Comparing HSERO_RS15925 FitnessBrowser__HerbieS:HSERO_RS15925 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 12 hits to proteins with known functional sites (download)
O04373 IAA-amino acid hydrolase ILR1-like 4; jasmonoyl-L-amino acid hydrolase; EC 3.5.1.-; EC 3.5.1.127 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
36% identity, 97% coverage: 6:394/399 of query aligns to 32:423/440 of O04373
P54955 N-acetylcysteine deacetylase; S-(2-succino)cysteine metabolism operon protein P; EC 3.5.1.- from Bacillus subtilis (strain 168)
38% identity, 91% coverage: 25:389/399 of query aligns to 13:371/380 of P54955
P54968 IAA-amino acid hydrolase ILR1; EC 3.5.1.- from Arabidopsis thaliana (Mouse-ear cress) (see paper)
35% identity, 97% coverage: 13:398/399 of query aligns to 38:431/442 of P54968
4ewtA The crystal structure of a putative aminohydrolase from methicillin resistant staphylococcus aureus (see paper)
35% identity, 92% coverage: 15:383/399 of query aligns to 9:377/389 of 4ewtA
6slfA Nalpha-acylglutamine aminoacylase from corynebacterium sp.Releasing human axilla odorants co-crystallised with high affinity inhibitor (see paper)
38% identity, 84% coverage: 12:347/399 of query aligns to 9:344/398 of 6slfA
Sites not aligning to the query:
3ramA Crystal structure of hmra (see paper)
24% identity, 78% coverage: 25:336/399 of query aligns to 21:311/391 of 3ramA
Sites not aligning to the query:
4pqaA Crystal structure of succinyl-diaminopimelate desuccinylase from neisseria meningitidis mc58 in complex with the inhibitor captopril (see paper)
22% identity, 93% coverage: 25:394/399 of query aligns to 8:375/375 of 4pqaA
4o23A Crystal structure of mono-zinc form of succinyl diaminopimelate desuccinylase from neisseria meningitidis mc58 (see paper)
22% identity, 93% coverage: 25:394/399 of query aligns to 8:375/376 of 4o23A
P44514 Succinyl-diaminopimelate desuccinylase; SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase; EC 3.5.1.18 from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see 3 papers)
22% identity, 78% coverage: 18:327/399 of query aligns to 1:314/377 of P44514
Sites not aligning to the query:
5vo3A Crystal structure of dape in complex with the products (succinic acid and diaminopimelic acid) (see paper)
22% identity, 78% coverage: 18:327/399 of query aligns to 5:318/380 of 5vo3A
Sites not aligning to the query:
3rzaA Crystal structure of a tripeptidase (sav1512) from staphylococcus aureus subsp. Aureus mu50 at 2.10 a resolution
22% identity, 64% coverage: 60:314/399 of query aligns to 53:296/373 of 3rzaA
Sites not aligning to the query:
7t1qA Crystal structure of the succinyl-diaminopimelate desuccinylase (dape) from acinetobacter baumannii in complex with succinic acid
27% identity, 35% coverage: 198:336/399 of query aligns to 186:323/377 of 7t1qA
Sites not aligning to the query:
>HSERO_RS15925 FitnessBrowser__HerbieS:HSERO_RS15925
MSHAHPGHLCEVGDLHDIQDEITAIRRHLHQHPELSFEEVDTAALVAQRLEQWGYAVTRH
IGGNGLVATLRVGSSARSIGLRADMDALPIQEETGLDWASVKPGAMHACGHDGHTAMLLG
AARHLARTRRFDGTLNLIFQPAEEAGFDSGAQKMLADGLFERFPCEAVFGIHNHPGVEAG
TFMFRSGPFMAACDTVKIRITGRGSHAARPHLSVDPVVVAASLVMALQTVVSRNIDPMDS
AVVTVGSLHAGKASNVIPEFATMELSVRSFKPEVRELLEQRIRALVSTHAQSYGAQAEID
YLRGYPVLVNSDAETDFARSVAEELVGPEKVIAPFGPIAGSEDFAYFLRQRPGCFLRVGN
GQGKPMLHNAGYDFNDANIPIGAAYWTRLVERWMPLQGE
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory