SitesBLAST
Comparing HSERO_RS19755 FitnessBrowser__HerbieS:HSERO_RS19755 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
43% identity, 99% coverage: 1:480/484 of query aligns to 13:488/491 of 5gtlA
- active site: N165 (= N157), K188 (= K180), E263 (= E255), C297 (= C289), E394 (= E386), E471 (= E463)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I161 (= I153), P163 (= P155), K188 (= K180), A190 (= A182), E191 (= E183), Q192 (≠ E184), G221 (= G213), G225 (= G217), G241 (= G233), S242 (= S234), T245 (≠ A237), L264 (= L256), C297 (= C289), E394 (= E386), F396 (= F388)
5gtkA NAD+ complex structure of aldehyde dehydrogenase from bacillus cereus
43% identity, 99% coverage: 1:480/484 of query aligns to 13:488/491 of 5gtkA
- active site: N165 (= N157), K188 (= K180), E263 (= E255), C297 (= C289), E394 (= E386), E471 (= E463)
- binding nicotinamide-adenine-dinucleotide: I161 (= I153), I162 (≠ L154), P163 (= P155), W164 (= W156), K188 (= K180), E191 (= E183), G221 (= G213), G225 (= G217), A226 (≠ R218), F239 (= F231), G241 (= G233), S242 (= S234), T245 (≠ A237), Y248 (≠ A240), L264 (= L256), C297 (= C289), Q344 (= Q336), R347 (= R339), E394 (= E386), F396 (= F388)
P15437 Aldehyde dehydrogenase 1A1; 3-deoxyglucosone dehydrogenase; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic; Retinal dehydrogenase 1; RALDH 1; RalDH1; EC 1.2.1.19; EC 1.2.1.28; EC 1.2.1.3; EC 1.2.1.36 from Equus caballus (Horse) (see paper)
45% identity, 99% coverage: 4:483/484 of query aligns to 20:497/501 of P15437
Sites not aligning to the query:
- 2 modified: N-acetylserine
P51977 Aldehyde dehydrogenase 1A1; 3-deoxyglucosone dehydrogenase; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic; Retinal dehydrogenase 1; RALDH 1; RalDH1; EC 1.2.1.19; EC 1.2.1.28; EC 1.2.1.3; EC 1.2.1.36 from Ovis aries (Sheep) (see 2 papers)
44% identity, 99% coverage: 4:483/484 of query aligns to 20:497/501 of P51977
5ac0A Ovis aries aldehyde dehydrogenase 1a1 in complex with a duocarmycin analog (see paper)
44% identity, 99% coverage: 4:483/484 of query aligns to 13:490/494 of 5ac0A
- active site: N163 (= N157), K186 (= K180), E262 (= E255), C296 (= C289), E393 (= E386), E470 (= E463)
- binding 1-[(1S)-1-methyl-5-oxidanyl-1,2-dihydrobenzo[e]indol-3-yl]hexan-1-one: M114 (= M104), F164 (≠ A158), W171 (= W165), Y290 (≠ V283), C295 (≠ V288), C296 (= C289)
- binding nicotinamide-adenine-dinucleotide: I159 (= I153), I160 (≠ L154), P161 (= P155), W162 (= W156), K186 (= K180), E189 (= E183), G219 (= G213), G223 (= G217), A224 (≠ R218), F237 (= F231), G239 (= G233), S240 (= S234), V243 (≠ A237), G264 (= G257), C296 (= C289), Q343 (= Q336), K346 (≠ R339), E393 (= E386)
5abmA Sheep aldehyde dehydrogenase 1a1 (see paper)
44% identity, 99% coverage: 4:483/484 of query aligns to 13:490/494 of 5abmA
- active site: N163 (= N157), K186 (= K180), E262 (= E255), C296 (= C289), E393 (= E386), E470 (= E463)
- binding [[(2R,3S,4R,5R)-5-[(3R)-3-aminocarbonyl-3,4-dihydro-2H-pyridin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanidyl-phosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphate: I159 (= I153), I160 (≠ L154), P161 (= P155), W162 (= W156), K186 (= K180), E189 (= E183), G219 (= G213), G223 (= G217), F237 (= F231), G239 (= G233), S240 (= S234), V243 (≠ A237), G264 (= G257), Q343 (= Q336), K346 (≠ R339), E393 (= E386), F395 (= F388)
1bxsA Sheep liver class 1 aldehyde dehydrogenase with NAD bound (see paper)
44% identity, 99% coverage: 4:483/484 of query aligns to 13:490/494 of 1bxsA
- active site: N163 (= N157), K186 (= K180), E262 (= E255), C296 (= C289), E393 (= E386), E470 (= E463)
- binding nicotinamide-adenine-dinucleotide: I159 (= I153), I160 (≠ L154), P161 (= P155), W162 (= W156), K186 (= K180), E189 (= E183), G219 (= G213), G223 (= G217), F237 (= F231), G239 (= G233), S240 (= S234), V243 (≠ A237), L263 (= L256), C296 (= C289), Q343 (= Q336), K346 (≠ R339), E393 (= E386), F395 (= F388)
P20000 Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI; EC 1.2.1.3 from Bos taurus (Bovine) (see 2 papers)
45% identity, 99% coverage: 3:480/484 of query aligns to 38:513/520 of P20000
Sites not aligning to the query:
- 1:21 modified: transit peptide, Mitochondrion
Q56YU0 Aldehyde dehydrogenase family 2 member C4; ALDH1a; Protein REDUCED EPIDERMAL FLUORESCENCE 1; EC 1.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
43% identity, 98% coverage: 8:482/484 of query aligns to 23:495/501 of Q56YU0
- G152 (≠ S140) mutation to E: In ref1-7; reduced activity on sinapaldehyde.
- G416 (≠ A403) mutation to R: In ref1-6; reduced activity on sinapaldehyde.
5teiA Structure of human aldh1a1 with inhibitor cm039
43% identity, 100% coverage: 2:483/484 of query aligns to 7:489/493 of 5teiA
- active site: N162 (= N157), K185 (= K180), E261 (= E255), C295 (= C289), E392 (= E386), E469 (= E463)
- binding 6-{[(3-fluorophenyl)methyl]sulfanyl}-5-(2-methylphenyl)-2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one: S113 (≠ M104), F163 (≠ A158), H285 (≠ L279), G286 (= G280), Y289 (≠ V283), C295 (= C289), G450 (≠ S444), V452 (≠ L446), F458 (≠ W452)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I158 (= I153), I159 (≠ L154), P160 (= P155), W161 (= W156), N162 (= N157), K185 (= K180), E188 (= E183), G218 (= G213), G222 (= G217), A223 (≠ R218), F236 (= F231), T237 (= T232), G238 (= G233), S239 (= S234), V242 (≠ A237), C295 (= C289), Q342 (= Q336), K345 (≠ R339), E392 (= E386), F394 (= F388)
4x4lA Structure of human aldh1a1 with inhibitor cm037 (see paper)
43% identity, 100% coverage: 2:483/484 of query aligns to 7:489/493 of 4x4lA
- active site: N162 (= N157), K185 (= K180), E261 (= E255), C295 (= C289), E392 (= E386), E469 (= E463)
- binding ethyl ({4-oxo-3-[3-(pyrrolidin-1-yl)propyl]-3,4-dihydro[1]benzothieno[3,2-d]pyrimidin-2-yl}sulfanyl)acetate: S113 (≠ M104), M167 (≠ I162), W170 (= W165), Y289 (≠ V283), G450 (≠ S444), F458 (≠ W452)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I158 (= I153), I159 (≠ L154), P160 (= P155), W161 (= W156), K185 (= K180), E188 (= E183), G218 (= G213), G222 (= G217), F236 (= F231), T237 (= T232), G238 (= G233), S239 (= S234), V242 (≠ A237), C295 (= C289), Q342 (= Q336), K345 (≠ R339), E392 (= E386), F394 (= F388)
4wb9A Human aldh1a1 complexed with nadh (see paper)
43% identity, 100% coverage: 2:483/484 of query aligns to 7:489/493 of 4wb9A
- active site: N162 (= N157), K185 (= K180), E261 (= E255), C295 (= C289), E392 (= E386), E469 (= E463)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I158 (= I153), I159 (≠ L154), P160 (= P155), W161 (= W156), N162 (= N157), K185 (= K180), E188 (= E183), G218 (= G213), G222 (= G217), F236 (= F231), T237 (= T232), G238 (= G233), S239 (= S234), V242 (≠ A237), G263 (= G257), C295 (= C289), Q342 (= Q336), K345 (≠ R339), E392 (= E386), F394 (= F388)
7um9A Human aldh1a1 with bound compound cm38 (see paper)
43% identity, 100% coverage: 2:483/484 of query aligns to 8:490/494 of 7um9A
- binding nicotinamide-adenine-dinucleotide: I159 (= I153), I160 (≠ L154), P161 (= P155), W162 (= W156), N163 (= N157), K186 (= K180), E189 (= E183), G219 (= G213), G223 (= G217), F237 (= F231), T238 (= T232), G239 (= G233), S240 (= S234), V243 (≠ A237), E262 (= E255), G264 (= G257), Q343 (= Q336), K346 (≠ R339), E393 (= E386), F395 (= F388)
- binding (4-methylfuro[3,2-c]quinolin-2-yl)(piperidin-1-yl)methanone: W171 (= W165), H286 (≠ L279), Y290 (≠ V283), I297 (≠ A290), G451 (≠ S444)
5l2oA Crystal structure of aldh1a1 in complex with buc22 (see paper)
43% identity, 100% coverage: 2:483/484 of query aligns to 8:490/494 of 5l2oA
5l2nA Structure of aldh1a1 in complex with buc25 (see paper)
43% identity, 100% coverage: 2:483/484 of query aligns to 8:490/494 of 5l2nA
- active site: N163 (= N157), K186 (= K180), E262 (= E255), C296 (= C289), E393 (= E386), E470 (= E463)
- binding 3-benzyl-4-methyl-2-oxo-2H-1-benzopyran-7-yl methanesulfonate: F164 (≠ A158), M168 (≠ I162), W171 (= W165), H286 (≠ L279), G287 (= G280), Y290 (≠ V283), C295 (≠ V288), C296 (= C289), I297 (≠ A290), Y450 (≠ W443), G451 (≠ S444), V453 (≠ L446), F459 (≠ W452)
5l2mA Structure of aldh1a1 in complex with buc11 (see paper)
43% identity, 100% coverage: 2:483/484 of query aligns to 8:490/494 of 5l2mA
- active site: N163 (= N157), K186 (= K180), E262 (= E255), C296 (= C289), E393 (= E386), E470 (= E463)
- binding 2,3,5-trimethyl-6-[3-oxo-3-(piperidin-1-yl)propyl]-7H-furo[3,2-g][1]benzopyran-7-one: F164 (≠ A158), F283 (≠ G276), H286 (≠ L279), Y290 (≠ V283)
4wpnA Structure of human aldh1a1 with inhibitor cm053 (see paper)
43% identity, 100% coverage: 2:483/484 of query aligns to 8:490/494 of 4wpnA
- active site: N163 (= N157), K186 (= K180), E262 (= E255), C296 (= C289), E393 (= E386), E470 (= E463)
- binding 1-{[1,3-dimethyl-7-(3-methylbutyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]methyl}piperidine-4-carboxamide: F164 (≠ A158), H286 (≠ L279), G287 (= G280), Y290 (≠ V283), C295 (≠ V288), I297 (≠ A290), G451 (≠ S444), V453 (≠ L446)
7jwwA Crystal structure of human aldh1a1 bound to compound (r)-28 (see paper)
43% identity, 100% coverage: 2:483/484 of query aligns to 8:490/494 of 7jwwA
- active site: N163 (= N157), K186 (= K180), E262 (= E255), C296 (= C289), E393 (= E386), E470 (= E463)
- binding 5-{4-[(Z)-2-hydroxyethenyl]phenyl}-1-methyl-6-{[(1R)-1-phenylethyl]sulfanyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one: G118 (≠ N108), T122 (≠ H112), F164 (≠ A158), M168 (≠ I162), Y290 (≠ V283), C295 (≠ V288), C296 (= C289), I297 (≠ A290), V453 (≠ L446), F459 (≠ W452)
7jwvA Crystal structure of human aldh1a1 bound to compound (r)-28 (see paper)
43% identity, 100% coverage: 2:483/484 of query aligns to 8:490/494 of 7jwvA
- active site: N163 (= N157), K186 (= K180), E262 (= E255), C296 (= C289), E393 (= E386), E470 (= E463)
- binding 5-[4-(hydroxymethyl)phenyl]-1-methyl-6-{[(1R)-1-phenylethyl]sulfanyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one: G118 (≠ N108), T122 (≠ H112), F164 (≠ A158), M168 (≠ I162), Y290 (≠ V283), C295 (≠ V288), I297 (≠ A290), V453 (≠ L446), F459 (≠ W452)
7jwuA Crystal structure of human aldh1a1 bound to compound (r)-28 (see paper)
43% identity, 100% coverage: 2:483/484 of query aligns to 8:490/494 of 7jwuA
- active site: N163 (= N157), K186 (= K180), E262 (= E255), C296 (= C289), E393 (= E386), E470 (= E463)
- binding nicotinamide-adenine-dinucleotide: I159 (= I153), I160 (≠ L154), P161 (= P155), W162 (= W156), N163 (= N157), K186 (= K180), E189 (= E183), G219 (= G213), G223 (= G217), A224 (≠ R218), F237 (= F231), T238 (= T232), G239 (= G233), S240 (= S234), V243 (≠ A237), L263 (= L256), C296 (= C289), Q343 (= Q336), K346 (≠ R339), E393 (= E386), F395 (= F388)
- binding 1-methyl-5-phenyl-6-{[(1R)-1-(pyridin-2-yl)ethyl]sulfanyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one: T122 (≠ H112), F164 (≠ A158), W171 (= W165), Y290 (≠ V283), C295 (≠ V288), I297 (≠ A290), V453 (≠ L446), F459 (≠ W452)
Query Sequence
>HSERO_RS19755 FitnessBrowser__HerbieS:HSERO_RS19755
MSLHLQHFIAGEATEASDGQRMNLVNPINEEIYASAAQGTAADVARAVAAAKAQLEGGAW
SKLSGLQRGQLLHKLAALVERDTDLLADMDARAIGRSPMEPRMMDVPNAISHLRAAAGWA
NQMEGRTIPTAGYMGKPTLSYTVREPIGVVGAILPWNAPLMITSWKVAALLAAGCTVVIK
PAEETPQSALHLARLAQEAGFPDGVINVVTGYGNSVGRALCEHPDVAKISFTGSPEAGRA
IQRIAGEQFKRVTLELGGKSPQIVFDDAPFEDALFGCTLGLFVNQGQVCAAGSRILVQRS
LAQRFAKALAEAAAGITVGDPSQPGVRMGPVAKKAQFERVNRYIQQGLDEGATLLAGGVS
RPDKGWFVQPTIFADANNGMSIAREEIFGPVGTIISFDTEEEAIALANDSKYGLAATVWT
TNLARAHRVAAGVKVGAVGVNCWSPLDANLPWGGIKDSGMGREGGLAGALAYTEEKTVTV
LLAS
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory