SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing N515DRAFT_2043 N515DRAFT_2043 putative ABC transport system ATP-binding protein to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

5xu1B Structure of a non-canonical abc transporter from streptococcus pneumoniae r6 (see paper)
50% identity, 95% coverage: 6:224/230 of query aligns to 3:220/226 of 5xu1B

query
sites
5xu1B

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binding magnesium ion: G45 (= G48), K46 (= K49), S47 (≠ T50)

1f3oA Crystal structure of mj0796 atp-binding cassette (see paper)
46% identity, 95% coverage: 6:224/230 of query aligns to 1:223/232 of 1f3oA

query
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1f3oA

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binding adenosine-5'-diphosphate: Y11 (= Y16), A20 (≠ V25), S40 (= S45), G41 (= G46), S42 (= S47), G43 (= G48), K44 (= K49), S45 (≠ T50), T46 (= T51)

1l2tA Dimeric structure of mj0796, a bacterial abc transporter cassette (see paper)
45% identity, 95% coverage: 6:224/230 of query aligns to 1:223/230 of 1l2tA

query
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1l2tA

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binding adenosine-5'-triphosphate: Y11 (= Y16), M13 (≠ R18), I18 (≠ V23), A20 (≠ V25), P39 (= P44), S40 (= S45), G41 (= G46), S42 (= S47), G43 (= G48), K44 (= K49), S45 (≠ T50), T46 (= T51), F138 (vs. gap), H141 (= H142), Q145 (≠ E146), S147 (= S148), G148 (= G149), G149 (= G150), Q150 (= Q151), A175 (≠ D176), H204 (= H205)

P75957 Lipoprotein-releasing system ATP-binding protein LolD; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
44% identity, 97% coverage: 6:227/230 of query aligns to 5:226/233 of P75957

query
sites
P75957

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G42 (= G43) mutation to D: Loss of lipoprotein release when overexpressed.

7mdyC Lolcde nucleotide-bound
44% identity, 97% coverage: 6:227/230 of query aligns to 2:223/226 of 7mdyC

query
sites
7mdyC

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binding adp orthovanadate: Y12 (= Y16), T19 (≠ V23), V21 (= V25), S40 (≠ P44), S41 (= S45), G42 (= G46), S43 (= S47), G44 (= G48), K45 (= K49), S46 (≠ T50), T47 (= T51), Q91 (= Q95), R135 (= R139), H138 (= H142), E142 (= E146), S144 (= S148), G145 (= G149), G146 (= G150), E147 (≠ Q151), E168 (= E172), N172 (≠ D176), H201 (= H205)
binding magnesium ion: S46 (≠ T50), Q91 (= Q95)

7arlD Lolcde in complex with lipoprotein and adp (see paper)
44% identity, 96% coverage: 6:225/230 of query aligns to 2:221/222 of 7arlD

query
sites
7arlD

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M

D

L

F

T

T

A

A

Q

L

R

E

N

N

V

V

E

A

L

M

P

P

L

L

L

I

T

G

K

K

L

K

S

K

A

P

A

A

Q

E

R

I

R

N

K

S

N

R

A

A

A

L

I

E

A

M

L

L

Q

K

L

A

V

V

G

G

L

L

D

D

E

H

R

R

S

A

S

N

H

H

K

R

P

P

S

S

E

E

L

L

S

S

G

G

Q

E

Q

R

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

I

L

V

V

S

N

D

N

P

P

T

R

L

L

L

V

V

L

C

A

D

D

E

E

P

P

T

T

G

G

D

N

L

L

D

D

R

A

Q

R

S

N

A

A

E

D

D

S

V

I

L

F

G

Q

L

L

R

G

T

E

L

L

N

N

R

R

E

L

H

Q

G

G

K

T

T

A

I

F

V

L

M

V

V

V

T

T

H

H

D

D

P

L

K

Q

A

L

A

A

E

K

Y

R

A

M

N

S

H

R

T

Q

L

L

H

E

L

M

D

R

K

D

G

G

T

R

L

L

V

T

binding adenosine-5'-diphosphate: Y12 (= Y16), G42 (= G46), G44 (= G48), K45 (= K49), S46 (≠ T50), T47 (= T51)

7v8iD Lolcd(e171q)e with bound amppnp in nanodiscs
43% identity, 97% coverage: 6:227/230 of query aligns to 4:225/229 of 7v8iD

query
sites
7v8iD

L

L

I

L

E

Q

V

C

R

D

D

N

L

L

S

C

K

K

V

R

Y

Y

E

Q

R

E

G

G

K

S

Q

V

K

Q

V

T

E

D

V
|
V

L

L

H

H

H

N

I

V

N

S

L

F

N

S

I

V

A

G

E

E

G

G

D

E

F

M

L

M

A

A

L

I

M

V

G

G

P

S

S
|
S

G
|
G

S
|
S

G
|
G

K
|
K

T
x
S

T
|
T

L

L

N

H

L

L

I

L

G

G

L

L

D

D

S

T

P

P

T

T

G

S

G

G

S

D

I

V

G

I

V

F

G

N

G

G

Q

Q

R

P

I

M

D

S

Q

K

L

L

G

S

A

S

G

A

A

A

L

K

A

A

K

E

W

L

R

R

A

N

A

Q

N

K

V

L

G

G

F

F

V

I

F

Y

Q
|
Q

F

F

Y

H

N

H

L

L

M

L

P

P

M

D

L

F

T

T

A

A

Q

L

R

E

N

N

V

V

E

A

L

M

P

P

L

L

L

I

T

G

K

K

L

K

S

K

A

P

A

A

Q

E

R

I

R

N

K

S

N

R

A

A

A

L

I

E

A

M

L

L

Q

K

L

A

V

V

G

G

L

L

D

D

E

H

R
|
R

S

A

S

N

H
|
H

K

R

P

P

S

S

E
|
E

L
|
L

S
|
S

G
|
G

Q
x
E

Q

R

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

I

L

V

V

S

N

D

N

P

P

T

R

L

L

L

V

V

L

C

A

D

D

E

Q

P

P

T

T

G

G

D
x
N

L

L

D

D

R

A

Q

R

S

N

A

A

E

D

D

S

V

I

L

F

G

Q

L

L

R

G

T

E

L

L

N

N

R

R

E

L

H

Q

G

G

K

T

T

A

I

F

V

L

M

V

V

V

T

T

H
|
H

D

D

P

L

K

Q

A

L

A

A

E

K

Y

R

A

M

N

S

H

R

T

Q

L

L

H

E

L

M

D

R

K

D

G

G

T

R

L

L

V

T

E

A

Q

E

binding phosphoaminophosphonic acid-adenylate ester: V23 (= V25), S43 (= S45), G44 (= G46), S45 (= S47), G46 (= G48), K47 (= K49), S48 (≠ T50), T49 (= T51), Q93 (= Q95), R137 (= R139), H140 (= H142), E144 (= E146), L145 (= L147), S146 (= S148), G147 (= G149), G148 (= G150), E149 (≠ Q151), N174 (≠ D176), H203 (= H205)
binding magnesium ion: S48 (≠ T50), Q93 (= Q95)

P75831 Macrolide export ATP-binding/permease protein MacB; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
44% identity, 97% coverage: 3:225/230 of query aligns to 1:222/648 of P75831

query
sites
P75831

M

M

G

T

T

P

L

L

I

L

E

E

V

L

R

K

D

D

L

I

S

R

K

R

V

S

Y

Y

E

P

R

A

G

G

K

D

Q

E

K

Q

V

V

E

E

V

V

L

L

H

K

H

G

I

I

N

S

L

L

N

D

I

I

A

Y

E

A

G

G

D

E

F

M

L

V

A

A

L

I

M

V

G

G

P

A

S

S

G

G

S

S

G

G

K
|
K

T

S

T

T

L

L

L

M

N

N

L

I

I

L

G

G

G

C

L

L

D

D

S

K

P

A

T

T

G

S

G

G

S

T

I

Y

G

R

V

V

G

A

G

G

Q

Q

R

D

I

V

D

A

Q

T

L

L

G

D

A

A

G

D

A

A

L

L

A

A

K

Q

W

L

R

R

A

R

A

E

N

H

V

F

G

G

F

F

V

I

F

F

Q

Q

F

R

Y

Y

N

H

L

L

M

L

P

S

M

H

L

L

T

T

A

A

Q

E

R

Q

N

N

V

V

E

E

L

V

P

P

L

A

L

V

L

Y

T

A

K

G

L

L

S

E

A

R

A

K

Q

Q

R

R

R

L

K

L

N

R

A

A

A

Q

I

E

A

L

L

L

Q

Q

L

R

V

L

G

G

L

L

D

E

E

D

R

R

S

T

S

E

H

Y

K

Y

P

P

S

A

E

Q

L

L

S

S

G

G

Q

Q

R

R

V

V

A

S

I

I

A

A

R

R

A

A

I

L

V

M

S

N

D

G

P

G

T

Q

L

V

L

I

V

L

C

A

D
|
D

E

E

P

P

T

T

G

G

D

A

L

L

D

D

R

S

Q

H

S

S

A

G

E

E

D

E

V

V

L

M

G

A

L

I

L

L

R

H

T

Q

L

L

N

-

R

R

E

D

H

R

G

G

K

H

T

T

I

V

V

I

M

I

V

V

T

T

H

H

D

D

P

P

K

Q

A

V

A

A

E

A

Y

Q

A

A

N

E

H

R

T

V

L

I

H

E

L

I

D

R

K

D

G

G

T

E

L

I

V

V

K47 (= K49) mutation to L: Lack of activity.
D169 (= D171) mutation to N: Lack of activity.

5lilA Structure of aggregatibacter actinomycetemcomitans macb bound to atpys (p21) (see paper)
44% identity, 96% coverage: 6:225/230 of query aligns to 3:221/615 of 5lilA

query
sites
5lilA

L

I

I

I

E

E

V

I

R

K

D

Q

L

L

S

N

K

R

V

Y

Y
x
F

E

G

R

E

G

G

K

E

Q

N

K

R

V

V

E

H

V
|
V

L

L

H

K

H

D

I

I

N

S

L

L

N

S

I

I

A

E

E

R

G

G

D

D

F

F

L

V

A

A

L

I

M

M

G

G

P

Q

S
|
S

G
|
G

S
|
S

G
|
G

K
|
K

T
x
S

T
|
T

L

L

L

M

N

N

L

I

I

I

G

G

G

C

L

L

D

D

S

T

P

A

T

T

G

G

S

S

I

S

G

K

V

I

G

D

G

G

Q

K

R

E

I

T

D

I

Q

E

L

L

G

T

A

N

G

D

A

Q

L

L

A

S

K

D

W

L

R

R

A

S

A

Q

N

K

V

F

G

G

F

F

V

I

F

F

Q
|
Q

F

R

Y

Y

N

N

L

L

M

L

P

S

M

S

L

L

T

T

A

A

Q

A

R

E

N

N

V

V

E

A

L

L

P

P

L

A

L

I

L

Y

T

A

K

G

L

M

S

P

A

Q

A

S

Q

Q

R

R

R

L

K

E

N

R

A

A

A

K

I

Q

A

L

L

L

Q

E

L

K

V

L

G

G

L

L

D

G

E

D

R
x
K

S

W

S

Q

H
x
N

K

K

P

P

S

N

E
x
Q

L
|
L

S
|
S

G
|
G

Q
|
Q

Q

Q

R

R

V

V

A

S

I

I

A

A

R

R

A

A

I

L

V

M

S

N

D

G

P

G

T

E

L

I

V

L

C

A

D
|
D

E
x
Q

P

P

T

T

G

G

D
x
A

L

L

D

D

R

S

Q

H

S

S

A

G

E

E

D

N

V

V

L

M

G

E

L

I

L

L

R

R

T

Q

L

L

N

H

R

-

E

E

H

E

G

G

K

H

T

T

I

I

V

I

M

M

V

V

T

T

H
|
H

D

D

P

K

K

H

A

I

A

A

E

A

Y

S

A

A

N

N

H

R

T

I

L

I

H

E

L

I

D

K

K

D

G

G

T

E

L

I

V

I

binding adenosine-5'-triphosphate: F13 (≠ Y16), V22 (= V25), S42 (= S45), G43 (= G46), S44 (= S47), G45 (= G48), K46 (= K49), S47 (≠ T50), T48 (= T51), Q92 (= Q95), K136 (≠ R139), N139 (≠ H142), Q143 (≠ E146), L144 (= L147), S145 (= S148), G146 (= G149), G147 (= G150), Q148 (= Q151), Q169 (≠ E172), A173 (≠ D176), H201 (= H205)
binding magnesium ion: S47 (≠ T50), Q92 (= Q95), D168 (= D171)

5lj7A Structure of aggregatibacter actinomycetemcomitans macb bound to atp (p21) (see paper)
44% identity, 96% coverage: 6:225/230 of query aligns to 3:221/592 of 5lj7A

query
sites
5lj7A

L

I

I

I

E

E

V

I

R

K

D

Q

L

L

S

N

K

R

V

Y

Y
x
F

E

G

R

E

G

G

K

E

Q

N

K

R

V

V

E

H

V
|
V

L

L

H

K

H

D

I

I

N

S

L

L

N

S

I

I

A

E

E

R

G

G

D

D

F

F

L

V

A

A

L

I

M

M

G

G

P

Q

S
|
S

G
|
G

S
|
S

G
|
G

K
|
K

T
x
S

T
|
T

L

L

L

M

N

N

L

I

I

I

G

G

G

C

L

L

D

D

S

T

P

A

T

T

G

G

S

S

I

S

G

K

V

I

G

D

G

G

Q

K

R

E

I

T

D

I

Q

E

L

L

G

T

A

N

G

D

A

Q

L

L

A

S

K

D

W

L

R

R

A

S

A

Q

N

K

V

F

G

G

F

F

V

I

F

F

Q
|
Q

F

R

Y

Y

N

N

L

L

M

L

P

S

M

S

L

L

T

T

A

A

Q

A

R

E

N

N

V

V

E

A

L

L

P

P

L

A

L

I

L

Y

T

A

K

G

L

M

S

P

A

Q

A

S

Q

Q

R

R

R

L

K

E

N

R

A

A

A

K

I

Q

A

L

L

L

Q

E

L

K

V

L

G

G

L

L

D

G

E

D

R
x
K

S

W

S

Q

H

N

K

K

P

P

S
x
N

E
x
Q

L
|
L

S
|
S

G
|
G

Q
|
Q

Q

Q

R

R

V

V

A

S

I

I

A

A

R

R

A

A

I

L

V

M

S

N

D

G

P

G

T

E

L

I

V

L

C

A

D
|
D

E
x
Q

P

P

T

T

G

G

D
x
A

L

L

D

D

R

S

Q

H

S

S

A

G

E

E

D

N

V

V

L

M

G

E

L

I

L

L

R

R

T

Q

L

L

N

H

R

-

E

E

H

E

G

G

K

H

T

T

I

I

V

I

M

M

V

V

T

T

H
|
H

D

D

P

K

K

H

A

I

A

A

E

A

Y

S

A

A

N

N

H

R

T

I

L

I

H

E

L

I

D

K

K

D

G

G

T

E

L

I

V

I

binding adenosine-5'-triphosphate: F13 (≠ Y16), V22 (= V25), S42 (= S45), G43 (= G46), S44 (= S47), G45 (= G48), K46 (= K49), S47 (≠ T50), T48 (= T51), Q92 (= Q95), K136 (≠ R139), N142 (≠ S145), Q143 (≠ E146), L144 (= L147), S145 (= S148), G146 (= G149), G147 (= G150), Q148 (= Q151), Q169 (≠ E172), A173 (≠ D176), H201 (= H205)
binding magnesium ion: S47 (≠ T50), Q92 (= Q95), D168 (= D171)

7tchB Bceab e169q variant atp-bound conformation (see paper)
41% identity, 97% coverage: 6:227/230 of query aligns to 2:223/245 of 7tchB

query
sites
7tchB

L

I

I

L

E

E

V

A

R

N

D

K

L

I

S

R

K

K

V

S

Y
|
Y

E

G

R

N

G

K

K

L

Q

N

K

K

V
x
Q

E

E

V
|
V

L

L

H

K

H

G

I

I

N

D

L

I

N

H

I

I

A

E

E

K

G

G

D

E

F

F

L

V

A

S

L

I

M

M

G

G

P

A

S
|
S

G
|
G

S
|
S

G
|
G

K
|
K

T
|
T

L

L

N

N

L

V

I

L

G

S

L

I

D

D

S

Q

P

V

T

S

G

H

G

G

S

T

I

I

G

H

V

I

G

N

G

G

Q

N

R

D

I

M

D

T

Q

A

L

M

G

K

A

E

G

K

A

Q

L

L

A

A

K

E

W

F

R

R

A

K

A

Q

N

H

V

L

G

G

F

F

V

I

F

F

Q
|
Q

F

D

Y

Y

N

N

L

L

M

L

P

D

M

T

L

L

T

T

A

V

Q

K

R

E

N

N

V

I

E

L

L

L

P

P

L

L

L

S

L

I

T

T

K

K

L

L

S

S

A

K

Q

E

-

A

R

N

R

R

K

K

N

F

A

E

I

V

A

A

L

K

Q

E

L

L

V

-

G

G

L

I

D

Y

E

E

R

L

S

R

S

D

H

K

K

Y

P

P

S

N

E
|
E

L

I

S
|
S

G
|
G

Q

Q

Q

K

Q

Q

R

R

V

T

A

S

I

A

A

G

R

R

A

A

I

F

V

I

S

H

D

D

P

P

T

S

L

I

V

F

C

A

D

D

E

Q

P

P

T

T

G

G

D

A

L

L

D

D

R

S

Q

K

S

S

A

A

E

S

D

D

V

L

L

L

G

N

L

K

L

L

R

S

T

Q

L

L

N

N

R

Q

E

K

H

R

G

N

K

A

T

T

I

I

V

I

M

M

V

V

T

T

H
|
H

D

D

P

P

K

V

A

A

E

S

Y

Y

A

C

N

G

H

R

T

V

L

I

H

F

L

I

D

K

K

D

G

G

T

Q

L

M

V

Y

E

T

Q

Q

binding adenosine-5'-triphosphate: Y12 (= Y16), Q19 (≠ V23), V21 (= V25), S41 (= S45), G42 (= G46), S43 (= S47), G44 (= G48), K45 (= K49), T46 (= T50), T47 (= T51), Q91 (= Q95), E142 (= E146), S144 (= S148), G145 (= G149), G146 (= G150), H201 (= H205)

5ws4A Crystal structure of tripartite-type abc transporter macb from acinetobacter baumannii (see paper)
41% identity, 96% coverage: 6:225/230 of query aligns to 4:222/650 of 5ws4A

query
sites
5ws4A

L

L

I

L

E

E

V

V

R

S

D

N

L

L

S

V

K

R

V

E

Y
x
F

E

P

R

A

G

G

K

E

Q

S

K

T

V

I

E

Q

V
x
I

L

L

H

K

H

G

I

I

N

D

L

L

N

T

I

I

A

Y

E

E

G

G

D

E

F

L

L

V

A

A

L

I

M

V

G

G

P

Q

S
|
S

G
|
G

S
|
S

G
|
G

K
|
K

T
x
S

T
|
T

L

L

L

M

N

N

L

I

I

L

G

G

G

C

L

L

D

D

S

R

P

P

T

T

G

S

G

G

S

S

I

Y

G

K

V

V

G

N

G

G

Q

Q

R

E

I

T

D

G

Q

K

L

L

G

E

A

P

G

D

A

Q

L

L

A

A

K

Q

W

L

R

R

A

R

A

E

N

Y

V

F

G

G

F

F

V

I

F

F

Q

Q

F

R

Y

Y

N

H

L

L

M

L

P

G

M

D

L

L

T

S

A

A

Q

E

R

G

N

N

V

V

E

E

L

V

P

P

L

A

L

V

L

Y

T

A

K

G

L

V

S

T

A

P

A

A

Q

D

R

R

R

K

K

Q

N

R

A

A

A

T

I

A

A

L

L

L

Q

T

L

E

V

L

G

G

L

L

D

G

E

T

R

K

S

T

S

Q

H

N

K

R

P

P

S

S

E

Q

L

L

S

S

G

G

Q

Q

R

R

V

V

A

S

I

I

A

A

R

R

A

A

I

L

V

M

S

N

D

G

P

G

T

D

L

V

L

I

V

L

C

A

D

D

E

E

P

P

T

T

G

G

D

A

L

L

D

D

R

S

Q

H

S

S

A

G

E

V

D

E

V

V

L

M

G

R

L

I

L

L

R

R

T

E

L

L

N

N

R

-

E

A

H

A

G

G

K

H

T

T

I

I

V

I

M

L

V

V

T

T

H

H

D

D

P

M

K

Q

A

V

A

A

E

K

Y

N

A

A

N

T

H

R

T

I

L

I

H

E

L

I

D

S

K

D

G

G

T

E

L

I

V

I

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: F14 (≠ Y16), I23 (≠ V25), S43 (= S45), G44 (= G46), S45 (= S47), G46 (= G48), K47 (= K49), S48 (≠ T50), T49 (= T51)

2pclA Crystal structure of abc transporter with complex (aq_297) from aquifex aeolicus vf5
43% identity, 88% coverage: 24:225/230 of query aligns to 17:217/223 of 2pclA

query
sites
2pclA

E

E

V

I

L

L

H

K

H

G

I

I

N

S

L

L

N

S

I

V

A

K

E

K

G

G

D

E

F

F

L

V

A

S

L

I

M

I

G

G

P

A

S

S

G

G

S

S

G

G

K

K

T

S

T

T

L

L

N

Y

L

I

I

L

G

G

G

L

L

L

D

D

S

A

P

P

T

T

G

E

G

G

S

K

I

V

G

F

V

L

G

E

G

G

Q

K

R

E

I

V

D

D

Q

Y

L

T

G

N

A

E

G

K

A

E

L

L

A

S

K

L

W

L

R

R

A

N

A

R

N

K

V

L

G

G

F

F

V

V

F

F

Q

Q

F

F

Y

H

N

Y

L

L

M

I

P

P

M

E

L

L

T

T

A

A

Q

L

R

E

N

N

V

V

E

I

L

V

P

P

L

M

L

L

L

K

T

M

K

G

L

K

S

P

A

K

Q

E

R

A

R

K

K

E

N

R

A

G

A

E

I

Y

A

L

L

L

Q

S

L

E

V

L

G

G

L

L

D

G

E

D

R

K

S

L

S

S

H

R

K

K

P

P

S

Y

E

E

L

L

S

S

G

G

Q

E

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

I

L

V

A

S

N

D

E

P

P

T

I

L

L

V

F

C

A

D

D

E
|
E

P
|
P

T
|
T

G

G

D

N

L

L

D

D

R

S

Q

A

S

N

A

T

E

K

D

R

V

V

L

M

G

D

L

I

L

F

R

L

T

K

L

I

N

N

R

-

E

E

H

G

G

G

K

T

T

S

I

I

V

V

M

M

V

V

T
|
T

H

H

D

E

P

R

K

E

A

L

A

A

E

E

Y

L

A

T

N

H

H

R

T

T

L

L

H

E

L

M

D

K

K

D

G

G

T

K

L

V

V

V

binding magnesium ion: E165 (= E172), P166 (= P173), T167 (= T174), T196 (= T204)

P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 3 papers)
36% identity, 97% coverage: 6:227/230 of query aligns to 1:222/343 of P30750

query
sites
P30750

L

M

I

I

E

K

V

L

R

S

D

N

L

I

S

T

K

K

V

V

Y

F

E

H

R

Q

G

G

K

T

Q

R

K

T

V

I

E

Q

V

A

L

L

H

N

I

V

N

S

L

L

N

H

I

V

A

P

E

A

G

G

D

Q

F

I

L

Y

A

G

L

V

M

I

G

G

P

A

S
|
S

G
|
G

S
x
A

G
|
G

K
|
K

T
x
S

T
|
T

L

L

L

I

N

R

L

C

I

V

G

N

G

L

L

L

D

E

S

R

P

P

T

T

G

E

G

G

S

S

I

V

G

L

V

V

G

D

G

G

Q

Q

R

E

I

L

D

T

Q

T

L

L

G

S

A

E

G

S

A

E

L

L

A

T

K

K

W

A

R

R

A

R

A

-

N

Q

V

I

G

G

F

M

V

I

F

F

Q

Q

F

H

Y

F

N

N

L

L

M

L

P

S

M

S

L

R

T

T

A

V

Q

F

R

G

N

N

V

V

E

A

L

L

P

P

L

L

L

E

L

L

T

D

K

N

L

T

S

P

A

K

A

D

Q

E

R

V

R

K

K

R

N

R

A

V

A

T

I

E

A

L

L

L

Q

S

L

L

V

V

G

G

L

L

D

G

E

D

R

K

S

H

S

D

H

S

K

Y

P

P

S

S

E

N

L

L

S

S

G

G

Q

Q

Q

K

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

I

L

V

A

S

S

D

N

P

P

T

K

L

V

L

L

V

L

C

C

D

D

E
|
E

P

A

T

T

G

S

D

A

L

L

D

D

R

P

Q

A

S

T

A

T

E

R

D

S

V

I

L

L

G

E

L

L

R

K

T

D

L

I

N

N

R

R

E

R

H

L

G

G

K

L

T

T

I

I

V

L

M

L

V

I

T

T

H

H

D

E

P

M

K

D

A

V

E

K

-

R

Y

I

A

C

N

D

H

C

T

V

L

A

H

V

L

I

D

S

K

N

G

G

T

E

L

L

V

I

E

E

Q

Q

40:46 (vs. 45:51, 71% identical) binding
E166 (= E172) mutation to Q: Exhibits little ATPase activity.

Sites not aligning to the query:

278:283 binding
295 N→A: Reduces the binding of L-methionine to undetectable levels.
295:296 binding

P9WQK5 Uncharacterized ABC transporter ATP-binding protein Rv0073 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
42% identity, 94% coverage: 3:219/230 of query aligns to 1:215/330 of P9WQK5

query
sites
P9WQK5

M

M

G

G

T

D

L

L

I

-

E

S

V

I

R

Q

D

N

L

L

S

V

K

V

V

E

Y

Y

E

Y

R

S

G

G

K

G

Q

Y

K

A

V

L

E

R

V

P

L

I

H

N

H

G

I

L

N

N

L

L

N

D

I

V

A

A

E

A

G

G

D

S

F

L

L

V

A

M

L

L

M

L

G

G

P

P

S

S

G

G

S

C

G

G

K

K

T

T

L

L

N

S

L

C

I

L

G

G

L

I

D

L

S

R

P

P

T

K

G

S

G

G

S

A

I

I

G
x
K

V

F

G

D

G

E

Q

V

R

D

I

I

D

T

Q

T

L

L

G

Q

A

G

G

A

A

E

L

L

A

A

K

N

W

Y

R

R

A

R

A

N

N

K

V

V

G

G

F

I

V

V

F

F

Q

Q

F

A

Y

F

N

N

L

L

M

V

P

P

M

S

L

L

T

T

A

A

Q

V

R

E

N

N

V

V

E

M

L

V

P

P

L

L

L

R

L

S

T

A

K

G

L

M

S

S

A

R

Q

A

R

S

R

R

K

R

N

R

A

A

A

E

I

E

A

L

L

L

Q

A

L

R

V

V

G

N

L

L

D

A

E

E

R

R

S

M

S

N

H

H

K

R

P

P

S

G

E

D

L

L

S

S

G

G

Q

Q

R

R

V

V

A

A

I

V

A

A

R

R

A

A

I

I

V

A

S

L

D

D

P

P

T

P

L

L

L

I

V

L

C

A

D

D

E

E

P

P

T

T

G

A

D

H

L

L

D

D

R

F

Q

I

S

Q

A

V

E

E

D

E

V

V

L

L

G

R

L

L

L

I

R

R

T

E

L

L

N

A

R

-

E

D

H

G

G

E

K

R

T

V

I

V

V

V

M

V

V

A

T

T

H

H

D

D

P

S

K

R

A

M

A

L

E

P

Y

M

A

A

N

D

H

R

T

V

L

V

H

E

L

L

K65 (≠ G68) modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)

3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form (see paper)
36% identity, 97% coverage: 6:227/230 of query aligns to 2:223/344 of 3tuzC

query
sites
3tuzC

L

M

I

I

E

K

V

L

R

S

D

N

L

I

S

T

K

K

V

V

Y
x
F

E

H

R
x
Q

G

G

K

T

Q

R

K

T

V

I

E

Q

V
x
A

L

L

H

N

I

V

N

S

L

L

N

H

I

V

A

P

E

A

G

G

D

Q

F

I

L

Y

A

G

L

V

M

I

G

G

P

A

S

S

G
|
G

S
x
A

G
|
G

K
|
K

T
x
S

T
|
T

L

L

L

I

N

R

L

C

I

V

G

N

G

L

L

L

D

E

S

R

P

P

T

T

G

E

G

G

S

S

I

V

G

L

V

V

G

D

G

G

Q

Q

R

E

I

L

D

T

Q

T

L

L

G

S

A

E

G

S

A

E

L

L

A

T

K

K

W

A

R

R

A

R

A

-

N

Q

V

I

G

G

F

M

V

I

F

F

Q

Q

F

H

Y

F

N

N

L

L

M

L

P

S

M

S

L

R

T

T

A

V

Q

F

R

G

N

N

V

V

E

A

L

L

P

P

L

L

L

E

L

L

T

D

K

N

L

T

S

P

A

K

A

D

Q

E

R

V

R

K

K

R

N

R

A

V

A

T

I

E

A

L

L

L

Q

S

L

L

V

V

G

G

L

L

D

G

E

D

R

K

S

H

S

D

H

S

K

Y

P

P

S

S

E

N

L

L

S

S

G

G

Q

Q

Q

K

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

I

L

V

A

S

S

D

N

P

P

T

K

L

V

L

L

V

L

C

C

D

D

E

Q

P

A

T

T

G

S

D

A

L

L

D

D

R

P

Q

A

S

T

A

T

E

R

D

S

V

I

L

L

G

E

L

L

R

K

T

D

L

I

N

N

R

R

E

R

H

L

G

G

K

L

T

T

I

I

V

L

M

L

V

I

T

T

H

H

D

E

P

M

K

D

A

V

E

K

-

R

Y

I

A

C

N

D

H

C

T

V

L

A

H

V

L

I

D

S

K

N

G

G

T

E

L

L

V

I

E

E

Q

Q

binding adenosine-5'-diphosphate: F12 (≠ Y16), Q14 (≠ R18), A21 (≠ V25), G42 (= G46), A43 (≠ S47), G44 (= G48), K45 (= K49), S46 (≠ T50), T47 (= T51)

Sites not aligning to the query:

binding selenomethionine: 274, 279, 281, 282, 283, 284, 311, 312, 313

3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form (see paper)
36% identity, 97% coverage: 6:227/230 of query aligns to 2:223/344 of 3tuiC

query
sites
3tuiC

L

M

I

I

E

K

V

L

R

S

D

N

L

I

S

T

K

K

V

V

Y
x
F

E

H

R
x
Q

G

G

K

T

Q

R

K

T

V

I

E

Q

V

A

L

L

H

N

I

V

N

S

L

L

N

H

I

V

A

P

E

A

G

G

D

Q

F

I

L

Y

A

G

L

V

M

I

G

G

P

A

S
|
S

G
|
G

S
x
A

G
|
G

K
|
K

T
x
S

T
|
T

L

L

L

I

N

R

L

C

I

V

G

N

G

L

L

L

D

E

S

R

P

P

T

T

G

E

G

G

S

S

I

V

G

L

V

V

G

D

G

G

Q

Q

R

E

I

L

D

T

Q

T

L

L

G

S

A

E

G

S

A

E

L

L

A

T

K

K

W

A

R

R

A

R

A

-

N

Q

V

I

G

G

F

M

V

I

F

F

Q

Q

F

H

Y

F

N

N

L

L

M

L

P

S

M

S

L

R

T

T

A

V

Q

F

R

G

N

N

V

V

E

A

L

L

P

P

L

L

L

E

L

L

T

D

K

N

L

T

S

P

A

K

A

D

Q

E

R

V

R

K

K

R

N

R

A

V

A

T

I

E

A

L

L

L

Q

S

L

L

V

V

G

G

L

L

D

G

E

D

R

K

S

H

S

D

H

S

K

Y

P

P

S

S

E

N

L

L

S

S

G

G

Q

Q

Q

K

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

I

L

V

A

S

S

D

N

P

P

T

K

L

V

L

L

V

L

C

C

D

D

E

Q

P

A

T

T

G

S

D

A

L

L

D

D

R

P

Q

A

S

T

A

T

E

R

D

S

V

I

L

L

G

E

L

L

R

K

T

D

L

I

N

N

R

R

E

R

H

L

G

G

K

L

T

T

I

I

V

L

M

L

V

I

T

T

H

H

D

E

P

M

K

D

A

V

E

K

-

R

Y

I

A

C

N

D

H

C

T

V

L

A

H

V

L

I

D

S

K

N

G

G

T

E

L

L

V

I

E

E

Q

Q

binding adenosine-5'-diphosphate: F12 (≠ Y16), Q14 (≠ R18), S41 (= S45), G42 (= G46), A43 (≠ S47), G44 (= G48), K45 (= K49), S46 (≠ T50), T47 (= T51)

6cvlD Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
36% identity, 97% coverage: 6:227/230 of query aligns to 2:223/344 of 6cvlD

query
sites
6cvlD

L

M

I

I

E

K

V

L

R

S

D

N

L

I

S

T

K

K

V

V

Y
x
F

E

H

R
x
Q

G

G

K

T

Q

R

K

T

V
x
I

E

Q

V

A

L

L

H

N

I

V

N

S

L

L

N

H

I

V

A

P

E

A

G

G

D

Q

F

I

L

Y

A

G

L

V

M

I

G

G

P

A

S
|
S

G
|
G

S
x
A

G
|
G

K
|
K

T
x
S

T
|
T

L

L

L

I

N

R

L

C

I

V

G

N

G

L

L

L

D

E

S

R

P

P

T

T

G

E

G

G

S

S

I

V

G

L

V

V

G

D

G

G

Q

Q

R

E

I

L

D

T

Q

T

L

L

G

S

A

E

G

S

A

E

L

L

A

T

K

K

W

A

R

R

A

R

A

-

N

Q

V

I

G

G

F

M

V

I

F

F

Q

Q

F

H

Y

F

N

N

L

L

M

L

P

S

M

S

L

R

T

T

A

V

Q

F

R

G

N

N

V

V

E

A

L

L

P

P

L

L

L

E

L

L

T

D

K

N

L

T

S

P

A

K

A

D

Q

E

R

V

R

K

K

R

N

R

A

V

A

T

I

E

A

L

L

L

Q

S

L

L

V

V

G

G

L

L

D

G

E

D

R

K

S

H

S

D

H

S

K

Y

P

P

S

S

E
x
N

L
|
L

S
|
S

G
|
G

Q
|
Q

Q

K

Q

Q

R

R

V

V

A

A

I

I

A

A

R

R

A

A

I

L

V

A

S

S

D

N

P

P

T

K

L

V

L

L

V

L

C

C

D

D

E

Q

P

A

T

T

G

S

D

A

L

L

D

D

R

P

Q

A

S

T

A

T

E

R

D

S

V

I

L

L

G

E

L

L

R

K

T

D

L

I

N

N

R

R

E

R

H

L

G

G

K

L

T

T

I

I

V

L

M

L

V

I

T

T

H
|
H

D

E

P

M

K

D

A

V

E

K

-

R

Y

I

A

C

N

D

H

C

T

V

L

A

H

V

L

I

D

S

K

N

G

G

T

E

L

L

V

I

E

E

Q

Q

binding phosphothiophosphoric acid-adenylate ester: F12 (≠ Y16), Q14 (≠ R18), I19 (≠ V23), S41 (= S45), G42 (= G46), A43 (≠ S47), G44 (= G48), K45 (= K49), S46 (≠ T50), T47 (= T51), N141 (≠ E146), L142 (= L147), S143 (= S148), G144 (= G149), G145 (= G150), Q146 (= Q151), H200 (= H205)

1oxvD Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
38% identity, 96% coverage: 7:226/230 of query aligns to 4:221/353 of 1oxvD

query
sites
1oxvD

I

I

E

I

V

V

R

K

D

N

L

V

S

S

K

K

V

V

Y
x
F

E

K

R

K

G

G

K

K

Q

-

K

-

V
|
V

E

V

V
x
A

L

L

H

D

H

N

I

V

N

N

L

I

N

N

I

I

A

E

E

N

G

G

D

E

F

R

L

F

A

G

L

I

M

L

G

G

P
|
P

S
|
S

G
|
G

S
x
A

G
|
G

K
|
K

T
|
T

L

F

L

M

N

R

L

I

I

I

G

A

G

G

L

L

D

D

S

V

P

P

T

S

G

T

G

G

S

E

I

L

G

Y

V

F

G

D

Q

R

R

L

I

V

D

A

Q

S

L

N

G

G

A

K

G

-

A

L

L

I

A

V

K

P

W

P

R

E

A

D

A

R

N

K

V

I

G

G

F

M

V

V

F

F

Q
|
Q

F

T

Y

W

N

A

L

L

M

Y

P

P

M

N

L

L

T

T

A

A

Q

F

R

E

N

N

V

I

E

A

L

F

P

P

L

L

L

T

L

N

T

M

K

K

L

M

S

S

A

K

A

E

Q

E

R

I

R

R

K

K

N

R

A

V

A

E

I

E

A

V

L

A

Q

K

L

I

V

L

G

D

L

I

D

H

E

H

R

V

S

L

S

N

H

H

K

F

P

P

S

R

E

E

L

L

S

S

G

G

Q

Q

R

R

V

V

A

A

I

L

A

A

R

R

A

A

I

L

V

V

S

K

D

D

P

P

T

S

L

L

V

L

C

L

D

D

E
|
E

P

P

T

F

G

S

D

N

L

L

D

D

R

A

Q

R

S

M

A

R

E

D

D

S

V

A

L

R

G

A

L

L

L

V

R

K

T

E

L

V

N

Q

R

S

E

R

H

L

G

G

K

V

T

T

I

L

V

L

M

V

V

V

T

S

H

H

D

D

P

P

-

A

K

D

A

I

A

F

E

A

Y

I

A

A

N

D

H

R

T

V

L

G

H

V

L

L

D

V

K

K

G

G

T

K

L

L

V

V

E

Q

binding phosphoaminophosphonic acid-adenylate ester: F13 (≠ Y16), V18 (= V23), A20 (≠ V25), P39 (= P44), S40 (= S45), G41 (= G46), A42 (≠ S47), G43 (= G48), K44 (= K49), T45 (= T50), T46 (= T51), Q89 (= Q95), E166 (= E172)
binding magnesium ion: T45 (= T50), Q89 (= Q95)

1oxvA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
38% identity, 96% coverage: 7:226/230 of query aligns to 4:221/353 of 1oxvA

query
sites
1oxvA

I

I

E

I

V

V

R

K

D

N

L

V

S

S

K

K

V

V

Y
x
F

E

K

R

K

G

G

K

K

Q

-

K

-

V
|
V

E

V

V
x
A

L

L

H

D

H

N

I

V

N

N

L

I

N

N

I

I

A

E

E

N

G

G

D

E

F

R

L

F

A

G

L

I

M

L

G

G

P
|
P

S
|
S

G
|
G

S
x
A

G
|
G

K
|
K

T
|
T

L

F

L

M

N

R

L

I

I

I

G

A

G

G

L

L

D

D

S

V

P

P

T

S

G

T

G

G

S

E

I

L

G

Y

V

F

G

D

Q

R

R

L

I

V

D

A

Q

S

L

N

G

G

A

K

G

-

A

L

L

I

A

V

K

P

W

P

R

E

A

D

A

R

N

K

V

I

G

G

F

M

V

V

F

F

Q
</