SitesBLAST
Comparing HSERO_RS16580 FitnessBrowser__HerbieS:HSERO_RS16580 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
3o0hB Crystal structure of glutathione reductase from bartonella henselae
44% identity, 99% coverage: 4:456/458 of query aligns to 2:448/459 of 3o0hB
- active site: S13 (= S15), I37 (≠ L39), C41 (= C43), C46 (= C48), K49 (= K51), D74 (≠ Q77), P75 (= P78), Y177 (= Y178), E181 (= E182), I314 (≠ L322), A433 (≠ G441), H435 (= H443), E440 (= E448)
- binding flavin-adenine dinucleotide: I9 (= I11), G10 (= G12), G12 (= G14), S13 (= S15), G14 (= G16), A32 (= A34), E33 (= E35), E34 (≠ K36), T40 (= T42), C41 (= C43), G45 (= G47), C46 (= C48), K49 (= K51), R112 (≠ F115), A113 (= A116), T139 (= T140), G140 (= G141), Y177 (= Y178), R262 (= R270), N265 (= N273), G301 (= G309), D302 (= D310), Q308 (≠ A316), L309 (= L317), T310 (= T318)
Sites not aligning to the query:
D0VWY5 Glutathione amide reductase; GAR; EC 1.8.1.16 from Marichromatium gracile (Chromatium gracile) (see 2 papers)
44% identity, 100% coverage: 1:457/458 of query aligns to 1:451/463 of D0VWY5
- M1 (= M1) modified: Initiator methionine, Removed
- T2 (≠ S2) binding
- Q3 (= Q3) binding
- H4 (≠ Y4) binding
- SG 14:15 (= SG 15:16) binding
- E34 (= E35) binding
- T41 (= T42) binding
- C42 (= C43) modified: Disulfide link with 47, Redox-active
- C47 (= C48) modified: Disulfide link with 42, Redox-active
- K50 (= K51) binding ; binding
- HA 113:114 (≠ FA 115:116) binding
- 174:180 (vs. 176:182, 57% identical) binding
- LE 197:198 (≠ RR 199:200) binding
- V230 (≠ I232) binding
- G261 (= G269) binding
- D302 (= D310) binding
- Q308 (≠ A316) binding
- QLT 308:310 (≠ ALT 316:318) binding
- V341 (≠ A348) binding
- H437 (= H443) active site, Proton acceptor; binding
Sites not aligning to the query:
- 2:463 modified: mature protein, Glutathione amide reductase
2rabA Structure of glutathione amide reductase from chromatium gracile in complex with NAD (see paper)
44% identity, 99% coverage: 6:457/458 of query aligns to 4:447/451 of 2rabA
- active site: S13 (= S15), L37 (= L39), C41 (= C43), C46 (= C48), K49 (= K51), Y173 (= Y178), E177 (= E182), I310 (≠ L322), A431 (≠ G441), H433 (= H443), E438 (= E448)
- binding flavin-adenine dinucleotide: G10 (= G12), G12 (= G14), S13 (= S15), G14 (= G16), I32 (≠ A34), E33 (= E35), S34 (≠ K36), T40 (= T42), G45 (= G47), C46 (= C48), K49 (= K51), H110 (≠ F115), A111 (= A116), T135 (= T140), G136 (= G141), R258 (= R270), G297 (= G309), D298 (= D310), Q304 (≠ A316), L305 (= L317), T306 (= T318)
- binding nicotinamide-adenine-dinucleotide: K49 (= K51), I169 (≠ L174), G172 (= G177), Y173 (= Y178), I174 (= I179), E177 (= E182), A193 (≠ Y198), L194 (≠ R199), E195 (≠ R200), V227 (≠ I232), V256 (≠ T268), G257 (= G269), Q304 (≠ A316), V337 (≠ A348)
2r9zB Glutathione amide reductase from chromatium gracile (see paper)
44% identity, 99% coverage: 6:457/458 of query aligns to 4:449/453 of 2r9zB
- active site: S13 (= S15), L37 (= L39), C41 (= C43), C46 (= C48), K49 (= K51), G74 (= G76), Y174 (= Y178), E178 (= E182), I312 (≠ L322), A433 (≠ G441), H435 (= H443), E440 (= E448)
- binding flavin-adenine dinucleotide: G12 (= G14), S13 (= S15), G14 (= G16), I32 (≠ A34), E33 (= E35), S34 (≠ K36), G39 (= G41), T40 (= T42), C41 (= C43), G45 (= G47), C46 (= C48), K49 (= K51), H111 (≠ F115), A112 (= A116), T136 (= T140), G137 (= G141), I175 (= I179), R260 (= R270), G299 (= G309), D300 (= D310), Q306 (≠ A316), L307 (= L317), T308 (= T318)
4dnaA Crystal structure of putative glutathione reductase from sinorhizobium meliloti 1021
45% identity, 99% coverage: 4:456/458 of query aligns to 2:450/461 of 4dnaA
- active site: Y37 (≠ L39), C41 (= C43), C46 (= C48), K49 (= K51), Y178 (= Y178), E182 (= E182), A435 (≠ G441), H437 (= H443), E442 (= E448)
- binding flavin-adenine dinucleotide: I9 (= I11), G10 (= G12), G11 (= G13), G12 (= G14), G14 (= G16), E33 (= E35), E34 (≠ K36), G39 (= G41), T40 (= T42), C41 (= C43), G45 (= G47), C46 (= C48), K49 (= K51), R112 (≠ F115), A113 (= A116), V139 (≠ T140), G140 (= G141), Y178 (= Y178), R264 (= R270), G303 (= G309), D304 (= D310), Q310 (≠ A316), L311 (= L317), T312 (= T318)
Sites not aligning to the query:
5grtA Human glutathione reductase a34e, r37w mutant, glutathionylspermidine complex (see paper)
41% identity, 98% coverage: 6:454/458 of query aligns to 4:461/461 of 5grtA
- active site: L37 (= L39), C41 (= C43), C46 (= C48), K49 (= K51), Y180 (= Y178), E184 (= E182), A448 (≠ G441), H450 (= H443), E455 (= E448)
- binding flavin-adenine dinucleotide: I9 (= I11), G12 (= G14), G14 (= G16), V32 (≠ A34), E33 (= E35), S34 (≠ K36), G39 (= G41), T40 (= T42), C41 (= C43), G45 (= G47), C46 (= C48), K49 (= K51), H112 (≠ F115), A113 (= A116), T139 (= T140), Y180 (= Y178), G313 (= G309), D314 (= D310), L320 (≠ A316), L321 (= L317), T322 (= T318)
- binding glutathionylspermidine disulfide: S13 (= S15), E17 (≠ R19), C41 (= C43), V42 (= V44), Y89 (≠ E92), L93 (= L96), I96 (= I99), Y97 (= Y100), T322 (= T318), I326 (≠ L322)
4grtA Human glutathione reductase a34e, r37w mutant, mixed disulfide between trypanothione and the enzyme (see paper)
41% identity, 98% coverage: 6:454/458 of query aligns to 4:461/461 of 4grtA
- active site: L37 (= L39), C41 (= C43), C46 (= C48), K49 (= K51), Y180 (= Y178), E184 (= E182), A448 (≠ G441), H450 (= H443), E455 (= E448)
- binding flavin-adenine dinucleotide: I9 (= I11), G10 (= G12), G11 (= G13), G12 (= G14), S13 (= S15), G14 (= G16), V32 (≠ A34), E33 (= E35), S34 (≠ K36), H35 (≠ G37), G39 (= G41), T40 (= T42), G45 (= G47), C46 (= C48), K49 (= K51), H112 (≠ F115), A113 (= A116), T139 (= T140), G140 (= G141), Y180 (= Y178), G313 (= G309), D314 (= D310), L320 (≠ A316), L321 (= L317), T322 (= T318), A325 (= A321)
- binding bis(gamma-glutamyl-cysteinyl-glycinyl)spermidine: S13 (= S15), L16 (≠ V18), E17 (≠ R19), C41 (= C43), V42 (= V44), V47 (≠ I49), L93 (= L96), Y97 (= Y100), I326 (≠ L322)
3grtA Human glutathione reductase a34e, r37w mutant, oxidized trypanothione complex (see paper)
41% identity, 98% coverage: 6:454/458 of query aligns to 4:461/461 of 3grtA
- active site: L37 (= L39), C41 (= C43), C46 (= C48), K49 (= K51), Y180 (= Y178), E184 (= E182), A448 (≠ G441), H450 (= H443), E455 (= E448)
- binding flavin-adenine dinucleotide: I9 (= I11), G10 (= G12), G12 (= G14), S13 (= S15), G14 (= G16), V32 (≠ A34), E33 (= E35), S34 (≠ K36), T40 (= T42), C41 (= C43), G45 (= G47), C46 (= C48), K49 (= K51), H112 (≠ F115), A113 (= A116), T139 (= T140), G140 (= G141), Y180 (= Y178), G313 (= G309), D314 (= D310), L321 (= L317), T322 (= T318)
- binding 2-amino-4-[4-(4-amino-4-carboxy-butyrylamino)-5,8,19,22-tetraoxo-1,2-dithia-6,9,13,18,21-pentaaza-cyclotetracos-23-ylcarbamoyl]-butyric acid: S13 (= S15), E17 (≠ R19), W20 (≠ R22), V42 (= V44), L93 (= L96), Y97 (= Y100), T322 (= T318), I326 (≠ L322)
2grtA Human glutathione reductase a34e, r37w mutant, oxidized glutathione complex (see paper)
41% identity, 98% coverage: 6:454/458 of query aligns to 4:461/461 of 2grtA
- active site: L37 (= L39), C41 (= C43), C46 (= C48), K49 (= K51), Y180 (= Y178), E184 (= E182), A448 (≠ G441), H450 (= H443), E455 (= E448)
- binding flavin-adenine dinucleotide: I9 (= I11), G12 (= G14), S13 (= S15), G14 (= G16), E33 (= E35), S34 (≠ K36), G39 (= G41), T40 (= T42), C41 (= C43), V44 (≠ L46), G45 (= G47), C46 (= C48), K49 (= K51), H112 (≠ F115), A113 (= A116), T139 (= T140), G140 (= G141), Y180 (= Y178), G313 (= G309), D314 (= D310), L321 (= L317), T322 (= T318)
- binding oxidized glutathione disulfide: E17 (≠ R19), W20 (≠ R22), V42 (= V44), L93 (= L96), I96 (= I99), Y97 (= Y100)
6n7fA 1.90 angstrom resolution crystal structure of glutathione reductase from streptococcus pyogenes in complex with fad.
42% identity, 98% coverage: 6:454/458 of query aligns to 6:451/451 of 6n7fA
- active site: C43 (= C43), C48 (= C48), K51 (= K51), Y178 (= Y178), E182 (= E182), H440 (= H443), E445 (= E448)
- binding flavin-adenine dinucleotide: I11 (= I11), G12 (= G12), G14 (= G14), S15 (= S15), A16 (≠ G16), A34 (= A34), E35 (= E35), G36 (≠ K36), K37 (≠ G37), G41 (= G41), T42 (= T42), C43 (= C43), G47 (= G47), C48 (= C48), K51 (= K51), Y115 (≠ F115), A116 (= A116), T140 (= T140), G141 (= G141), Y178 (= Y178), I179 (= I179), R264 (= R270), G303 (= G309), D304 (= D310), L311 (= L317), T312 (= T318)
- binding riboflavin: G36 (≠ K36), K37 (≠ G37), Y115 (≠ F115), G270 (= G276)
4gr1A The binding of the retro-analogue of glutathione disulfide to glutathione reductase (see paper)
41% identity, 98% coverage: 6:454/458 of query aligns to 4:461/461 of 4gr1A
- active site: L37 (= L39), C41 (= C43), C46 (= C48), K49 (= K51), Y180 (= Y178), E184 (= E182), A448 (≠ G441), H450 (= H443), E455 (= E448)
- binding flavin-adenine dinucleotide: G12 (= G14), S13 (= S15), G14 (= G16), E33 (= E35), S34 (≠ K36), G39 (= G41), T40 (= T42), C41 (= C43), G45 (= G47), C46 (= C48), K49 (= K51), H112 (≠ F115), A113 (= A116), T139 (= T140), G140 (= G141), Y180 (= Y178), G313 (= G309), D314 (= D310), L321 (= L317), T322 (= T318)
- binding 4n-malonyl-cysteinyl-2,4-diaminobutyrate disulfide: L93 (= L96), Y97 (= Y100), R330 (≠ M326)
3sqpA Structure of human glutathione reductase complexed with pyocyanin, an agent with antimalarial activity (see paper)
41% identity, 98% coverage: 6:454/458 of query aligns to 4:461/461 of 3sqpA
- active site: L37 (= L39), C41 (= C43), C46 (= C48), K49 (= K51), Y180 (= Y178), E184 (= E182), A448 (≠ G441), H450 (= H443), E455 (= E448)
- binding 5-methylphenazin-1(5H)-one: V57 (≠ H59), V57 (≠ H59), H58 (≠ Y60), F61 (≠ E63), F61 (≠ E63)
- binding flavin-adenine dinucleotide: G10 (= G12), G12 (= G14), S13 (= S15), G14 (= G16), E33 (= E35), S34 (≠ K36), T40 (= T42), C41 (= C43), G45 (= G47), C46 (= C48), K49 (= K51), H112 (≠ F115), A113 (= A116), T139 (= T140), Y180 (= Y178), R274 (= R270), G313 (= G309), D314 (= D310), L320 (≠ A316), L321 (= L317), T322 (= T318), P323 (= P319)
2gh5A Crystal structure of human glutathione reductase complexed with a fluoro-analogue of the menadione derivative m5 (see paper)
41% identity, 98% coverage: 6:454/458 of query aligns to 4:461/461 of 2gh5A
- active site: L37 (= L39), C41 (= C43), C46 (= C48), K49 (= K51), Y180 (= Y178), E184 (= E182), A448 (≠ G441), H450 (= H443), E455 (= E448)
- binding 6-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)hexanoic acid: S13 (= S15), A17 (≠ R19), R20 (= R22), C41 (= C43), V42 (= V44), L93 (= L96), Y97 (= Y100)
- binding flavin-adenine dinucleotide: G10 (= G12), G12 (= G14), S13 (= S15), G14 (= G16), V32 (≠ A34), E33 (= E35), S34 (≠ K36), G39 (= G41), T40 (= T42), G45 (= G47), C46 (= C48), K49 (= K51), H112 (≠ F115), A113 (= A116), T139 (= T140), G140 (= G141), Y180 (= Y178), I181 (= I179), R274 (= R270), G313 (= G309), D314 (= D310), L320 (≠ A316), L321 (= L317), T322 (= T318)
2aaqA Crystal structure analysis of the human glutahione reductase, complexed with gopi (see paper)
41% identity, 98% coverage: 6:454/458 of query aligns to 4:461/461 of 2aaqA
- active site: L37 (= L39), C41 (= C43), C46 (= C48), K49 (= K51), Y180 (= Y178), E184 (= E182), A448 (≠ G441), H450 (= H443), E455 (= E448)
- binding gold ion: C41 (= C43), C46 (= C48), T322 (= T318)
- binding 2-(2-phenyl-3-pyridin-2-yl-4,5,6,7-tetrahydro-2h-isophosphindol-1-yl)pyridine: L156 (= L154), I158 (= I156), G162 (≠ D160), L244 (vs. gap), D266 (≠ Q262), C267 (= C263)
- binding flavin-adenine dinucleotide: G10 (= G12), G12 (= G14), G14 (= G16), V32 (≠ A34), E33 (= E35), S34 (≠ K36), G39 (= G41), T40 (= T42), C41 (= C43), G45 (= G47), C46 (= C48), K49 (= K51), H112 (≠ F115), A113 (= A116), T139 (= T140), G140 (= G141), S160 (= S158), R274 (= R270), D314 (= D310), L321 (= L317), T322 (= T318)
1xanA Human glutathione reductase in complex with a xanthene inhibitor (see paper)
41% identity, 98% coverage: 6:454/458 of query aligns to 4:461/461 of 1xanA
- active site: L37 (= L39), C41 (= C43), C46 (= C48), K49 (= K51), Y180 (= Y178), E184 (= E182), A448 (≠ G441), H450 (= H443), E455 (= E448)
- binding flavin-adenine dinucleotide: G10 (= G12), G12 (= G14), S13 (= S15), G14 (= G16), E33 (= E35), S34 (≠ K36), H35 (≠ G37), T40 (= T42), C41 (= C43), G45 (= G47), C46 (= C48), K49 (= K51), H112 (≠ F115), A113 (= A116), T139 (= T140), Y180 (= Y178), R274 (= R270), G313 (= G309), D314 (= D310), L320 (≠ A316), L321 (= L317), T322 (= T318)
- binding 3,6-dihydroxy-xanthene-9-propionic acid: V57 (≠ H59), F61 (≠ E63), H65 (≠ A67), Y390 (≠ K383)
1grbA Substrate binding and catalysis by glutathione reductase as derived from refined enzyme: substrate crystal structures at 2 angstroms resolution (see paper)
41% identity, 98% coverage: 6:454/458 of query aligns to 4:461/461 of 1grbA
- active site: L37 (= L39), C41 (= C43), C46 (= C48), K49 (= K51), Y180 (= Y178), E184 (= E182), A448 (≠ G441), H450 (= H443), E455 (= E448)
- binding flavin-adenine dinucleotide: G12 (= G14), G14 (= G16), E33 (= E35), S34 (≠ K36), T40 (= T42), G45 (= G47), C46 (= C48), K49 (= K51), H112 (≠ F115), A113 (= A116), T139 (= T140), G140 (= G141), G313 (= G309), D314 (= D310), L320 (≠ A316), L321 (= L317), T322 (= T318)
- binding nicotinamide-adenine-dinucleotide: K49 (= K51), A178 (≠ G176), G179 (= G177), Y180 (= Y178), I181 (= I179), E184 (= E182), R201 (= R199), A271 (= A267), I272 (≠ T268), G273 (= G269), L320 (≠ A316), V353 (≠ A348)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: K49 (= K51), A178 (≠ G176), G179 (= G177), Y180 (= Y178), I181 (= I179), E184 (= E182), R201 (= R199), R207 (= R205), I272 (≠ T268), G273 (= G269), L320 (≠ A316), V353 (≠ A348)
- binding phosphate ion: R201 (= R199), H202 (≠ R200), R207 (= R205)
1dncA Human glutathione reductase modified by diglutathione-dinitroso-iron (see paper)
41% identity, 98% coverage: 6:454/458 of query aligns to 4:461/461 of 1dncA
- active site: L37 (= L39), C41 (= C43), C46 (= C48), K49 (= K51), Y180 (= Y178), E184 (= E182), A448 (≠ G441), H450 (= H443), E455 (= E448)
- binding flavin-adenine dinucleotide: G12 (= G14), E33 (= E35), S34 (≠ K36), G39 (= G41), T40 (= T42), G45 (= G47), C46 (= C48), K49 (= K51), H112 (≠ F115), A113 (= A116), T139 (= T140), G140 (= G141), Y180 (= Y178), R274 (= R270), G313 (= G309), D314 (= D310), L320 (≠ A316), L321 (= L317), T322 (= T318)
- binding glutathione: S13 (= S15), R20 (= R22), C41 (= C43), V42 (= V44), Y97 (= Y100), I326 (≠ L322), R330 (≠ M326)
1bwcA Structure of human glutathione reductase complexed with ajoene inhibitor and subversive substrate (see paper)
41% identity, 98% coverage: 6:454/458 of query aligns to 4:461/461 of 1bwcA
- active site: L37 (= L39), C41 (= C43), C46 (= C48), K49 (= K51), Y180 (= Y178), E184 (= E182), A448 (≠ G441), H450 (= H443), E455 (= E448)
- binding 3-(prop-2-ene-1-sulfinyl)-propene-1-thiol: S13 (= S15), C41 (= C43), V42 (= V44), Y97 (= Y100), R330 (≠ M326)
- binding flavin-adenine dinucleotide: G10 (= G12), S13 (= S15), G14 (= G16), E33 (= E35), S34 (≠ K36), T40 (= T42), C41 (= C43), G45 (= G47), C46 (= C48), K49 (= K51), H112 (≠ F115), A113 (= A116), T139 (= T140), G140 (= G141), Y180 (= Y178), R274 (= R270), D314 (= D310), L320 (≠ A316), L321 (= L317), T322 (= T318)
3djjA Catalytic cycle of human glutathione reductase near 1 a resolution (see paper)
41% identity, 98% coverage: 6:454/458 of query aligns to 5:462/462 of 3djjA
- active site: L38 (= L39), C42 (= C43), C47 (= C48), K50 (= K51), Y181 (= Y178), E185 (= E182), A449 (≠ G441), H451 (= H443), E456 (= E448)
- binding flavin-adenine dinucleotide: G13 (= G14), E34 (= E35), S35 (≠ K36), G40 (= G41), T41 (= T42), G46 (= G47), C47 (= C48), K50 (= K51), H113 (≠ F115), A114 (= A116), T140 (= T140), G141 (= G141), R275 (= R270), G314 (= G309), D315 (= D310), L321 (≠ A316), L322 (= L317), T323 (= T318)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: A179 (≠ G176), G180 (= G177), Y181 (= Y178), I182 (= I179), E185 (= E182), R202 (= R199), R208 (= R205), I273 (≠ T268), G274 (= G269), L321 (≠ A316), V354 (≠ A348)
P00390 Glutathione reductase, mitochondrial; GR; GRase; EC 1.8.1.7 from Homo sapiens (Human) (see 2 papers)
41% identity, 98% coverage: 6:454/458 of query aligns to 65:522/522 of P00390
- C102 (= C43) modified: Disulfide link with 107, Redox-active
- C107 (= C48) modified: Disulfide link with 102, Redox-active
- C134 (≠ G76) modified: Interchain
- R153 (≠ H95) to C: in dbSNP:rs8190955
- G232 (≠ Q169) to S: in dbSNP:rs8190976
- I261 (≠ Y198) to V: in dbSNP:rs8190997
- E297 (≠ A234) to D: in dbSNP:rs8191004
- G374 (= G309) to A: in HAGRD; decreased glutathione reductase activity; decreased enzyme stability; dbSNP:rs1586033745
Query Sequence
>HSERO_RS16580 FitnessBrowser__HerbieS:HSERO_RS16580
MSQYDYDLFTIGGGSGGVRAARFASQAGARVGLAEKGDLGGTCVNLGCIPKKLMSYSAHY
HEEFADAAGYGWTLNGQPSFDWSALMANKDREIAHLNDIYLRLLDNAKVSLHRGFAKVED
AHTVNVDGQRFTARHILVATGGRPDKPAIPGAELGITSDDFFHLKALPQRAVVLGGGYIA
VELASILNGLGCEVTLVYRRERLLRNMDADLGIHLADEMAKKGIRIVFNASIEAIEAEQA
GEASEASVKTVRLTNGEALSAQCVLFATGRTANTAGLGLQEAGVKLKANGAIEVNQDFES
SVPSILAVGDVIDRVALTPVALAEAMAVVSRLFGKGERGMSYANIPTAVFSHPNVGTVGL
SEEEARQQFGELRIFKTDFKPLKNTLSRNTERTFMKLVVDARTDRVLGVHMVGGDAGEVI
QGFAVALQCGATKAQFDTTIGIHPTSAEEFVTLRTPVA
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory