SitesBLAST – Find functional sites

 

SitesBLAST

Comparing HSERO_RS19250 HSERO_RS19250 glutamate ABC transporter permease to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 2 hits to proteins with known functional sites (download)

4ymwC Crystal structure of an amino acid abc transporter with histidines (see paper)
29% identity, 86% coverage: 18:232/249 of query aligns to 9:206/214 of 4ymwC

query
sites
4ymwC
I
 
V
P
 
K
Y
 
Y
I
 
T
D
 
P
T
 
L
L
 
F
L
 
I
A
 
S
G
 
G
L
 
L
K
 
I
W
 
M
T
 
T
L
 
L
A
 
K
T
 
L
A
 
T
A
 
F
C
 
L
A
 
A
W
 
V
I
 
T
M
 
I
A
 
G
L
 
V
I
 
L
L
 
M
G
 
G
T
 
L
I
 
F
F
 
I
G
 
A
T
 
L
L
 
M
R
 
K
T
 
M
T
 
S
T
 
S
K
 
I
P
 
K
W
 
P
V
 
I
V
 
K
R
 
L
I
 
V
A
 
A
N
 
S
G
 
S
Y
 
Y
V
 
I
E
 
E
L
 
V
F
 
I
R
 
R
N
 
G
I
 
T
P
 
P
L
 
L
L
 
L
V
 
V
Q
 
Q
M
 
L
F
 
L
L
 
L
W
 
I
Y
 
Y
F
 
N
V
 
G
M
 
L
P
 
M
E
 
Q
L
 
-
L
 
-
P
 
-
A
 
-
F
 
-
I
 
-
G
 
-
D
 
-
W
 
F
I
 
G
K
 
M
S
 
N
L
 
I
P
 
P
D
 
-
A
 
-
S
 
A
F
 
F
V
 
T
T
 
A
A
 
G
T
 
V
L
 
S
A
 
A
L
 
L
G
 
A
F
 
I
F
x
N
T
 
S
S
 
S
S
 
A
R
x
Y
V
 
V
A
 
A
V
 
E
Q
 
I
V
 
I
T
 
R
T
 
A
G
 
G
I
 
I
Q
 
Q
A
 
A
L
 
V
P
 
D
R
 
P
G
 
G
Q
 
Q
R
 
N
M
 
E
A
 
A
G
 
A
A
 
R
A
 
S
L
 
L
G
 
G
L
 
M
T
 
T
P
 
H
V
 
A
Q
 
M
T
 
A
Y
 
M
R
 
R
Y
 
Y
V
 
V
L
 
I
L
 
I
P
 
P
M
 
Q
A
 
A
F
 
I
R
 
K
I
 
N
I
 
I
I
 
L
P
 
P
A
 
A
L
 
L
T
 
G
N
 
N
E
|
E
F
 
F
A
 
I
A
 
V
I
 
M
I
 
L
K
 
K
N
x
E
S
 
S
S
 
A
V
 
I
A
 
V
L
 
S
T
 
V
I
 
I
G
 
G
L
 
F
V
 
A
E
 
D
L
 
L
T
 
T
A
 
R
A
 
Q
T
 
A
Y
 
D
S
 
I
M
 
I
R
 
Q
E
 
S
F
 
V
T
 
T
F
 
Y
Q
 
R
T
 
Y
F
 
F
E
 
E
A
 
P
L
 
-
T
 
-
G
 
-
A
 
-
T
 
-
I
 
-
I
 
-
Y
 
Y
V
 
I
I
 
I
I
 
I
S
 
A
V
 
A
I
 
I
A
 
Y
L
 
F
F
 
V
M
 
M
A
 
T
R
 
L
L
 
T
L
 
F
E
 
S
K
 
K
V
 
L

4ymtC Crystal structure of an amino acid abc transporter complex with arginines (see paper)
29% identity, 86% coverage: 18:232/249 of query aligns to 9:206/215 of 4ymtC

query
sites
4ymtC
I
 
V
P
 
K
Y
 
Y
I
 
T
D
 
P
T
 
L
L
 
F
L
 
I
A
 
S
G
 
G
L
 
L
K
 
I
W
 
M
T
 
T
L
 
L
A
 
K
T
 
L
A
 
T
A
 
F
C
 
L
A
 
A
W
 
V
I
 
T
M
 
I
A
 
G
L
 
V
I
 
L
L
 
M
G
 
G
T
 
L
I
 
F
F
 
I
G
 
A
T
 
L
L
 
M
R
 
K
T
 
M
T
 
S
T
 
S
K
 
I
P
 
K
W
 
P
V
 
I
V
 
K
R
 
L
I
 
V
A
 
A
N
 
S
G
 
S
Y
 
Y
V
 
I
E
 
E
L
 
V
F
 
I
R
 
R
N
 
G
I
 
T
P
|
P
L
|
L
L
 
L
V
 
V
Q
 
Q
M
 
L
F
 
L
L
 
L
W
 
I
Y
 
Y
F
 
N
V
 
G
M
 
L
P
 
M
E
 
Q
L
 
-
L
 
-
P
 
-
A
 
-
F
 
-
I
 
-
G
 
-
D
 
-
W
 
F
I
 
G
K
 
M
S
 
N
L
 
I
P
 
P
D
 
-
A
 
-
S
 
A
F
 
F
V
 
T
T
 
A
A
 
G
T
 
V
L
 
S
A
 
A
L
 
L
G
 
A
F
 
I
F
x
N
T
 
S
S
 
S
S
 
A
R
x
Y
V
 
V
A
 
A
V
 
E
Q
 
I
V
 
I
T
 
R
T
 
A
G
 
G
I
 
I
Q
 
Q
A
 
A
L
 
V
P
 
D
R
 
P
G
 
G
Q
 
Q
R
 
N
M
 
E
A
 
A
G
 
A
A
 
R
A
 
S
L
 
L
G
 
G
L
 
M
T
 
T
P
 
H
V
 
A
Q
 
M
T
 
A
Y
 
M
R
 
R
Y
 
Y
V
 
V
L
 
I
L
 
I
P
 
P
M
 
Q
A
 
A
F
 
I
R
 
K
I
 
N
I
 
I
I
 
L
P
 
P
A
 
A
L
 
L
T
 
G
N
 
N
E
|
E
F
 
F
A
 
I
A
 
V
I
x
M
I
 
L
K
|
K
N
x
E
S
 
S
S
 
A
V
 
I
A
 
V
L
 
S
T
 
V
I
 
I
G
 
G
L
 
F
V
 
A
E
 
D
L
 
L
T
 
T
A
 
R
A
 
Q
T
 
A
Y
 
D
S
 
I
M
 
I
R
 
Q
E
 
S
F
 
V
T
 
T
F
 
Y
Q
 
R
T
 
Y
F
 
F
E
 
E
A
 
P
L
 
-
T
 
-
G
 
-
A
 
-
T
 
-
I
 
-
I
 
-
Y
 
Y
V
 
I
I
 
I
I
 
I
S
 
A
V
 
A
I
 
I
A
 
Y
L
 
F
F
 
V
M
 
M
A
 
T
R
 
L
L
 
T
L
 
F
E
 
S
K
 
K
V
 
L

Query Sequence

>HSERO_RS19250 HSERO_RS19250 glutamate ABC transporter permease
MHYNWNWGIFWEMSPDGIPYIDTLLAGLKWTLATAACAWIMALILGTIFGTLRTTTKPWV
VRIANGYVELFRNIPLLVQMFLWYFVMPELLPAFIGDWIKSLPDASFVTATLALGFFTSS
RVAVQVTTGIQALPRGQRMAGAALGLTPVQTYRYVLLPMAFRIIIPALTNEFAAIIKNSS
VALTIGLVELTAATYSMREFTFQTFEALTGATIIYVIISVIALFMARLLEKVTAVPGYIT
GGSTSAGGH

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory