Comparing N515DRAFT_0914 FitnessBrowser__Dyella79:N515DRAFT_0914 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 10 hits to proteins with known functional sites (download)
P58315 Fructose-bisphosphate aldolase class 1; Fructose-bisphosphate aldolase class I; FBP aldolase; FBPA; EC 4.1.2.13 from Thermoproteus tenax (strain ATCC 35583 / DSM 2078 / JCM 9277 / NBRC 100435 / Kra 1) (see paper)
40% identity, 81% coverage: 38:284/305 of query aligns to 14:237/263 of P58315
2yceE Structure of an archaeal fructose-1,6-bisphosphate aldolase with the catalytic lys covalently bound to the carbinolamine intermediate of the substrate. (see paper)
40% identity, 81% coverage: 38:284/305 of query aligns to 12:235/255 of 2yceE
1w8sA The mechanism of the schiff base forming fructose-1,6-bisphosphate aldolase: structural analysis of reaction intermediates (see paper)
40% identity, 81% coverage: 38:284/305 of query aligns to 12:235/250 of 1w8sA
P58314 Fructose-bisphosphate aldolase class 1; Fructose-bisphosphate aldolase class I; FBP aldolase; EC 4.1.2.13 from Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) (see paper)
32% identity, 85% coverage: 39:298/305 of query aligns to 20:267/281 of P58314
P0A991 Fructose-bisphosphate aldolase class 1; Fructose-bisphosphate aldolase class I; FBP aldolase; EC 4.1.2.13 from Escherichia coli (strain K12) (see 2 papers)
32% identity, 90% coverage: 27:299/305 of query aligns to 51:341/350 of P0A991
Sites not aligning to the query:
2qjgA M. Jannaschii adh synthase complexed with f1,6p (see paper)
30% identity, 91% coverage: 23:300/305 of query aligns to 11:257/272 of 2qjgA
P76143 3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase; EC 2.3.1.245 from Escherichia coli (strain K12) (see paper)
25% identity, 92% coverage: 19:300/305 of query aligns to 31:273/291 of P76143
3gndA Crystal structure of e. Coli lsrf in complex with ribulose-5-phosphate (see paper)
24% identity, 92% coverage: 19:300/305 of query aligns to 22:260/276 of 3gndA
3glcA Crystal structure of e. Coli lsrf in complex with ribose-5-phosphate (see paper)
24% identity, 92% coverage: 19:300/305 of query aligns to 22:260/276 of 3glcA
4p2vA Structure of the ai-2 processing enzyme lsrf in complex with the product of the lsrg reaction p-hpd (see paper)
24% identity, 92% coverage: 19:300/305 of query aligns to 23:265/281 of 4p2vA
>N515DRAFT_0914 FitnessBrowser__Dyella79:N515DRAFT_0914
MIQSTQALSKTSERFSKLALSHGKRTRLWRLLYGHGPRNGSLLVLPLDQGLEHGPTDFFP
NPPAVDPDYQFRLAVEGNFSAIALGVGLAEKYMGEYCGRIPLILKLNGKTNIPSDAEATS
PLFASVEDAVRLGADAVGYTMYVGSPRQAEEIRQFERVRQDCERYGMPLVMWSYPRGEAV
EAKGGKNSLFAQDYAARVALEMGADIVKLHEPNDHRANAPAPYDQLQEDAAARSARVVRS
AGRTMVLFSGGEKNDDDAAVLRKVEFYMASGAQGVMFGRNMWLRPLDQAVALVNEVHKIM
AKYPR
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory