SitesBLAST – Find functional sites

 

SitesBLAST

Comparing HSERO_RS17560 FitnessBrowser__HerbieS:HSERO_RS17560 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 2 hits to proteins with known functional sites (download)

4ymwC Crystal structure of an amino acid abc transporter with histidines (see paper)
35% identity, 91% coverage: 20:225/227 of query aligns to 17:214/214 of 4ymwC

query
sites
4ymwC
D
 
S
G
 
G
L
 
L
L
 
I
V
 
M
S
 
T
L
 
L
K
 
K
I
 
L
T
 
T
L
 
F
V
 
L
A
 
A
I
 
V
V
 
T
F
 
I
G
 
G
M
 
V
V
 
L
W
 
M
G
 
G
T
 
L
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F
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I
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A
M
 
L
M
 
M
R
 
K
L
 
M
S
 
S
R
 
S
H
 
I
S
 
K
P
 
P
L
 
I
Q
 
K
W
 
L
F
 
V
A
 
A
A
 
S
G
 
S
Y
 
Y
V
 
I
N
 
E
L
 
V
F
 
I
R
 
R
S
 
G
I
 
T
P
 
P
L
 
L
V
 
L
M
 
V
V
 
Q
L
 
L
L
 
L
W
 
-
F
 
-
F
 
-
L
 
L
I
 
I
V
 
Y
P
 
N
Q
 
G
L
 
L
L
 
M
Q
 
Q
K
 
-
L
 
-
F
 
F
G
 
G
L
 
M
S
 
N
-
 
I
P
 
P
A
 
A
N
 
-
D
 
-
L
 
-
R
 
-
M
 
F
T
 
T
S
 
A
A
 
G
L
 
V
V
 
S
A
 
A
F
 
L
A
 
A
L
 
I
F
x
N
E
 
S
A
 
S
A
 
A
Y
|
Y
Y
 
V
A
 
A
E
 
E
I
 
I
I
 
I
R
 
R
A
 
A
G
 
G
I
 
I
N
 
Q
S
 
A
V
 
V
S
 
D
R
 
P
G
 
G
Q
 
Q
M
 
N
A
 
E
A
 
A
A
 
A
Y
 
R
A
 
S
L
 
L
G
 
G
L
 
M
T
 
T
Y
 
H
P
 
A
Q
 
M
A
 
A
M
 
M
G
 
R
M
 
Y
V
 
V
I
 
I
L
 
I
P
 
P
Q
 
Q
A
 
A
F
 
I
R
 
K
N
 
N
M
 
I
V
 
L
P
 
P
L
 
A
L
 
L
L
 
G
T
 
N
Q
x
E
G
 
F
I
 
I
V
 
V
L
 
M
F
 
L
Q
 
K
D
x
E
T
 
S
S
 
A
L
 
I
V
 
V
Y
 
S
V
 
V
S
 
I
A
 
G
L
 
F
A
 
A
D
 
D
F
 
L
F
 
T
G
 
R
R
 
Q
A
 
A
Y
 
D
S
 
I
I
 
I
G
 
Q
E
 
S
R
 
V
N
 
T
G
 
Y
R
 
R
I
 
Y
I
 
F
E
 
E
M
 
P
L
 
Y
F
 
I
V
 
I
A
 
I
G
 
A
A
 
A
V
 
I
Y
 
Y
F
 
F
I
 
V
I
 
M
C
 
T
F
 
L
S
 
T
M
 
F
S
 
S
L
 
K
M
 
L
V
 
L
K
 
S
R
 
L
Y
 
F
R
 
E
K
 
R
K
 
R
V
 
L

4ymtC Crystal structure of an amino acid abc transporter complex with arginines (see paper)
35% identity, 91% coverage: 20:225/227 of query aligns to 17:214/215 of 4ymtC

query
sites
4ymtC
D
 
S
G
 
G
L
 
L
L
 
I
V
 
M
S
 
T
L
 
L
K
 
K
I
 
L
T
 
T
L
 
F
V
 
L
A
 
A
I
 
V
V
 
T
F
 
I
G
 
G
M
 
V
V
 
L
W
 
M
G
 
G
T
 
L
L
 
F
L
 
I
A
 
A
M
 
L
M
 
M
R
 
K
L
 
M
S
 
S
R
 
S
H
 
I
S
 
K
P
 
P
L
 
I
Q
 
K
W
 
L
F
 
V
A
 
A
A
 
S
G
 
S
Y
 
Y
V
 
I
N
 
E
L
 
V
F
 
I
R
 
R
S
 
G
I
 
T
P
|
P
L
|
L
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L
M
 
V
V
 
Q
L
 
L
L
 
L
W
 
-
F
 
-
F
 
-
L
 
L
I
 
I
V
 
Y
P
 
N
Q
 
G
L
 
L
L
 
M
Q
 
Q
K
 
-
L
 
-
F
 
F
G
 
G
L
 
M
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N
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A
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-
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F
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T
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A
A
 
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S
A
 
A
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L
A
 
A
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I
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S
A
 
S
A
 
A
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|
Y
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V
A
 
A
E
 
E
I
 
I
I
 
I
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R
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A
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G
I
 
I
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A
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D
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G
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M
 
N
A
 
E
A
 
A
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A
Y
 
R
A
 
S
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L
G
 
G
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M
T
 
T
Y
 
H
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A
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M
A
 
A
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M
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Y
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V
I
 
I
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I
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P
Q
 
Q
A
 
A
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I
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A
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D
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A
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I
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V
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S
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I
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G
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A
 
A
D
 
D
F
 
L
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R
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Q
A
 
A
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D
S
 
I
I
 
I
G
 
Q
E
 
S
R
 
V
N
 
T
G
 
Y
R
 
R
I
 
Y
I
 
F
E
 
E
M
 
P
L
 
Y
F
 
I
V
 
I
A
 
I
G
 
A
A
 
A
V
 
I
Y
 
Y
F
 
F
I
 
V
I
 
M
C
 
T
F
 
L
S
 
T
M
 
F
S
 
S
L
 
K
M
 
L
V
 
L
K
 
S
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L
Y
 
F
R
 
E
K
 
R
K
 
R
V
 
L

Query Sequence

>HSERO_RS17560 FitnessBrowser__HerbieS:HSERO_RS17560
MAYEFDFSAVTPAALRVLGDGLLVSLKITLVAIVFGMVWGTLLAMMRLSRHSPLQWFAAG
YVNLFRSIPLVMVLLWFFLIVPQLLQKLFGLSPANDLRMTSALVAFALFEAAYYAEIIRA
GINSVSRGQMAAAYALGLTYPQAMGMVILPQAFRNMVPLLLTQGIVLFQDTSLVYVSALA
DFFGRAYSIGERNGRIIEMLFVAGAVYFIICFSMSLMVKRYRKKVAT

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory