Comparing HSERO_RS18990 FitnessBrowser__HerbieS:HSERO_RS18990 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
2ag8A NADP complex of pyrroline-5-carboxylate reductase from neisseria meningitidis (see paper)
41% identity, 99% coverage: 1:257/260 of query aligns to 11:262/263 of 2ag8A
Sites not aligning to the query:
3triA Structure of a pyrroline-5-carboxylate reductase (proc) from coxiella burnetii (see paper)
42% identity, 97% coverage: 1:253/260 of query aligns to 13:267/272 of 3triA
Sites not aligning to the query:
5bshA Crystal structure of medicago truncatula (delta)1-pyrroline-5- carboxylate reductase (mtp5cr) in complex with l-proline (see paper)
37% identity, 85% coverage: 34:253/260 of query aligns to 53:271/272 of 5bshA
5bsgA Crystal structure of medicago truncatula (delta)1-pyrroline-5- carboxylate reductase (mtp5cr) in complex with NADP+ (see paper)
37% identity, 85% coverage: 34:253/260 of query aligns to 53:271/272 of 5bsgA
Sites not aligning to the query:
5bsfA Crystal structure of medicago truncatula (delta)1-pyrroline-5- carboxylate reductase (mtp5cr) in complex with NAD+ (see paper)
37% identity, 85% coverage: 34:253/260 of query aligns to 53:271/272 of 5bsfA
Sites not aligning to the query:
5bseA Crystal structure of medicago truncatula (delta)1-pyrroline-5- carboxylate reductase (mtp5cr) (see paper)
37% identity, 85% coverage: 34:253/260 of query aligns to 53:271/272 of 5bseA
2rcyA Crystal structure of plasmodium falciparum pyrroline carboxylate reductase (mal13p1.284) with NADP bound
32% identity, 78% coverage: 51:254/260 of query aligns to 59:261/262 of 2rcyA
Sites not aligning to the query:
6xp3A Structure of human pycr1 complexed with cyclopentanecarboxylic acid (see paper)
30% identity, 89% coverage: 23:253/260 of query aligns to 39:271/276 of 6xp3A
5uatC Structure of human pycr-1 complexed with NADPH (see paper)
30% identity, 89% coverage: 23:253/260 of query aligns to 40:272/277 of 5uatC
Sites not aligning to the query:
5uavA Structure of human pycr-1 complexed with NADPH and l-tetrahydrofuroic acid (see paper)
30% identity, 89% coverage: 23:253/260 of query aligns to 40:272/278 of 5uavA
Sites not aligning to the query:
5uauA Structure of human pycr-1 complexed with proline (see paper)
30% identity, 89% coverage: 23:253/260 of query aligns to 36:268/274 of 5uauA
2graA Crystal structure of human pyrroline-5-carboxylate reductase complexed with NADP (see paper)
30% identity, 89% coverage: 23:253/260 of query aligns to 38:270/277 of 2graA
2gr9A Crystal structure of p5cr complexed with nadh (see paper)
30% identity, 89% coverage: 23:253/260 of query aligns to 38:270/277 of 2gr9A
6xp1B Structure of human pycr1 complexed with l-thiazolidine-2-carboxylate (see paper)
30% identity, 89% coverage: 23:253/260 of query aligns to 42:274/281 of 6xp1B
2izzA Crystal structure of human pyrroline-5-carboxylate reductase
30% identity, 89% coverage: 23:253/260 of query aligns to 37:269/272 of 2izzA
Sites not aligning to the query:
P32322 Pyrroline-5-carboxylate reductase 1, mitochondrial; P5C reductase 1; P5CR 1; EC 1.5.1.2 from Homo sapiens (Human) (see 4 papers)
30% identity, 89% coverage: 23:253/260 of query aligns to 36:268/319 of P32322
Sites not aligning to the query:
6xp2A Structure of human pycr1 complexed with l-thiazolidine-4-carboxylate (see paper)
31% identity, 84% coverage: 35:253/260 of query aligns to 40:261/267 of 6xp2A
6xp0A Structure of human pycr1 complexed with n-formyl l-proline (see paper)
31% identity, 84% coverage: 35:253/260 of query aligns to 46:267/272 of 6xp0A
2ahrE Crystal structures of 1-pyrroline-5-carboxylate reductase from human pathogen streptococcus pyogenes (see paper)
29% identity, 97% coverage: 1:253/260 of query aligns to 14:259/259 of 2ahrE
Sites not aligning to the query:
2amfA Crystal structure of 1-pyrroline-5-carboxylate reductase from human pathogen streptococcus pyogenes (see paper)
29% identity, 97% coverage: 1:253/260 of query aligns to 12:257/257 of 2amfA
>HSERO_RS18990 FitnessBrowser__HerbieS:HSERO_RS18990
MAAALIGGLVGKVAAAQDIHVVDLNAQALASLKDRFGVSVAPAMDGALASADVVVLAVKP
QQMRDVVGSLKPFIGAQLVVSIAAGIRMVDLSRWLDGHEAIVRAMPNTPALIGKGITGLV
PHEKVSTLQRAQADSILKAVGQTLWLSDEAQIDAVTAVSGSGPAYVFYFLEAMEQAAAQL
GLSPAEGLELAKATFEGATELARRSEESVATLRERVTSKGGTTYAALTSLEQSGVKDAIV
KALQAAAVRSKELGDEFGKA
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory