Comparing N515DRAFT_3546 FitnessBrowser__Dyella79:N515DRAFT_3546 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
Q3L181 Perakine reductase; EC 1.1.1.317 from Rauvolfia serpentina (Serpentine wood) (Ophioxylon serpentinum) (see paper)
45% identity, 98% coverage: 6:330/330 of query aligns to 6:333/337 of Q3L181
3v0sA Crystal structure of perakine reductase, founder member of a novel akr subfamily with unique conformational changes during NADPH binding (see paper)
43% identity, 95% coverage: 6:318/330 of query aligns to 6:285/287 of 3v0sA
O14295 Pyridoxal reductase; PL reductase; PL-red; EC 1.1.1.65 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
34% identity, 96% coverage: 9:324/330 of query aligns to 5:327/333 of O14295
1pz0A Structure of NADPH-dependent family 11 aldo-keto reductase akr11a(holo) (see paper)
34% identity, 93% coverage: 6:312/330 of query aligns to 5:310/311 of 1pz0A
P46336 Aldo-keto reductase IolS; AKR11A; Vegetative protein 147; VEG147; EC 1.1.1.- from Bacillus subtilis (strain 168) (see paper)
34% identity, 94% coverage: 1:310/330 of query aligns to 1:309/310 of P46336
P80874 Aldo-keto reductase YhdN; AKR11B; General stress protein 69; GSP69; EC 1.1.1.- from Bacillus subtilis (strain 168) (see paper)
37% identity, 87% coverage: 1:288/330 of query aligns to 1:288/331 of P80874
1pz1A Structure of NADPH-dependent family 11 aldo-keto reductase akr11b(holo) (see paper)
37% identity, 87% coverage: 1:288/330 of query aligns to 1:288/333 of 1pz1A
6kiyA Crystal structure of a thermostable aldo-keto reductase tm1743 in complex with inhibitor epalrestat (see paper)
35% identity, 94% coverage: 1:309/330 of query aligns to 2:274/275 of 6kiyA
6kikA Crystal structure of a thermostable aldo-keto reductase tm1743 in complex with inhibitor tolrestat (see paper)
35% identity, 94% coverage: 1:309/330 of query aligns to 2:274/275 of 6kikA
5danA Crystal structure of a novel aldo keto reductase tm1743 from thermotoga maritima in complex with NADP+
35% identity, 94% coverage: 1:309/330 of query aligns to 1:273/274 of 5danA
6ow0A Crystal structure of mithramycin 3-side chain keto-reductase mtmw in complex with NAD+ and peg (see paper)
34% identity, 94% coverage: 1:310/330 of query aligns to 1:316/323 of 6ow0A
4aubB The complex structure of the bacterial aldo-keto reductase akr14a1 with NADP and citrate (see paper)
33% identity, 93% coverage: 1:307/330 of query aligns to 11:318/335 of 4aubB
Sites not aligning to the query:
6ow0B Crystal structure of mithramycin 3-side chain keto-reductase mtmw in complex with NAD+ and peg (see paper)
34% identity, 94% coverage: 1:310/330 of query aligns to 1:292/301 of 6ow0B
P77256 NADH-specific methylglyoxal reductase; AKR11B2; EC 1.1.1.- from Escherichia coli (strain K12) (see paper)
33% identity, 90% coverage: 6:302/330 of query aligns to 6:313/326 of P77256
8hnqA The structure of a alcohol dehydrogenase akr13b2 with NADP
30% identity, 89% coverage: 13:307/330 of query aligns to 25:286/286 of 8hnqA
3n6qD Crystal structure of yghz from e. Coli (see paper)
32% identity, 93% coverage: 1:307/330 of query aligns to 12:305/315 of 3n6qD
6hg6A Clostridium beijerinckii aldo-keto reductase cbei_3974 with NADPH (see paper)
30% identity, 88% coverage: 21:309/330 of query aligns to 29:310/313 of 6hg6A
Q9P7U2 Putative aryl-alcohol dehydrogenase C977.14c; EC 1.1.1.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
32% identity, 93% coverage: 6:312/330 of query aligns to 12:344/351 of Q9P7U2
7wf3C Composite map of human kv1.3 channel in apo state with beta subunits (see paper)
31% identity, 93% coverage: 4:310/330 of query aligns to 7:322/328 of 7wf3C
Q13303 Voltage-gated potassium channel subunit beta-2; K(+) channel subunit beta-2; Kv-beta-2; hKvbeta2; EC 1.1.1.- from Homo sapiens (Human) (see 2 papers)
31% identity, 93% coverage: 4:310/330 of query aligns to 40:355/367 of Q13303
Sites not aligning to the query:
>N515DRAFT_3546 FitnessBrowser__Dyella79:N515DRAFT_3546
MQTRLLGRNGPQVSALGLGCMGMSEFYGARDDAESIATIHHALDRGLTLLDTADIYGPYI
NEELVGKAIRARRGQVFLATKFGIVRDPANPQSRAVSGRPEYVRESVDGSLKRLGVEQID
LYYQHRLDPRTPIEDTVGAMAELVQAGKVRYLGLSEVSAETLERAHAVHPIAAVQSEFSL
WTRDPQENGVLAMCRKLGTALVAYSPLGRGFLTGAYKSPDDFAADDYRRSSPRFLGENFT
RNLQLVDKVTELARDKGCTPAQLALAWVLAQGDDVIGIPGTKRRDRLDENLGALDVKLSG
AELEAIDAIFPPDAAAGPRYAEAMLKFLNA
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
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