠ W156), I156 (= I157), T157 (≠ S158), K200 (≠ I205), N208 (≠ T213), L358 (= L362), T365 (= T370), Q367 (≠ L372), I368 (= I373)
3pfdC Crystal structure of an acyl-coa dehydrogenase from mycobacterium thermoresistibile bound to reduced flavin adenine dinucleotide solved by combined iodide ion sad mr (see paper)
34% identity, 92% coverage: 10:365/388 of query aligns to 1:351/369 of 3pfdC
- active site: L116 (≠ V125), S117 (≠ T126), T233 (≠ E246)
- binding dihydroflavine-adenine dinucleotide: Y114 (≠ M123), L116 (≠ V125), S117 (≠ T126), G122 (= G131), S123 (≠ T132), W147 (= W156), I148 (= I157), T149 (≠ S158), R259 (= R272), F262 (= F275), V266 (≠ I279), N269 (= N282), Q326 (= Q340), L327 (≠ T341), G330 (= G344), I348 (≠ L362)
Sites not aligning to the query:
6fahD Molecular basis of the flavin-based electron-bifurcating caffeyl-coa reductase reaction (see paper)
31% identity, 93% coverage: 7:365/388 of query aligns to 4:360/379 of 6fahD
- active site: L124 (≠ V125), T125 (= T126), G241 (≠ E246)
- binding flavin-adenine dinucleotide: F122 (≠ M123), L124 (≠ V125), T125 (= T126), R152 (≠ Q153), F155 (≠ W156), T157 (≠ S158), E198 (≠ V202), R267 (= R272), Q269 (≠ V274), F270 (= F275), I274 (= I279), F277 (≠ N282), Q335 (= Q340), I336 (≠ T341), G339 (= G344)
Sites not aligning to the query:
1ukwB Crystal structure of medium-chain acyl-coa dehydrogenase from thermus thermophilus hb8
31% identity, 97% coverage: 7:382/388 of query aligns to 6:377/379 of 1ukwB
- active site: L124 (≠ V125), S125 (≠ T126), T241 (≠ E246), E362 (≠ P367), R374 (≠ E379)
- binding cobalt (ii) ion: D145 (= D146), H146 (≠ R147)
- binding flavin-adenine dinucleotide: F122 (≠ M123), L124 (≠ V125), S125 (≠ T126), G130 (= G131), S131 (≠ T132), W155 (= W156), S157 (= S158), K200 (≠ I205), L357 (= L362), Y361 (≠ A366), E362 (≠ P367), T364 (≠ S369), E366 (≠ N371), L370 (≠ S375)
1ukwA Crystal structure of medium-chain acyl-coa dehydrogenase from thermus thermophilus hb8
31% identity, 97% coverage: 7:382/388 of query aligns to 6:377/379 of 1ukwA
- active site: L124 (≠ V125), S125 (≠ T126), T241 (≠ E246), E362 (≠ P367), R374 (≠ E379)
- binding flavin-adenine dinucleotide: F122 (≠ M123), L124 (≠ V125), S125 (≠ T126), G130 (= G131), S131 (≠ T132), W155 (= W156), S157 (= S158), L357 (= L362), Y361 (≠ A366), E362 (≠ P367), T364 (≠ S369), E366 (≠ N371), L370 (≠ S375)
2jifA Structure of human short-branched chain acyl-coa dehydrogenase (acadsb)
29% identity, 97% coverage: 5:381/388 of query aligns to 5:377/381 of 2jifA
- active site: L125 (≠ V125), S126 (≠ T126), G242 (≠ E246), E363 (≠ P367), K375 (≠ E379)
- binding coenzyme a persulfide: S132 (≠ T132), S134 (≠ T134), Y178 (≠ S182), Y232 (≠ F236), I236 (≠ L240), L239 (= L243), N240 (= N244), R243 (= R247), Y362 (≠ A366), E363 (≠ P367), G364 (≠ I368), I368 (≠ L372)
- binding flavin-adenine dinucleotide: F123 (≠ M123), L125 (≠ V125), S126 (≠ T126), G131 (= G131), S132 (≠ T132), W156 (= W156), I157 (= I157), S158 (= S158), K201 (≠ I205), T209 (= T213), R268 (= R272), F271 (= F275), L275 (≠ I279), F278 (≠ N282), L281 (≠ V285), E336 (≠ Q340), W337 (≠ T341), G340 (= G344), N367 (= N371), I368 (≠ L372)
P45954 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial; SBCAD; 2-methyl branched chain acyl-CoA dehydrogenase; 2-MEBCAD; 2-methylbutyryl-coenzyme A dehydrogenase; 2-methylbutyryl-CoA dehydrogenase; EC 1.3.8.5 from Homo sapiens (Human) (see 6 papers)
29% identity, 97% coverage: 5:381/388 of query aligns to 56:428/432 of P45954
- V137 (≠ A86) mutation to L: Decreased acyl-CoA dehydrogenase activity.
- F138 (vs. gap) mutation to L: Increased acyl-CoA dehydrogenase activity. No effect on substrate specificity.
- 174:183 (vs. 123:132, 20% identical) binding in other chain
- S183 (≠ T132) binding
- WIS 207:209 (= WIS 156:158) binding in other chain
- S210 (≠ R159) mutation to N: Increased acyl-CoA dehydrogenase activity. Changed substrate specificity.
- Y229 (≠ S182) binding
- L255 (≠ M208) to F: in SBCADD; loss of protein expression; loss of 2-methylbutyryl-CoA dehydrogenase activity; dbSNP:rs137852649
- Y283 (≠ F236) binding
- NEGR 291:294 (≠ NAER 244:247) binding
- I316 (≠ A269) to V: in dbSNP:rs1131430
- R319 (= R272) binding
- Q330 (= Q283) binding
- EWMGG 387:391 (≠ QTHGG 340:344) binding
- A416 (≠ S369) mutation to T: Increased acyl-CoA dehydrogenase activity. No effect on substrate specificity.
- ASN 416:418 (≠ STN 369:371) binding in other chain
Sites not aligning to the query:
- 1:33 modified: transit peptide, Mitochondrion
- 13 R → K: in dbSNP:rs12263012
1jqiA Crystal structure of rat short chain acyl-coa dehydrogenase complexed with acetoacetyl-coa (see paper)
29% identity, 97% coverage: 8:382/388 of query aligns to 9:380/384 of 1jqiA
- active site: G377 (≠ E379)
- binding acetoacetyl-coenzyme a: L95 (≠ M91), F125 (≠ M123), S134 (≠ T132), F234 (= F236), M238 (≠ L240), Q239 (≠ D241), L241 (= L243), D242 (≠ N244), R245 (= R247), Y364 (≠ A366), E365 (≠ P367), G366 (≠ I368)
- binding flavin-adenine dinucleotide: F125 (≠ M123), L127 (≠ V125), S128 (≠ T126), G133 (= G131), S134 (≠ T132), W158 (= W156), T160 (≠ S158), R270 (= R272), F273 (= F275), L280 (≠ N282), Q338 (= Q340), I339 (≠ T341), G342 (= G344), I360 (≠ L362), T367 (≠ S369), E369 (≠ N371), I370 (≠ L372)
P15651 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Rattus norvegicus (Rat) (see 2 papers)
29% identity, 98% coverage: 8:387/388 of query aligns to 36:412/412 of P15651
Sites not aligning to the query:
- 1:24 modified: transit peptide, Mitochondrion
7w0jE Acyl-coa dehydrogenase, tfu_1647
33% identity, 93% coverage: 7:365/388 of query aligns to 8:364/382 of 7w0jE
- binding [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4S)-5-azanyl-2,3,4-tris(oxidanyl)pentyl] hydrogen phosphate: S127 (≠ T126), W157 (= W156), R270 (= R272), Q272 (≠ V274), F273 (= F275), I277 (= I279), F280 (≠ N282), I283 (≠ V285), Q339 (= Q340), L340 (≠ T341), G343 (= G344)
Sites not aligning to the query:
- binding [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4S)-5-azanyl-2,3,4-tris(oxidanyl)pentyl] hydrogen phosphate: 365, 366, 368, 370, 371
8i4rA Crystal structure of acyl-coa dehydrogenase complexed with acetyl-coa from thermobifida fusca
33% identity, 93% coverage: 7:365/388 of query aligns to 7:363/381 of 8i4rA
- binding acetyl coenzyme *a: S132 (≠ T132), T134 (= T134), R180 (= R180), R234 (= R237), L237 (= L240), R238 (≠ D241), L240 (= L243), D241 (≠ N244), R244 (= R247)
- binding flavin-adenine dinucleotide: Y123 (≠ M123), L125 (≠ V125), S126 (≠ T126), G131 (= G131), S132 (≠ T132), W156 (= W156), I157 (= I157), T158 (≠ S158), I360 (≠ L362)
Sites not aligning to the query:
8i4pA Crystal structure of acyl-coa dehydrogenase from thermobifida fusca
33% identity, 93% coverage: 7:365/388 of query aligns to 7:363/381 of 8i4pA
Sites not aligning to the query:
4l1fA Electron transferring flavoprotein of acidaminococcus fermentans: towards a mechanism of flavin-based electron bifurcation (see paper)
29% identity, 95% coverage: 13:382/388 of query aligns to 12:377/380 of 4l1fA
- active site: L125 (≠ V125), T126 (= T126), G242 (≠ E246), E363 (≠ P367), R375 (≠ H380)
- binding coenzyme a persulfide: T132 (= T132), H179 (≠ E183), F232 (= F236), M236 (≠ L240), E237 (≠ D241), L239 (= L243), D240 (≠ N244), R243 (= R247), Y362 (≠ A366), E363 (≠ P367), G364 (≠ S369), R375 (≠ H380)
- binding flavin-adenine dinucleotide: F123 (≠ M123), L125 (≠ V125), T126 (= T126), G131 (= G131), T132 (= T132), F156 (≠ W156), I157 (= I157), T158 (≠ S158), R268 (= R272), Q270 (≠ V274), F271 (= F275), I275 (= I279), F278 (≠ N282), L281 (≠ V285), Q336 (= Q340), I337 (≠ T341), G340 (= G344), I358 (≠ L362), Y362 (≠ A366), T365 (= T370), Q367 (≠ L372)
Sites not aligning to the query:
3mpjB Structure of the glutaryl-coenzyme a dehydrogenase (see paper)
32% identity, 97% coverage: 13:387/388 of query aligns to 12:387/393 of 3mpjB
- active site: I128 (≠ V125), T129 (= T126), T245 (≠ E246), E367 (≠ P367), L379 (≠ E379)
- binding flavin-adenine dinucleotide: F126 (≠ M123), I128 (≠ V125), T129 (= T126), G134 (= G131), S135 (≠ T132), W159 (= W156), I160 (= I157), S161 (= S158), V366 (≠ A366), S369 (= S369), N371 (= N371), M375 (≠ S375)
- binding : H36 (≠ G37), F37 (≠ Y38), Y39 (vs. gap), A164 (≠ Q161), Q165 (≠ H162), D167 (= D164), N193 (≠ E194)
3mpiC Structure of the glutaryl-coenzyme a dehydrogenase glutaryl-coa complex (see paper)
32% identity, 97% coverage: 13:387/388 of query aligns to 12:387/395 of 3mpiC
- active site: I128 (≠ V125), T129 (= T126), T245 (≠ E246), E367 (≠ P367), L379 (≠ E379)
- binding flavin-adenine dinucleotide: I128 (≠ V125), T129 (= T126), G134 (= G131), S135 (≠ T132), W159 (= W156), I160 (= I157), S161 (= S158), M365 (≠ V365), V366 (≠ A366), S369 (= S369), N371 (= N371), M375 (≠ S375)
- binding glutaryl-coenzyme A: R87 (≠ A86), F126 (≠ M123), S135 (≠ T132), V137 (≠ T134), S181 (= S182), F239 (≠ L240), R246 (= R247), N315 (≠ S315), V366 (≠ A366), E367 (≠ P367), G368 (≠ I368), I376 (≠ Y376), R385 (≠ P385)
Sites not aligning to the query:
4n5fA Crystal structure of a putative acyl-coa dehydrogenase with bound fadh2 from burkholderia cenocepacia j2315
31% identity, 91% coverage: 13:365/388 of query aligns to 13:362/378 of 4n5fA
Sites not aligning to the query:
Query Sequence
>HSERO_RS14055 FitnessBrowser__HerbieS:HSERO_RS14055
MSYPTASDSHADLRDAVRDLCKTFPPEYWRKIDEARGYPEQFVDALTKAGWLAALIPQEY
GGSGLGLTEASVIMEEINRTGGNSGACHGQMYNMGTLLRHGSPEQKERYLPRIASGELRL
QSMAVTEPTTGTDTTRIKTVAVKKGDRYVINGQKVWISRVQHSDLMILLARTTPLEQVSR
KSEGMSIFLVDLKEAIGHGMEVRPILNMVNHETNELFFDNLEIPAENLIGEEGRGFRYIL
DGLNAERTLIAAECIGDGYWFIDKATQYARERVVFDRPIGMNQGVQFPLAEAYIEVEAAN
LMRYQACALFDAQQSCGAQANMAKYLAAKAAWEAANVCLQTHGGFGFACEYDVERKFRET
RLYQVAPISTNLIFSYVAEHVLGLPRSF
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory