SitesBLAST
Comparing NP_350163.1 NCBI__GCF_000008765.1:NP_350163.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 16 hits to proteins with known functional sites (download)
7e1sC Crystal structure of dehydrogenase/isomerase fabx from helicobacter pylori in complex with octanoyl-acp (see paper)
40% identity, 97% coverage: 3:347/355 of query aligns to 8:363/366 of 7e1sC
- binding S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] octanethioate: L104 (≠ M89), A129 (= A114), G130 (= G115), L131 (= L116), I150 (= I134), I151 (≠ V135), S152 (= S136), E178 (= E162), H185 (= H169), Y280 (≠ M270), I324 (= I308), L328 (= L312)
- binding flavin mononucleotide: G25 (= G20), G26 (= G21), M27 (= M22), G28 (= G23), N102 (= N87), E178 (= E162), S182 (≠ A166), G183 (= G167), G223 (= G212), G224 (= G213), M244 (= M233), A245 (= A234), T246 (= T235), L249 (≠ I238), F342 (= F326), T343 (= T327)
- binding iron/sulfur cluster: C303 (= C292), N306 (= N294), C307 (= C295), V308 (≠ L296), C311 (= C299), G314 (vs. gap), A317 (≠ P301), C323 (= C307), I324 (= I308)
- binding : L131 (= L116), T133 (= T118), N134 (≠ A119), K155 (= K139), I159 (≠ V143), K162 (= K146), R163 (≠ M147), R167 (≠ H151)
7e1sA Crystal structure of dehydrogenase/isomerase fabx from helicobacter pylori in complex with octanoyl-acp (see paper)
40% identity, 97% coverage: 3:347/355 of query aligns to 8:363/366 of 7e1sA
- binding S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] octanethioate: L104 (≠ M89), A129 (= A114), G130 (= G115), I150 (= I134), I151 (≠ V135), S152 (= S136), E178 (= E162), H185 (= H169), G187 (= G171), Y280 (≠ M270), L328 (= L312)
- binding flavin mononucleotide: G25 (= G20), G26 (= G21), M27 (= M22), G28 (= G23), N102 (= N87), L104 (≠ M89), E178 (= E162), G183 (= G167), G223 (= G212), G224 (= G213), Q243 (= Q232), M244 (= M233), A245 (= A234), T246 (= T235)
- binding iron/sulfur cluster: C303 (= C292), N306 (= N294), C307 (= C295), V308 (≠ L296), C311 (= C299), G314 (vs. gap), A317 (≠ P301), C323 (= C307), I324 (= I308)
7e1rA Crystal structure of dehydrogenase/isomerase fabx from helicobacter pylori in complex with holo-acp (see paper)
40% identity, 97% coverage: 3:347/355 of query aligns to 8:363/366 of 7e1rA
- binding flavin mononucleotide: G25 (= G20), G26 (= G21), M27 (= M22), G28 (= G23), N102 (= N87), L104 (≠ M89), E178 (= E162), G183 (= G167), G224 (= G213), Q243 (= Q232), M244 (= M233), A245 (= A234), T246 (= T235), F342 (= F326)
- binding N~3~-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-(2-sulfanylethyl)-beta-alaninamide: G128 (= G113), A129 (= A114), G130 (= G115), E178 (= E162), H185 (= H169), G187 (= G171)
- binding iron/sulfur cluster: C303 (= C292), N306 (= N294), C307 (= C295), V308 (≠ L296), C311 (= C299), G314 (vs. gap), A317 (≠ P301), C323 (= C307), I324 (= I308)
7e1qA Crystal structure of dehydrogenase/isomerase fabx from helicobacter pylori (see paper)
40% identity, 97% coverage: 3:347/355 of query aligns to 8:363/366 of 7e1qA
- binding flavin mononucleotide: G25 (= G20), G26 (= G21), M27 (= M22), G28 (= G23), N102 (= N87), L104 (≠ M89), E178 (= E162), S182 (≠ A166), G183 (= G167), G223 (= G212), G224 (= G213), M244 (= M233), A245 (= A234), T246 (= T235), F342 (= F326)
- binding iron/sulfur cluster: P277 (= P267), C303 (= C292), N306 (= N294), C307 (= C295), V308 (≠ L296), C311 (= C299), G314 (vs. gap), A317 (≠ P301), C323 (= C307), I324 (= I308)
7l00C Crystal structure of c. Difficile enoyl-acyl carrier protein reductase (fabk) in complex with an inhibitor
27% identity, 95% coverage: 16:352/355 of query aligns to 19:307/315 of 7l00C
- binding flavin mononucleotide: G23 (= G20), G24 (= G21), M25 (= M22), A26 (≠ G23), N74 (= N87), E142 (= E162), G146 (≠ A166), G147 (= G167), G174 (= G212), G175 (= G213), Q194 (= Q232), G196 (≠ A234), T197 (= T235), M281 (≠ F326), S285 (≠ K330)
- binding N-[6-(methylsulfonyl)-1,3-benzothiazol-2-yl]-2-[2-(1H-pyrrol-1-yl)-1,3-thiazol-4-yl]acetamide: A26 (≠ G23), M76 (= M89), G100 (= G113), A101 (= A114), G102 (= G115), V121 (≠ I134), P123 (≠ S136), H149 (= H169), L266 (vs. gap), M281 (≠ F326)
5gvhA Structure of fabk from thermotoga maritima (see paper)
26% identity, 96% coverage: 11:350/355 of query aligns to 10:299/311 of 5gvhA
- binding flavin mononucleotide: G19 (= G20), G20 (= G21), M21 (= M22), A22 (≠ G23), N70 (= N87), I72 (≠ M89), E138 (= E162), S142 (≠ A166), G143 (= G167), G170 (= G212), G171 (= G213), Q190 (= Q232), G192 (≠ A234), T193 (= T235), M275 (≠ F326), S279 (≠ K330)
2z6iB Crystal structure of s. Pneumoniae enoyl-acyl carrier protein reductase (fabk) (see paper)
25% identity, 96% coverage: 11:350/355 of query aligns to 9:301/321 of 2z6iB
- binding calcium ion: E137 (= E162), H144 (= H169), A158 (≠ L192), I161 (= I195)
- binding flavin mononucleotide: G18 (= G20), G19 (= G21), M20 (= M22), A21 (≠ G23), N69 (= N87), E137 (= E162), A141 (= A166), G142 (= G167), G169 (= G212), G170 (= G213), G191 (≠ A234), T192 (= T235), M281 (≠ F326)
4iqlA Crystal structure of porphyromonas gingivalis enoyl-acp reductase ii (fabk) with cofactors NADPH and fmn (see paper)
29% identity, 94% coverage: 16:348/355 of query aligns to 13:299/313 of 4iqlA
- binding flavin mononucleotide: G18 (= G21), M19 (= M22), V20 (= V24), N68 (= N87), S94 (≠ G113), E136 (= E162), A140 (= A166), G141 (= G167), G170 (= G212), G171 (= G213), Q190 (= Q232), G192 (≠ A234), T193 (= T235), E277 (≠ F326)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: W21 (≠ G25), W21 (≠ G25), W25 (≠ S29), S44 (≠ F51), M45 (≠ D52), M45 (≠ D52), H46 (≠ E53), N49 (≠ A67), H52 (≠ K70), H53 (= H71), Y73 (≠ M92), P74 (≠ N93), E75 (≠ D94), S202 (≠ D244), K263 (= K302), F267 (≠ Y306)
2z6jA Crystal structure of s. Pneumoniae enoyl-acyl carrier protein reductase (fabk) in complex with an inhibitor (see paper)
25% identity, 96% coverage: 11:350/355 of query aligns to 9:288/307 of 2z6jA
- binding calcium ion: A158 (≠ L192), I161 (= I195)
- binding flavin mononucleotide: G18 (= G20), G19 (= G21), M20 (= M22), A21 (≠ G23), N69 (= N87), E137 (= E162), A141 (= A166), G142 (= G167), G169 (= G212), G170 (= G213), G191 (≠ A234), T192 (= T235)
- binding 2-(4-(2-((3-(5-(pyridin-2-ylthio)thiazol-2-yl)ureido)methyl)-1h-imidazol-4-yl)phenoxy)acetic acid: N45 (= N62), M71 (= M89), L73 (≠ A91), A96 (= A114), G97 (= G115), V116 (≠ I134), P118 (≠ S136), L122 (≠ A140), E137 (= E162), H144 (= H169)
4q4kA Crystal structure of nitronate monooxygenase from pseudomonas aeruginosa pao1 (see paper)
25% identity, 74% coverage: 16:279/355 of query aligns to 14:284/351 of 4q4kA
- binding flavin mononucleotide: A18 (≠ G20), P19 (≠ G21), M20 (= M22), L21 (≠ V24), N69 (= N64), F71 (≠ L68), H133 (≠ I134), Q176 (≠ E162), A180 (= A166), G181 (= G167), G182 (= G168), G217 (= G212), G218 (= G213), G239 (≠ A234), T240 (= T235)
Sites not aligning to the query:
Q9HWH9 Nitronate monooxygenase; NMO; Propionate 3-nitronate monooxygenase; P3N monooxygenase; EC 1.13.12.- from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
25% identity, 74% coverage: 16:279/355 of query aligns to 14:284/351 of Q9HWH9
- L21 (≠ V24) binding FMN
- N69 (= N64) binding FMN
- Q176 (≠ E162) binding FMN
- G181 (= G167) binding FMN
- G218 (= G213) binding FMN
- QMGT 237:240 (≠ QMAT 232:235) binding FMN
4qitA Crystal structure of nitroalkane oxidase from pseudomonas aeruginosa in mutant complex form
24% identity, 74% coverage: 16:279/355 of query aligns to 14:284/350 of 4qitA
- binding flavin mononucleotide: A18 (≠ G20), P19 (≠ G21), M20 (= M22), L21 (≠ V24), N69 (= N64), F71 (≠ L68), H133 (≠ I134), Q176 (≠ E162), A180 (= A166), G181 (= G167), G217 (= G212), G218 (= G213), M238 (= M233), G239 (≠ A234), T240 (= T235)
- binding nitroethane: F71 (≠ L68), G182 (= G168), S183 (≠ H169)
Sites not aligning to the query:
5lsmA Crystal structure of nitronate monooxygenase (so_0471) from shewanella oneidensis mr-1
25% identity, 75% coverage: 14:280/355 of query aligns to 10:275/339 of 5lsmA
- binding flavin mononucleotide: A16 (≠ G20), P17 (≠ G21), M18 (= M22), A19 (≠ G23), N67 (≠ H71), H123 (≠ G113), A170 (= A166), G171 (= G167), G207 (= G212), G208 (= G213), G229 (≠ A234), T230 (= T235)
Sites not aligning to the query:
4qiuB Crystal structure of nitroalkane oxidase from pseudomonas aeruginosa in mutant complex form
24% identity, 74% coverage: 16:279/355 of query aligns to 13:283/350 of 4qiuB
- binding flavin mononucleotide: A17 (≠ G20), P18 (≠ G21), M19 (= M22), L20 (≠ V24), N68 (= N64), F70 (≠ L68), H132 (≠ I134), Q175 (≠ E162), A179 (= A166), G180 (= G167), G181 (= G168), G216 (= G212), G217 (= G213), G238 (≠ A234), T239 (= T235)
- binding 1-nitropropane: L20 (≠ V24)
Sites not aligning to the query:
3bw2A Crystal structures and site-directed mutagenesis study of nitroalkane oxidase from streptomyces ansochromogenes (see paper)
29% identity, 36% coverage: 157:283/355 of query aligns to 162:281/347 of 3bw2A
Sites not aligning to the query:
3bw3A Crystal structures and site-directed mutagenesis study of nitroalkane oxidase from streptomyces ansochromogenes (see paper)
28% identity, 36% coverage: 157:283/355 of query aligns to 162:281/346 of 3bw3A
Sites not aligning to the query:
- binding flavin mononucleotide: 14, 15, 16, 17, 66, 68, 124, 315
- binding nitroethane: 18, 42, 293, 300
Query Sequence
>NP_350163.1 NCBI__GCF_000008765.1:NP_350163.1
MKLPPLQIGDLKADIPIIQGGMGVGISRSSLASAVANCGGVGTISGVQIGFDEPDFETNT
FNANIRALNKHIKKAKQESKRGIIAVNFMVAMNDYDKYVKSAVDAGADLIVSGAGLPTAL
PKIVEGSKVKIAPIVSSPKAASVICKMWDKHHGRIPDLIVVEGPEAGGHLGFKAEQVKGS
HEELSDILTGVLTAIKPFEEKHGVKIPVVCGGGVFYGKDIAKYIKLGASGVQMATRFIAT
EECDANLNYKNVYVNCKEDDIKIVKSPVGMPGRAISNKFVQSNDKNITITKCYNCLKPCN
PKDTPYCISKALINAVNGNVDEALLFTGAKSYKIDKIVKVKELINELISDAECEF
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory