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Comparing N515DRAFT_2810 FitnessBrowser__Dyella79:N515DRAFT_2810 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
7aqrF Cryo-em structure of arabidopsis thaliana complex-i (peripheral arm) (see paper)
52% identity, 83% coverage: 50:413/436 of query aligns to 49:415/434 of 7aqrF
- binding flavin mononucleotide: G60 (= G61), R61 (= R62), G62 (= G63), K71 (= K72), N89 (= N88), D91 (= D90), Y177 (= Y177), G180 (= G180), E181 (= E181), E182 (= E182), T216 (≠ N216), N217 (= N217)
- binding iron/sulfur cluster: S351 (= S349), C352 (= C350), G353 (= G351), Q354 (= Q352), C355 (= C353), C358 (= C356), T396 (= T394), C398 (= C396), L400 (≠ F398)
7arcF Cryo-em structure of polytomella complex-i (peripheral arm) (see paper)
51% identity, 86% coverage: 50:423/436 of query aligns to 50:426/430 of 7arcF
- binding flavin mononucleotide: G61 (= G61), R62 (= R62), K72 (= K72), N90 (= N88), D92 (= D90), E93 (= E91), S94 (= S92), Y178 (= Y177), G181 (= G180), E182 (= E181), T217 (≠ N216), N218 (= N217), L401 (≠ F398)
- binding iron/sulfur cluster: S352 (= S349), C353 (= C350), G354 (= G351), Q355 (= Q352), C356 (= C353), C359 (= C356), T397 (= T394), C399 (= C396), L401 (≠ F398)
8eswV1 NADH dehydrogenase (Ubiquinone) 24 kDa subunit, isoform A (see paper)
46% identity, 95% coverage: 3:418/436 of query aligns to 12:427/439 of 8eswV1
- binding flavin mononucleotide: G67 (= G61), G69 (= G63), K78 (= K72), N96 (= N88), D98 (= D90), E99 (= E91), G187 (= G180), E188 (= E181), N224 (= N217), A406 (= A397)
- binding iron/sulfur cluster: I185 (= I178), P203 (= P196), C359 (= C350), Q361 (= Q352), C362 (= C353), C365 (= C356), T403 (= T394), I404 (= I395), C405 (= C396), L407 (≠ F398)
- binding : Y143 (≠ H135), N144 (≠ H136), Q150 (≠ E143), D174 (= D167)
8b9zF Drosophila melanogaster complex i in the active state (dm1) (see paper)
46% identity, 95% coverage: 3:418/436 of query aligns to 14:429/441 of 8b9zF
- binding flavin mononucleotide: G69 (= G61), G71 (= G63), K80 (= K72), N98 (= N88), D100 (= D90), G189 (= G180), E191 (= E182), N226 (= N217), A408 (= A397), L409 (≠ F398)
- binding iron/sulfur cluster: P205 (= P196), C361 (= C350), G362 (= G351), Q363 (= Q352), C364 (= C353), C367 (= C356), T405 (= T394), C407 (= C396), L409 (≠ F398)
7b0nF 3.7-angstrom structure of Yarrowia lipolytica complex I with an R121M mutation in NUCM. (see paper)
45% identity, 94% coverage: 8:418/436 of query aligns to 7:421/460 of 7b0nF
- binding flavin mononucleotide: G60 (= G63), K69 (= K72), N90 (= N88), D92 (= D90), E93 (= E91), G94 (≠ S92), Y178 (= Y177), G181 (= G180), E182 (= E181), N218 (= N217)
- binding iron/sulfur cluster: P197 (= P196), S352 (= S349), C353 (= C350), Q355 (= Q352), C356 (= C353), C359 (= C356), T397 (= T394), C399 (= C396)
7o6yB Cryo-em structure of respiratory complex i under turnover (see paper)
45% identity, 94% coverage: 8:418/436 of query aligns to 6:420/457 of 7o6yB
- binding flavin mononucleotide: G57 (= G61), G59 (= G63), K68 (= K72), N89 (= N88), D91 (= D90), E92 (= E91), G180 (= G180), E181 (= E181), E182 (= E182), T216 (≠ N216), N217 (= N217)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G59 (= G63), G60 (= G64), F63 (= F67), K68 (= K72), E94 (= E93), Y177 (= Y177), E182 (= E182), F202 (= F202), T324 (≠ S322)
- binding iron/sulfur cluster: P196 (= P196), S351 (= S349), C352 (= C350), G353 (= G351), Q354 (= Q352), C355 (= C353), C358 (= C356), T396 (= T394), C398 (= C396), L400 (≠ F398)
P49821 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; NDUFV1; Complex I-51kD; CI-51kD; NADH dehydrogenase flavoprotein 1; NADH-ubiquinone oxidoreductase 51 kDa subunit; EC 7.1.1.2 from Homo sapiens (Human) (see paper)
47% identity, 94% coverage: 8:418/436 of query aligns to 36:447/464 of P49821
- C379 (= C350) binding
- C382 (= C353) binding
- C385 (= C356) binding
- C425 (= C396) binding
P25708 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; NDUFV1; Complex I-51kD; CI-51kD; NADH dehydrogenase flavoprotein 1; NADH-ubiquinone oxidoreductase 51 kDa subunit; EC 7.1.1.2 from Bos taurus (Bovine) (see paper)
46% identity, 94% coverage: 8:418/436 of query aligns to 36:447/464 of P25708
- C379 (= C350) binding
- C382 (= C353) binding
- C385 (= C356) binding
- C425 (= C396) binding
6zk91 Peripheral domain of open complex i during turnover (see paper)
46% identity, 94% coverage: 8:418/436 of query aligns to 8:419/430 of 6zk91
- binding flavin mononucleotide: G59 (= G61), G61 (= G63), K70 (= K72), N88 (= N88), D90 (= D90), E91 (= E91), G179 (= G180), E180 (= E181), A215 (≠ N216), N216 (= N217), A398 (= A397), L399 (≠ F398)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G61 (= G63), G62 (= G64), A63 (= A65), F65 (= F67), K70 (= K72), E93 (= E93), Y176 (= Y177), E181 (= E182), F201 (= F202), T323 (≠ S322)
- binding iron/sulfur cluster: I177 (= I178), P195 (= P196), C351 (= C350), G352 (= G351), Q353 (= Q352), C354 (= C353), C357 (= C356), T395 (= T394), C397 (= C396), L399 (≠ F398)
5lnk1 Entire ovine respiratory complex i (see paper)
46% identity, 94% coverage: 8:418/436 of query aligns to 10:421/432 of 5lnk1
- binding fe2/s2 (inorganic) cluster: P96 (= P94), G97 (= G95)
- binding flavin mononucleotide: G61 (= G61), R62 (= R62), K72 (= K72), N90 (= N88), D92 (= D90), E93 (= E91), G94 (≠ S92), Y178 (= Y177), G181 (= G180), E182 (= E181), V216 (≠ I215), A217 (≠ N216), N218 (= N217), T221 (= T220), L401 (≠ F398)
- binding iron/sulfur cluster: P197 (= P196), S352 (= S349), C353 (= C350), Q355 (= Q352), C356 (= C353), C359 (= C356), T397 (= T394), I398 (= I395), C399 (= C396)
7dgq8 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial (see paper)
46% identity, 94% coverage: 8:418/436 of query aligns to 5:416/427 of 7dgq8
- binding flavin mononucleotide: G58 (= G63), K67 (= K72), N85 (= N88), D87 (= D90), E88 (= E91), G89 (≠ S92), C175 (= C179), G176 (= G180), A212 (≠ N216), N213 (= N217)
- binding iron/sulfur cluster: S347 (= S349), C348 (= C350), G349 (= G351), C351 (= C353), C354 (= C356), C394 (= C396), L396 (≠ F398)
- binding : R121 (≠ T124), Y132 (≠ H135), Q139 (≠ E143), R143 (≠ K147), Y146 (= Y150), E147 (≠ A151), F165 (≠ Y169), R168 (≠ L172)
7v2cA Active state complex i from q10 dataset (see paper)
46% identity, 94% coverage: 8:418/436 of query aligns to 11:422/433 of 7v2cA
- binding flavin mononucleotide: G62 (= G61), K73 (= K72), N91 (= N88), Y179 (= Y177), G182 (= G180), E183 (= E181), N219 (= N217), A401 (= A397), L402 (≠ F398)
- binding iron/sulfur cluster: P198 (= P196), C354 (= C350), G355 (= G351), Q356 (= Q352), C357 (= C353), C360 (= C356), T398 (= T394), C400 (= C396), L402 (≠ F398)
8gymv1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (see paper)
47% identity, 95% coverage: 8:421/436 of query aligns to 7:422/442 of 8gymv1
- binding flavin mononucleotide: G58 (= G61), G60 (= G63), N88 (= N88), D90 (= D90), Y176 (= Y177), E180 (= E181), E181 (= E182), T215 (≠ N216), N216 (= N217), T219 (= T220), A398 (= A397), L399 (≠ F398)
- binding iron/sulfur cluster: I177 (= I178), P195 (= P196), C351 (= C350), G352 (= G351), Q353 (= Q352), C354 (= C353), C357 (= C356), T395 (= T394), C397 (= C396), L399 (≠ F398), G400 (= G399)
Q56222 NADH-quinone oxidoreductase subunit 1; NADH dehydrogenase I chain 1; NDH-1 subunit 1; EC 7.1.1.- from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
47% identity, 94% coverage: 7:417/436 of query aligns to 11:421/438 of Q56222
4hea1 Crystal structure of the entire respiratory complex i from thermus thermophilus (see paper)
47% identity, 94% coverage: 7:417/436 of query aligns to 10:420/437 of 4hea1
- binding flavin mononucleotide: G63 (= G61), K74 (= K72), N91 (= N88), D93 (= D90), Y179 (= Y177), G182 (= G180), E183 (= E181), N218 (= N216), N219 (= N217), L401 (≠ F398)
- binding iron/sulfur cluster: I180 (= I178), P198 (= P196), S351 (= S349), C352 (= C350), G353 (= G351), K354 (≠ Q352), C355 (= C353), C358 (= C356), F398 (≠ I395), C399 (= C396), L401 (≠ F398)
2ybb1 Fitted model for bovine mitochondrial supercomplex i1iii2iv1 by single particle cryo-em (emd-1876) (see paper)
47% identity, 94% coverage: 7:417/436 of query aligns to 10:420/437 of 2ybb1
- binding flavin mononucleotide: G63 (= G61), G65 (= G63), N91 (= N88), D93 (= D90), G182 (= G180), E183 (= E181), E184 (= E182), N218 (= N216), N219 (= N217), T222 (= T220), P400 (≠ A397)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G65 (= G63), G66 (= G64), F69 (= F67), K74 (= K72), F77 (= F75), E96 (= E93), Y179 (= Y177), E184 (= E182), K201 (= K199), F204 (= F202), T324 (≠ S322)
- binding iron/sulfur cluster: S351 (= S349), C352 (= C350), K354 (≠ Q352), C355 (= C353), C358 (= C356), F398 (≠ I395), C399 (= C396), L401 (≠ F398), A402 (≠ G399)
Q91YT0 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; NDUFV1; Complex I-51kD; CI-51kD; NADH-ubiquinone oxidoreductase 51 kDa subunit; EC 7.1.1.2 from Mus musculus (Mouse) (see 2 papers)
46% identity, 94% coverage: 8:418/436 of query aligns to 36:447/464 of Q91YT0
- C379 (= C350) binding
- C382 (= C353) binding
- C385 (= C356) binding
- C425 (= C396) binding
Sites not aligning to the query:
- 1:20 modified: transit peptide, Mitochondrion
7zm7B Cryoem structure of mitochondrial complex i from chaetomium thermophilum (inhibited by ddm) (see paper)
46% identity, 94% coverage: 8:418/436 of query aligns to 8:422/456 of 7zm7B
- binding flavin mononucleotide: G59 (= G61), G61 (= G63), K70 (= K72), N91 (= N88), D93 (= D90), G182 (= G180), E183 (= E181), E184 (= E182), A218 (≠ N216), N219 (= N217), A401 (= A397), L402 (≠ F398)
- binding iron/sulfur cluster: P198 (= P196), C354 (= C350), G355 (= G351), Q356 (= Q352), C357 (= C353), C360 (= C356), T398 (= T394), C400 (= C396), L402 (≠ F398)
8e9hF Mycobacterial respiratory complex i, fully-inserted quinone (see paper)
45% identity, 93% coverage: 21:424/436 of query aligns to 15:424/436 of 8e9hF
- binding flavin mononucleotide: G53 (= G61), R54 (= R62), G55 (= G63), A57 (= A65), K64 (= K72), N90 (= N88), D92 (= D90), Y178 (= Y177), G181 (= G180), E182 (= E181), E183 (= E182), N217 (= N216), N218 (= N217), S221 (≠ T220), L398 (≠ F398)
- binding iron/sulfur cluster: P197 (= P196), S349 (= S349), C350 (= C350), G351 (= G351), K352 (≠ Q352), C353 (= C353), C356 (= C356), S394 (≠ T394), F395 (≠ I395), C396 (= C396), L398 (≠ F398), G399 (= G399)
- binding zinc ion: C333 (= C333), E371 (≠ V371), H420 (≠ Y420)
Sites not aligning to the query:
7t30B Structure of electron bifurcating ni-fe hydrogenase complex hydabcsl in fmn/NAD(h) bound state (see paper)
43% identity, 96% coverage: 8:425/436 of query aligns to 2:418/425 of 7t30B
- binding fe2/s2 (inorganic) cluster: C326 (= C333), C364 (≠ V371), H413 (≠ Y420)
- binding flavin mononucleotide: G54 (= G61), G56 (= G63), K65 (= K72), N82 (= N88), D84 (= D90), E85 (= E91), G173 (= G180), E175 (= E182), N210 (= N217), G390 (≠ A397), L391 (≠ F398)
- binding nicotinamide-adenine-dinucleotide: G56 (= G63), G57 (= G64), A58 (= A65), F60 (= F67), K65 (= K72), F68 (= F75), E85 (= E91), E175 (= E182), R192 (≠ K199), F195 (= F202), I312 (≠ G319), M313 (≠ L320), S315 (= S322)
- binding iron/sulfur cluster: S342 (= S349), C343 (= C350), G344 (= G351), C346 (= C353), C349 (= C356), S387 (≠ T394), C389 (= C396), L391 (≠ F398), G392 (= G399)
Sites not aligning to the query:
Query Sequence
>N515DRAFT_2810 FitnessBrowser__Dyella79:N515DRAFT_2810
MAYGPAPQEHQVVYTTLHFDKPWAMDSYTQVGGYEAWKKILAEKPDPNALIEEIKKSNLR
GRGGAGFPTGLKWSFMPKGNMQKYILCNSDESEPGTCKDRDILRFNPHAVIEGMAIACYC
TGSTAAYNYLRGEFHHEPYEHFEEALKEAYAAGLLGKNIQGTGIDVDIYGALGAGAYICG
EETALMESLEGKKGQPRFKPPFPANFGLYGKPSTINNTETYASVPAILRKGADWFLAQSK
TKNGGPKIFSVSGCVQKGGNFEVPLGTTFDELLEMAGGLRPGRKLKGAIPGGVSMPVLKA
EQLKGLPFDYDTLRDLKTGLGSGAIVVLDDTVCTVRFTRRISQFFHKESCGQCTPCREGT
GWMHRVLDRIVEGKGTMEDLHRLKAIAGQIEGHTICAFGEAAAWPVQGFLRQFWDEFEYY
IVNGRSIVDDQIGVAA
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory