SitesBLAST – Find functional sites

 

SitesBLAST

Comparing HSERO_RS19525 FitnessBrowser__HerbieS:HSERO_RS19525 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 3 hits to proteins with known functional sites (download)

O31645 PTS system mannose-specific EIIBCA component; EIIBCA-Man; EII-Man; EC 2.7.1.191 from Bacillus subtilis (strain 168) (see 2 papers)
28% identity, 61% coverage: 39:133/157 of query aligns to 538:633/650 of O31645

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O31645
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Sites not aligning to the query:

C0H3V2 Mannitol-specific phosphotransferase enzyme IIA component; EIIA; EIII; PTS system mannitol-specific EIIA component from Bacillus subtilis (strain 168) (see paper)
31% identity, 78% coverage: 6:127/157 of query aligns to 2:120/143 of C0H3V2

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C0H3V2
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O31644 Transcriptional regulator ManR; Mannose operon transcriptional activator; EC 2.7.1.191 from Bacillus subtilis (strain 168) (see paper)
27% identity, 83% coverage: 9:138/157 of query aligns to 513:638/648 of O31644

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O31644
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Sites not aligning to the query:

Query Sequence

>HSERO_RS19525 FitnessBrowser__HerbieS:HSERO_RS19525
MTNLAKILSPENVVLDLEVSSKKRAFEQAGLTFENNSGIARSTVSENLFARERLGSTGLG
HGVAVPHGRIKGLKAPLALFMRLAAPIPFESPDGQPVKLLVFLLIPDHVTQQHLEILSEI
AEMFSDDAFRNELTHEPDPAVVHARIVTWQTSMEKAG

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory