Comparing HSERO_RS17185 FitnessBrowser__HerbieS:HSERO_RS17185 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P9WQB3 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
53% identity, 96% coverage: 4:548/567 of query aligns to 40:641/644 of P9WQB3
Sites not aligning to the query:
3figB Crystal structure of leucine-bound leua from mycobacterium tuberculosis (see paper)
55% identity, 96% coverage: 4:548/567 of query aligns to 23:574/577 of 3figB
3hpzB Crystal structure of mycobacterium tuberculosis leua complexed with bromopyruvate
55% identity, 96% coverage: 4:548/567 of query aligns to 23:574/576 of 3hpzB
3hq1A Crystal structure of mycobacterium tuberculosis leua complexed with citrate and mn2+
55% identity, 96% coverage: 4:548/567 of query aligns to 23:571/573 of 3hq1A
1sr9A Crystal structure of leua from mycobacterium tuberculosis (see paper)
55% identity, 96% coverage: 4:548/567 of query aligns to 23:571/573 of 1sr9A
3hpsA Crystal structure of mycobacterium tuberculosis leua complexed with ketoisocaproate (kic)
55% identity, 96% coverage: 4:548/567 of query aligns to 23:573/575 of 3hpsA
4ov4A Isopropylmalate synthase binding with ketoisovalerate (see paper)
30% identity, 69% coverage: 39:432/567 of query aligns to 11:379/379 of 4ov4A
4ov9A Structure of isopropylmalate synthase binding with alpha- isopropylmalate (see paper)
30% identity, 69% coverage: 39:430/567 of query aligns to 11:379/380 of 4ov9A
Q9JZG1 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Neisseria meningitidis serogroup B (strain MC58) (see 2 papers)
26% identity, 91% coverage: 33:548/567 of query aligns to 8:501/517 of Q9JZG1
Sites not aligning to the query:
6e1jA Crystal structure of methylthioalkylmalate synthase (bjumam1.1) from brassica juncea (see paper)
28% identity, 72% coverage: 23:430/567 of query aligns to 4:406/409 of 6e1jA
3rmjB Crystal structure of truncated alpha-isopropylmalate synthase from neisseria meningitidis (see paper)
29% identity, 53% coverage: 33:333/567 of query aligns to 5:293/308 of 3rmjB
Q9FN52 Methylthioalkylmalate synthase 3, chloroplastic; 2-isopropylmalate synthase 2; Methylthioalkylmalate synthase-like; EC 2.3.3.17 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
27% identity, 70% coverage: 35:430/567 of query aligns to 88:473/503 of Q9FN52
Q9FG67 Methylthioalkylmalate synthase 1, chloroplastic; 2-isopropylmalate synthase 3; EC 2.3.3.17 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
26% identity, 72% coverage: 23:430/567 of query aligns to 71:473/506 of Q9FG67
6ktqA Crystal structure of catalytic domain of homocitrate synthase from sulfolobus acidocaldarius (sahcs(dram)) in complex with alpha- ketoglutarate/zn2+/coa (see paper)
25% identity, 62% coverage: 35:384/567 of query aligns to 25:343/399 of 6ktqA
3ivtB Homocitrate synthase lys4 bound to 2-og (see paper)
26% identity, 60% coverage: 6:343/567 of query aligns to 12:320/400 of 3ivtB
Q9Y823 Homocitrate synthase, mitochondrial; HCS; EC 2.3.3.14 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
27% identity, 60% coverage: 2:343/567 of query aligns to 16:325/418 of Q9Y823
Sites not aligning to the query:
3mi3A Homocitrate synthase lys4 bound to lysine (see paper)
26% identity, 56% coverage: 28:343/567 of query aligns to 9:291/370 of 3mi3A
3ivsA Homocitrate synthase lys4 (see paper)
29% identity, 24% coverage: 209:343/567 of query aligns to 156:289/364 of 3ivsA
Sites not aligning to the query:
2ztjA Crystal structure of homocitrate synthase from thermus thermophilus complexed with alpha-ketoglutarate (see paper)
26% identity, 46% coverage: 34:293/567 of query aligns to 4:235/312 of 2ztjA
2zyfA Crystal structure of homocitrate synthase from thermus thermophilus complexed with magnesuim ion and alpha-ketoglutarate (see paper)
26% identity, 46% coverage: 34:293/567 of query aligns to 4:237/314 of 2zyfA
>HSERO_RS17185 FitnessBrowser__HerbieS:HSERO_RS17185
MMLSNPAAKYRPFPAIDLPDRTWPSKVINTPPIWMSTDLRDGNQALIEPMNAERKLRFFE
LLLKTGLKEIEVGFPSASQTDFDFVRKLIVENRIPDDVTIIVLTQSREELIRRTIESLEG
AKKAIVHLYNSVAPAFRKIVFNMSREEIKNIAVTGTRLVKELTDARPGTEWRFEYSPESF
STTELDFSKEICDAVCETWGASPERKVILNLPSTVECATPNVYADQIEWMCRNLKDRAST
IISVHPHNDRGTAVASAELAVMAGADRVEGCLFGNGERTGNVDLVTLALNLYTQGVNPGL
DFSDIDVVRQVVEECNQIPVHPRHPYVGDLVFTAFSGSHQDAIKKGFAKQQPDAIWEVPY
LPIDPADLGRSYDAVIRVNSQSGKGGMAYLLEQEYGLALPRRLQIEFSRAIQREADATGK
EIAASDIHAIFQREYLERVEPYVYRAHRMSEDSSKAESINIEVDIVRNGQPVTVRGSGNG
PIDAFVHALGLDIKLMDFHEHAIGAGADAKAASYIELRLNEAPTGFGVGIDANIVTASFK
AVLSAVNRQIAISESANQAGSSQAKAA
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory