SitesBLAST
Comparing N515DRAFT_2155 FitnessBrowser__Dyella79:N515DRAFT_2155 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
4jdrA Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase from escherichia coli (see paper)
63% identity, 79% coverage: 124:594/594 of query aligns to 1:471/471 of 4jdrA
- active site: P15 (= P138), L40 (= L163), C44 (= C167), C49 (= C172), S52 (= S175), E77 (≠ K200), P78 (= P201), I184 (= I307), E188 (= E311), V324 (≠ T447), H442 (= H565), H444 (= H567), E449 (= E572), N467 (≠ M590), P468 (= P591)
- binding flavin-adenine dinucleotide: G12 (= G135), G14 (= G137), P15 (= P138), A16 (≠ G139), E35 (= E158), R36 (= R159), Y37 (= Y160), V43 (= V166), C44 (= C167), G48 (= G171), C49 (= C172), K53 (= K176), L115 (≠ V238), G116 (= G239), A144 (= A267), G145 (= G268), I185 (= I308), G311 (= G434), D312 (= D435), M318 (= M441), L319 (= L442), A320 (= A443), H321 (= H444)
P0A9P0 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes; Glycine cleavage system L protein; EC 1.8.1.4 from Escherichia coli (strain K12) (see 2 papers)
63% identity, 79% coverage: 124:594/594 of query aligns to 2:472/474 of P0A9P0
- K220 (= K342) modified: N6-acetyllysine
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
1bhyA Low temperature middle resolution structure of p64k from masc data (see paper)
60% identity, 76% coverage: 141:594/594 of query aligns to 19:482/482 of 1bhyA
- active site: L41 (= L163), C45 (= C167), C50 (= C172), S53 (= S175), I195 (= I307), E199 (= E311), H454 (= H565), H456 (= H567), E461 (= E572), P479 (= P591), Q480 (≠ K592)
- binding flavin-adenine dinucleotide: E36 (= E158), R37 (= R159), Y38 (= Y160), G43 (= G165), V44 (= V166), C45 (= C167), G49 (= G171), C50 (= C172), K54 (= K176), D116 (≠ V238), G117 (= G239), Y135 (vs. gap), A156 (= A267), G157 (= G268), D324 (= D435), L331 (= L442), A332 (= A443)
Sites not aligning to the query:
P11959 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; E3 component of pyruvate complex; EC 1.8.1.4 from Geobacillus stearothermophilus (Bacillus stearothermophilus) (see paper)
45% identity, 77% coverage: 127:584/594 of query aligns to 8:463/470 of P11959
- 39:47 (vs. 158:167, 60% identical) binding
- K56 (= K176) binding
- D314 (= D435) binding
- A322 (= A443) binding
1ebdA Dihydrolipoamide dehydrogenase complexed with the binding domain of the dihydrolipoamide acetylase (see paper)
45% identity, 76% coverage: 127:580/594 of query aligns to 2:453/455 of 1ebdA
- active site: P13 (= P138), L37 (= L163), C41 (= C167), C46 (= C172), S49 (= S175), N74 (≠ K200), V75 (≠ P201), Y180 (≠ I307), E184 (= E311), S320 (≠ T447), H438 (= H565), H440 (= H567), E445 (= E572)
- binding flavin-adenine dinucleotide: G10 (= G135), G12 (= G137), P13 (= P138), V32 (= V157), E33 (= E158), K34 (≠ R159), G39 (= G165), V40 (= V166), C41 (= C167), G45 (= G171), C46 (= C172), K50 (= K176), E112 (≠ V238), A113 (≠ G239), T141 (≠ A267), G142 (= G268), Y180 (≠ I307), I181 (= I308), R268 (= R395), D308 (= D435), A314 (≠ M441), L315 (= L442), A316 (= A443)
P14218 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; E3 component of 2-oxoglutarate dehydrogenase complex; EC 1.8.1.4 from Pseudomonas fluorescens (see 2 papers)
42% identity, 78% coverage: 131:594/594 of query aligns to 7:478/478 of P14218
- 34:49 (vs. 158:167, 38% identical) binding
- C49 (= C167) modified: Disulfide link with 54, Redox-active
- C54 (= C172) modified: Disulfide link with 49, Redox-active
- K58 (= K176) binding
- G122 (= G239) binding
- D319 (= D435) binding
- A327 (= A443) binding
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
5u8uD Dihydrolipoamide dehydrogenase (lpdg) from pseudomonas aeruginosa (see paper)
43% identity, 76% coverage: 131:583/594 of query aligns to 9:469/477 of 5u8uD
- active site: P16 (= P138), L47 (= L163), C51 (= C167), C56 (= C172), S59 (= S175), G85 (≠ K200), V86 (≠ P201), V193 (≠ I307), E197 (= E311), S333 (≠ T447), F451 (≠ H565), H453 (= H567), E458 (= E572)
- binding flavin-adenine dinucleotide: I12 (≠ L134), G15 (= G137), P16 (= P138), G17 (= G139), E36 (= E158), K37 (≠ R159), G49 (= G165), T50 (≠ V166), C51 (= C167), G55 (= G171), C56 (= C172), K60 (= K176), H123 (≠ V238), G124 (= G239), A152 (= A266), S153 (≠ A267), G154 (= G268), I194 (= I308), R281 (= R395), G320 (= G434), D321 (= D435), M327 (= M441), L328 (= L442), A329 (= A443), H330 (= H444), H453 (= H567), P454 (= P568)
Sites not aligning to the query:
5u8vA Dihydrolipoamide dehydrogenase (lpdg) from pseudomonas aeruginosa bound to NAD+ (see paper)
43% identity, 76% coverage: 131:583/594 of query aligns to 5:465/472 of 5u8vA
- active site: P12 (= P138), L43 (= L163), C47 (= C167), C52 (= C172), S55 (= S175), G81 (≠ K200), V82 (≠ P201), V189 (≠ I307), E193 (= E311), S329 (≠ T447), F447 (≠ H565), H449 (= H567), E454 (= E572)
- binding flavin-adenine dinucleotide: I8 (≠ L134), G11 (= G137), P12 (= P138), G13 (= G139), E32 (= E158), G45 (= G165), T46 (≠ V166), C47 (= C167), G51 (= G171), C52 (= C172), K56 (= K176), H119 (≠ V238), G120 (= G239), A148 (= A266), S149 (≠ A267), G150 (= G268), S169 (= S287), I190 (= I308), R277 (= R395), G316 (= G434), D317 (= D435), M323 (= M441), L324 (= L442), A325 (= A443), H326 (= H444), H449 (= H567), P450 (= P568)
- binding nicotinamide-adenine-dinucleotide: I185 (≠ V303), G186 (= G304), G188 (= G306), V189 (≠ I307), I190 (= I308), L208 (≠ V326), E209 (= E327), A210 (≠ F328), V243 (= V361), V275 (= V393), G276 (= G394)
Sites not aligning to the query:
5u8wA Dihydrolipoamide dehydrogenase (lpdg) from pseudomonas aeruginosa bound to nadh (see paper)
43% identity, 76% coverage: 131:583/594 of query aligns to 6:466/473 of 5u8wA
- active site: P13 (= P138), L44 (= L163), C48 (= C167), C53 (= C172), S56 (= S175), G82 (≠ K200), V83 (≠ P201), V190 (≠ I307), E194 (= E311), S330 (≠ T447), F448 (≠ H565), H450 (= H567), E455 (= E572)
- binding flavin-adenine dinucleotide: I9 (≠ L134), G12 (= G137), P13 (= P138), G14 (= G139), E33 (= E158), K34 (≠ R159), G46 (= G165), T47 (≠ V166), C48 (= C167), G52 (= G171), C53 (= C172), K57 (= K176), H120 (≠ V238), G121 (= G239), A149 (= A266), S150 (≠ A267), G151 (= G268), S170 (= S287), G317 (= G434), D318 (= D435), M324 (= M441), L325 (= L442), A326 (= A443), H327 (= H444), Y357 (≠ F474), H450 (= H567), P451 (= P568)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I186 (≠ V303), G189 (= G306), V190 (≠ I307), I191 (= I308), E194 (= E311), E210 (= E327), A211 (≠ F328), L212 (≠ M329), A275 (= A392), V276 (= V393), G277 (= G394), R278 (= R395), M324 (= M441), L325 (= L442), V355 (= V472), Y357 (≠ F474)
Sites not aligning to the query:
6uziC Crystal structure of dihydrolipoyl dehydrogenase from elizabethkingia anophelis nuhp1
45% identity, 75% coverage: 133:578/594 of query aligns to 11:459/470 of 6uziC
- active site: C45 (= C167), C50 (= C172), S53 (= S175), V187 (≠ I307), E191 (= E311), H448 (= H567), E453 (= E572)
- binding flavin-adenine dinucleotide: I12 (≠ L134), G13 (= G135), G15 (= G137), P16 (= P138), G17 (= G139), E36 (= E158), K37 (≠ R159), G43 (= G165), T44 (≠ V166), C45 (= C167), G49 (= G171), C50 (= C172), S53 (= S175), K54 (= K176), V117 (= V238), G118 (= G239), T147 (≠ A267), G148 (= G268), I188 (= I308), R276 (= R395), D316 (= D435), M322 (= M441), L323 (= L442), A324 (= A443)
- binding zinc ion: H448 (= H567), E453 (= E572)
6awaA 1.83 angstrom resolution crystal structure of dihydrolipoyl dehydrogenase from pseudomonas putida in complex with fad and adenosine-5'-monophosphate.
42% identity, 76% coverage: 131:583/594 of query aligns to 7:467/475 of 6awaA
- active site: L45 (= L163), C49 (= C167), C54 (= C172), S57 (= S175), V191 (≠ I307), E195 (= E311), F449 (≠ H565), H451 (= H567), E456 (= E572)
- binding adenosine monophosphate: I187 (≠ V303), E211 (= E327), A212 (≠ F328), L213 (≠ M329), V245 (= V361), V277 (= V393)
- binding flavin-adenine dinucleotide: I10 (≠ L134), G13 (= G137), P14 (= P138), G15 (= G139), E34 (= E158), K35 (≠ R159), T48 (≠ V166), C49 (= C167), G53 (= G171), C54 (= C172), K58 (= K176), H121 (≠ V238), G122 (= G239), S151 (≠ A267), G152 (= G268), I192 (= I308), R279 (= R395), G318 (= G434), D319 (= D435), M325 (= M441), L326 (= L442), A327 (= A443), Y358 (≠ F474)
Sites not aligning to the query:
P18925 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; E3 component of pyruvate complex; EC 1.8.1.4 from Azotobacter vinelandii (see 2 papers)
42% identity, 76% coverage: 131:583/594 of query aligns to 7:467/477 of P18925
- 34:49 (vs. 158:167, 38% identical) binding
- C49 (= C167) modified: Disulfide link with 54, Redox-active
- C54 (= C172) modified: Disulfide link with 49, Redox-active
- K58 (= K176) binding
- D319 (= D435) binding
- A327 (= A443) binding
3ladA Refined crystal structure of lipoamide dehydrogenase from azotobacter vinelandii at 2.2 angstroms resolution. A comparison with the structure of glutathione reductase (see paper)
42% identity, 76% coverage: 131:583/594 of query aligns to 6:466/472 of 3ladA
- active site: L44 (= L163), C48 (= C167), C53 (= C172), S56 (= S175), V190 (≠ I307), E194 (= E311), F448 (≠ H565), H450 (= H567), E455 (= E572)
- binding flavin-adenine dinucleotide: I9 (≠ L134), G10 (= G135), G12 (= G137), P13 (= P138), E33 (= E158), K34 (≠ R159), G46 (= G165), T47 (≠ V166), C48 (= C167), G52 (= G171), C53 (= C172), H120 (≠ V238), G121 (= G239), A149 (= A266), S150 (≠ A267), G151 (= G268), I191 (= I308), R278 (= R395), D318 (= D435), L325 (= L442), A326 (= A443)
2eq6A Crystal structure of lipoamide dehydrogenase from thermus thermophilus hb8
46% identity, 76% coverage: 131:581/594 of query aligns to 6:451/460 of 2eq6A
- active site: V37 (≠ L163), C41 (= C167), C46 (= C172), T49 (≠ S175), A176 (≠ I307), E180 (= E311), H435 (= H565), H437 (= H567), E442 (= E572)
- binding flavin-adenine dinucleotide: I9 (≠ L134), G10 (= G135), G12 (= G137), P13 (= P138), G14 (= G139), E33 (= E158), A34 (≠ R159), G39 (= G165), V40 (= V166), C41 (= C167), G45 (= G171), C46 (= C172), K50 (= K176), F111 (≠ V238), A112 (≠ G239), A135 (= A266), T136 (≠ A267), G137 (= G268), S155 (= S287), R269 (≠ N398), D306 (= D435), L312 (≠ M441), L313 (= L442), A314 (= A443), H315 (= H444), Y344 (≠ F474)
Sites not aligning to the query:
3urhB Crystal structure of a dihydrolipoamide dehydrogenase from sinorhizobium meliloti 1021
42% identity, 75% coverage: 131:578/594 of query aligns to 3:456/465 of 3urhB
- active site: Y35 (≠ L163), C39 (= C167), C44 (= C172), S47 (= S175), V183 (≠ I307), E187 (= E311), H443 (= H565), H445 (= H567), E450 (= E572)
- binding flavin-adenine dinucleotide: I6 (≠ L134), G7 (= G135), G9 (= G137), P10 (= P138), G11 (= G139), E30 (= E158), K31 (≠ R159), G37 (= G165), T38 (≠ V166), C39 (= C167), G43 (= G171), C44 (= C172), K48 (= K176), T111 (≠ V238), G112 (= G239), A140 (= A266), T141 (≠ A267), G142 (= G268), I184 (= I308), R273 (= R395), G312 (= G434), D313 (= D435), M319 (= M441), L320 (= L442), A321 (= A443), H322 (= H444)
1dxlA Dihydrolipoamide dehydrogenase of glycine decarboxylase from pisum sativum (see paper)
43% identity, 76% coverage: 128:578/594 of query aligns to 3:457/467 of 1dxlA
- active site: L38 (= L163), C42 (= C167), C47 (= C172), S50 (= S175), Y184 (≠ I307), E188 (= E311), H444 (= H565), H446 (= H567), E451 (= E572)
- binding flavin-adenine dinucleotide: I9 (≠ L134), P13 (= P138), G14 (= G139), E33 (= E158), K34 (≠ R159), R35 (≠ Y160), G40 (= G165), T41 (≠ V166), C42 (= C167), G46 (= G171), C47 (= C172), K51 (= K176), Y114 (≠ V238), G115 (= G239), T144 (≠ A267), G145 (= G268), Y184 (≠ I307), I185 (= I308), R274 (= R395), D314 (= D435), M320 (= M441), L321 (= L442), A322 (= A443), H323 (= H444)
P31023 Dihydrolipoyl dehydrogenase, mitochondrial; Dihydrolipoamide dehydrogenase; Glycine cleavage system L protein; Pyruvate dehydrogenase complex E3 subunit; E3; PDC-E3; EC 1.8.1.4 from Pisum sativum (Garden pea) (Lathyrus oleraceus) (see 2 papers)
43% identity, 76% coverage: 128:578/594 of query aligns to 37:491/501 of P31023
- 67:76 (vs. 158:167, 50% identical) binding
- C76 (= C167) modified: Disulfide link with 81, Redox-active
- C81 (= C172) modified: Disulfide link with 76, Redox-active
- G149 (= G239) binding
- D348 (= D435) binding
- MLAH 354:357 (= MLAH 441:444) binding
Sites not aligning to the query:
- 1:31 modified: transit peptide, Mitochondrion
6hg8B Crystal structure of the r460g disease-causing mutant of the human dihydrolipoamide dehydrogenase.
41% identity, 76% coverage: 127:577/594 of query aligns to 13:470/482 of 6hg8B
- active site: C53 (= C167), C58 (= C172), S61 (= S175), V196 (≠ I307), E200 (= E311), H460 (= H567), E465 (= E572)
- binding flavin-adenine dinucleotide: I20 (≠ L134), G23 (= G137), P24 (= P138), G25 (= G139), E44 (= E158), K45 (≠ R159), N46 (≠ Y160), G51 (= G165), T52 (≠ V166), C53 (= C167), G57 (= G171), C58 (= C172), K62 (= K176), Y126 (≠ V238), G127 (= G239), T156 (≠ A267), G157 (= G268), I197 (= I308), R288 (= R395), F291 (≠ N398), G327 (= G434), D328 (= D435), M334 (= M441), L335 (= L442), A336 (= A443), H337 (= H444)
1zmdA Crystal structure of human dihydrolipoamide dehydrogenase complexed to nadh (see paper)
41% identity, 75% coverage: 127:573/594 of query aligns to 3:456/472 of 1zmdA
- active site: L39 (= L163), C43 (= C167), C48 (= C172), S51 (= S175), V186 (≠ I307), E190 (= E311), H448 (= H565), H450 (= H567), E455 (= E572)
- binding flavin-adenine dinucleotide: I10 (≠ L134), G11 (= G135), G13 (= G137), P14 (= P138), G15 (= G139), E34 (= E158), K35 (≠ R159), N36 (≠ Y160), G41 (= G165), T42 (≠ V166), C43 (= C167), G47 (= G171), C48 (= C172), K52 (= K176), Y116 (≠ V238), G117 (= G239), T146 (≠ A267), G147 (= G268), S166 (= S287), R278 (= R395), F281 (≠ N398), G317 (= G434), D318 (= D435), M324 (= M441), L325 (= L442), A326 (= A443), H327 (= H444)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I182 (≠ V303), G183 (= G304), G185 (= G306), V186 (≠ I307), I187 (= I308), E190 (= E311), E206 (= E327), F207 (= F328), L208 (≠ M329), I276 (≠ V393), G277 (= G394), R278 (= R395), M324 (= M441), L325 (= L442), V355 (= V472), Y357 (≠ F474)
1zmcA Crystal structure of human dihydrolipoamide dehydrogenase complexed to NAD+ (see paper)
41% identity, 75% coverage: 127:573/594 of query aligns to 3:456/472 of 1zmcA
- active site: L39 (= L163), C43 (= C167), C48 (= C172), S51 (= S175), V186 (≠ I307), E190 (= E311), H448 (= H565), H450 (= H567), E455 (= E572)
- binding flavin-adenine dinucleotide: I10 (≠ L134), G11 (= G135), G13 (= G137), P14 (= P138), G15 (= G139), E34 (= E158), K35 (≠ R159), N36 (≠ Y160), G41 (= G165), T42 (≠ V166), C43 (= C167), G47 (= G171), C48 (= C172), K52 (= K176), Y116 (≠ V238), G117 (= G239), T146 (≠ A267), G147 (= G268), S166 (= S287), I187 (= I308), F281 (≠ N398), G317 (= G434), D318 (= D435), M324 (= M441), L325 (= L442), A326 (= A443), H327 (= H444)
- binding nicotinamide-adenine-dinucleotide: G183 (= G304), G185 (= G306), V205 (= V326), E206 (= E327), F207 (= F328), L208 (≠ M329), K240 (= K360), V241 (= V361), I276 (≠ V393), G277 (= G394), R278 (= R395), R297 (= R414), M324 (= M441)
Query Sequence
>N515DRAFT_2155 FitnessBrowser__Dyella79:N515DRAFT_2155
MANTIEVKVPDIGGHDSVPVIEVLVKAGDSVTKDQSLITLESDKATMEIPSSAAGTIKEV
KVKVGDELSEGAVIVILEVSGDAAAPAAEAPKAAAAPAPAPASAPAPAKAAAPAPQAAGA
SGRTADIECKLVVLGSGPGGYTAAFRAADLGVDTVLVERYATLGGVCLNVGCIPSKALLH
AAAVIDEAEAMAAHGVSFGKPKLDLDKLRSFKNKVVGQLTGGLAGMSRQRKVRTVQGVGS
FVSPHELEVETAEGKKLVRFEHAIIAAGSQSVKLPAFPWDDERVMDSTGALELKDVPGKL
LVVGGGIIGLEMATVYAALGSEVTVVEFMDQLIPGADADLIKPLAKRLGGKLKGVHLKTK
VTEAKATKKGIEVAYEGDSIPETKLFDRVLVAVGRSPNGGKIGADKAGVAVTERGFINVD
TQMRTNVPHIFAIGDLVGQPMLAHKATHEARVAAEVVAGMKSHFDARVIPSVAFTDPEVA
WVGVTEREAKEKGLKIGVGKFPWAASGRAIGIDRTEGFTKLIFDEETHRVVGGAIVGPHA
GDLIAEITHAIEMGSEAADIGLTIHPHPTLSESVGMAAEVYEGTITDLYMPKRK
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory