SitesBLAST – Find functional sites

 

SitesBLAST

Comparing HSERO_RS22755 FitnessBrowser__HerbieS:HSERO_RS22755 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 3 hits to proteins with known functional sites (download)

2e2qA Crystal structure of sulfolobus tokodaii hexokinase in complex with xylose, mg2+, and adp (see paper)
33% identity, 57% coverage: 7:183/308 of query aligns to 4:173/297 of 2e2qA

query
sites
2e2qA
L
 
I
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V
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G
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V
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D
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A
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T
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Y
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S
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Y
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N
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A
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D
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E
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N
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L
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Y
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L
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L

Sites not aligning to the query:

2e2pA Crystal structure of sulfolobus tokodaii hexokinase in complex with adp (see paper)
33% identity, 57% coverage: 7:183/308 of query aligns to 4:173/298 of 2e2pA

query
sites
2e2pA
L
 
I
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V
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G
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V
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D
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A
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V
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A
A
 
Y
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D
L
 
C
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E
G
 
G
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N
T
 
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L
 
I
G
 
G
Q
 
E
-
 
G
A
 
S
S
 
S
G
 
G
P
 
P
G
 
G
S
 
N
A
 
Y
L
 
H
R
 
N
N
 
V
G
 
G
A
 
L
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R
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A
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I
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E
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N
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I
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A
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A
 
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-
F
 
I
A
 
A
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A
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G
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A
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M
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A
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A
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E
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I
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L
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Y
D
 
N
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K
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V
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L

Sites not aligning to the query:

2e2oA Crystal structure of sulfolobus tokodaii hexokinase in complex with glucose (see paper)
33% identity, 57% coverage: 7:183/308 of query aligns to 4:173/299 of 2e2oA

query
sites
2e2oA
L
 
I
V
 
V
G
 
G
V
 
V
D
 
D
G
 
A
G
 
G
G
 
G
T
 
T
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T
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K
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A
R
 
V
L
 
A
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Y
S
 
D
L
 
C
H
 
E
G
 
G
K
 
N
T
 
F
L
 
I
G
 
G
Q
 
E
-
 
G
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S
G
 
G
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P
G
 
G
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N
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Y
L
 
H
R
 
N
N
 
V
G
 
G
A
 
L
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T
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A
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I
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I
 
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A
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F
 
I
A
 
A
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A
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L
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K
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A
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V
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K
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I
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L
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Y
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N
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K
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V
L
 
L

Query Sequence

>HSERO_RS22755 FitnessBrowser__HerbieS:HSERO_RS22755
MDGIAYLVGVDGGGTKTLVRLASLHGKTLGQASGPGSALRNGAAHAWRVIGRTIEASFAA
AGLKRPADQALAVGIGIAGENVAQWSADFRTMAPAFGALDIVNDGVATLLGAHGGAPGAI
VAVGTGTIGLALDIDGSRRVVDGWGFPSGDDGSGGWMGLRALHHAQLALDGRSPRGPLAD
AVLALCRAELPAHPGQPARDERATLLDWLSQADQAAFARAARPVVAQAANDEAARAILQA
AAAEISLMIATLDPAQRLPLALCGGLAAALQAYLDPRQQARIVAPQADAVDGALLLAQRA
LQAKETPA

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory