SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing N515DRAFT_4302 FitnessBrowser__Dyella79:N515DRAFT_4302 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

5ifyA Crystal structure of glucose-1-phosphate thymidylyltransferase from burkholderia vietnamiensis in complex with 2 -deoxyuridine-5'- monophosphate and 2'-deoxy-thymidine-b-l-rhamnose
70% identity, 98% coverage: 4:291/295 of query aligns to 2:289/293 of 5ifyA

query
sites
5ifyA

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binding 2'-deoxy-thymidine-beta-l-rhamnose: L7 (= L9), G9 (= G11), Q81 (= Q83), P84 (= P86), G86 (= G88), L87 (= L89), D109 (= D111), Y144 (= Y146), G145 (= G147), E160 (= E162), K161 (= K163), V171 (= V173), Y175 (= Y177), R193 (= R195)
binding 2'-deoxyuridine 5'-monophosphate: Y113 (= Y115), G114 (= G116), H115 (≠ V117), D116 (≠ G118), G217 (= G219), R218 (= R220), G219 (= G221), E254 (= E256), I255 (= I257)

6n0uA Crystal structure of a glucose-1-phosphate thymidylyltransferase from burkholderia phymatum bound to 2'-deoxy-thymidine-b-l-rhamnose
70% identity, 97% coverage: 4:290/295 of query aligns to 4:290/295 of 6n0uA

query
sites
6n0uA

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binding 2'-deoxy-thymidine-beta-l-rhamnose: L9 (= L9), G11 (= G11), G12 (= G12), Q83 (= Q83), P86 (= P86), G88 (= G88), L89 (= L89), L109 (= L109), D111 (= D111), Y146 (= Y146), G147 (= G147), E162 (= E162), K163 (= K163), V173 (= V173), G175 (= G175), Y177 (= Y177), R195 (= R195)

4b2xB Pseudomonas aeruginosa rmla in complex with allosteric inhibitor (see paper)
70% identity, 98% coverage: 4:291/295 of query aligns to 12:299/302 of 4b2xB

query
sites
4b2xB

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binding 6-amino-1-butyl-5-(cyclopentylamino)pyrimidine-2,4(1H,3H)-dione: L54 (= L46), Y122 (≠ F114), E264 (= E256), Q269 (≠ N261)

4asjA Pseudomonas aeruginosa rmla in complex with allosteric inhibitor (see paper)
70% identity, 98% coverage: 4:291/295 of query aligns to 2:289/292 of 4asjA

query
sites
4asjA

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E

binding N-(6-amino-1-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylbenzenesulfonamide: S40 (≠ A42), L44 (= L46), Y112 (≠ F114), G114 (= G116), F117 (≠ L119), V249 (= V251), E254 (= E256)
binding phosphate ion: A155 (≠ V157), V213 (≠ L215)

1g3lA The structural basis of the catalytic mechanism and regulation of glucose-1-phosphate thymidylyltransferase (rmla). Tdp-l-rhamnose complex. (see paper)
70% identity, 98% coverage: 4:291/295 of query aligns to 2:289/292 of 1g3lA

query
sites
1g3lA

R

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K

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I

I

L

L

V

I

I

I

N

S

T

T

P

P

H

Q

E

D

Q

T

P

P

L

R

F

F

E

Q

R

Q

L

L

G

G

D

D

G

G

S

S

Q

N

W

W

G

G

I

L

D

D

I

L

R

Q

Y

Y

A

A

V

V

Q
|
Q

P

P

S

S

P
|
P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

L

L

I

I

G

G

R

E

E

S

F

F

I

I

G

G

N

N

D

D

P

L

S

S

C

A

L

L

V

V

L

L

G

G

D
|
D

N

N

I

L

F

Y

Y
|
Y

G
|
G

V
x
H

G
x
D

L
x
F

T
x
H

E

E

R

L

L

L

K

G

R

S

A

A

S

S

S

Q

R

R

E

Q

H

T

G

G

A

A

T

S

V

V

F

F

G

A

Y

Y

W

H

V

V

R

L

D

D

P

P

E

E

R

R

Y
|
Y

G
|
G

V

V

A

V

E

E

F

F

D

D

S

Q

S

G

G

G

R

K

V

A

I

I

G

S

L

L

E

E

E
|
E

K
|
K

P

P

A

L

Q

E

P

P

K

K

S

S

S

N

Y

Y

A

A

V
|
V

T
|
T

G
|
G

L

L

Y
|
Y

F

F

Y

Y

D

D

N

Q

R

Q

V

V

C

V

D

D

Y

I

A

A

A

R

S

D

L

L

K

K

P

P

S

S

A

P

R
|
R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

L

V

N

N

R

R

V

A

Y

Y

L

L

Q

E

D

R

N

G

S

Q

L

L

H

S

L

V

E

E

Q

I

L

M

G
|
G

R
|
R

G
|
G

F

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

E

D

S

S

L

L

M

L

E

E

A

A

G

G

N

Q

Y

F

I

I

E

A

T

T

I

L

E

E

N

N

R

R

Q

Q

G

G

L

L

K

K

V

V

C

A

C

C

P

P

E

E

E
|
E

I
|
I

A

A

F

Y

I
x
R

N

Q

G

K

W

W

I

I

D

D

A

A

E

A

Q

Q

V

L

L

E

R

K

A

L

A

A

P

P

L

L

A

A

K

K

T

N

G

G

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

K

R

R

L

L

V

L

T

T

Q

E

binding 2'-deoxy-thymidine-beta-l-rhamnose: L7 (= L9), G9 (= G11), G10 (= G12), Q81 (= Q83), P84 (= P86), D109 (= D111), Y113 (= Y115), G114 (= G116), H115 (≠ V117), D116 (≠ G118), F117 (≠ L119), H118 (≠ T120), Y144 (= Y146), G145 (= G147), E160 (= E162), K161 (= K163), V171 (= V173), T172 (= T174), G173 (= G175), Y175 (= Y177), R193 (= R195), G217 (= G219), R218 (= R220), G219 (= G221), E254 (= E256), I255 (= I257), R258 (≠ I260)

1g2vA The structural basis of the catalytic mechanism and regulation of glucose-1-phosphate thymidylyltransferase (rmla). Ttp complex. (see paper)
70% identity, 98% coverage: 4:291/295 of query aligns to 2:289/292 of 1g2vA

query
sites
1g2vA

R

R

K

K

G

G

I

I

L
|
L

A
|
A

G
|
G

S

S

G
|
G

T
|
T

R
|
R

L

L

Y

H

P

P

I

A

T

T

Q

L

A

A

V

I

S

S

K

K

Q
|
Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

A

S

T

T

L

L

M

M

L

L

A

A

G

G

V

I

R

R

E

E

I

I

L

L

V

I

I

I

N

S

T

T

P

P

H

Q

E

D

Q

T

P

P

L

R

F

F

E

Q

R

Q

L

L

G

G

D

D

G

G

S

S

Q

N

W

W

G

G

I

L

D

D

I

L

R

Q

Y

Y

A

A

V

V

Q
|
Q

P

P

S

S

P
|
P

D

D

G

G

L
|
L

A

A

Q

Q

A

A

F

F

L

L

I

I

G

G

R

E

E

S

F

F

I

I

G

G

N

N

D

D

P

L

S

S

C

A

L

L

V

V

L

L

G

G

D
|
D

N

N

I

L

F

Y

Y
|
Y

G
|
G

V
x
H

G
x
D

L
x
F

T
x
H

E

E

R

L

L

L

K

G

R

S

A

A

S

S

S

Q

R

R

E

Q

H

T

G

G

A

A

T

S

V

V

F

F

G

A

Y

Y

W

H

V

V

R

L

D

D

P

P

E

E

R

R

Y

Y

G

G

V

V

A

V

E

E

F

F

D

D

S

Q

S

G

G

G

R

K

V

A

I

I

G

S

L

L

E

E

K

K

P

P

A

L

Q

E

P

P

K

K

S

S

S

N

Y

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

N

Q

R

Q

V

V

C

V

D

D

Y

I

A

A

A

R

S

D

L

L

K

K

P

P

S

S

A

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

L

V

N

N

R

R

V

A

Y

Y

L

L

Q

E

D

R

N

G

S

Q

L

L

H

S

L

V

E

E

Q

I

L

M

G
|
G

R
|
R

G
|
G

F

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

E

D

S

S

L

L

M

L

E

E

A

A

G

G

N

Q

Y

F

I

I

E

A

T

T

I

L

E

E

N

N

R

R

Q

Q

G

G

L

L

K

K

V

V

C

A

C

C

P

P

E

E

E
|
E

I
|
I

A

A

F

Y

I

R

N

Q

G

K

W

W

I

I

D

D

A

A

E

A

Q

Q

V

L

L

E

R

K

A

L

A

A

P

P

L

L

A

A

K

K

T

N

G

G

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

K

R

R

L

L

V

L

T

T

Q

E

binding thymidine-5'-triphosphate: L7 (= L9), A8 (= A10), G9 (= G11), G10 (= G12), G12 (= G14), T13 (= T15), R14 (= R16), Q25 (= Q27), Q81 (= Q83), P84 (= P86), L87 (= L89), D109 (= D111), Y113 (= Y115), G114 (= G116), H115 (≠ V117), D116 (≠ G118), F117 (≠ L119), H118 (≠ T120), G217 (= G219), R218 (= R220), G219 (= G221), E254 (= E256), I255 (= I257)

1g1lA The structural basis of the catalytic mechanism and regulation of glucose-1-phosphate thymidylyltransferase (rmla). Tdp-glucose complex. (see paper)
70% identity, 98% coverage: 4:291/295 of query aligns to 2:289/292 of 1g1lA

query
sites
1g1lA

R

R

K

K

G

G

I

I

L
|
L

A

A

G
|
G

S

S

G

G

T

T

R

R

L

L

Y

H

P

P

I

A

T

T

Q

L

A

A

V

I

S

S

K

K

Q
|
Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

A

S

T

T

L

L

M

M

L

L

A

A

G

G

V

I

R

R

E

E

I

I

L

L

V

I

I

I

N

S

T

T

P

P

H

Q

E

D

Q

T

P

P

L

R

F

F

E

Q

R

Q

L

L

G

G

D

D

G

G

S

S

Q

N

W

W

G

G

I

L

D

D

I

L

R

Q

Y

Y

A

A

V

V

Q
|
Q

P

P

S

S

P
|
P

D

D

G
|
G

L
|
L

A

A

Q

Q

A

A

F

F

L

L

I

I

G

G

R

E

E

S

F

F

I

I

G

G

N

N

D

D

P

L

S

S

C

A

L

L

V

V

L
|
L

G

G

D
|
D

N

N

I

L

F

Y

Y
|
Y

G
|
G

V
x
H

G
x
D

L
x
F

T
x
H

E
|
E

R

L

L

L

K

G

R

S

A

A

S

S

S

Q

R

R

E

Q

H

T

G

G

A

A

T

S

V

V

F

F

G

A

Y

Y

W

H

V

V

R

L

D

D

P

P

E

E

R

R

Y
|
Y

G
|
G

V

V

A

V

E

E

F

F

D

D

S

Q

S

G

G

G

R

K

V

A

I

I

G

S

L

L

E

E

E
|
E

K
|
K

P

P

A

L

Q

E

P

P

K

K

S

S

S

N

Y

Y

A

A

V
|
V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

N

Q

R

Q

V

V

C

V

D

D

Y

I

A

A

A

R

S

D

L

L

K

K

P

P

S

S

A

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

L

V

N

N

R

R

V

A

Y

Y

L

L

Q

E

D

R

N

G

S

Q

L

L

H

S

L

V

E

E

Q

I

L

M

G
|
G

R
|
R

G
|
G

F

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

E

D

S

S

L

L

M

L

E

E

A

A

G

G

N

Q

Y

F

I

I

E

A

T

T

I

L

E

E

N

N

R

R

Q

Q

G

G

L

L

K

K

V
|
V

C
x
A

C

C

P

P

E

E

E
|
E

I
|
I

A

A

F

Y

I
x
R

N

Q

G

K

W

W

I

I

D

D

A

A

E

A

Q

Q

V

L

L

E

R

K

A

L

A

A

P

P

L

L

A

A

K

K

T

N

G

G

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

K

R

R

L

L

V

L

T

T

Q

E

binding 2'deoxy-thymidine-5'-diphospho-alpha-d-glucose: L7 (= L9), G9 (= G11), G10 (= G12), Q25 (= Q27), Q81 (= Q83), P84 (= P86), G86 (= G88), L87 (= L89), L107 (= L109), D109 (= D111), Y113 (= Y115), G114 (= G116), H115 (≠ V117), D116 (≠ G118), F117 (≠ L119), H118 (≠ T120), E119 (= E121), Y144 (= Y146), G145 (= G147), E160 (= E162), K161 (= K163), V171 (= V173), G217 (= G219), R218 (= R220), G219 (= G221), V249 (= V251), A250 (≠ C252), E254 (= E256), I255 (= I257), R258 (≠ I260)

Sites not aligning to the query:

binding 2'deoxy-thymidine-5'-diphospho-alpha-d-glucose: 292

1g0rA The structural basis of the catalytic mechanism and regulation of glucose-1-phosphate thymidylyltransferase (rmla). Thymidine/glucose- 1-phosphate complex. (see paper)
70% identity, 98% coverage: 4:291/295 of query aligns to 2:289/292 of 1g0rA

query
sites
1g0rA

R

R

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

Y

H

P

P

I

A

T

T

Q

L

A

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

A

S

T

T

L

L

M

M

L

L

A

A

G

G

V

I

R

R

E

E

I

I

L

L

V

I

I

I

N

S

T

T

P

P

H

Q

E

D

Q

T

P

P

L

R

F

F

E

Q

R

Q

L

L

G

G

D

D

G

G

S

S

Q

N

W

W

G

G

I

L

D

D

I

L

R

Q

Y

Y

A

A

V

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L
|
L

A

A

Q

Q

A

A

F

F

L

L

I

I

G

G

R

E

E

S

F

F

I

I

G

G

N

N

D

D

P

L

S

S

C

A

L

L

V

V

L

L

G

G

D

D

N

N

I

L

F

Y

Y

Y

G

G

V

H

G

D

L

F

T

H

E

E

R

L

L

L

K

G

R

S

A

A

S

S

S

Q

R

R

E

Q

H

T

G

G

A

A

T

S

V

V

F

F

G

A

Y

Y

W

H

V

V

R

L

D

D

P

P

E

E

R

R

Y
|
Y

G
|
G

V

V

A

V

E

E

F

F

D

D

S

Q

S

G

G

G

R

K

V

A

I

I

G

S

L

L

E

E

E
|
E

K
|
K

P

P

A

L

Q

E

P

P

K

K

S

S

S

N

Y

Y

A

A

V
|
V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

N

Q

R

Q

V

V

C

V

D

D

Y

I

A

A

A

R

S

D

L

L

K

K

P

P

S

S

A

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

L

V

N

N

R

R

V

A

Y

Y

L

L

Q

E

D

R

N

G

S

Q

L

L

H

S

L

V

E

E

Q

I

L

M

G

G

R

R

G

G

F

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

E

D

S

S

L

L

M

L

E

E

A

A

G

G

N

Q

Y

F

I

I

E

A

T

T

I

L

E

E

N

N

R

R

Q

Q

G

G

L

L

K

K

V

V

C

A

C

C

P

P

E

E

I

I

A

A

F

Y

I

R

N

Q

G

K

W

W

I

I

D

D

A

A

E

A

Q

Q

V

L

L

E

R

K

A

L

A

A

P

P

L

L

A

A

K

K

T

N

G

G

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

K

R

R

L

L

V

L

T

T

Q

E

binding 1-O-phosphono-alpha-D-glucopyranose: L87 (= L89), Y144 (= Y146), G145 (= G147), E160 (= E162), K161 (= K163), V171 (= V173)

1fxoA The structural basis of the catalytic mechanism and regulation of glucose-1-phosphate thymidylyltransferase (rmla). Tmp complex. (see paper)
70% identity, 98% coverage: 4:291/295 of query aligns to 2:289/292 of 1fxoA

query
sites
1fxoA

R

R

K

K

G

G

I

I

L
|
L

A

A

G
|
G

S

S

G

G

T

T

R

R

L

L

Y

H

P

P

I

A

T

T

Q

L

A

A

V

I

S

S

K

K

Q
|
Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

A

S

T

T

L

L

M

M

L

L

A

A

G

G

V

I

R

R

E

E

I

I

L

L

V

I

I

I

N

S

T

T

P

P

H

Q

E

D

Q

T

P

P

L

R

F

F

E

Q

R

Q

L

L

G

G

D

D

G

G

S

S

Q

N

W

W

G

G

I

L

D

D

I

L

R

Q

Y

Y

A

A

V

V

Q
|
Q

P

P

S

S

P
|
P

D

D

G
|
G

L
|
L

A

A

Q

Q

A

A

F

F

L

L

I

I

G

G

R

E

E

S

F

F

I

I

G

G

N

N

D

D

P

L

S

S

C

A

L

L

V

V

L

L

G

G

D
|
D

N

N

I

L

F

Y

Y
|
Y

G
|
G

V
x
H

G
x
D

L

F

T

H

E

E

R

L

L

L

K

G

R

S

A

A

S

S

S

Q

R

R

E

Q

H

T

G

G

A

A

T

S

V

V

F

F

G

A

Y

Y

W

H

V

V

R

L

D

D

P

P

E

E

R

R

Y

Y

G

G

V

V

A

V

E

E

F

F

D

D

S

Q

S

G

G

G

R

K

V

A

I

I

G

S

L

L

E

E

K

K

P

P

A

L

Q

E

P

P

K

K

S

S

S

N

Y

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

N

Q

R

Q

V

V

C

V

D

D

Y

I

A

A

A

R

S

D

L

L

K

K

P

P

S

S

A

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

L

V

N

N

R

R

V

A

Y

Y

L

L

Q

E

D

R

N

G

S

Q

L

L

H

S

L

V

E

E

Q

I

L

M

G
|
G

R
|
R

G
|
G

F

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

E

D

S

S

L

L

M

L

E

E

A

A

G

G

N

Q

Y

F

I

I

E

A

T

T

I

L

E

E

N

N

R

R

Q

Q

G

G

L

L

K

K

V
|
V

C

A

C

C

P

P

E

E

E
|
E

I
|
I

A

A

F

Y

I
x
R

N

Q

G

K

W

W

I

I

D

D

A

A

E

A

Q

Q

V

L

L

E

R

K

A

L

A

A

P

P

L

L

A

A

K

K

T

N

G

G

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

K

R

R

L

L

V

L

T

T

Q

E

binding thymidine-5'-phosphate: L7 (= L9), G9 (= G11), G10 (= G12), Q25 (= Q27), Q81 (= Q83), P84 (= P86), G86 (= G88), L87 (= L89), D109 (= D111), Y113 (= Y115), G114 (= G116), H115 (≠ V117), D116 (≠ G118), G217 (= G219), R218 (= R220), G219 (= G221), V249 (= V251), E254 (= E256), I255 (= I257), R258 (≠ I260)

4b5bA Pseudomonas aeruginosa rmla in complex with allosteric inhibitor (see paper)
70% identity, 98% coverage: 4:291/295 of query aligns to 3:290/293 of 4b5bA

query
sites
4b5bA

R

R

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

Y

H

P

P

I

A

T

T

Q

L

A

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

A
x
S

T

T

L

L

M

M

L
|
L

A

A

G

G

V

I

R

R

E

E

I

I

L

L

V

I

I

I

N

S

T

T

P

P

H

Q

E

D

Q

T

P

P

L

R

F

F

E

Q

R

Q

L

L

G

G

D

D

G

G

S

S

Q

N

W

W

G

G

I

L

D

D

I

L

R

Q

Y

Y

A

A

V

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

L

L

I

I

G

G

R

E

E

S

F

F

I

I

G

G

N

N

D

D

P

L

S

S

C

A

L

L

V

V

L

L

G

G

D

D

N

N

I

L

F
x
Y

Y

Y

G
|
G

V

H

G

D

L

F

T

H

E

E

R

L

L

L

K

G

R

S

A

A

S

S

S

Q

R

R

E

Q

H

T

G

G

A

A

T

S

V

V

F

F

G

A

Y

Y

W

H

V

V

R

L

D

D

P

P

E

E

R

R

Y

Y

G

G

V

V

A

V

E

E

F

F

D

D

S

Q

S

G

G

G

R

K

V

A

I

I

G

S

L

L

E

E

K

K

P

P

A

L

Q

E

P

P

K

K

S

S

S

N

Y

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

N

Q

R

Q

V

V

C

V

D

D

Y

I

A

A

A

R

S

D

L

L

K

K

P

P

S

S

A

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

L

V

N

N

R

R

V

A

Y

Y

L

L

Q

E

D

R

N

G

S

Q

L

L

H

S

L

V

E

E

Q

I

L

M

G

G

R

R

G

G

F

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

E

D

S

S

L

L

M

L

E

E

A

A

G

G

N

Q

Y

F

I

I

E

A

T

T

I

L

E

E

N

N

R

R

Q

Q

G

G

L

L

K

K

V
|
V

C
x
A

C

C

P

P

E

E

E
|
E

I
|
I

A

A

F

Y

I

R

N

Q

G

K

W

W

I

I

D

D

A

A

E

A

Q

Q

V

L

L

E

R

K

A

L

A

A

P

P

L

L

A

A

K

K

T

N

G

G

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

K

R

R

L

L

V

L

T

T

Q

E

binding N-(6-amino-1-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N,3-dimethylbenzenesulfonamide: S41 (≠ A42), L45 (= L46), Y113 (≠ F114), G115 (= G116), V250 (= V251), A251 (≠ C252), E255 (= E256), I256 (= I257)

4b4gA Pseudomonas aeruginosa rmla in complex with allosteric inhibitor (see paper)
70% identity, 98% coverage: 4:291/295 of query aligns to 3:290/293 of 4b4gA

query
sites
4b4gA

R

R

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

Y

H

P

P

I

A

T

T

Q

L

A

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

A

S

T

T

L

L

M

M

L
|
L

A

A

G

G

V

I

R

R

E

E

I

I

L

L

V

I

I

I

N

S

T

T

P

P

H

Q

E

D

Q

T

P

P

L

R

F

F

E

Q

R

Q

L

L

G

G

D

D

G

G

S

S

Q

N

W

W

G

G

I

L

D

D

I

L

R

Q

Y

Y

A

A

V

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

L

L

I

I

G

G

R

E

E

S

F

F

I

I

G

G

N

N

D

D

P

L

S

S

C

A

L

L

V

V

L

L

G

G

D

D

N

N

I

L

F
x
Y

Y

Y

G
|
G

V

H

G

D

L
x
F

T

H

E

E

R

L

L

L

K

G

R

S

A

A

S

S

S

Q

R

R

E

Q

H

T

G

G

A

A

T

S

V

V

F

F

G

A

Y

Y

W

H

V

V

R

L

D

D

P

P

E

E

R

R

Y

Y

G

G

V

V

A

V

E

E

F

F

D

D

S

Q

S

G

G

G

R

K

V

A

I

I

G

S

L

L

E

E

K

K

P

P

A

L

Q

E

P

P

K

K

S

S

S

N

Y

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

N

Q

R

Q

V

V

C

V

D

D

Y

I

A

A

A

R

S

D

L

L

K

K

P

P

S

S

A

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

L

V

N

N

R

R

V

A

Y

Y

L

L

Q

E

D

R

N

G

S

Q

L

L

H

S

L

V

E

E

Q

I

L

M

G

G

R

R

G

G

F

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

E

D

S

S

L

L

M

L

E

E

A

A

G

G

N

Q

Y

F

I

I

E

A

T

T

I

L

E

E

N

N

R

R

Q

Q

G

G

L

L

K

K

V
|
V

C
x
A

C

C

P

P

E

E

E
|
E

I
|
I

A

A

F

Y

I
x
R

N

Q

G

K

W

W

I

I

D

D

A

A

E

A

Q

Q

V

L

L

E

R

K

A

L

A

A

P

P

L

L

A

A

K

K

T

N

G

G

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

K

R

R

L

L

V

L

T

T

Q

E

binding N-(6-amino-1-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylbutane-1-sulfonamide: L45 (= L46), Y113 (≠ F114), G115 (= G116), F118 (≠ L119), V250 (= V251), A251 (≠ C252), E255 (= E256), I256 (= I257), R259 (≠ I260)

4b42A Pseudomonas aeruginosa rmla in complex with allosteric inhibitor (see paper)
70% identity, 98% coverage: 4:291/295 of query aligns to 3:290/293 of 4b42A

query
sites
4b42A

R

R

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

Y

H

P

P

I

A

T

T

Q

L

A

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

A
x
S

T
|
T

L

L

M

M

L

L

A

A

G

G

V

I

R

R

E

E

I

I

L

L

V

I

I

I

N

S

T

T

P

P

H

Q

E

D

Q

T

P

P

L

R

F

F

E

Q

R

Q

L

L

G

G

D

D

G

G

S

S

Q

N

W

W

G

G

I

L

D

D

I

L

R

Q

Y

Y

A

A

V

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

L

L

I

I

G

G

R

E

E

S

F

F

I

I

G

G

N

N

D

D

P

L

S

S

C

A

L

L

V

V

L

L

G

G

D

D

N

N

I

L

F
x
Y

Y

Y

G

G

V

H

G

D

L
x
F

T

H

E

E

R

L

L

L

K

G

R

S

A

A

S

S

S

Q

R

R

E

Q

H

T

G

G

A

A

T

S

V

V

F

F

G

A

Y

Y

W

H

V

V

R

L

D

D

P

P

E

E

R

R

Y

Y

G

G

V

V

A

V

E

E

F

F

D

D

S

Q

S

G

G

G

R

K

V

A

I

I

G

S

L

L

E

E

K

K

P

P

A

L

Q

E

P

P

K

K

S

S

S

N

Y

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

N

Q

R

Q

V

V

C

V

D

D

Y

I

A

A

A

R

S

D

L

L

K

K

P

P

S

S

A

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

L

V

N

N

R

R

V

A

Y

Y

L

L

Q

E

D

R

N

G

S

Q

L

L

H

S

L

V

E

E

Q

I

L

M

G

G

R

R

G

G

F

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

E

D

S

S

L

L

M

L

E

E

A

A

G

G

N

Q

Y

F

I

I

E

A

T

T

I

L

E

E

N

N

R

R

Q

Q

G

G

L

L

K

K

V
|
V

C

A

C

C

P

P

E

E

E
|
E

I
|
I

A

A

F

Y

I

R

N

Q

G

K

W

W

I

I

D

D

A

A

E

A

Q

Q

V

L

L

E

R

K

A

L

A

A

P

P

L

L

A

A

K

K

T

N

G

G

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

K

R

R

L

L

V

L

T

T

Q

E

binding N-[6-azanyl-1-butyl-2,4-bis(oxidanylidene)pyrimidin-5-yl]-N-methyl-benzamide: S41 (≠ A42), T42 (= T43), Y113 (≠ F114), F118 (≠ L119), V250 (= V251), E255 (= E256), I256 (= I257)

4b3uA Pseudomonas aeruginosa rmla in complex with allosteric inhibitor (see paper)
70% identity, 98% coverage: 4:291/295 of query aligns to 9:296/299 of 4b3uA

query
sites
4b3uA

R

R

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

Y

H

P

P

I

A

T

T

Q

L

A

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

A

S

T

T

L

L

M

M

L
|
L

A

A

G

G

V

I

R

R

E

E

I

I

L

L

V

I

I

I

N

S

T

T

P

P

H

Q

E

D

Q

T

P

P

L

R

F

F

E

Q

R

Q

L

L

G

G

D

D

G

G

S

S

Q

N

W

W

G

G

I

L

D

D

I

L

R

Q

Y

Y

A

A

V

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

L

L

I

I

G

G

R

E

E

S

F

F

I

I

G

G

N

N

D

D

P

L

S

S

C

A

L

L

V

V

L

L

G

G

D

D

N

N

I

L

F

Y

Y

Y

G

G

V

H

G

D

L

F

T

H

E

E

R

L

L

L

K

G

R

S

A

A

S

S

S

Q

R

R

E

Q

H

T

G

G

A

A

T

S

V

V

F

F

G

A

Y

Y

W

H

V

V

R

L

D

D

P

P

E

E

R

R

Y

Y

G

G

V

V

A

V

E

E

F

F

D

D

S

Q

S

G

G

G

R

K

V

A

I

I

G

S

L

L

E

E

K

K

P

P

A

L

Q

E

P

P

K

K

S

S

S

N

Y

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

N

Q

R

Q

V

V

C

V

D

D

Y

I

A

A

A

R

S

D

L

L

K

K

P

P

S

S

A

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

L

V

N

N

R

R

V

A

Y

Y

L

L

Q

E

D

R

N

G

S

Q

L

L

H

S

L

V

E

E

Q

I

L

M

G

G

R

R

G

G

F

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

E

D

S

S

L

L

M

L

E

E

A

A

G

G

N

Q

Y

F

I

I

E

A

T

T

I

L

E

E

N

N

R

R

Q

Q

G

G

L

L

K

K

V

V

C

A

C

C

P

P

E

E

E
|
E

I
|
I

A

A

F

Y

I
x
R

N
x
Q

G

K

W

W

I

I

D

D

A

A

E

A

Q

Q

V

L

L

E

R

K

A

L

A

A

P

P

L

L

A

A

K

K

T

N

G

G

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

K

R

R

L

L

V

L

T

T

Q

E

binding 6-amino-1-benzyl-5-(ethylamino)pyrimidine-2,4(1H,3H)-dione: L51 (= L46), E261 (= E256), I262 (= I257), R265 (≠ I260), Q266 (≠ N261)

4asyA Pseudomonas aeruginosa rmla in complex with allosteric inhibitor (see paper)
70% identity, 98% coverage: 4:291/295 of query aligns to 3:290/293 of 4asyA

query
sites
4asyA

R

R

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

Y

H

P

P

I

A

T

T

Q

L

A

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

A
x
S

T
|
T

L

L

M

M

L
|
L

A

A

G

G

V

I

R

R

E

E

I

I

L

L

V

I

I

I

N

S

T

T

P

P

H

Q

E

D

Q

T

P

P

L

R

F

F

E

Q

R

Q

L

L

G

G

D

D

G

G

S

S

Q

N

W

W

G

G

I

L

D

D

I

L

R

Q

Y

Y

A

A

V

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

L

L

I

I

G

G

R

E

E

S

F

F

I

I

G

G

N

N

D

D

P

L

S

S

C

A

L

L

V

V

L

L

G

G

D

D

N

N

I

L

F
x
Y

Y

Y

G
|
G

V

H

G

D

L

F

T

H

E

E

R

L

L

L

K

G

R

S

A

A

S

S

S

Q

R

R

E

Q

H

T

G

G

A

A

T

S

V

V

F

F

G

A

Y

Y

W

H

V

V

R

L

D

D

P

P

E

E

R

R

Y

Y

G

G

V

V

A

V

E

E

F

F

D

D

S

Q

S

G

G

G

R

K

V

A

I

I

G

S

L

L

E

E

K

K

P

P

A

L

Q

E

P

P

K

K

S

S

S

N

Y

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

N

Q

R

Q

V

V

C

V

D

D

Y

I

A

A

A

R

S

D

L

L

K

K

P

P

S

S

A

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

L

V

N

N

R

R

V

A

Y

Y

L

L

Q

E

D

R

N

G

S

Q

L

L

H

S

L

V

E

E

Q

I

L

M

G

G

R

R

G

G

F

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

E

D

S

S

L

L

M

L

E

E

A

A

G

G

N

Q

Y

F

I

I

E

A

T

T

I

L

E

E

N

N

R

R

Q

Q

G

G

L

L

K

K

V
|
V

C

A

C

C

P

P

E

E

E
|
E

I

I

A

A

F

Y

I

R

N

Q

G

K

W

W

I

I

D

D

A

A

E

A

Q

Q

V

L

L

E

R

K

A

L

A

A

P

P

L

L

A

A

K

K

T

N

G

G

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

K

R

R

L

L

V

L

T

T

Q

E

binding N-(6-amino-1-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylbenzamide: S41 (≠ A42), T42 (= T43), L45 (= L46), Y113 (≠ F114), G115 (= G116), V250 (= V251), E255 (= E256)

5fuhA Pseudomonas aeruginosa rmla in complex with allosteric inhibitor
70% identity, 98% coverage: 4:291/295 of query aligns to 8:295/298 of 5fuhA

query
sites
5fuhA

R

R

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

Y

H

P

P

I

A

T

T

Q

L

A

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

A

S

T
|
T

L

L

M

M

L
|
L

A

A

G

G

V

I

R

R

E

E

I

I

L

L

V

I

I

I

N

S

T

T

P

P

H

Q

E

D

Q

T

P

P

L

R

F

F

E

Q

R

Q

L

L

G

G

D

D

G

G

S

S

Q

N

W

W

G

G

I

L

D

D

I

L

R

Q

Y

Y

A

A

V

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

L

L

I

I

G

G

R

E

E

S

F

F

I

I

G

G

N

N

D

D

P

L

S

S

C

A

L

L

V

V

L

L

G

G

D

D

N

N

I

L

F
x
Y

Y

Y

G
|
G

V

H

G

D

L
x
F

T

H

E

E

R

L

L

L

K

G

R

S

A

A

S

S

S

Q

R

R

E

Q

H

T

G

G

A

A

T

S

V

V

F

F

G

A

Y

Y

W

H

V

V

R

L

D

D

P

P

E

E

R

R

Y

Y

G

G

V

V

A

V

E

E

F

F

D

D

S

Q

S

G

G

G

R

K

V

A

I

I

G

S

L

L

E

E

K

K

P

P

A

L

Q

E

P

P

K

K

S

S

S

N

Y

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

N

Q

R

Q

V

V

C

V

D

D

Y

I

A

A

A

R

S

D

L

L

K

K

P

P

S

S

A

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

L

V

N

N

R

R

V

A

Y

Y

L

L

Q

E

D

R

N

G

S

Q

L

L

H

S

L

V

E

E

Q

I

L

M

G

G

R

R

G

G

F

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

E

D

S

S

L

L

M

L

E

E

A

A

G

G

N

Q

Y

F

I

I

E

A

T

T

I

L

E

E

N

N

R

R

Q

Q

G

G

L

L

K

K

V

V

C
x
A

C

C

P

P

E

E

I

I

A

A

F

Y

I
x
R

N
x
Q

G

K

W

W

I

I

D

D

A

A

E

A

Q

Q

V

L

L

E

R

K

A

L

A

A

P

P

L

L

A

A

K

K

T

N

G

G

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

K

R

R

L

L

V

L

T

T

Q

E

binding N-[6-amino-1-(3-bromobenzyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl]-N-methylbenzenesulfonamide: T47 (= T43), L50 (= L46), Y118 (≠ F114), G120 (= G116), F123 (≠ L119), A256 (≠ C252), R264 (≠ I260), Q265 (≠ N261)

4b4bA Pseudomonas aeruginosa rmla in complex with allosteric inhibitor (see paper)
70% identity, 98% coverage: 4:291/295 of query aligns to 8:295/298 of 4b4bA

query
sites
4b4bA

R

R

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

Y

H

P

P

I

A

T

T

Q

L

A

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

A

S

T

T

L

L

M

M

L

L

A

A

G

G

V

I

R

R

E

E

I

I

L

L

V

I

I

I

N

S

T

T

P

P

H

Q

E

D

Q

T

P

P

L

R

F

F

E

Q

R

Q

L

L

G

G

D

D

G

G

S

S

Q

N

W

W

G

G

I

L

D

D

I

L

R

Q

Y

Y

A

A

V

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

L

L

I

I

G

G

R

E

E

S

F

F

I

I

G

G

N

N

D

D

P

L

S

S

C

A

L

L

V

V

L

L

G

G

D

D

N

N

I

L

F

Y

Y

Y

G

G

V

H

G

D

L

F

T

H

E

E

R

L

L

L

K

G

R

S

A

A

S

S

S

Q

R

R

E

Q

H

T

G

G

A

A

T

S

V

V

F

F

G

A

Y

Y

W

H

V

V

R

L

D

D

P

P

E

E

R

R

Y

Y

G

G

V

V

A

V

E

E

F

F

D

D

S

Q

S

G

G

G

R

K

V

A

I

I

G

S

L

L

E

E

K

K

P

P

A

L

Q

E

P

P

K

K

S

S

S

N

Y

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

N

Q

R

Q

V

V

C

V

D

D

Y

I

A

A

A

R

S

D

L

L

K

K

P

P

S

S

A

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

L

V

N

N

R

R

V

A

Y

Y

L

L

Q

E

D

R

N

G

S

Q

L

L

H

S

L

V

E

E

Q

I

L

M

G

G

R

R

G

G

F

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

E

D

S

S

L

L

M

L

E

E

A

A

G

G

N

Q

Y

F

I

I

E

A

T

T

I

L

E

E

N

N

R

R

Q

Q

G

G

L

L

K

K

V
|
V

C
x
A

C

C

P

P

E

E

E
|
E

I
|
I

A

A

F

Y

I
x
R

N

Q

G

K

W

W

I

I

D

D

A

A

E

A

Q

Q

V

L

L

E

R

K

A

L

A

A

P

P

L

L

A

A

K

K

T

N

G

G

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

K

R

R

L

L

V

L

T

T

Q

E

binding 1-(2-phenylethyl)pyrimidine-2,4,6(1H,3H,5H)-trione: V255 (= V251), A256 (≠ C252), E260 (= E256), I261 (= I257), R264 (≠ I260)

5fyeA Pseudomonas aeruginosa rmla in complex with allosteric inhibitor
70% identity, 98% coverage: 4:291/295 of query aligns to 6:293/296 of 5fyeA

query
sites
5fyeA

R

R

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

Y

H

P

P

I

A

T

T

Q

L

A

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

A
x
S

T

T

L

L

M

M

L
|
L

A

A

G

G

V

I

R

R

E

E

I

I

L

L

V

I

I

I

N

S

T

T

P

P

H

Q

E

D

Q

T

P

P

L

R

F

F

E

Q

R

Q

L

L

G

G

D

D

G

G

S

S

Q

N

W

W

G

G

I

L

D

D

I

L

R

Q

Y

Y

A

A

V

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

L

L

I

I

G

G

R

E

E

S

F

F

I

I

G

G

N

N

D

D

P

L

S

S

C

A

L

L

V

V

L

L

G

G

D

D

N

N

I

L

F
x
Y

Y

Y

G
|
G

V

H

G

D

L

F

T

H

E

E

R

L

L

L

K

G

R

S

A

A

S

S

S

Q

R

R

E

Q

H

T

G

G

A

A

T

S

V

V

F

F

G

A

Y

Y

W

H

V

V

R

L

D

D

P

P

E

E

R

R

Y

Y

G

G

V

V

A

V

E

E

F

F

D

D

S

Q

S

G

G

G

R

K

V

A

I

I

G

S

L

L

E

E

K

K

P

P

A

L

Q

E

P

P

K

K

S

S

S

N

Y

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

N

Q

R

Q

V

V

C

V

D

D

Y

I

A

A

A

R

S

D

L

L

K

K

P

P

S

S

A

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

L

V

N

N

R

R

V

A

Y

Y

L

L

Q

E

D

R

N

G

S

Q

L

L

H

S

L

V

E

E

Q

I

L

M

G

G

R

R

G

G

F

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

E

D

S

S

L

L

M

L

E

E

A

A

G

G

N

Q

Y

F

I

I

E

A

T

T

I

L

E

E

N

N

R

R

Q

Q

G

G

L

L

K

K

V
|
V

C
x
A

C

C

P

P

E

E

E
|
E

I

I

A

A

F

Y

I
x
R

N

Q

G

K

W

W

I

I

D

D

A

A

E

A

Q

Q

V

L

L

E

R

K

A

L

A

A

P

P

L

L

A

A

K

K

T

N

G

G

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

K

R

R

L

L

V

L

T

T

Q

E

binding N-(6-Amino-1-(3-fluorobenzyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylbenzenesulfonamide: S44 (≠ A42), L48 (= L46), Y116 (≠ F114), G118 (= G116), V253 (= V251), A254 (≠ C252), E258 (= E256), R262 (≠ I260)

5fu0A Pseudomonas aeruginosa rmla in complex with allosteric inhibitor
70% identity, 98% coverage: 4:291/295 of query aligns to 6:293/296 of 5fu0A

query
sites
5fu0A

R

R

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

Y

H

P

P

I

A

T

T

Q

L

A

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

A
x
S

T

T

L

L

M

M

L
|
L

A

A

G

G

V

I

R

R

E

E

I

I

L

L

V

I

I

I

N

S

T

T

P

P

H

Q

E

D

Q

T

P

P

L

R

F

F

E

Q

R

Q

L

L

G

G

D

D

G

G

S

S

Q

N

W

W

G

G

I

L

D

D

I

L

R

Q

Y

Y

A

A

V

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

L

L

I

I

G

G

R

E

E

S

F

F

I

I

G

G

N

N

D

D

P

L

S

S

C

A

L

L

V

V

L

L

G

G

D

D

N

N

I

L

F
x
Y

Y
|
Y

G
|
G

V

H

G

D

L

F

T
x
H

E

E

R

L

L

L

K

G

R

S

A

A

S

S

S

Q

R

R

E

Q

H

T

G

G

A

A

T

S

V

V

F

F

G

A

Y

Y

W

H

V

V

R

L

D

D

P

P

E

E

R

R

Y

Y

G

G

V

V

A

V

E

E

F

F

D

D

S

Q

S

G

G

G

R

K

V

A

I

I

G

S

L

L

E

E

K

K

P

P

A

L

Q

E

P

P

K

K

S

S

S

N

Y

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

N

Q

R

Q

V

V

C

V

D

D

Y

I

A

A

A

R

S

D

L

L

K

K

P

P

S

S

A

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

L

V

N

N

R

R

V

A

Y

Y

L

L

Q

E

D

R

N

G

S

Q

L

L

H

S

L

V

E

E

Q

I

L

M

G

G

R

R

G

G

F

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

E

D

S

S

L

L

M

L

E

E

A

A

G

G

N

Q

Y

F

I

I

E

A

T

T

I

L

E

E

N

N

R

R

Q

Q

G

G

L

L

K

K

V
|
V

C
x
A

C

C

P

P

E

E

E
|
E

I

I

A

A

F

Y

I

R

N
x
Q

G

K

W

W

I

I

D

D

A

A

E

A

Q

Q

V

L

L

E

R

K

A

L

A

A

P

P

L

L

A

A

K

K

T

N

G

G

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

K

R

R

L

L

V

L

T

T

Q

E

binding n-(6-amino-1-(3-methylbenzyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-n-methylbenzenesulfonamide: S44 (≠ A42), L48 (= L46), Y116 (≠ F114), Y117 (= Y115), G118 (= G116), H122 (≠ T120), V253 (= V251), A254 (≠ C252), E258 (= E256), Q263 (≠ N261)

5ftvA Pseudomonas aeruginosa rmla in complex with allosteric inhibitor
70% identity, 98% coverage: 4:291/295 of query aligns to 6:293/296 of 5ftvA

query
sites
5ftvA

R

R

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

Y

H

P

P

I

A

T

T

Q

L

A

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

A
x
S

T

T

L

L

M

M

L
|
L

A

A

G

G

V

I

R

R

E

E

I

I

L

L

V

I

I

I

N

S

T

T

P

P

H

Q

E

D

Q

T

P

P

L

R

F

F

E

Q

R

Q

L

L

G

G

D

D

G

G

S

S

Q

N

W

W

G

G

I

L

D

D

I

L

R

Q

Y

Y

A

A

V

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

L

L

I

I

G

G

R

E

E

S

F

F

I

I

G

G

N

N

D

D

P

L

S

S

C

A

L

L

V

V

L

L

G

G

D

D

N

N

I

L

F
x
Y

Y
|
Y

G
|
G

V

H

G

D

L
x
F

T

H

E

E

R

L

L

L

K

G

R

S

A

A

S

S

S

Q

R

R

E

Q

H

T

G

G

A

A

T

S

V

V

F

F

G

A

Y

Y

W

H

V

V

R

L

D

D

P

P

E

E

R

R

Y

Y

G

G

V

V

A

V

E

E

F

F

D

D

S

Q

S

G

G

G

R

K

V

A

I

I

G

S

L

L

E

E

K

K

P

P

A

L

Q

E

P

P

K

K

S

S

S

N

Y

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

N

Q

R

Q

V

V

C

V

D

D

Y

I

A

A

A

R

S

D

L

L

K

K

P

P

S

S

A

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

L

V

N

N

R

R

V

A

Y

Y

L

L

Q

E

D

R

N

G

S

Q

L

L

H

S

L

V

E

E

Q

I

L

M

G

G

R

R

G

G

F

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

E

D

S

S

L

L

M

L

E

E

A

A

G

G

N

Q

Y

F

I

I

E

A

T

T

I

L

E

E

N

N

R

R

Q

Q

G

G

L

L

K

K

V
|
V

C
x
A

C

C

P

P

E

E

E
|
E

I

I

A

A

F

Y

I
x
R

N
x
Q

G

K

W

W

I

I

D

D

A

A

E

A

Q

Q

V

L

L

E

R

K

A

L

A

A

P

P

L

L

A

A

K

K

T

N

G

G

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

K

R

R

L

L

V

L

T

T

Q

E

binding n-(6-amino-1-(4-bromobenzyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-n-methylbenzenesulfonamide: S44 (≠ A42), L48 (= L46), Y116 (≠ F114), Y117 (= Y115), G118 (= G116), F121 (≠ L119), V253 (= V251), A254 (≠ C252), E258 (= E256), R262 (≠ I260), Q263 (≠ N261)

5ftsA Pseudomonas aeruginosa rmla in complex with allosteric inhibitor
70% identity, 98% coverage: 4:291/295 of query aligns to 6:293/296 of 5ftsA

query
sites
5ftsA

R

R

K

K

G

G

I

I

L

L

A

A

G

G

S

S

G

G

T

T

R

R

L

L

Y

H

P

P

I

A

T

T

Q

L

A

A

V

I

S

S

K

K

Q

Q

L

L

P

P

V

V

Y

Y

D

D

K

K

P

P

M

M

I

I

Y

Y

P

P

L

L

A
x
S

T

T

L

L

M

M

L
|
L

A

A

G

G

V

I

R

R

E

E

I

I

L

L

V

I

I

I

N

S

T

T

P

P

H

Q

E

D

Q

T

P

P

L

R

F

F

E

Q

R

Q

L

L

G

G

D

D

G

G

S

S

Q

N

W

W

G

G

I

L

D

D

I

L

R

Q

Y

Y

A

A

V

V

Q

Q

P

P

S

S

P

P

D

D

G

G

L

L

A

A

Q

Q

A

A

F

F

L

L

I

I

G

G

R

E

E

S

F

F

I

I

G

G

N

N

D

D

P

L

S

S

C

A

L

L

V

V

L

L

G

G

D

D

N

N

I

L

F
x
Y

Y

Y

G
|
G

V

H

G

D

L

F

T
x
H

E

E

R

L

L

L

K

G

R

S

A

A

S

S

S

Q

R

R

E

Q

H

T

G

G

A

A

T

S

V

V

F

F

G

A

Y

Y

W

H

V

V

R

L

D

D

P

P

E

E

R

R

Y

Y

G

G

V

V

A

V

E

E

F

F

D

D

S

Q

S

G

G

G

R

K

V

A

I

I

G

S

L

L

E

E

K

K

P

P

A

L

Q

E

P

P

K

K

S

S

S

N

Y

Y

A

A

V

V

T

T

G

G

L

L

Y

Y

F

F

Y

Y

D

D

N

Q

R

Q

V

V

C

V

D

D

Y

I

A

A

A

R

S

D

L

L

K

K

P

P

S

S

A

P

R

R

G

G

E

E

L

L

E

E

I

I

T

T

D

D

L

V

N

N

R

R

V

A

Y

Y

L

L

Q

E

D

R

N

G

S

Q

L

L

H

S

L

V

E

E

Q

I

L

M

G

G

R

R

G

G

F

Y

A

A

W

W

L

L

D

D

T

T

G

G

T

T

H

H

E

D

S

S

L

L

M

L

E

E

A

A

G

G

N

Q

Y

F

I

I

E

A

T

T

I

L

E

E

N

N

R

R

Q

Q

G

G

L

L

K

K

V
|
V

C
x
A

C

C

P

P

E

E

E
|
E

I
|
I

A

A

F

Y

I

R

N

Q

G

K

W

W

I

I

D

D

A

A

E

A

Q

Q

V

L

L

E

R

K

A

L

A

A

P

P

L

L

A

A

K

K

T

N

G

G

Y

Y

G

G

Q

Q

Y

Y

L

L

Q

K

R

R

L

L

V

L

T

T

Q

E

binding N-(6-Amino-1-(2-bromobenzyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylbenzenesulfonamide: S44 (≠ A42), L48 (= L46), Y116 (≠ F114), G118 (= G116), H122 (≠ T120), V253 (= V251), A254 (≠ C252), E258 (= E256), I259 (= I257)

Query Sequence

>N515DRAFT_4302 FitnessBrowser__Dyella79:N515DRAFT_4302
MSTRKGIILAGGSGTRLYPITQAVSKQLLPVYDKPMIYYPLATLMLAGVREILVINTPHE
QPLFERLLGDGSQWGIDIRYAVQPSPDGLAQAFLIGREFIGNDPSCLVLGDNIFYGVGLT
ERLKRASSREHGATVFGYWVRDPERYGVAEFDSSGRVIGLEEKPAQPKSSYAVTGLYFYD
NRVCDYAASLKPSARGELEITDLNRVYLQDNSLHLEQLGRGFAWLDTGTHESLMEAGNYI
ETIENRQGLKVCCPEEIAFINGWIDAEQVLRAAAPLAKTGYGQYLQRLVTQGHIR

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory