SitesBLAST

S109 (≠ V56) to W: in D2HGA1; unknown pathological significance; significant loss of catalytic activity; dbSNP:rs142050154
N127 (≠ V74) to K: in D2HGA1; unknown pathological significance; complete loss of catalytic activity; dbSNP:rs762857195
G131 (= G78) to V: in D2HGA1; unknown pathological significance; complete loss of catalytic activity
I147 (≠ V94) to S: in D2HGA1; severe phenotype; unknown pathological significance; almost complete loss of catalytic activity; dbSNP:rs121434361
M153 (= M100) to T: in D2HGA1; unknown pathological significance; significant loss of catalytic activity; to V: in D2HGA1; unknown pathological significance; significant loss of catalytic activity; dbSNP:rs1432270139
C172 (≠ I119) to Y: in D2HGA1; unknown pathological significance; moderate reduction in catalytic activity; dbSNP:rs773735172
P189 (= P136) to L: in D2HGA1; unknown pathological significance; almost complete loss of catalytic activity; dbSNP:rs587783517
A205 (= A152) to V: in D2HGA1; unknown pathological significance; almost complete loss of catalytic activity; dbSNP:rs750889931
A231 (≠ G178) to V: in D2HGA1; unknown pathological significance; significant loss of catalytic activity
G233 (= G180) to S: in D2HGA1; unknown pathological significance; no effect on catalytic activity; dbSNP:rs374535734
D375 (≠ S319) to Y: in D2HGA1; unknown pathological significance; moderate reduction in catalytic activity; dbSNP:rs267606759
R386 (= R330) binding ; binding ; binding ; mutation to A: Loss of catalytic activity.
T390 (= T334) binding ; binding ; mutation to A: Significantly reduced catalytic activity.
V399 (≠ P342) to M: in D2HGA1; unknown pathological significance; moderate reduction in catalytic activity; dbSNP:rs746519212
K401 (= K344) binding ; binding ; mutation to A: Loss of catalytic activity.
R419 (≠ Q362) to H: in D2HGA1; unknown pathological significance; moderate reduction in catalytic activity; dbSNP:rs199908032
A426 (≠ Y369) to T: in D2HGA1; unknown pathological significance; no effect on catalytic activity; dbSNP:rs146578303
H434 (= H379) binding ; mutation to A: Loss of catalytic activity.
G436 (= G381) to V: slight reduction in catalytic activity
N439 (= N384) to D: in D2HGA1; mild phenotype; unknown pathological significance; moderate reduction in catalytic activity; dbSNP:rs121434362
H441 (= H386) binding ; mutation to A: Loss of catalytic activity.
N443 (= N388) binding ; mutation to A: Significantly reduced catalytic activity.
V444 (= V389) to A: in D2HGA1; severe phenotype; unknown pathological significance; significant reduction in catalytic activity; dbSNP:rs121434360
A446 (≠ C404) to V: in D2HGA1; unknown pathological significance; moderate reduction in catalytic activity; dbSNP:rs746956176
E475 (= E425) binding ; mutation to A: Loss of catalytic activity.
H476 (= H426) binding ; binding ; binding ; mutation to A: Loss of catalytic activity.
G477 (= G427) to R: in D2HGA1; unknown pathological significance; almost complete loss of catalytic activity; dbSNP:rs1453924640

Sites not aligning to the query:

15 R → G: in dbSNP:rs4675887
169:521 natural variant: Missing (in D2HGA1; unknown pathological significance)
400:521 natural variant: Missing (in D2HGA1; unknown pathological significance; complete loss of catalytic activity)

P39976 D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3; D-2HG--pyruvate transhydrogenase DLD3; (R)-2-hydroxyglutarate--pyruvate transhydrogenase; D-lactate dehydrogenase [cytochrome] 3; D-lactate ferricytochrome C oxidoreductase; D-LCR; EC 1.1.99.40; EC 1.1.2.4 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
33% identity, 94% coverage: 28:465/467 of query aligns to 49:494/496 of P39976

query
sites
P39976

A

A

P

P

A

E

D

E

L

L

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A

H

S

Y

F

G

N

R

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D

D

W

W

T

M

R

K

W

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T

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P

G

A

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A

L

I

I

A

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K

A

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A

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K

W

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A

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N

N

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D

H

K

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K

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A

A

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V

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G

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G

D

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