SitesBLAST
Comparing N515DRAFT_0348 FitnessBrowser__Dyella79:N515DRAFT_0348 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1cevA Arginase from bacillus caldovelox, native structure at ph 5.6 (see paper)
44% identity, 98% coverage: 4:302/304 of query aligns to 2:299/299 of 1cevA
- active site: H99 (= H99), D122 (= D126), H124 (= H128), D126 (= D130), H139 (= H143), D226 (= D229), D228 (= D231), E271 (= E274)
- binding manganese (ii) ion: H99 (= H99), D122 (= D126), D122 (= D126), H124 (= H128), D126 (= D130), D226 (= D229), D226 (= D229), D228 (= D231)
P53608 Arginase; EC 3.5.3.1 from Bacillus caldovelox (see paper)
44% identity, 98% coverage: 4:302/304 of query aligns to 2:299/299 of P53608
5cevA Arginase from bacillus caldevelox, l-lysine complex (see paper)
44% identity, 98% coverage: 4:302/304 of query aligns to 1:298/298 of 5cevA
- active site: H98 (= H99), D121 (= D126), H123 (= H128), D125 (= D130), H138 (= H143), D225 (= D229), D227 (= D231), E270 (= E274)
- binding guanidine: H251 (≠ Q255), E255 (= E259)
- binding lysine: S134 (= S139), H138 (= H143), E270 (= E274)
- binding manganese (ii) ion: H98 (= H99), D121 (= D126), D121 (= D126), H123 (= H128), D125 (= D130), D225 (= D229), D225 (= D229), D227 (= D231)
4cevA Arginase from bacillus caldevelox, l-ornithine complex (see paper)
44% identity, 98% coverage: 4:302/304 of query aligns to 1:298/298 of 4cevA
- active site: H98 (= H99), D121 (= D126), H123 (= H128), D125 (= D130), H138 (= H143), D225 (= D229), D227 (= D231), E270 (= E274)
- binding guanidine: H251 (≠ Q255), E255 (= E259)
- binding manganese (ii) ion: H98 (= H99), D121 (= D126), D121 (= D126), H123 (= H128), D125 (= D130), D225 (= D229), D225 (= D229), D227 (= D231)
- binding L-ornithine: H123 (= H128), D125 (= D130), S134 (= S139), H138 (= H143), D177 (= D182)
3cevA Arginase from bacillus caldevelox, complexed with l-arginine (see paper)
44% identity, 98% coverage: 4:302/304 of query aligns to 1:298/298 of 3cevA
- active site: H98 (= H99), D121 (= D126), H123 (= H128), D125 (= D130), H138 (= H143), D225 (= D229), D227 (= D231), E270 (= E274)
- binding arginine: H123 (= H128), D125 (= D130), S134 (= S139), H138 (= H143), D225 (= D229), H251 (≠ Q255), E255 (= E259), E270 (= E274), E295 (≠ K299), L297 (≠ T301)
- binding manganese (ii) ion: H98 (= H99), D121 (= D126), D125 (= D130), D225 (= D229)
2cevB Arginase from bacillus caldevelox, native structure at ph 8.5 (see paper)
44% identity, 98% coverage: 4:302/304 of query aligns to 1:298/298 of 2cevB
- active site: H98 (= H99), D121 (= D126), H123 (= H128), D125 (= D130), H138 (= H143), D225 (= D229), D227 (= D231), E270 (= E274)
- binding guanidine: H251 (≠ Q255), E255 (= E259)
- binding manganese (ii) ion: H98 (= H99), D121 (= D126), D121 (= D126), H123 (= H128), D125 (= D130), D225 (= D229), D225 (= D229), D227 (= D231)
6nfpA 1.7 angstrom resolution crystal structure of arginase from bacillus subtilis subsp. Subtilis str. 168
43% identity, 98% coverage: 4:302/304 of query aligns to 1:292/292 of 6nfpA
6nfpD 1.7 angstrom resolution crystal structure of arginase from bacillus subtilis subsp. Subtilis str. 168
42% identity, 99% coverage: 3:302/304 of query aligns to 3:289/289 of 6nfpD
6dktA Crystal structure of arginase from bacillus subtilis
42% identity, 98% coverage: 4:302/304 of query aligns to 1:283/283 of 6dktA
6nbkA Crystal structure of arginase from bacillus cereus
41% identity, 97% coverage: 4:299/304 of query aligns to 1:286/289 of 6nbkA
6dktE Crystal structure of arginase from bacillus subtilis
39% identity, 98% coverage: 4:302/304 of query aligns to 1:268/268 of 6dktE
2ef5A Crystal structure of the arginase from thermus thermophilus
43% identity, 97% coverage: 4:299/304 of query aligns to 1:270/273 of 2ef5A
- active site: H80 (= H99), D102 (= D126), H104 (= H128), D106 (= D130), H118 (= H143), D200 (= D229), D202 (= D231), E245 (= E274)
- binding lysine: P9 (= P12), D15 (≠ S23), M16 (= M24), S19 (≠ E27)
- binding manganese (ii) ion: H80 (= H99), D102 (= D126), D102 (= D126), H104 (= H128), D106 (= D130), D200 (= D229), D200 (= D229), D202 (= D231)
6q39A Complex of arginase 2 with example 49 (see paper)
38% identity, 98% coverage: 4:300/304 of query aligns to 1:303/306 of 6q39A
- active site: H97 (= H99), D120 (= D126), H122 (= H128), D124 (= D130), H137 (= H143), D228 (= D229), D230 (= D231), E273 (= E274)
- binding 3-[(3~{S},4~{R})-4-azanyl-4-carboxy-1-[[(2~{S})-piperidin-2-yl]methyl]pyrrolidin-3-yl]propyl-tris(oxidanyl)boranuide: H97 (= H99), D120 (= D126), H122 (= H128), D124 (= D130), N126 (= N132), S133 (= S139), H137 (= H143), D177 (≠ S180), D179 (= D182), D228 (= D229), T242 (= T243), E273 (= E274)
- binding manganese (ii) ion: H97 (= H99), D120 (= D126), D120 (= D126), H122 (= H128), D124 (= D130), D228 (= D229), D228 (= D229), D230 (= D231)
6q37A Complex of arginase 2 with example 23 (see paper)
38% identity, 98% coverage: 4:300/304 of query aligns to 1:303/306 of 6q37A
- active site: H97 (= H99), D120 (= D126), H122 (= H128), D124 (= D130), H137 (= H143), D228 (= D229), D230 (= D231), E273 (= E274)
- binding 3-[(3~{S},4~{R})-4-azanyl-4-carboxy-pyrrolidin-3-yl]propyl-tris(oxidanyl)boranuide: H97 (= H99), D120 (= D126), H122 (= H128), D124 (= D130), N126 (= N132), S133 (= S139), H137 (= H143), G138 (= G144), D179 (= D182), D228 (= D229)
- binding manganese (ii) ion: H97 (= H99), D120 (= D126), D120 (= D126), H122 (= H128), D124 (= D130), D228 (= D229), D228 (= D229), D230 (= D231)
4ixvA Crystal structure of human arginase-2 complexed with inhibitor 2d: {(5r)-5-amino-5-carboxy-5-[1-(4-chlorobenzyl)piperidin-4- yl]pentyl}(trihydroxy)borate(1-) (see paper)
38% identity, 98% coverage: 4:300/304 of query aligns to 1:303/306 of 4ixvA
- active site: H97 (= H99), D120 (= D126), H122 (= H128), D124 (= D130), H137 (= H143), D228 (= D229), D230 (= D231), E273 (= E274)
- binding manganese (ii) ion: H97 (= H99), D120 (= D126), D120 (= D126), H122 (= H128), D124 (= D130), D228 (= D229), D228 (= D229), D230 (= D231)
- binding {(5R)-5-amino-5-carboxy-5-[1-(4-chlorobenzyl)piperidin-4-yl]pentyl}(trihydroxy)borate(1-): D120 (= D126), H122 (= H128), D124 (= D130), S132 (≠ P138), S133 (= S139), H137 (= H143), G138 (= G144), D179 (= D182), D228 (= D229), E273 (= E274)
4ixuA Crystal structure of human arginase-2 complexed with inhibitor 11d: {(5r)-5-amino-5-carboxy-5-[(3-endo)-8-(3,4-dichlorobenzyl)-8- azabicyclo[3.2.1]oct-3-yl]pentyl}(trihydroxy)borate(1-) (see paper)
38% identity, 98% coverage: 4:300/304 of query aligns to 1:303/306 of 4ixuA
- active site: H97 (= H99), D120 (= D126), H122 (= H128), D124 (= D130), H137 (= H143), D228 (= D229), D230 (= D231), E273 (= E274)
- binding {(5R)-5-amino-5-carboxy-5-[(3-endo)-8-(3,4-dichlorobenzyl)-8-azabicyclo[3.2.1]oct-3-yl]pentyl}(trihydroxy)borate(1-): D120 (= D126), H122 (= H128), D124 (= D130), N126 (= N132), S133 (= S139), H137 (= H143), G138 (= G144), D179 (= D182), D228 (= D229)
- binding manganese (ii) ion: H97 (= H99), D120 (= D126), D120 (= D126), H122 (= H128), D124 (= D130), D228 (= D229), D228 (= D229), D230 (= D231)
4ie3A Crystal structure of human arginase-2 complexed with inhbitor 1o (see paper)
38% identity, 98% coverage: 4:300/304 of query aligns to 1:303/306 of 4ie3A
- active site: H97 (= H99), D120 (= D126), H122 (= H128), D124 (= D130), H137 (= H143), D228 (= D229), D230 (= D231), E273 (= E274)
- binding [(5R)-5-amino-5-carboxy-7-(4-hydroxypiperidin-1-yl)heptyl](trihydroxy)borate(1-): D120 (= D126), H122 (= H128), D124 (= D130), N126 (= N132), S133 (= S139), H137 (= H143), D179 (= D182), D228 (= D229)
- binding manganese (ii) ion: H97 (= H99), D120 (= D126), D120 (= D126), H122 (= H128), D124 (= D130), D228 (= D229), D228 (= D229), D230 (= D231)
4ie2A Crystal structure of human arginase-2 complexed with inhibitor 1h (see paper)
38% identity, 98% coverage: 4:300/304 of query aligns to 1:303/306 of 4ie2A
- active site: H97 (= H99), D120 (= D126), H122 (= H128), D124 (= D130), H137 (= H143), D228 (= D229), D230 (= D231), E273 (= E274)
- binding [(5R)-5-amino-5-carboxy-8-hydroxyoctyl](trihydroxy)borate(1-): H97 (= H99), D120 (= D126), H122 (= H128), D124 (= D130), S133 (= S139), H137 (= H143), G138 (= G144), D179 (= D182), D228 (= D229)
- binding manganese (ii) ion: H97 (= H99), D120 (= D126), D120 (= D126), H122 (= H128), D124 (= D130), D228 (= D229), D228 (= D229), D230 (= D231)
4i06A Crystal structure of human arginase-2 complexed with inhibitor 14 (see paper)
38% identity, 98% coverage: 4:300/304 of query aligns to 1:303/306 of 4i06A
- active site: H97 (= H99), D120 (= D126), H122 (= H128), D124 (= D130), H137 (= H143), D228 (= D229), D230 (= D231), E273 (= E274)
- binding manganese (ii) ion: H97 (= H99), D120 (= D126), D120 (= D126), H122 (= H128), D124 (= D130), D228 (= D229), D228 (= D229), D230 (= D231)
- binding [(5R)-5-carboxy-5-(methylamino)-7-(piperidin-1-yl)heptyl](trihydroxy)borate(1-): H97 (= H99), D120 (= D126), H122 (= H128), D124 (= D130), S133 (= S139), H137 (= H143), G138 (= G144), D179 (= D182), D228 (= D229)
4hzeA Crystal structure of human arginase-2 complexed with inhibitor 9 (see paper)
38% identity, 98% coverage: 4:300/304 of query aligns to 1:303/306 of 4hzeA
- active site: H97 (= H99), D120 (= D126), H122 (= H128), D124 (= D130), H137 (= H143), D228 (= D229), D230 (= D231), E273 (= E274)
- binding manganese (ii) ion: H97 (= H99), D120 (= D126), D120 (= D126), H122 (= H128), D124 (= D130), D228 (= D229), D228 (= D229), D230 (= D231)
- binding [(5R)-5-amino-5-carboxy-7-(piperidin-1-yl)heptyl](trihydroxy)borate(1-): H97 (= H99), D120 (= D126), H122 (= H128), D124 (= D130), S133 (= S139), H137 (= H143), D179 (= D182), D228 (= D229)
Query Sequence
>N515DRAFT_0348 FitnessBrowser__Dyella79:N515DRAFT_0348
MGNQAVSLIGAPTDIGAGHRGASMGPEALRVANLQARLKARGIDVVDRGNLQGPLNPWEP
PREGYRHLSAVVDWNRAVYEAIYGELSLGRLPVMLGGDHCLAIGSITAVARHCREHHKKL
RVLWLDAHADFNTAQITPSGNIHGMPVACLCGMGPEELTTLGGSKPATAPDVFRQIGIRS
VDEGEKRLVREARVSIFDMRQIDESGMKRVMEEALEGVDADTHLHVSFDVDFLDPAIAPG
VGTTVRGGPNYREAQLCMEMIADTGRLASLDIVELNPAFDKRNQTAKLAVDLVESLFGKS
TLIR
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory