SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing N515DRAFT_2413 N515DRAFT_2413 simple sugar transport system ATP-binding protein to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

P04983 Ribose import ATP-binding protein RbsA; EC 7.5.2.7 from Escherichia coli (strain K12) (see paper)
37% identity, 95% coverage: 12:489/505 of query aligns to 4:477/501 of P04983

query
sites
P04983

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K43 (= K51) mutation to R: Loss of transport.

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
33% identity, 42% coverage: 20:231/505 of query aligns to 9:217/240 of 4ymuJ

query
sites
4ymuJ

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binding adenosine-5'-triphosphate: F11 (= F22), L14 (≠ T25), V16 (≠ A27), S36 (≠ N47), G37 (= G48), S38 (≠ A49), G39 (= G50), K40 (= K51), S41 (= S52), T42 (= T53), E51 (= E62), E162 (= E176), H194 (= H208)
binding magnesium ion: S41 (= S52), E162 (= E176)

3c4jA Abc protein artp in complex with atp-gamma-s
30% identity, 45% coverage: 12:237/505 of query aligns to 3:225/242 of 3c4jA

query
sites
3c4jA

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binding phosphothiophosphoric acid-adenylate ester: F13 (= F22), V18 (≠ A27), P37 (≠ Q46), S38 (≠ N47), G39 (= G48), S40 (≠ A49), G41 (= G50), K42 (= K51), S43 (= S52), T44 (= T53), H133 (≠ R132), Y135 (= Y151), E164 (= E176)

3c41J Abc protein artp in complex with amp-pnp/mg2+
30% identity, 45% coverage: 12:237/505 of query aligns to 3:225/242 of 3c41J

query
sites
3c41J

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binding phosphoaminophosphonic acid-adenylate ester: F13 (= F22), V18 (≠ A27), P37 (≠ Q46), S38 (≠ N47), G39 (= G48), S40 (≠ A49), G41 (= G50), K42 (= K51), S43 (= S52), T44 (= T53), R47 (≠ K56), H133 (≠ R132), Y135 (= Y151)
binding magnesium ion: S43 (= S52), D163 (= D175)

2olkA Abc protein artp in complex with adp-beta-s
30% identity, 45% coverage: 12:237/505 of query aligns to 3:225/242 of 2olkA

query
sites
2olkA

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G

K
|
K

S
|
S

T
|
T

L

F

I

L

K

R

L

C

L

L

T

N

G

L

V

L

E

E

R

D

P

F

D

D

R

E

G

G

S

E

V

I

E

I

L

I

D

D

G

G

-

I

R

N

V

L

I

K

A

A

P

K

S

D

T

T

P

N

M

L

E

N

A

K

Q

V

R

R

D

E

G

E

I

V

G

G

T

M

V

V

Y

F

Q

Q

E

R

V

F

N

N

L

L

C

F

P

P

N

H

L

M

S

T

V

V

A

L

E

N

N

N

L

I

Y

T

A

L

G

A

-

P

-

M

-

K

-

V

-

R

R

K

Y

W

P

P

R

R

R

E

R

K

R

A

-

E

-

A

-

K

-

A

L

M

R

E

M

L

I

L

D

D

W

K

R

V

Q

G

V

L

R

K

D

D

G

K

A

A

R

H

S

A

L

-

R

-

Q

-

L

-

H

-

L

-

E

-

L

-

D

-

V

-

D

-

A

-

P

-

L

-

G

-

S

-

Y

Y

P

P

V

D

A

S

I

L

R

S

-

G

-

Q

-

A

Q

Q

M

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

G

A

V

M

S

E

A

P

R

K

V

I

L

M

I

L

L

F

D

D

E

E

P

P

T

T

S

S

S

A

L

L

D

D

E

P

G

E

E

M

V

V

R

G

E

E

L

V

F

L

R

S

V

V

I

M

A

K

Q

Q

L

L

R

A

E

N

R

E

G

G

M

M

A

T

I

M

L

V

F

V

V

V

T

T

H

H

F

E

L

M

D

G

Q

F

V

A

Y

R

A

E

V

V

S

G

D

D

R

R

I

V

T

L

V

F

L

M

R

D

D

G

G

G

C

Y

R

I

V

I

G

E

E

E

Y

G

A

K

V

P

A

E

D

D

L

L

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: F13 (= F22), L16 (≠ T25), V18 (≠ A27), S38 (≠ N47), G39 (= G48), S40 (≠ A49), G41 (= G50), K42 (= K51), S43 (= S52), T44 (= T53)

2oljA Abc protein artp in complex with adp/mg2+
30% identity, 45% coverage: 12:237/505 of query aligns to 3:225/242 of 2oljA

query
sites
2oljA

V

M

L

I

Q

D

A

V

R

H

G

Q

L

L

G

K

K

K

R

S

F
|
F

G

G

A

S

T

L

L

E

A
x
V

L

L

D

K

G

G

V

I

D

N

L

V

A

H

L

I

R

R

A

E

G

G

E

E

V

V

H

V

A

V

L

V

M

I

G

G

Q

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

F

I

L

K

R

L

C

L

L

T

N

G

L

V

L

E

E

R

D

P

F

D

D

R

E

G

G

S

E

V

I

E

I

L

I

D

D

G

G

-

I

R

N

V

L

I

K

A

A

P

K

S

D

T

T

P

N

M

L

E

N

A

K

Q

V

R

R

D

E

G

E

I

V

G

G

T

M

V

V

Y

F

Q

Q

E

R

V

F

N

N

L

L

C

F

P

P

N

H

L

M

S

T

V

V

A

L

E

N

N

N

L

I

Y

T

A

L

G

A

-

P

-

M

-

K

-

V

-

R

R

K

Y

W

P

P

R

R

R

E

R

K

R

A

-

E

-

A

-

K

-

A

L

M

R

E

M

L

I

L

D

D

W

K

R

V

Q

G

V

L

R

K

D

D

G

K

A

A

R
x
H

S

A

L

-

R

-

Q

-

L

-

H

-

L

-

E

-

L

-

D

-

V

-

D

-

A

-

P

-

L

-

G

-

S

-

Y
|
Y

P

P

V

D

A

S

I

L

R

S

-

G

-

Q

-

A

Q

Q

M

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

G

A

V

M

S

E

A

P

R

K

V

I

L

M

I

L

L

F

D

D

E

E

P

P

T

T

S

S

S

A

L

L

D

D

E

P

G

E

E

M

V

V

R

G

E

E

L

V

F

L

R

S

V

V

I

M

A

K

Q

Q

L

L

R

A

E

N

R

E

G

G

M

M

A

T

I

M

L

V

F

V

V

V

T

T

H

H

F

E

L

M

D

G

Q

F

V

A

Y

R

A

E

V

V

S

G

D

D

R

R

I

V

T

L

V

F

L

M

R

D

D

G

G

G

C

Y

R

I

V

I

G

E

E

E

Y

G

A

K

V

P

A

E

D

D

L

L

binding adenosine-5'-diphosphate: F13 (= F22), V18 (≠ A27), S38 (≠ N47), G39 (= G48), S40 (≠ A49), G41 (= G50), K42 (= K51), S43 (= S52), T44 (= T53), H133 (≠ R132), Y135 (= Y151)

4u00A Crystal structure of ttha1159 in complex with adp (see paper)
31% identity, 44% coverage: 12:231/505 of query aligns to 2:216/241 of 4u00A

query
sites
4u00A

V

I

L

I

Q

R

A

I

R

R

G

N

L

L

G

H

K

K

R

W

F
|
F

G

G

A

P

T
x
L

L

H

A
x
V

L

L

D

K

G

G

V

I

D

H

L

L

A

E

L

V

R

A

A

P

G

G

E

E

V

K

H

L

A

V

L

I

M

I

G

G

Q

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

I

I

K

R

L

T

L

I

T

N

G

R

V

L

E

E

R

D

P

F

D

Q

R

E

G

G

S

E

V

V

E

V

L

V

D

D

G

G

R

L

V

S

I

V

A

K

P

D

S

D

T

R

P

A

M

L

E

R

A

E

Q

I

R

R

D

R

G

E

I

V

G

G

T

M

V

V

Y

F

Q

Q

E

Q

V

F

N

N

L

L

C

F

P

P

N

H

L

M

S

T

V

V

A

L

E

E

N

N

L

V

Y

T

A

L

G

A

-

P

-

M

-

R

-

V

-

R

R

R

Y

W

P

P

R

R

-

E

-

K

-

A

-

E

R

K

R

A

L

L

R

E

M

L

I

L

D

E

W

R

R

V

Q

G

V

I

R

L

D

D

G

Q

A

A

R

R

S

-

L

-

R

-

Q

-

L

-

H

-

L

-

E

-

L

-

D

-

V

-

D

-

A

-

P

-

L

-

G

-

S

K

Y

Y

P

P

V

A

A

Q

I

L

-

S

-

G

-

Q

R

Q

Q

Q

M

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

G

A

V

M

S

E

A

P

R

K

V

I

L

M

I

L

L

F

D

D

E

E

P

P

T

T

S

S

S

A

L

L

D

D

E

P

G

E

E

M

V

V

R

G

E

E

L

V

F

L

R

D

V

V

I

M

A

R

Q

D

L

L

R

A

E

Q

R

G

G

G

M

M

A

T

I

M

L

V

F

V

V

V

T

T

H

H

F

E

L

M

D

G

Q

F

V

A

Y

R

A

E

V

V

S

A

D

D

R

R

I

V

T

-

V

V

L

F

R

M

D

D

G

G

C

G

R

Q

V

I

G

V

E

E

binding adenosine-5'-diphosphate: F12 (= F22), L15 (≠ T25), V17 (≠ A27), S37 (≠ N47), G38 (= G48), S39 (≠ A49), G40 (= G50), K41 (= K51), S42 (= S52), T43 (= T53)

1g6hA Crystal structure of the adp conformation of mj1267, an atp- binding cassette of an abc transporter (see paper)
29% identity, 44% coverage: 12:231/505 of query aligns to 4:231/254 of 1g6hA

query
sites
1g6hA

V

I

L

L

Q

R

A

T

R

E

G

N

L

I

G

V

K

K

R

Y

F
|
F

G

G

A

E

T
x
F

L

K

A

A

L

L

D

D

G

G

V

V

D

S

L

I

A

S

L

V

R

N

A

K

G

G

E

D

V

V

H

T

A

L

L

I

M

I

G

G

Q

P

N
|
N

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

I

I

K

N

L

V

L

I

T

T

G

G

V

F

E

L

R

K

P

A

D

D

R

E

G

G

S

R

V

V

E

Y

L

F

D

E

G

N

R

K

V

D

I

I

A

T

P

N

S

K

T

E

P

P

M

A

E

E

A

L

Q

Y

R

H

D

Y

G

G

I

I

G

V

T

R

V

T

Y

F

Q

Q

E

T

V

P

N

Q

L

P

C

L

P

K

N

E

L

M

S

T

V

V

A

L

E

E

N

N

L

L

Y

L

A

I

G

G

R

E

Y

I

-

C

P

P

R

G

R

E

R

S

R

P

L

L

R

N

M

S

I

L

D

F

W

Y

R

K

-

K

-

W

-

I

-

P

-

K

-

E

Q

E

V

M

R

V

D

E

G

K

A

A

R

F

S

K

L

I

L

L

R

E

Q

F

L

L

H

K

L

L

E

S

L

H

D

L

V

Y

D

D

A

R

P

K

L

A

G

G

S

E

Y

L

P

S

V

G

A

G

I

Q

R

M

Q

K

M

L

V

V

A

E

I

I

A

G

R

R

A

A

L

L

G

M

V

T

S

N

A

P

R

K

V

M

L

I

I

V

L

M

D

D

E

E

P

P

T

I

S

A

S

G

L

V

D

A

E

P

G

G

E

L

V

A

R

H

E

D

L

I

F

F

R

N

V

H

I

V

A

L

Q

E

L

L

R

K

E

A

R

K

G

G

M

I

A

T

I

F

L

L

F

I

V

I

T

E

H

H

F

R

L

L

D

D

Q

I

V

V

Y

L

A

N

V

Y

S

I

D

D

R

H

I

L

T

Y

V

V

L

M

R

F

D

N

G

G

C

Q

R

I

V

I

G

A

E

E

binding adenosine-5'-diphosphate: F14 (= F22), F17 (≠ T25), N39 (= N47), G40 (= G48), S41 (≠ A49), G42 (= G50), K43 (= K51), S44 (= S52), T45 (= T53)

1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter (see paper)
29% identity, 44% coverage: 12:231/505 of query aligns to 4:231/253 of 1g9xB

query
sites
1g9xB

V

I

L

L

Q

R

A

T

R

E

G

N

L

I

G

V

K

K

R

Y

F
|
F

G

G

A

E

T
x
F

L

K

A

A

L

L

D

D

G

G

V

V

D

S

L

I

A

S

L

V

R

C

A

K

G

G

E

D

V

V

H

T

A

L

L

I

M

I

G

G

Q

P

N
|
N

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

I

I

K

N

L

V

L

I

T

T

G

G

V

F

E

L

R

K

P

A

D

D

R

E

G

G

S

R

V

V

E

Y

L

F

D

E

G

N

R

K

V

D

I

I

A

T

P

N

S

K

T

E

P

P

M

A

E

E

A

L

Q

Y

R

H

D

Y

G

G

I

I

G

V

T

R

V

T

Y

F

Q

Q

E

T

V

P

N

Q

L

P

C

L

P

K

N

E

L

M

S

T

V

V

A

L

E

E

N

N

L

L

Y

L

A

I

G

G

R

E

Y

I

-

N

P

P

R

G

R

E

R

S

R

P

L

L

R

N

M

S

I

L

D

F

W

Y

R

K

-

K

-

W

-

I

-

P

-

K

-

E

Q

E

V

M

R

V

D

E

G

K

A

A

R

F

S

K

L

I

L

L

R

E

Q

F

L

L

H

K

L

L

E

S

L

H

D

L

V

Y

D

D

A

R

P

K

L

A

G

G

S

E

Y

L

P

S

V

G

A

G

I

Q

R

M

Q

K

M

L

V

V

A

E

I

I

A

G

R

R

A

A

L

L

G

M

V

T

S

N

A

P

R

K

V

M

L

I

I

V

L

M

D

D

E
|
E

P

P

T

I

S

A

S

G

L

V

D

A

E

P

G

G

E

L

V

A

R

H

E

D

L

I

F

F

R

N

V

H

I

V

A

L

Q

E

L

L

R

K

E

A

R

K

G

G

M

I

A

T

I

F

L

L

F

I

V

I

T

E

H

H

F

R

L

L

D

D

Q

I

V

V

Y

L

A

N

V

Y

S

I

D

D

R

H

I

L

T

Y

V

V

L

M

R

F

D

N

G

G

C

Q

R

I

V

I

G

A

E

E

binding adenosine-5'-diphosphate: F14 (= F22), F17 (≠ T25), N39 (= N47), G40 (= G48), S41 (≠ A49), G42 (= G50), K43 (= K51), S44 (= S52), T45 (= T53)
binding magnesium ion: S44 (= S52), E176 (= E176)

3d31A Modbc from methanosarcina acetivorans (see paper)
31% identity, 40% coverage: 25:226/505 of query aligns to 13:204/348 of 3d31A

query
sites
3d31A

T

N

L

F

A

S

L

L

D

D

G

N

V

L

D

S

L

L

A

K

L

V

R

E

A

S

G

G

E

E

V

Y

H

F

A

V

L

I

M

L

G

G

Q

P

N

T

G

G

A

A

G

G

K

K

S

T

T

L

L

F

I

L

K

E

L

L

L

I

T

A

G

G

V

F

E

H

R

V

P

P

D

D

R

S

G

G

S

R

V

I

E

L

L

L

D

D

G

G

R

K

V

D

I

V

A

T

P

D

S

L

T

S

P

P

M

-

E

-

A

-

Q

E

R

K

D

H

G

D

I

I

G

A

T

F

V

V

Y

Y

Q

Q

E

N

V

Y

N

S

L

L

C

F

P

P

N

H

L

M

S

N

V

V

A

K

E

K

N

N

L

L

Y

E

A

F

G

G

R

-

Y

-

P

-

R

-

R

M

R

R

R

M

L

K

R

K

M

I

I

K

D

D

W

P

R

K

Q

R

V

V

R

L

D

D

G

T

A

A

R

R

S

-

L

-

R

-

Q

-

L

-

H

-

L

-

E

D

L

L

D

K

V

I

D

E

A

H

P

L

L

L

G

D

S

R

Y

N

P

P

V

L

A

T

I

L

-

S

-

G

-

E

R

Q

Q

Q

M

R

V

V

A

A

I

L

A

A

R

R

A

A

L

L

G

V

V

T

S

N

A

P

R

K

V

I

L

L

I

L

L

L

D

D

E

E

P

P

T

L

S

S

S

A

L

L

D

D

-

P

-

R

-

T

E

Q

G

E

E

N

V

A

R

R

E

E

L

M

F

L

R

S

V

V

I

L

A

H

Q

-

L

-

R

K

E

K

R

N

G

K

M

L

A

T

I

V

L

L

F

H

V

I

T

T

H

H

F

D

L

Q

D

T

Q

E

V

A

Y

R

A

I

V

M

S

A

D

D

R

R

I

I

T

A

V

V

L

V

R

M

D

D

G

G

Sites not aligning to the query:

binding tungstate(vi)ion: 286, 287, 288, 319, 320, 323, 340, 341, 342

Q5SSE9 ATP-binding cassette sub-family A member 13; EC 7.6.2.- from Mus musculus (Mouse) (see paper)
32% identity, 40% coverage: 23:226/505 of query aligns to 4707:4907/5034 of Q5SSE9

query
sites
Q5SSE9

G

G

A

K

T

T

L

T

A

A

L

V

D

H

G

G

V

I

D

S

L

L

A

G

L

I

R

P

A

R

G

G

E

E

V

C

H

F

A

G

L

L

M

L

G

G

Q

V

N

N

G

G

A

A

G

G

K
|
K

S

S

T

T

L

T

I

F

K

K

L

I

L

L

T

N

G

G

V

E

E

T

R

P

P

P

D

S

R

S

G

G

S

Y

V

T

E

V

L

I

D

-

G

-

R

-

V

-

I

-

A

-

P

-

S

R

T

T

P

P

M

Q

E

G

A

D

Q

M

R

V

D

D

-

L

-

A

G

S

I

A

G

G

T

K

V

A

Y

G

Q

I

E

L

V

I

N

G

L

Y

C

C

P

P

N

Q

L

Q

S

D

V

A

A

L

E

D

N

E

L

L

Y

L

A

T

G

G

-

W

-

E

R

H

Y

L

P

Q

R

Y

R

C

R

R

L

L

R

R

M

G

I

I

D

P

W

K

R

Q

Q

Y

V

I

R

P

D

E

G

V

A

A

R

A

S

D

L

L

L

V

R

R

Q
x
R

L

L

H

H

L

L

E

E

L

S

D

H

V

V

D

D

A

K

P

P

L

V

G

A

S

T

Y

Y

P

S

V

G

A

G

I

T

R

R

Q

R

M

K

V

L

A

S

I

T

A

A

R

L

A

A

L

L

G

V

V

G

S

K

A

P

R

D

V

I

L

L

I

L

L

L

D

D

E

E

P

P

T

S

S

S

S

G

L

M

D

D

E

P

G

C

E

S

V

K

R

R

E

Y

L

L

F

W

R

Q

V

T

I

I

A

T

Q

Q

L

E

R

V

E

R

R

D

G

G

M

C

A

A

I

A

L

V

F

L

V

T

T

S

H

H

F

S

L

M

D

E

Q

E

V

C

Y

E

A

A

V

L

S

C

D

T

R

R

I

L

T

A

V

I

L

M

R

V

D

D

G

G

K4735 (= K51) mutation to M: Does not affect intracellular vesicle localization.Affects cholesterol internalization.
R4818 (≠ Q137) mutation to C: Does not affect protein expression. Decreases intracellular cholesterol accumulation in the vesicle.

Sites not aligning to the query:

3577 H→P: Does not affect protein expression. Decreases intracellular cholesterol accumulation in the vesicle.
3849 K→M: Does not affect intracellular vesicle localization. Affects cholesterol internalization.
3999 T→A: Does not affect protein expression. Affects intracellular vesicles localization. Impairs intracellular cholesterol accumulation in the vesicle.

7o12B Abc transporter nosdfy, amppnp-bound in gdn (see paper)
35% identity, 43% coverage: 13:227/505 of query aligns to 3:204/298 of 7o12B

query
sites
7o12B

L

V

Q

E

A

I

R

Q

G

G

L

V

G

S

K

Q

R

R

F
x
Y

G

G

A

S

T

M

L

T

A
x
V

L

L

D

H

G

D

V

L

D

N

L

L

A

N

L

L

R

G

A

E

G

G

E

E

V

V

H

L

A

G

L

L

M

F

G

G

Q
x
H

N
|
N

G
|
G

A
|
A

G
|
G

K
|
K

S
x
T

T
|
T

L

S

I

M

K

K

L

L

L

I

T

L

G

G

V

L

E

L

R

S

P

P

D

S

R

E

G

G

S

Q

V

V

E

K

L

V

D

L

G

G

R

R

V

-

I

-

A

A

P

P

S

N

T

D

P

P

M

Q

E

-

A

-

Q

V

R

R

D

R

G

Q

I

L

G

G

T

Y

V

L

Y

P

Q
x
E

E

N

V

V

N

T

L

F

C

Y

P

P

N

Q

L

L

S

S

V

G

A

R

E

E

N

T

L

L

Y

R

A

-

G

-

R

-

Y

-

P

-

R

H

R

F

R

A

R

R

L

L

R

K

M

G

I

A

D

A

W

L

R

T

Q

Q

V

V

R

D

D

E

G

-

A

-

R

-

S

-

L

L

R

E

Q

Q

L

V

H

G

L

L

E

A

L

H

D

A

V

A

D

D

A

R

P

R

L

V

G

K

S

T

Y

Y

P

S

V

K

A

G

I

M

R

R

Q

Q

M

R

V

L

A

G

I

L

A

A

R

Q

A

A

L

L

G

L

V

G

S

E

A

P

R

R

V

L

L

L

I

L

L

L

D
|
D

E

E

P

P

T

T

S

V

S

G

L

L

D

D

E

P

G

I

E

A

V

T

R

Q

E

D

L

L

F

Y

R

L

V

L

I

I

A

D

Q

R

L

L

R

R

E

Q

R

R

G

G

M

T

A

S

I

I

L

I

F

L

V

C

T

S

H

H

F

V

L

L

D

P

Q

G

V

V

Y

E

A

A

V

H

S

I

D

N

R

R

I

A

T

A

V

I

L

L

R

A

D

K

G

G

C

C

binding phosphoaminophosphonic acid-adenylate ester: Y12 (≠ F22), V17 (≠ A27), H36 (≠ Q46), N37 (= N47), G38 (= G48), A39 (= A49), G40 (= G50), K41 (= K51), T42 (≠ S52), T43 (= T53), E80 (≠ Q94)
binding magnesium ion: T42 (≠ S52), E80 (≠ Q94), D152 (= D175)

7o17B Abc transporter nosdfy e154q, atp-bound in lipid nanodisc (see paper)
34% identity, 43% coverage: 13:227/505 of query aligns to 3:204/298 of 7o17B

query
sites
7o17B

L

V

Q

E

A

I

R

Q

G

G

L

V

G

S

K

Q

R

R

F
x
Y

G

G

A

S

T

M

L

T

A
x
V

L

L

D

H

G

D

V

L

D

N

L

L

A

N

L

L

R

G

A

E

G

G

E

E

V

V

H

L

A

G

L

L

M

F

G

G

Q

H

N
|
N

G
|
G

A
|
A

G
|
G

K
|
K

S
x
T

T
|
T

L

S

I

M

K

K

L

L

L

I

T

L

G

G

V

L

E

L

R

S

P

P

D

S

R

E

G

G

S

Q

V

V

E

K

L

V

D

L

G

G

R

R

V

-

I

-

A

A

P

P

S

N

T

D

P

P

M

Q

E

V

A

-

Q

-

R

R

D

R

G

Q

I

L

G

G

T

Y

V

L

Y

P

Q
x
E

E

N

V

V

N

T

L

F

C

Y

P

P

N

Q

L

L

S

S

V

G

A

R

E

E

N

T

L

L

Y

R

A

-

G

-

R

-

Y

-

P

-

R

H

R

F

R

A

R

R

L

L

R

K

M

G

I

A

D

A

W

L

R

T

Q

Q

V

V

R

D

D

E

G

-

A

-

R

-

S

-

L

L

R

E

Q

Q

L

V

H

G

L

L

E

A

L

H

D

A

V

A

D

D

A
x
R

P

R

L

V

G

K

S
x
T

Y
|
Y

P
x
S

V
x
K

A
x
G

I
x
M

R

R

Q

Q

M

R

V

L

A

G

I

L

A

A

R

Q

A

A

L

L

G

L

V

G

S

E

A

P

R

R

V

L

L

L

I

L

L

L

D

D

E

Q

P

P

T

T

S

V

S

G

L

L

D

D

E

P

G

I

E

A

V

T

R

Q

E

D

L

L

F

Y

R

L

V

L

I

I

A

D

Q

R

L

L

R

R

E

Q

R

R

G

G

M

T

A

S

I

I

L

I

F

L

V

C

T

S

H

H

F

V

L

L

D

P

Q

G

V

V

Y

E

A

A

V

H

S

I

D

N

R

R

I

A

T

A

V

I

L

L

R

A

D

K

G

G

C

C

binding adenosine-5'-triphosphate: Y12 (≠ F22), V17 (≠ A27), N37 (= N47), G38 (= G48), A39 (= A49), G40 (= G50), K41 (= K51), T42 (≠ S52), T43 (= T53), E80 (≠ Q94), R123 (≠ A146), T127 (≠ S150), Y128 (= Y151), S129 (≠ P152), K130 (≠ V153), G131 (≠ A154), M132 (≠ I155)
binding magnesium ion: K41 (= K51), T42 (≠ S52), E80 (≠ Q94)

P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 3 papers)
31% identity, 44% coverage: 5:226/505 of query aligns to 10:224/378 of P69874

query
sites
P69874

S

Q

P

P

A

S

R

L

P

S

V

P

V

L

L

V

Q

Q

A

L

R

A

G

G

L

I

G

R

K

K

R
x
C

F
|
F

G

D

A

G

T

K

L

E

A

V

L

I

D

P

G

Q

V

L

D

D

L

L

A

T

L

I

R

N

A

N

G

G

E

E

V
x
F

H

L

A

T

L

L

M

L

G

G

Q

P

N

S

G

G

A
x
C

G

G

K

K

S

T

T

T

L

V

I
x
L

K

R

L

L

L

I

T

A

G

G

V

L

E

E

R

T

P

V

D

D

R

S

G

G

S

R

V

I

E

M

L
|
L

D

D

G

N

R

E

V

D

I

I

A

-

P

-

S

-

T

T

P

H

M

V

E

P

A

A

Q

E

R

N

D

R

G

Y

I

V

G

N

T

T

V

V

Y

F

Q

Q

E

S

V

Y

N

A

L

L

C

F

P

P

N

H

L

M

S

T

V

V

A

F

E

E

N

N

L

V

Y

A

A

F

G

G

R

-

Y

-

P

-

R

-

R

L

R

R

L

M

R

Q

M

K

I

T

D

P

W

A

R

A

Q

E

V

I

R

T

D

P

G

R

A

V

R

M

S

E

L

A

L

L

R

R

Q

M

L
x
V

H

Q

L

L

E

E

L

T

D

F

V

A

D

Q

A

R

P

K

L

P

G

H

S

Q

Y

L

P

S

V

G

A

G

I

Q

R

Q

Q

Q

M

R

V

V

A

A

I

I

A

A

R

R

A

A

L

V

G

V

V

N

S

K

A

P

R

R

V

L

L

L

I

L

L

L

D
|
D

E

E

P

S

T

L

S

S

S

A

L

L

D

D

E

Y

G

K

E

L

V

R

R

K

E

Q

L

M

F

Q

R

N

V

E

I

L

A

K

Q

A

L

L

-

Q

R

R

E

K

R

L

G

G

M

I

A

T

I

F

L

V

F

F

V

V

T

T

H

H

F

D

L

Q

D

E

Q

E

V

A

Y

L

A

T

V

M

S

S

D

D

R

R

I

I

T

V

V

V

L

M

R

R

D

D

G

G

C26 (≠ R21) mutation to A: Lower ATPase activity and transport efficiency.
F27 (= F22) mutation to L: Lower ATPase activity and transport efficiency.
F45 (≠ V40) mutation to L: Lower ATPase activity and transport efficiency.
C54 (≠ A49) mutation to T: Loss of ATPase activity and transport.
L60 (≠ I55) mutation to F: Lower ATPase activity and transport efficiency.
L76 (= L71) mutation to P: Lower ATPase activity and transport efficiency.
V135 (≠ L138) mutation to M: Loss of ATPase activity and transport.
D172 (= D175) mutation to N: Loss of ATPase activity and transport.

Sites not aligning to the query:

276 C→A: Lower ATPase activity and transport efficiency.
297 mutation E->K,D: Lower ATPase activity and transport efficiency.; E→Q: Loss of ATPase activity and transport.

4yerA Crystal structure of an abc transporter atp-binding protein (tm_1403) from thermotoga maritima msb8 at 2.35 a resolution
29% identity, 43% coverage: 12:226/505 of query aligns to 4:212/285 of 4yerA

query
sites
4yerA

V

I

L

I

Q

V

A

V

R

E

G

N

L

L

G

V

K

K

R

K

F
|
F

G

G

A

D

T
x
F

L

E

A
|
A

L

V

D

K

G

G

V

V

D

S

L

F

A

S

L

V

R

K

A

K

G

G

E

E

V

I

H

F

A

A

L

F

M

L

G

G

Q
x
P

N
|
N

G
|
G

A
|
A

G
|
G

K
|
K

S
x
T

T
|
T

L

T

I

I

K

H

L

M

L

L

T

T

G

T

V

L

E

L

R

K

P

P

D

T

R

S

G

G

S

K

V

A

E

W

L

V

D

A

G

G

R

H

V

D

I

V

A

L

P

K

S

E

T

-

P

P

M

R

E

E

A

V

Q

R

R

R

D

K

G

-

I

I

G

G

T

I

V

V

Y

F

Q

Q

E

D

V

Q

N

S

L

L

C

D

P

R

N

E

L

L

S

T

V

A

A

Y

E

E

N

N

L

M

Y

Y

A

I

G

-

R

-

Y

-

P

-

R

-

R

H

R

G

R

K

L

I

R

Y

M

G

I

Y

D

G

W

G

R

E

Q

K

V

L

R

K

D

K

G

R

A

I

R

L

S

E

L

L

R

E

Q

F

L

V

H

E

L

L

E

L

L

E

D

F

V

K

D

D

A

K

P

P

L

V

G

K

S
x
T

Y
x
F

P
x
S

V

G

A

G

I

M

R

A

Q

R

M

R

V

L

A

E

I

I

A

A

R

R

A

S

L

L

G

I

V

H

S

E

A

P

R

E

V

V

L

L

I

F

L

L

D

D

E

E

P

P

T

T

S

I

S

G

L

L

D

D

E

P

G

H

E

T

V

R

R

A

E

H

L

M

F

W

R

E

V

Y

I

I

A

S

Q

K

L

M

-

K

R

K

E

E

R

H

G

N

M

M

A

T

I

I

L

F

F

L

V

T

T

T

H

H

F

Y

L

M

D

D

Q

E

V

A

Y

E

A

Q

V

L

S

A

D

D

R

R

I

V

T

A

V

I

L

I

R

D

D

H

G

G

binding adenosine-5'-diphosphate: F14 (= F22), F17 (≠ T25), A19 (= A27), P38 (≠ Q46), N39 (= N47), G40 (= G48), A41 (= A49), G42 (= G50), K43 (= K51), T44 (≠ S52), T45 (= T53), T135 (≠ S150), F136 (≠ Y151), S137 (≠ P152)

P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 3 papers)
29% identity, 49% coverage: 27:271/505 of query aligns to 20:269/343 of P30750

query
sites
P30750

A

A

L

L

D

N

G

N

V

V

D

S

L

L

A

H

L

V

R

P

A

A

G

G

E

Q

V

I

H

Y

A

G

L

V

M

I

G

G

Q

A

N
x
S

G
|
G

A
|
A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

I

I

K

R

L

C

L

V

T

N

G

L

V

L

E

E

R

R

P

P

D

T

R

E

G

G

S

S

V

V

E

L

L

V

D

D

G

G

R

Q

V

E

I

L

A

T

-

T

-

L

P

S

S

E

T

S

P

E

M

L

E

T

A

K

Q

A

R

R

D

R

G

Q

I

I

G

G

T

M

V

I

Y

F

Q

Q

E

H

V

F

N

N

L

L

C

L

P

S

N

S

L

R

S

T

V

V

A

F

E

G

N

N

-

V

-

A

-

L

-

P

L

L

Y

E

A

L

G

D

R

N

Y

T

P

P

R

K

R

-

L

-

R

-

M

-

I

-

D

-

W

-

R

D

Q

E

V

V

R

K

D

R

G

R

A

V

R

T

S

E

L

L

R

S

Q

L

L

V

H

G

L

L

E

G

L

D

D

K

V

H

D

D

A

-

P

-

L

-

G

-

S

S

Y

Y

P

P

V

S

A

N

I

L

-

S

-

G

-

Q

R

K

Q

Q

M

R

V

V

A

A

I

I

A

A

R

R

A

A

L

L

G

A

V

S

S

N

A

P

R

K

V

V

L

L

I

L

L

C

D

D

E
|
E

P

A

T

T

S

S

S

A

L

L

D

D

E

P

G

A

E

T

V

T

R

R

E

S

L

I

F

L

R

E

V

L

I

L

A

K

Q

D

L

I

R

N

E

R

R

R

-

L

G

G

M

L

A

T

I

I

L

L

F

L

V

I

T

T

H

H

F

E

L

M

D

D

Q

V

V

V

Y

K

A

R

V

I

S

C

D

D

R

C

I

V

T

A

V

V

L

I

R

S

D

N

G

G

C

E

R

L

V

I

G

E

E

Q

Y

D

A

T

V

V

A

S

D

E

L

V

-

F

-

S

-

H

-

P

-

K

P

T

P

P

A

L

A

A

-

Q

-

K

L

F

V

I

N

Q

A

S

M

T

V

L

G

H

R

L

D

D

L

I

P

P

T

E

V

D

A

Y

G

Q

A

E

D

R

A

L

E

Q

R

A

A

E

P

P

P

F

P

T

D

D

A

C

P

V

P

P

A

M

I

L

40:46 (vs. 47:53, 86% identical) binding
E166 (= E176) mutation to Q: Exhibits little ATPase activity.

Sites not aligning to the query:

278:283 binding
295 N→A: Reduces the binding of L-methionine to undetectable levels.
295:296 binding

1oxvD Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
29% identity, 46% coverage: 15:248/505 of query aligns to 6:242/353 of 1oxvD

query
sites
1oxvD

A

V

R

K

G

N

L

V

G

S

K

K

R

V

F
|
F

-

K

G

G

A

K

T
x
V

L

V

A
|
A

L

L

D

D

G

N

V

V

D

N

L

I

A

N

L

I

R

E

A

N

G

G

E

E

V

R

H

F

A

G

L

I

M

L

G

G

Q
x
P

N
x
S

G
|
G

A
|
A

G
|
G

K
|
K

S
x
T

T
|
T

L

F

I

M

K

R

L

I

T

A

G

G

V

L

E

D

R

V

P

P

D

S

R

T

G

G

S

E

V

L

E

Y

L

F

D

D

G

D

R

R

V

L

I

V

A

A

P

S

S

N

-

G

-

K

-

L

-

I

T

V

P

P

M

P

E

E

A

D

Q

R

R

K

D

-

G

-

I

I

G

G

T

M

V

V

Y

F

Q
|
Q

E

T

V

W

N

A

L

L

C

Y

P

P

N

N

L

L

S

T

V

A

A

F

E

E

N

N

L

I

Y

-

A

-

G

-

R

A

Y

F

P

P

R

-

L

-

R

-

M

L

I

T

D

N

W

M

R

K

Q

M

V

S

R

K

D

E

G

E

A

I

R

R

S

K

L

R

L

V

R

E

Q

E

L

V

H

A

L

K

E

I

L

L

D

D

V

I

D

H

A

H

P

V

L

L

G

N

S

H

Y

F

P

P

V

R

A

E

I

L

-

S

-

G

-

Q

R

Q

Q

Q

M

R

V

V

A

A

I

L

A

A

R

R

A

A

L

L

G

V

V

K

S

D

A

P

R

S

V

L

L

L

I

L

L

L

D

D

E
|
E

P

P

T

F

S

S

S

N

L

L

D

D

E

-

G

A

E

R

V

M

R

R

E

D

L

S

F

A

R

R

-

A

V

L

I

V

A

K

Q

E

L

V

R

Q

E

S

R

R

-

L

G

G

M

V

A

T

I

L

L

L

F

V

V

V

T

S

H

H

F

D

L

P

D

A

Q

D

V

I

Y

F

A

A

V

I

S

A

D

D

R

R

I

V

T

G

V

V

L

L

R

V

D

K

G

G

-

K

-

L

C

V

R

Q

V

V

G

G

E

K

-

P

Y

E

A

D

V

L

A

Y

D

D

L

N

P

P

P

V

A

S

A

I

L

Q

V

V

N

A

A

S

M

L

V

I

G

G

binding phosphoaminophosphonic acid-adenylate ester: F13 (= F22), V18 (≠ T25), A20 (= A27), P39 (≠ Q46), S40 (≠ N47), G41 (= G48), A42 (= A49), G43 (= G50), K44 (= K51), T45 (≠ S52), T46 (= T53), Q89 (= Q94), E166 (= E176)
binding magnesium ion: T45 (≠ S52), Q89 (= Q94)

1oxvA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
29% identity, 46% coverage: 15:248/505 of query aligns to 6:242/353 of 1oxvA

query
sites
1oxvA

A

V

R

K

G

N

L

V

G

S

K

K

R

V

F
|
F

-

K

G

G

A

K

T
x
V

L

V

A
|
A

L

L

D

D

G

N

V

V

D

N

L

I

A

N

L

I

R

E

A

N

G

G

E

E

V

R

H

F

A

G

L

I

M

L

G

G

Q
x
P

N
x
S

G
|
G

A
|
A

G
|
G

K
|
K

S
x
T

T
|
T

L

F

I

M

K

R

L

I

T

A

G

G

V

L

E

D

R

V

P

P

D

S

R

T

G

G

S

E

V

L

E

Y

L

F

D

D

G

D

R

R

V

L

I

V

A

A

P

S

S

N

-

G

-

K

-

L

-

I

T

V

P

P

M

P

E

E

A

D

Q

R

R

K

D

-

G

-

I

I

G

G

T

M

V

V

Y

F

Q

Q

E

T

V

W

N

A

L

L

C

Y

P

P

N

N

L

L

S

T

V

A

A

F

E

E

N

N

L

I

Y

-

A

-

G

-

R

A

Y

F

P

P

R

-

L

-

R

-

M

L

I

T

D

N

W

M

R

K

Q

M

V

S

R

K

D

E

G

E

A

I

R

R

S

K

L

R

L

V

R

E

Q

E

L

V

H

A

L

K

E

I

L

L

D

D

V

I

D

H

A

H

P

V

L

L

G

N

S

H

Y

F

P

P

V

R

A

E

I

L

-

S

-

G

-

Q

R

Q

Q

Q

M

R

V

V

A

A

I

L

A

A

R

R

A

A

L

L

G

V

V

K

S

D

A

P

R

S

V

L

L

L

I

L

L

L

D

D

E
|
E

P

P

T

F

S

S

S

N

L

L

D

D

E

-

G

A

E

R

V

M

R

R

E

D

L

S

F

A

R

R

-

A

V

L

I

V

A

K

Q

E

L

V

R

Q

E

S

R

R

-

L

G

G

M

V

A

T

I

L

L

L

F

V

V

V

T

S

H

H

F

D

L

P

D

A

Q

D

V

I

Y

F

A

A

V

I

S

A

D

D

R

R

I

V

T

G

V

V

L

L

R

V

D

K

G

G

-

K

-

L

C

V

R

Q

V

V

G

G

E

K

-

P

Y

E

A

D

V

L

A

Y

D

D

L

N

P

P

P

V

A

S

A

I

L

Q

V

V

N

A

A

S

M

L

V

I

G

G

binding phosphoaminophosphonic acid-adenylate ester: F13 (= F22), V18 (≠ T25), A20 (= A27), P39 (≠ Q46), S40 (≠ N47), G41 (= G48), A42 (= A49), G43 (= G50), K44 (= K51), T45 (≠ S52), T46 (= T53), E166 (= E176)

1oxuA Crystal structure of glcv, the abc-atpase of the glucose abc transporter from sulfolobus solfataricus (see paper)
29% identity, 46% coverage: 15:248/505 of query aligns to 6:242/353 of 1oxuA

query
sites
1oxuA

A

V

R

K

G

N

L

V

G

S

K

K

R

V

F
|
F

-

K

G

G

A

K

T

V

L

V

A
|
A

L

L

D

D

G

N

V

V

D

N

L

I

A

N

L

I

R

E

A

N

G

G

E

E

V

R

H

F

A

G

L

I

M

L

G

G

Q

P

N
x
S

G
|
G

A
|
A