SitesBLAST
Comparing N515DRAFT_1999 N515DRAFT_1999 D-lactate dehydrogenase to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
7qh2C Cryo-em structure of ldh-etfab complex from acetobacterium woodii (see paper)
36% identity, 91% coverage: 38:454/456 of query aligns to 42:463/467 of 7qh2C
- binding flavin-adenine dinucleotide: V73 (≠ A69), G75 (= G71), S76 (≠ R72), G77 (= G73), T78 (= T74), G79 (≠ N75), L80 (≠ T76), A83 (= A79), C84 (≠ T80), P137 (= P133), G138 (≠ T134), E139 (≠ S135), A142 (≠ C139), T143 (≠ S140), G146 (= G143), N147 (= N144), S149 (≠ A146), T150 (≠ C147), A152 (≠ S149), G153 (≠ A150), E203 (= E200), G204 (= G201), I209 (= I206), E422 (= E413), H423 (= H414)
- binding fe (iii) ion: H377 (= H371), H384 (= H378), E422 (= E413)
P9WIT1 Uncharacterized FAD-linked oxidoreductase Rv2280; EC 1.-.-.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
36% identity, 89% coverage: 47:451/456 of query aligns to 46:452/459 of P9WIT1
- K354 (≠ E350) modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
8jdvA Crystal structure of mldhd in complex with 2-ketohexanoic acid (see paper)
33% identity, 99% coverage: 3:455/456 of query aligns to 1:454/454 of 8jdvA
- binding 2-Ketohexanoic acid: V75 (≠ T76), R317 (= R322), W321 (≠ S326), H368 (= H371), H375 (= H378), H413 (= H414)
- binding flavin-adenine dinucleotide: P68 (≠ A69), G70 (= G71), T71 (≠ R72), G72 (= G73), T73 (= T74), G74 (≠ N75), G78 (≠ A79), V79 (≠ T80), L90 (≠ F91), P132 (= P133), G133 (≠ T134), A134 (≠ S135), G140 (= G143), M141 (≠ N144), A143 (= A146), T144 (≠ C147), A146 (≠ S149), S147 (≠ A150), E200 (= E200), G201 (= G201), I206 (= I206), W321 (≠ S326), Y322 (≠ P327), E412 (= E413), H413 (= H414), N449 (= N450)
- binding manganese (ii) ion: H368 (= H371), H375 (= H378), E412 (= E413)
8jdsA Crystal structure of mldhd in complex with pyruvate (see paper)
33% identity, 99% coverage: 3:455/456 of query aligns to 1:456/456 of 8jdsA
- binding flavin-adenine dinucleotide: E32 (≠ N34), P68 (≠ A69), G70 (= G71), T71 (≠ R72), G72 (= G73), T73 (= T74), G74 (≠ N75), G78 (≠ A79), V79 (≠ T80), L90 (≠ F91), P132 (= P133), G133 (≠ T134), A134 (≠ S135), G140 (= G143), M141 (≠ N144), A143 (= A146), T144 (≠ C147), A146 (≠ S149), S147 (≠ A150), E200 (= E200), G201 (= G201), I206 (= I206), W323 (≠ S326), E414 (= E413), H415 (= H414), N451 (= N450)
- binding manganese (ii) ion: H370 (= H371), H377 (= H378), E414 (= E413)
- binding pyruvic acid: R319 (= R322), H370 (= H371), H377 (= H378), H415 (= H414)
8jduA Crystal structure of mldhd in complex with 2-ketovaleric acid (see paper)
33% identity, 99% coverage: 3:455/456 of query aligns to 1:455/455 of 8jduA
- binding 2-oxopentanoic acid: R318 (= R322), W322 (≠ S326), H369 (= H371), H376 (= H378), H414 (= H414)
- binding flavin-adenine dinucleotide: P68 (≠ A69), G70 (= G71), T71 (≠ R72), G72 (= G73), T73 (= T74), G74 (≠ N75), G78 (≠ A79), V79 (≠ T80), L90 (≠ F91), P132 (= P133), G133 (≠ T134), A134 (≠ S135), G140 (= G143), M141 (≠ N144), A143 (= A146), T144 (≠ C147), A146 (≠ S149), S147 (≠ A150), E200 (= E200), G201 (= G201), I206 (= I206), W322 (≠ S326), E413 (= E413), N450 (= N450)
- binding manganese (ii) ion: H369 (= H371), H376 (= H378), E413 (= E413)
8jdtA Crystal structure of mldhd in complex with 2-ketobutanoic acid (see paper)
33% identity, 99% coverage: 3:455/456 of query aligns to 1:455/455 of 8jdtA
- binding 2-ketobutyric acid: R318 (= R322), H369 (= H371), H376 (= H378), H414 (= H414)
- binding flavin-adenine dinucleotide: P68 (≠ A69), G70 (= G71), T71 (≠ R72), G72 (= G73), T73 (= T74), G74 (≠ N75), G78 (≠ A79), V79 (≠ T80), L90 (≠ F91), P132 (= P133), G133 (≠ T134), A134 (≠ S135), G140 (= G143), M141 (≠ N144), A143 (= A146), T144 (≠ C147), A146 (≠ S149), S147 (≠ A150), E200 (= E200), G201 (= G201), I206 (= I206), W322 (≠ S326), E413 (= E413), H414 (= H414), N450 (= N450)
- binding manganese (ii) ion: H369 (= H371), H376 (= H378), E413 (= E413)
8jdpA Crystal structure of h405a mldhd in complex with d-2-hydroxyisovaleric acid (see paper)
33% identity, 99% coverage: 3:455/456 of query aligns to 1:455/455 of 8jdpA
- binding flavin-adenine dinucleotide: P68 (≠ A69), G70 (= G71), T71 (≠ R72), G72 (= G73), T73 (= T74), G74 (≠ N75), G78 (≠ A79), V79 (≠ T80), L90 (≠ F91), P132 (= P133), G133 (≠ T134), A134 (≠ S135), G140 (= G143), M141 (≠ N144), A143 (= A146), T144 (≠ C147), A146 (≠ S149), S147 (≠ A150), E200 (= E200), G201 (= G201), I206 (= I206), H369 (= H371), E413 (= E413), N450 (= N450)
- binding deaminohydroxyvaline: R319 (= R322), H414 (= H414)
8jdeA Crystal structure of mldhd in complex with d-lactate (see paper)
33% identity, 99% coverage: 3:455/456 of query aligns to 1:455/455 of 8jdeA
- binding flavin-adenine dinucleotide: P68 (≠ A69), G70 (= G71), T71 (≠ R72), G72 (= G73), T73 (= T74), G74 (≠ N75), G78 (≠ A79), V79 (≠ T80), L90 (≠ F91), P132 (= P133), G133 (≠ T134), A134 (≠ S135), G140 (= G143), M141 (≠ N144), A143 (= A146), T144 (≠ C147), A146 (≠ S149), S147 (≠ A150), E200 (= E200), G201 (= G201), I206 (= I206), W322 (≠ S326), E413 (= E413), H414 (= H414), N450 (= N450)
- binding lactic acid: R318 (= R322), H369 (= H371), H376 (= H378), H414 (= H414)
- binding manganese (ii) ion: H369 (= H371), H376 (= H378), E413 (= E413)
8jdxA Crystal structure of mldhd in complex with 2-ketoisovaleric acid (see paper)
33% identity, 99% coverage: 3:455/456 of query aligns to 1:455/455 of 8jdxA
- binding flavin-adenine dinucleotide: E32 (≠ N34), P68 (≠ A69), G70 (= G71), T71 (≠ R72), G72 (= G73), T73 (= T74), G74 (≠ N75), G78 (≠ A79), V79 (≠ T80), L90 (≠ F91), P132 (= P133), G133 (≠ T134), A134 (≠ S135), G140 (= G143), M141 (≠ N144), A143 (= A146), T144 (≠ C147), A146 (≠ S149), S147 (≠ A150), E200 (= E200), G201 (= G201), I206 (= I206), W322 (≠ S326), E413 (= E413), H414 (= H414), N450 (= N450)
- binding 3-methyl-2-oxobutanoic acid: R318 (= R322), H369 (= H371), H376 (= H378), H414 (= H414)
- binding manganese (ii) ion: H369 (= H371), H376 (= H378), E413 (= E413)
8jdrA Crystal structure of h405a mldhd in complex with d-2-hydroxy-3-methyl- valeric acid (see paper)
33% identity, 99% coverage: 3:455/456 of query aligns to 1:456/456 of 8jdrA
- binding flavin-adenine dinucleotide: P68 (≠ A69), G70 (= G71), T71 (≠ R72), G72 (= G73), T73 (= T74), G74 (≠ N75), G78 (≠ A79), V79 (≠ T80), L90 (≠ F91), P132 (= P133), G133 (≠ T134), A134 (≠ S135), G140 (= G143), M141 (≠ N144), A143 (= A146), T144 (≠ C147), A146 (≠ S149), S147 (≠ A150), E200 (= E200), G201 (= G201), I206 (= I206), Y324 (≠ P327), H370 (= H371), E414 (= E413), N451 (= N450)
- binding (2R,3S)-3-methyl-2-oxidanyl-pentanoic acid: R319 (= R322), W323 (≠ S326), H415 (= H414)
8jdqA Crystal structure of h405a mldhd in complex with d-2-hydroxyisocaproic acid (see paper)
33% identity, 99% coverage: 3:455/456 of query aligns to 1:456/456 of 8jdqA
- binding (2R)-2-hydroxy-4-methylpentanoic acid: R319 (= R322), W323 (≠ S326), H370 (= H371), H415 (= H414)
- binding flavin-adenine dinucleotide: P68 (≠ A69), G70 (= G71), T71 (≠ R72), G72 (= G73), T73 (= T74), G74 (≠ N75), G78 (≠ A79), V79 (≠ T80), L90 (≠ F91), P132 (= P133), G133 (≠ T134), A134 (≠ S135), G140 (= G143), M141 (≠ N144), A143 (= A146), T144 (≠ C147), A146 (≠ S149), S147 (≠ A150), E200 (= E200), G201 (= G201), I206 (= I206), H370 (= H371), E414 (= E413), N451 (= N450)
8jdoA Crystal structure of h405a mldhd in complex with d-2-hydroxyhexanoic acid (see paper)
33% identity, 99% coverage: 3:455/456 of query aligns to 1:456/456 of 8jdoA
- binding (2R)-2-hydroxyhexanoic acid: R319 (= R322), W323 (≠ S326), H415 (= H414)
- binding flavin-adenine dinucleotide: P68 (≠ A69), G70 (= G71), T71 (≠ R72), G72 (= G73), T73 (= T74), G74 (≠ N75), G78 (≠ A79), V79 (≠ T80), L90 (≠ F91), P132 (= P133), G133 (≠ T134), A134 (≠ S135), G140 (= G143), M141 (≠ N144), A143 (= A146), T144 (≠ C147), A146 (≠ S149), S147 (≠ A150), E200 (= E200), G201 (= G201), I206 (= I206), Y324 (≠ P327), H370 (= H371), E414 (= E413), N451 (= N450)
8jdnA Crystal structure of h405a mldhd in complex with d-2-hydroxyvaleric acid (see paper)
33% identity, 99% coverage: 3:455/456 of query aligns to 1:456/456 of 8jdnA
- binding flavin-adenine dinucleotide: P68 (≠ A69), G70 (= G71), T71 (≠ R72), G72 (= G73), T73 (= T74), G74 (≠ N75), G78 (≠ A79), V79 (≠ T80), L90 (≠ F91), P132 (= P133), G133 (≠ T134), A134 (≠ S135), G140 (= G143), M141 (≠ N144), A143 (= A146), T144 (≠ C147), A146 (≠ S149), S147 (≠ A150), E200 (= E200), G201 (= G201), I206 (= I206), H370 (= H371), E414 (= E413), N451 (= N450)
- binding (2R)-2-oxidanylpentanoic acid: R319 (= R322), W323 (≠ S326), H415 (= H414)
8jdgA Crystal structure of h405a mldhd in complex with d-2-hydroxybutanoic acid (see paper)
33% identity, 99% coverage: 3:455/456 of query aligns to 1:456/456 of 8jdgA
- binding flavin-adenine dinucleotide: P68 (≠ A69), G70 (= G71), T71 (≠ R72), G72 (= G73), T73 (= T74), G74 (≠ N75), G78 (≠ A79), V79 (≠ T80), L90 (≠ F91), P132 (= P133), G133 (≠ T134), A134 (≠ S135), G140 (= G143), M141 (≠ N144), A143 (= A146), T144 (≠ C147), A146 (≠ S149), S147 (≠ A150), E200 (= E200), G201 (= G201), I206 (= I206), H370 (= H371), E414 (= E413), N451 (= N450)
- binding (2R)-2-oxidanylbutanoic acid: R319 (= R322), H415 (= H414)
8jdbA Crystal structure of h405a mldhd in complex with d-2-hydroxyoctanoic acid (see paper)
33% identity, 99% coverage: 3:455/456 of query aligns to 1:456/456 of 8jdbA
- binding flavin-adenine dinucleotide: P68 (≠ A69), G70 (= G71), T71 (≠ R72), G72 (= G73), T73 (= T74), G74 (≠ N75), G78 (≠ A79), V79 (≠ T80), L90 (≠ F91), P132 (= P133), G133 (≠ T134), A134 (≠ S135), G140 (= G143), M141 (≠ N144), A143 (= A146), T144 (≠ C147), A146 (≠ S149), S147 (≠ A150), E200 (= E200), G201 (= G201), I206 (= I206), Y324 (≠ P327), H370 (= H371), E414 (= E413), N451 (= N450)
- binding (2R)-2-oxidanyloctanoic acid: V75 (≠ T76), R319 (= R322), W323 (≠ S326), H415 (= H414)
8jdzA Crystal structure of mldhd in complex with 2-keto-3-methylvaleric acid (see paper)
33% identity, 99% coverage: 3:455/456 of query aligns to 1:454/454 of 8jdzA
- binding (3S)-3-methyl-2-oxopentanoic acid: R318 (= R322), W322 (≠ S326), H369 (= H371), H376 (= H378), H413 (= H414)
- binding flavin-adenine dinucleotide: E32 (≠ N34), P68 (≠ A69), G70 (= G71), T71 (≠ R72), G72 (= G73), T73 (= T74), G74 (≠ N75), G78 (≠ A79), V79 (≠ T80), L90 (≠ F91), P132 (= P133), G133 (≠ T134), A134 (≠ S135), G140 (= G143), M141 (≠ N144), A143 (= A146), T144 (≠ C147), A146 (≠ S149), S147 (≠ A150), E200 (= E200), G201 (= G201), I206 (= I206), W322 (≠ S326), E412 (= E413), H413 (= H414), N449 (= N450)
- binding manganese (ii) ion: H369 (= H371), H376 (= H378), E412 (= E413)
8jdyA Crystal structure of mldhd in complex with 2-ketoisocaproic acid (see paper)
33% identity, 99% coverage: 3:455/456 of query aligns to 1:454/454 of 8jdyA
- binding 2-oxo-4-methylpentanoic acid: R318 (= R322), W322 (≠ S326), S336 (≠ N338), H369 (= H371), H376 (= H378), H413 (= H414)
- binding flavin-adenine dinucleotide: P68 (≠ A69), G70 (= G71), T71 (≠ R72), G72 (= G73), T73 (= T74), G74 (≠ N75), G78 (≠ A79), V79 (≠ T80), L90 (≠ F91), P132 (= P133), G133 (≠ T134), A134 (≠ S135), G140 (= G143), M141 (≠ N144), A143 (= A146), T144 (≠ C147), A146 (≠ S149), S147 (≠ A150), E200 (= E200), G201 (= G201), I206 (= I206), E412 (= E413), N449 (= N450)
- binding manganese (ii) ion: H369 (= H371), H376 (= H378), E412 (= E413)
3pm9A Crystal structure of a putative dehydrogenase (rpa1076) from rhodopseudomonas palustris cga009 at 2.57 a resolution
33% identity, 90% coverage: 44:455/456 of query aligns to 44:465/465 of 3pm9A
- active site: A149 (≠ S149), L159 (≠ S159)
- binding flavin-adenine dinucleotide: P69 (≠ A69), Q70 (≠ R70), G71 (= G71), G72 (≠ R72), N73 (≠ G73), T74 (= T74), G75 (≠ N75), L76 (≠ T76), G79 (≠ A79), Q80 (≠ T80), L91 (≠ F91), L133 (≠ P133), G134 (≠ T134), A135 (≠ S135), C139 (= C139), T140 (≠ S140), G142 (= G142), G143 (= G143), S146 (≠ A146), T147 (≠ C147), A149 (≠ S149), G150 (≠ A150), E200 (= E200), G201 (= G201), I205 (≠ L205), I206 (= I206), E423 (= E413)
6lpxA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with 2-oxoglutarate (2-og) (see paper)
31% identity, 90% coverage: 47:456/456 of query aligns to 53:465/466 of 6lpxA
- binding 2-oxoglutaric acid: R333 (= R322), T337 (≠ S326), K348 (≠ N338), Y379 (≠ F369), H381 (= H371), H388 (= H378), H423 (= H414)
- binding flavin-adenine dinucleotide: P75 (≠ A69), Q76 (≠ R70), G77 (= G71), G78 (≠ R72), N79 (≠ G73), T80 (= T74), G81 (≠ N75), M82 (≠ T76), G85 (≠ A79), S86 (≠ T80), L139 (≠ P133), G140 (≠ T134), A141 (≠ S135), C145 (= C139), G149 (= G143), N150 (= N144), A152 (= A146), T153 (≠ C147), G157 (= G151), G207 (= G201), I212 (= I206), E422 (= E413), N459 (= N450)
- binding zinc ion: H381 (= H371), H388 (= H378), E422 (= E413)
Sites not aligning to the query:
6lpuA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with l-2-hydroxyglutarate (l-2-hg) (see paper)
31% identity, 90% coverage: 47:456/456 of query aligns to 53:465/466 of 6lpuA
- binding flavin-adenine dinucleotide: P75 (≠ A69), G77 (= G71), G78 (≠ R72), N79 (≠ G73), T80 (= T74), G81 (≠ N75), G85 (≠ A79), S86 (≠ T80), L139 (≠ P133), G140 (≠ T134), A141 (≠ S135), C145 (= C139), H146 (≠ S140), G148 (= G142), G149 (= G143), N150 (= N144), A152 (= A146), T153 (≠ C147), A155 (≠ S149), E206 (= E200), G207 (= G201), I211 (≠ L205), I212 (= I206), E422 (= E413), N459 (= N450)
- binding (2s)-2-hydroxypentanedioic acid: R333 (= R322), T337 (≠ S326), K348 (≠ N338), Y379 (≠ F369), H381 (= H371), H388 (= H378), H423 (= H414)
- binding zinc ion: H381 (= H371), H388 (= H378), E422 (= E413)
Sites not aligning to the query:
Query Sequence
>N515DRAFT_1999 N515DRAFT_1999 D-lactate dehydrogenase
MTLPTALLEALHASFAGDALSLGEAERLAYAYDNSRRNALPDAVVFPTSHEQTEALVRAC
REHRVPLVARGRGTNTTGATVPVDGGVVASFERMNRILRIDPDNRLAVVEPGVLNGDLQQ
ALKPHGFFWPPDPTSSPWCSIGGNLACNSAGPRTVKYGSPRENTLGLRAVAGTGVGFRCG
TYTSKGSTGYDLTRLLIGSEGTLALITEATLKLTPKPSGLRTLRATYRDVSAAARAVARI
MAQPVTPCALEFIDDVALKLARDHGGDSVPVAGAMLMIEVDGEPDTLAGAVEAVSRAARG
DGLESLQVAQSAEETQALWSARKALSPAQRTISPNKINEDVVVPVSRLPELVDGIKALAA
KHDVLIVSFGHAGNGNLHVNLLPRDEAERERAHACLAEVFALVIRLDGTLSGEHGIGLVK
REFMPLALQPETLGLMRGVKAAFDPDGILNPRKLLP
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory