Comparing HSERO_RS16825 HSERO_RS16825 NADP-dependent malic enzyme oxidoreductase to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P76558 NADP-dependent malic enzyme; NADP-ME; EC 1.1.1.40 from Escherichia coli (strain K12) (see paper)
64% identity, 98% coverage: 14:769/770 of query aligns to 4:757/759 of P76558
6zngF Maeb full-length acetyl-coa bound state (see paper)
47% identity, 97% coverage: 17:766/770 of query aligns to 6:743/753 of 6zngF
6zn4A Maeb malic enzyme domain apoprotein (see paper)
60% identity, 52% coverage: 17:417/770 of query aligns to 5:405/406 of 6zn4A
6zn7A Maeb malic enzyme domain apoprotein (see paper)
60% identity, 52% coverage: 17:417/770 of query aligns to 5:405/405 of 6zn7A
5ceeA Malic enzyme from candidatus phytoplasma aywb in complex with NAD and mg2+ (see paper)
46% identity, 52% coverage: 15:414/770 of query aligns to 1:385/387 of 5ceeA
2dvmA NAD complex structure of ph1275 protein from pyrococcus horikoshii
47% identity, 52% coverage: 15:415/770 of query aligns to 1:397/438 of 2dvmA
2a9fA Crystal structure of a putative malic enzyme ((s)-malate:nad+ oxidoreductase (decarboxylating))
49% identity, 46% coverage: 11:363/770 of query aligns to 1:350/383 of 2a9fA
2haeD Crystal structure of a putative malic enzyme (malate oxidoreductase)
44% identity, 51% coverage: 19:409/770 of query aligns to 2:373/373 of 2haeD
2haeB Crystal structure of a putative malic enzyme (malate oxidoreductase)
44% identity, 51% coverage: 19:409/770 of query aligns to 2:373/373 of 2haeB
1xcoD Crystal structure of a phosphotransacetylase from bacillus subtilis in complex with acetylphosphate (see paper)
31% identity, 42% coverage: 446:767/770 of query aligns to 10:325/325 of 1xcoD
Q8ZND6 Phosphate acetyltransferase; Phosphotransacetylase; EC 2.3.1.222; EC 2.3.1.8 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
28% identity, 45% coverage: 425:770/770 of query aligns to 372:713/714 of Q8ZND6
Sites not aligning to the query:
6ioxA Crystal structure of porphyromonas gingivalis phosphotransacetylase in complex with acetyl-coa (see paper)
32% identity, 43% coverage: 443:770/770 of query aligns to 8:338/339 of 6ioxA
2af3C Phosphotransacetylase from methanosarcina thermophila soaked with coenzyme a (see paper)
26% identity, 43% coverage: 438:770/770 of query aligns to 2:332/332 of 2af3C
P38503 Phosphate acetyltransferase; Phosphotransacetylase; EC 2.3.1.8 from Methanosarcina thermophila (see 2 papers)
26% identity, 43% coverage: 438:770/770 of query aligns to 3:333/333 of P38503
Sites not aligning to the query:
1gq2A Malic enzyme from pigeon liver (see paper)
27% identity, 51% coverage: 37:426/770 of query aligns to 76:528/555 of 1gq2A
P40927 NADP-dependent malic enzyme; NADP-ME; EC 1.1.1.40 from Columba livia (Rock dove) (see 3 papers)
27% identity, 51% coverage: 37:426/770 of query aligns to 77:529/557 of P40927
7x11A Crystal structure of me1 in complex with NADPH (see paper)
27% identity, 42% coverage: 42:362/770 of query aligns to 90:482/564 of 7x11A
6w29A Trypanosoma cruzi malic enzyme in complex with inhibitor (mec013) (see paper)
27% identity, 36% coverage: 77:352/770 of query aligns to 133:469/545 of 6w29A
Sites not aligning to the query:
6w59A Trypanosoma cruzi malic enzyme in complex with inhibitor (mec063) (see paper)
27% identity, 36% coverage: 77:352/770 of query aligns to 131:467/544 of 6w59A
Sites not aligning to the query:
6w56A Trypanosoma cruzi malic enzyme in complex with inhibitor (mec062) (see paper)
27% identity, 36% coverage: 77:352/770 of query aligns to 131:467/544 of 6w56A
Sites not aligning to the query:
>HSERO_RS16825 HSERO_RS16825 NADP-dependent malic enzyme oxidoreductase
MDSMISKKEEVRQQLRQAALDYHEFPTPGKIAVTPTKLLTNQRDLSLAYSPGVAAACEEI
VADPLNAFRYTARGNLVAVISNGTAVLGLGNIGALASKPVMEGKGVLFKKFAGIDVFDIE
VNETDPDKLIDVIAALEPTFGGINLEDIKAPECFYIERKLREKMKIPVFHDDQHGTAIIV
GAAILNGLKVVGKDIKNVKLVVSGAGAAALACLDLIVDLGFPIENIYVTDLAGVVYKGRK
ELMDPDKERFARETEARTLAEVIPDADIFLGLSAAGVLKPEMVKQMAARPLVLALANPTP
EILPEEVKAVRDDAIIATGRSDYPNQVNNVLCFPYIFRGALDSGATTITREMEIATVHAI
AELAQAEQSDIVATTYGIANLSFGPEYIIPKPFDPRLMIKIAPAVARAAESSGVAARPIQ
DMDAYIEKLEQFVYHSGTFMRPIFQVAKKAAEAKKRIVYAEGEEERVLRAVQVIVDENLA
KPILVGRPEVLEQRIQKFGLRLRAGTDFEVINPNFDNRYRDYWQTFLEMSRRKGVTEQYA
KLEMRRRHTLIGSMAIHKGDADGMICGTYGTTQLHLHYIDQVLGKREGVNVYAAMNAVIL
PNRQLVMVDTHVNENPNARELAEITMLAAEEMRRFGLHPRAALLSHSNFGSSNSESARKM
REALAILREIAPELEVDGEMHGDTALDSKLLNAVIPDSPLKGDANLLVMPNIDAANIAYN
LLKTASGNGVAIGPILLGCAKPVHILTPSATVRRIINMTALCVMDALSER
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory