SitesBLAST
Comparing PP_1394 FitnessBrowser__Putida:PP_1394 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
6lpiB Crystal structure of ahas holo-enzyme (see paper)
32% identity, 98% coverage: 3:534/545 of query aligns to 7:517/539 of 6lpiB
- active site: I27 (= I23), G29 (= G25), G30 (≠ V26), S31 (≠ H27), I32 (≠ T28), E53 (= E48), C76 (≠ I71), F115 (≠ L112), Q116 (≠ H113), E117 (= E114), K165 (≠ L163), M256 (≠ T251), A283 (≠ D280), V375 (≠ S383), G401 (= G410), M403 (≠ L412), D428 (= D442), N455 (= N469), A457 (≠ G471), L458 (≠ Y472), L460 (≠ E474), V461 (≠ I475), Q464 (≠ Y478)
- binding flavin-adenine dinucleotide: R155 (= R153), G212 (= G209), G213 (= G210), G214 (= G211), T236 (= T233), L237 (≠ I234), M238 (≠ N235), L254 (vs. gap), M256 (≠ T251), H257 (≠ Q252), G276 (= G271), A277 (≠ T272), R278 (≠ E273), D280 (≠ T277), R282 (≠ Y279), A283 (≠ D280), D300 (= D297), I301 (= I298), D319 (= D316), V320 (≠ A317), M380 (≠ Y388), G398 (≠ T407)
- binding magnesium ion: D428 (= D442), N455 (= N469)
- binding thiamine diphosphate: E53 (= E48), C76 (≠ I71), P79 (= P74), G376 (≠ T384), Q377 (= Q385), H378 (≠ P386), G401 (= G410), M403 (≠ L412), G427 (= G441), D428 (= D442), G429 (= G443), S430 (≠ G444), M433 (≠ F447), N455 (= N469), A457 (≠ G471), L458 (≠ Y472), G459 (≠ E473), L460 (≠ E474), V461 (≠ I475)
6bd9A Saccharomyces cerevisiae acetohydroxyacid synthase
28% identity, 98% coverage: 3:538/545 of query aligns to 11:541/542 of 6bd9A
- active site: Y31 (≠ I23), G33 (= G25), G34 (≠ V26), A35 (≠ H27), I36 (≠ T28), E57 (= E48), T80 (≠ I71), F119 (≠ G110), Q120 (= Q118), E121 (≠ A119), K169 (≠ L163), R228 (vs. gap), M264 (≠ T251), V291 (vs. gap), V407 (≠ N391), L432 (≠ Y409), G433 (= G410), M435 (≠ L412), D460 (= D442), N487 (= N469), E489 (= E474), L502 (≠ V499), G507 (= G504), L508 (≠ A505), K541 (≠ Q538)
- binding flavin-adenine dinucleotide: R159 (= R153), G217 (= G209), A218 (≠ G210), G219 (= G211), N222 (≠ A214), T244 (= T233), L245 (≠ I234), L262 (≠ G249), G263 (≠ S250), H265 (≠ Q252), G284 (= G271), A285 (≠ T272), R286 (≠ E273), D288 (≠ A275), R290 (vs. gap), V291 (vs. gap), E317 (≠ D297), V318 (≠ I298), N322 (≠ Q302), G335 (≠ A315), D336 (= D316), A337 (= A317)
- binding magnesium ion: D460 (= D442), N487 (= N469)
- binding oxygen molecule: G34 (≠ V26), T80 (≠ I71), Q120 (= Q118), A461 (≠ G443), Q494 (≠ M479)
- binding pyruvic acid: G33 (= G25), G34 (≠ V26), G34 (≠ V26), A35 (≠ H27), Q120 (= Q118)
- binding thiamine diphosphate: P32 (= P24), E57 (= E48), V407 (≠ N391), G408 (≠ L392), Q409 (≠ T393), H410 (≠ L394), G433 (= G410), M435 (≠ L412), G459 (= G441), D460 (= D442), A461 (≠ G443), S462 (≠ G444), M465 (≠ F447), N487 (= N469)
1t9bB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
27% identity, 98% coverage: 3:538/545 of query aligns to 9:555/595 of 1t9bB
- active site: Y29 (≠ I23), G31 (= G25), G32 (≠ V26), A33 (≠ H27), I34 (≠ T28), E55 (= E48), T78 (≠ I71), F117 (≠ N117), Q118 (= Q118), E119 (≠ A119), K167 (≠ L163), R226 (vs. gap), M262 (≠ T251), V289 (vs. gap), V405 (≠ N391), L430 (≠ Y409), G431 (= G410), M433 (≠ L412), D458 (= D442), N485 (= N469), E487 (≠ G471), Q488 (≠ Y472), M490 (≠ E474), V491 (≠ I475), W494 (≠ Y478), L516 (≠ V499), G521 (= G504), L522 (≠ A505), K555 (≠ Q538)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (≠ Q100), P108 (≠ S101), D287 (≠ E276), R288 (vs. gap), M490 (≠ E474), W494 (≠ Y478)
- binding flavin-adenine dinucleotide: R157 (= R153), G215 (= G209), A216 (≠ G210), G217 (= G211), N220 (≠ A214), T242 (= T233), L243 (≠ I234), Q244 (≠ N235), M259 (≠ I248), L260 (≠ G249), M262 (≠ T251), H263 (≠ Q252), G282 (= G271), A283 (≠ T272), R284 (≠ E273), D286 (≠ A275), R288 (vs. gap), V289 (vs. gap), E315 (≠ D297), V316 (≠ I298), N320 (≠ Q302), G333 (≠ A315), D334 (= D316), A335 (= A317), Q409 (≠ D395), M410 (= M396), G428 (≠ T407), G429 (= G408)
- binding magnesium ion: D458 (= D442), N485 (= N469), E487 (≠ G471)
1jscA Crystal structure of the catalytic subunit of yeast acetohydroxyacid synthase: a target for herbicidal inhibitors (see paper)
28% identity, 98% coverage: 3:538/545 of query aligns to 11:540/541 of 1jscA
- active site: Y31 (≠ I23), G33 (= G25), G34 (≠ V26), A35 (≠ H27), I36 (≠ T28), E57 (= E48), T80 (≠ I71), F119 (≠ G110), Q120 (= Q118), E121 (≠ A119), K169 (≠ L163), M263 (≠ T251), V290 (vs. gap), V406 (≠ N391), G432 (= G410), M434 (≠ L412), D459 (= D442), N486 (= N469), E488 (= E474), K540 (≠ Q538)
- binding dihydrogenphosphate ion: G33 (= G25), G34 (≠ V26), Q120 (= Q118)
- binding flavin-adenine dinucleotide: R159 (= R153), G216 (= G209), A217 (≠ G210), G218 (= G211), N221 (≠ A214), T243 (= T233), L244 (≠ I234), L261 (≠ G249), G262 (≠ S250), H264 (≠ Q252), G283 (= G271), A284 (≠ T272), R285 (≠ E273), D287 (≠ A275), R289 (vs. gap), V290 (vs. gap), E316 (≠ D297), V317 (≠ I298), N321 (≠ Q302), G334 (≠ A315), D335 (= D316), A336 (= A317)
- binding magnesium ion: D459 (= D442), N486 (= N469)
- binding thiamine diphosphate: Y31 (≠ I23), P32 (= P24), E57 (= E48), P83 (= P74), V406 (≠ N391), G407 (≠ L392), Q408 (≠ T393), H409 (≠ L394), M434 (≠ L412), D459 (= D442), A460 (≠ G443), S461 (≠ G444), N486 (= N469)
1t9aA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
27% identity, 98% coverage: 3:538/545 of query aligns to 10:557/597 of 1t9aA
- active site: Y30 (≠ I23), G32 (= G25), G33 (≠ V26), A34 (≠ H27), I35 (≠ T28), E56 (= E48), T79 (≠ I71), F118 (≠ N117), Q119 (= Q118), E120 (≠ A119), K168 (≠ L163), R228 (vs. gap), M264 (≠ T251), V291 (vs. gap), V407 (≠ N391), L432 (≠ Y409), G433 (= G410), M435 (≠ L412), D460 (= D442), N487 (= N469), E489 (≠ G471), Q490 (≠ Y472), M492 (≠ E474), V493 (≠ I475), W496 (≠ Y478), L518 (≠ V499), G523 (= G504), L524 (≠ A505), K557 (≠ Q538)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: G33 (≠ V26), V108 (≠ Q100), P109 (≠ S101), F118 (≠ N117), K168 (≠ L163), M264 (≠ T251), D289 (≠ E276), R290 (vs. gap), M492 (≠ E474), V493 (≠ I475), W496 (≠ Y478)
- binding flavin-adenine dinucleotide: R158 (= R153), G217 (= G209), A218 (≠ G210), G219 (= G211), N222 (≠ A214), T244 (= T233), L245 (≠ I234), Q246 (≠ N235), L262 (≠ G249), M264 (≠ T251), H265 (≠ Q252), G284 (= G271), A285 (≠ T272), R286 (≠ E273), D288 (≠ A275), R290 (vs. gap), V291 (vs. gap), E317 (≠ D297), V318 (≠ I298), N322 (≠ Q302), G335 (≠ A315), D336 (= D316), A337 (= A317), Q411 (≠ D395), M412 (= M396), G430 (≠ T407), G431 (= G408)
- binding magnesium ion: D460 (= D442), N487 (= N469), E489 (≠ G471)
- binding propyl trihydrogen diphosphate: V407 (≠ N391), G408 (≠ L392), Q409 (≠ T393), H410 (≠ L394), M435 (≠ L412), G459 (= G441), D460 (= D442), A461 (≠ G443), S462 (≠ G444), N487 (= N469), E489 (≠ G471), Q490 (≠ Y472), G491 (≠ E473), M492 (≠ E474)
- binding 5-{[ethyl(methyl)amino]methyl}-2-methyl-5,6-dihydropyrimidin-4-amine: G433 (= G410), M435 (≠ L412), M465 (≠ F447)
6bd3A Saccharomyces cerevisiae acetohydroxyacid synthase
27% identity, 98% coverage: 3:538/545 of query aligns to 11:537/538 of 6bd3A
- active site: Y31 (≠ I23), G33 (= G25), G34 (≠ V26), A35 (≠ H27), I36 (≠ T28), E57 (= E48), T80 (≠ I71), F119 (≠ G110), Q120 (= Q118), E121 (≠ A119), K169 (≠ L163), R225 (vs. gap), M261 (≠ T251), V288 (vs. gap), V404 (≠ N391), L429 (≠ Y409), G430 (= G410), M432 (≠ L412), D457 (= D442), N484 (= N469), L498 (≠ V499), G503 (= G504), L504 (≠ A505), K537 (≠ Q538)
- binding flavin-adenine dinucleotide: R159 (= R153), G214 (= G209), A215 (≠ G210), G216 (= G211), N219 (≠ A214), T241 (= T233), L242 (≠ I234), Q243 (≠ N235), L259 (≠ G249), G260 (≠ S250), H262 (≠ Q252), G281 (= G271), A282 (≠ T272), R283 (≠ E273), D285 (≠ A275), R287 (vs. gap), V288 (vs. gap), E314 (≠ D297), V315 (≠ I298), D333 (= D316), A334 (= A317)
- binding 2-acetyl-thiamine diphosphate: P32 (= P24), E57 (= E48), P83 (= P74)
- binding magnesium ion: D457 (= D442), N484 (= N469)
- binding oxygen molecule: A35 (≠ H27), T80 (≠ I71), S81 (≠ T72), Q120 (= Q118)
- binding thiamine diphosphate: V404 (≠ N391), G405 (≠ L392), Q406 (≠ T393), H407 (≠ L394), G430 (= G410), M432 (≠ L412), D457 (= D442), A458 (≠ G443), S459 (≠ G444), M462 (≠ F447), N484 (= N469)
1t9dA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
27% identity, 98% coverage: 3:538/545 of query aligns to 9:556/596 of 1t9dA
- active site: Y29 (≠ I23), G31 (= G25), G32 (≠ V26), A33 (≠ H27), I34 (≠ T28), E55 (= E48), T78 (≠ I71), F117 (≠ N117), Q118 (= Q118), E119 (≠ A119), K167 (≠ L163), R227 (vs. gap), M263 (≠ T251), V290 (vs. gap), V406 (≠ N391), L431 (≠ Y409), G432 (= G410), M434 (≠ L412), D459 (= D442), N486 (= N469), E488 (≠ G471), Q489 (≠ Y472), M491 (≠ E474), V492 (≠ I475), W495 (≠ Y478), L517 (≠ V499), G522 (= G504), L523 (≠ A505), K556 (≠ Q538)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (≠ V26), A33 (≠ H27), V107 (≠ Q100), P108 (≠ S101), F117 (≠ N117), K167 (≠ L163), M263 (≠ T251), D288 (≠ E276), R289 (vs. gap), W495 (≠ Y478)
- binding flavin-adenine dinucleotide: R157 (= R153), G216 (= G209), A217 (≠ G210), G218 (= G211), N221 (≠ A214), T243 (= T233), L244 (≠ I234), Q245 (≠ N235), M260 (≠ I248), L261 (≠ G249), H264 (≠ Q252), G283 (= G271), A284 (≠ T272), R285 (≠ E273), D287 (≠ A275), R289 (vs. gap), V290 (vs. gap), E316 (≠ D297), V317 (≠ I298), N321 (≠ Q302), G334 (≠ A315), D335 (= D316), A336 (= A317), Q410 (≠ D395), M411 (= M396), G429 (≠ T407), G430 (= G408)
- binding magnesium ion: D459 (= D442), N486 (= N469), E488 (≠ G471)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E55 (= E48), P81 (= P74), Q118 (= Q118), G432 (= G410), M434 (≠ L412), M464 (≠ F447)
1t9dB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
27% identity, 98% coverage: 3:538/545 of query aligns to 8:542/582 of 1t9dB
- active site: Y28 (≠ I23), G30 (= G25), G31 (≠ V26), A32 (≠ H27), I33 (≠ T28), E54 (= E48), T77 (≠ I71), F116 (≠ N117), Q117 (= Q118), E118 (≠ A119), K166 (≠ L163), R213 (vs. gap), M249 (≠ T251), V276 (vs. gap), V392 (≠ N391), L417 (≠ Y409), G418 (= G410), M420 (≠ L412), D445 (= D442), N472 (= N469), E474 (≠ G471), Q475 (≠ Y472), M477 (≠ E474), V478 (≠ I475), W481 (≠ Y478), L503 (≠ V499), G508 (= G504), L509 (≠ A505), K542 (≠ Q538)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G31 (≠ V26), A32 (≠ H27), V106 (≠ Q100), P107 (≠ S101), F116 (≠ N117), K166 (≠ L163), M249 (≠ T251), D274 (≠ E276), R275 (vs. gap), W481 (≠ Y478)
- binding flavin-adenine dinucleotide: R156 (= R153), G202 (= G209), A203 (≠ G210), G204 (= G211), N207 (≠ A214), T229 (= T233), L230 (≠ I234), Q231 (≠ N235), L247 (≠ G249), M249 (≠ T251), H250 (≠ Q252), G269 (= G271), A270 (≠ T272), R271 (≠ E273), D273 (≠ A275), R275 (vs. gap), V276 (vs. gap), E302 (≠ D297), V303 (≠ I298), N307 (≠ Q302), G320 (≠ A315), D321 (= D316), A322 (= A317), Q396 (≠ D395), M397 (= M396), G415 (≠ T407), G416 (= G408)
- binding magnesium ion: D445 (= D442), N472 (= N469), E474 (≠ G471)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E54 (= E48), P80 (= P74), G418 (= G410), M420 (≠ L412), M450 (≠ F447)
5imsA Saccharomyces cerevisiae acetohydroxyacid synthase
27% identity, 98% coverage: 3:538/545 of query aligns to 11:541/541 of 5imsA
- active site: Y31 (≠ I23), G33 (= G25), G34 (≠ V26), A35 (≠ H27), I36 (≠ T28), E57 (= E48), T80 (≠ I71), F119 (≠ G110), Q120 (= Q118), E121 (≠ A119), K169 (≠ L163), R229 (vs. gap), M265 (≠ T251), V292 (vs. gap), V408 (≠ N391), L433 (≠ Y409), G434 (= G410), M436 (≠ L412), D461 (= D442), N488 (= N469), E490 (≠ G471), L502 (≠ V499), G507 (= G504), L508 (≠ A505), K541 (≠ Q538)
- binding flavin-adenine dinucleotide: R159 (= R153), G218 (= G209), A219 (≠ G210), G220 (= G211), N223 (≠ A214), T245 (= T233), L246 (≠ I234), L263 (≠ G249), G264 (≠ S250), H266 (≠ Q252), G285 (= G271), A286 (≠ T272), R287 (≠ E273), D289 (≠ A275), R291 (vs. gap), V292 (vs. gap), E318 (≠ D297), V319 (≠ I298), N323 (≠ Q302), D337 (= D316), A338 (= A317)
- binding magnesium ion: D461 (= D442), N488 (= N469)
- binding oxygen molecule: G34 (≠ V26), T80 (≠ I71), Q120 (= Q118)
- binding thiamine diphosphate: P32 (= P24), E57 (= E48), V408 (≠ N391), G409 (≠ L392), Q410 (≠ T393), H411 (≠ L394), G434 (= G410), M436 (≠ L412), G460 (= G441), D461 (= D442), A462 (≠ G443), S463 (≠ G444), M466 (≠ F447), N488 (= N469)
1t9bA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
27% identity, 98% coverage: 3:538/545 of query aligns to 9:543/583 of 1t9bA
- active site: Y29 (≠ I23), G31 (= G25), G32 (≠ V26), A33 (≠ H27), I34 (≠ T28), E55 (= E48), T78 (≠ I71), F117 (≠ N117), Q118 (= Q118), E119 (≠ A119), K167 (≠ L163), R214 (vs. gap), M250 (≠ T251), V277 (vs. gap), V393 (≠ N391), L418 (≠ Y409), G419 (= G410), M421 (≠ L412), D446 (= D442), N473 (= N469), E475 (≠ G471), Q476 (≠ Y472), M478 (≠ E474), V479 (≠ I475), W482 (≠ Y478), L504 (≠ V499), G509 (= G504), L510 (≠ A505), K543 (≠ Q538)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (≠ Q100), P108 (≠ S101), F117 (≠ N117), D275 (≠ E276), R276 (vs. gap), M478 (≠ E474), W482 (≠ Y478)
- binding flavin-adenine dinucleotide: R157 (= R153), G203 (= G209), A204 (≠ G210), G205 (= G211), N208 (≠ A214), T230 (= T233), L231 (≠ I234), Q232 (≠ N235), M247 (≠ I248), L248 (≠ G249), M250 (≠ T251), H251 (≠ Q252), G270 (= G271), A271 (≠ T272), R272 (≠ E273), D274 (≠ A275), R276 (vs. gap), V277 (vs. gap), E303 (≠ D297), V304 (≠ I298), N308 (≠ Q302), D322 (= D316), A323 (= A317), Q397 (≠ D395), M398 (= M396), G416 (≠ T407), G417 (= G408)
- binding magnesium ion: D446 (= D442), N473 (= N469), E475 (≠ G471)
1n0hA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorimuron ethyl (see paper)
27% identity, 98% coverage: 3:538/545 of query aligns to 11:559/599 of 1n0hA
- active site: Y31 (≠ I23), G33 (= G25), G34 (≠ V26), A35 (≠ H27), I36 (≠ T28), E57 (= E48), T80 (≠ I71), F119 (≠ N117), Q120 (= Q118), E121 (≠ A119), K169 (≠ L163), R230 (vs. gap), M266 (≠ T251), V293 (vs. gap), V409 (≠ N391), L434 (≠ Y409), G435 (= G410), M437 (≠ L412), D462 (= D442), N489 (= N469), E491 (≠ G471), Q492 (≠ Y472), M494 (≠ E474), V495 (≠ I475), W498 (≠ Y478), L520 (≠ V499), G525 (= G504), L526 (≠ A505), K559 (≠ Q538)
- binding 4-{[(4'-amino-2'-methylpyrimidin-5'-yl)methyl]amino}pent-3-enyl diphosphate: V409 (≠ N391), G410 (≠ L392), Q411 (≠ T393), H412 (≠ L394), G435 (= G410), M437 (≠ L412), G461 (= G441), D462 (= D442), A463 (≠ G443), S464 (≠ G444), M467 (≠ F447), N489 (= N469), E491 (≠ G471), Q492 (≠ Y472), G493 (≠ E473), V495 (≠ I475)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: G34 (≠ V26), A35 (≠ H27), V109 (≠ Q100), P110 (≠ S101), F119 (≠ N117), K169 (≠ L163), M266 (≠ T251), D291 (≠ E276), R292 (vs. gap), V495 (≠ I475), W498 (≠ Y478)
- binding flavin-adenine dinucleotide: R159 (= R153), G219 (= G209), A220 (≠ G210), G221 (= G211), N224 (≠ A214), T246 (= T233), L247 (≠ I234), Q248 (≠ N235), L264 (≠ G249), G265 (≠ S250), M266 (≠ T251), H267 (≠ Q252), G286 (= G271), A287 (≠ T272), R288 (≠ E273), D290 (≠ A275), R292 (vs. gap), V293 (vs. gap), E319 (≠ D297), V320 (≠ I298), N324 (≠ Q302), G337 (≠ A315), D338 (= D316), A339 (= A317), M414 (= M396), G432 (≠ T407), G433 (= G408)
- binding magnesium ion: D462 (= D442), N489 (= N469), E491 (≠ G471)
- binding thiamine diphosphate: Y31 (≠ I23), E57 (= E48), P83 (= P74)
1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
27% identity, 98% coverage: 3:538/545 of query aligns to 9:556/596 of 1t9cA
- active site: Y29 (≠ I23), G31 (= G25), G32 (≠ V26), A33 (≠ H27), I34 (≠ T28), E55 (= E48), T78 (≠ I71), F117 (≠ N117), Q118 (= Q118), E119 (≠ A119), K167 (≠ L163), R227 (vs. gap), M263 (≠ T251), V290 (vs. gap), V406 (≠ N391), L431 (≠ Y409), G432 (= G410), M434 (≠ L412), D459 (= D442), N486 (= N469), E488 (≠ G471), Q489 (≠ Y472), M491 (≠ E474), V492 (≠ I475), W495 (≠ Y478), L517 (≠ V499), G522 (= G504), L523 (≠ A505), K556 (≠ Q538)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (≠ V26), V107 (≠ Q100), P108 (≠ S101), F117 (≠ N117), K167 (≠ L163), D288 (≠ E276), R289 (vs. gap), W495 (≠ Y478)
- binding flavin-adenine dinucleotide: R157 (= R153), G216 (= G209), A217 (≠ G210), G218 (= G211), N221 (≠ A214), T243 (= T233), L244 (≠ I234), Q245 (≠ N235), L261 (≠ G249), M263 (≠ T251), H264 (≠ Q252), G283 (= G271), A284 (≠ T272), R285 (≠ E273), D287 (≠ A275), R289 (vs. gap), V290 (vs. gap), E316 (≠ D297), V317 (≠ I298), N321 (≠ Q302), G334 (≠ A315), D335 (= D316), A336 (= A317), M411 (= M396), G429 (≠ T407), G430 (= G408)
- binding magnesium ion: D459 (= D442), N486 (= N469), E488 (≠ G471)
6u9dB Saccharomyces cerevisiae acetohydroxyacid synthase (see paper)
27% identity, 98% coverage: 3:538/545 of query aligns to 13:567/607 of 6u9dB
- active site: Y33 (≠ I23), G35 (= G25), G36 (≠ V26), A37 (≠ H27), I38 (≠ T28), E59 (= E48), T82 (≠ I71), F121 (≠ N117), Q122 (= Q118), E123 (≠ A119), K171 (≠ L163), M274 (≠ T251), V301 (vs. gap), V417 (≠ N391), G443 (= G410), M445 (≠ L412), D470 (= D442), N497 (= N469), E499 (≠ G471), Q500 (≠ Y472), M502 (≠ E474), V503 (≠ I475), W506 (≠ Y478)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: G36 (≠ V26), V111 (≠ Q100), P112 (≠ S101), F121 (≠ N117), K171 (≠ L163), D299 (≠ E276), R300 (vs. gap), M502 (≠ E474), W506 (≠ Y478)
- binding flavin-adenine dinucleotide: R161 (= R153), A228 (≠ G210), G229 (= G211), N232 (≠ A214), T254 (= T233), L255 (≠ I234), Q256 (≠ N235), L272 (≠ G249), M274 (≠ T251), G294 (= G271), R296 (≠ E273), D298 (≠ A275), R300 (vs. gap), V301 (vs. gap), E327 (≠ D297), V328 (≠ I298), N332 (≠ Q302), D346 (= D316), A347 (= A317), M422 (= M396), G440 (≠ T407), G441 (= G408)
- binding magnesium ion: D470 (= D442), N497 (= N469)
- binding thiamine diphosphate: E59 (= E48), P85 (= P74), V417 (≠ N391), G418 (≠ L392), Q419 (≠ T393), H420 (≠ L394), G443 (= G410), M445 (≠ L412), A471 (≠ G443), S472 (≠ G444), N497 (= N469), E499 (≠ G471), Q500 (≠ Y472), G501 (≠ E473), M502 (≠ E474), V503 (≠ I475)
5wkcA Saccharomyces cerevisiae acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
27% identity, 98% coverage: 3:538/545 of query aligns to 9:551/591 of 5wkcA
- active site: Y29 (≠ I23), G31 (= G25), G32 (≠ V26), A33 (≠ H27), I34 (≠ T28), E55 (= E48), T78 (≠ I71), F117 (≠ N117), Q118 (= Q118), E119 (≠ A119), K167 (≠ L163), R222 (vs. gap), M258 (≠ T251), V285 (vs. gap), V401 (≠ N391), L426 (≠ Y409), G427 (= G410), M429 (≠ L412), D454 (= D442), N481 (= N469), E483 (≠ G471), Q484 (≠ Y472), M486 (≠ E474), V487 (≠ I475), W490 (≠ Y478), L512 (≠ V499), G517 (= G504), L518 (≠ A505), K551 (≠ Q538)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V401 (≠ N391), G402 (≠ L392), Q403 (≠ T393), H404 (≠ L394), G427 (= G410), M429 (≠ L412), G453 (= G441), D454 (= D442), A455 (≠ G443), S456 (≠ G444), M459 (≠ F447), N481 (= N469), E483 (≠ G471), Q484 (≠ Y472), G485 (≠ E473), M486 (≠ E474), V487 (≠ I475)
- binding ethaneperoxoic acid: G32 (≠ V26), Q118 (= Q118)
- binding flavin-adenine dinucleotide: R157 (= R153), G211 (= G209), A212 (≠ G210), G213 (= G211), N216 (≠ A214), T238 (= T233), L239 (≠ I234), Q240 (≠ N235), L256 (≠ G249), M258 (≠ T251), G278 (= G271), A279 (≠ T272), R280 (≠ E273), R284 (vs. gap), V285 (vs. gap), E311 (≠ D297), V312 (≠ I298), N316 (≠ Q302), D330 (= D316), A331 (= A317), M406 (= M396), G424 (≠ T407)
- binding magnesium ion: D454 (= D442), N481 (= N469), E483 (≠ G471)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: G32 (≠ V26), A33 (≠ H27), V107 (≠ Q100), F117 (≠ N117), K167 (≠ L163), M258 (≠ T251), R284 (vs. gap), M486 (≠ E474), W490 (≠ Y478)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: P30 (= P24), E55 (= E48)
P07342 Acetolactate synthase catalytic subunit, mitochondrial; Acetohydroxy-acid synthase catalytic subunit; AHAS; ALS; EC 2.2.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
27% identity, 98% coverage: 3:538/545 of query aligns to 93:647/687 of P07342
- R241 (= R153) binding
- 355:376 (vs. 252:273, 23% identical) binding
- 407:426 (vs. 297:316, 15% identical) binding
8beoB Crystal structure of e. Coli glyoxylate carboligase mutant i393a with map
30% identity, 96% coverage: 11:534/545 of query aligns to 12:552/592 of 8beoB
- binding methyl hydrogen (s)-acetylphosphonate: C490 (≠ M479), Q492 (≠ N481)
- binding flavin-adenine dinucleotide: R153 (= R153), P154 (= P154), G210 (= G209), G211 (= G210), G212 (= G211), N215 (≠ A214), T236 (= T233), L237 (≠ I234), M238 (≠ N235), V254 (≠ T251), G255 (≠ Q252), Q257 (≠ L254), T258 (≠ P255), G277 (= G271), N278 (≠ T272), R279 (≠ E273), A281 (= A275), R283 (≠ T277), H284 (≠ D278), D301 (= D297), I302 (= I298), Q306 (= Q302), D320 (= D316), A321 (= A317), G415 (≠ S406)
- binding magnesium ion: D445 (= D442), F450 (= F447), L451 (≠ T448), E453 (≠ P450), N472 (= N469), Y474 (≠ G471)
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-{(1s)-1-hydroxy-1-[(r)-hydroxy(methoxy)phosphoryl]ethyl}-5-(2-{[(s)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: R283 (≠ T277), G393 (≠ N391), L394 (= L392), S395 (≠ T393), L420 (= L412), G444 (= G441), D445 (= D442), F446 (≠ G443), D447 (≠ G444), N472 (= N469), Y474 (≠ G471), L475 (≠ Y472), G476 (≠ E473), L477 (≠ E474), I478 (= I475)
- binding 2,3-dimethoxy-5-methyl-1,4-benzoquinone: Q352 (≠ A346), R356 (≠ K350)
Sites not aligning to the query:
8beoA Crystal structure of e. Coli glyoxylate carboligase mutant i393a with map
30% identity, 96% coverage: 11:534/545 of query aligns to 12:552/592 of 8beoA
- binding flavin-adenine dinucleotide: R153 (= R153), P154 (= P154), G210 (= G209), G211 (= G210), G212 (= G211), N215 (≠ A214), T236 (= T233), L237 (≠ I234), M238 (≠ N235), V254 (≠ T251), G255 (≠ Q252), Q257 (≠ L254), T258 (≠ P255), G277 (= G271), N278 (≠ T272), R279 (≠ E273), A281 (= A275), R283 (≠ T277), H284 (≠ D278), D301 (= D297), I302 (= I298), Q306 (= Q302), D320 (= D316), A321 (= A317), I397 (vs. gap), G415 (≠ S406)
- binding magnesium ion: R384 (≠ D382), V405 (≠ M396), F406 (≠ Q397), H410 (≠ R401), D445 (= D442), F450 (= F447), L451 (≠ T448), E453 (≠ P450), N472 (= N469), Y474 (≠ G471)
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-{(1s)-1-hydroxy-1-[(r)-hydroxy(methoxy)phosphoryl]ethyl}-5-(2-{[(s)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: R283 (≠ T277), G393 (≠ N391), L394 (= L392), S395 (≠ T393), L420 (= L412), G444 (= G441), D445 (= D442), F446 (≠ G443), D447 (≠ G444), N472 (= N469), Y474 (≠ G471), L475 (≠ Y472), G476 (≠ E473), L477 (≠ E474), I478 (= I475)
- binding 2,3-dimethoxy-5-methyl-1,4-benzoquinone: E248 (≠ P245), Q352 (≠ A346)
Sites not aligning to the query:
1y9dD Pyruvate oxidase variant v265a from lactobacillus plantarum (see paper)
30% identity, 97% coverage: 4:532/545 of query aligns to 5:507/560 of 1y9dD
- active site: I24 (= I23), G26 (= G25), G27 (≠ V26), S28 (≠ H27), I29 (≠ T28), E51 (= E48), S74 (≠ I71), E108 (≠ K111), V155 (≠ L163), R241 (vs. gap), V361 (≠ S383), A387 (≠ G410), M389 (≠ L412), D414 (= D442), N441 (= N469), Q443 (≠ G471), Y444 (= Y472), F446 (≠ E474), I447 (= I475), E450 (≠ Y478)
- binding flavin-adenine dinucleotide: I198 (≠ G210), G199 (= G211), T221 (= T233), P223 (≠ N235), G261 (= G271), N262 (≠ T277), N263 (≠ D278), D273 (= D297), I274 (= I298), K278 (≠ Q302), D292 (= D316), A293 (= A317)
- binding magnesium ion: D414 (= D442), N441 (= N469), Q443 (≠ G471)
- binding thiamine diphosphate: E51 (= E48), S74 (≠ I71), P77 (= P74), H81 (≠ N78), D363 (≠ Q385), M389 (≠ L412), G413 (= G441), G415 (= G443), N441 (= N469), Q443 (≠ G471), Y444 (= Y472), G445 (≠ E473), F446 (≠ E474), I447 (= I475)
Sites not aligning to the query:
4feeA High-resolution structure of pyruvate oxidase in complex with reaction intermediate 2-hydroxyethyl-thiamin diphosphate carbanion-enamine, crystal b (see paper)
30% identity, 97% coverage: 4:532/545 of query aligns to 5:532/586 of 4feeA
- binding flavin-adenine dinucleotide: H93 (≠ S90), G212 (= G209), I213 (≠ G210), G214 (= G211), T236 (= T233), Y237 (≠ I234), P238 (≠ N235), A254 (≠ T251), N255 (≠ Q252), V257 (≠ L254), G276 (= G271), N277 (≠ T272), N278 (≠ E273), P280 (≠ A275), F281 (≠ E276), D298 (= D297), I299 (= I298), K303 (≠ Q302), D317 (= D316), A318 (= A317), N390 (≠ V387), N409 (≠ T407)
- binding magnesium ion: D439 (= D442), N466 (= N469), Q468 (≠ G471)
- binding pyruvic acid: N255 (≠ Q252), R256 (≠ S253)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V386 (≠ S383), D388 (≠ Q385), A412 (≠ G410), M414 (≠ L412), G438 (= G441), G440 (= G443), N466 (= N469), Q468 (≠ G471), Y469 (= Y472), G470 (≠ E473), F471 (≠ E474), I472 (= I475)
Sites not aligning to the query:
1powA The refined structures of a stabilized mutant and of wild-type pyruvate oxidase from lactobacillus plantarum (see paper)
30% identity, 97% coverage: 4:532/545 of query aligns to 5:532/585 of 1powA
- active site: I24 (= I23), G26 (= G25), G27 (≠ V26), S28 (≠ H27), I29 (≠ T28), E51 (= E48), S74 (≠ I71), F113 (≠ L112), Q114 (≠ H113), E115 (= E114), V162 (≠ L163), R256 (≠ S253), E283 (≠ D278), V386 (≠ S383), A412 (≠ G410), M414 (≠ L412), D439 (= D442), N466 (= N469), Q468 (≠ G471), Y469 (= Y472), F471 (≠ E474), I472 (= I475), E475 (≠ Y478)
- binding flavin-adenine dinucleotide: H93 (≠ S90), G212 (= G209), I213 (≠ G210), G214 (= G211), T236 (= T233), Y237 (≠ I234), A254 (≠ T251), V257 (≠ L254), G276 (= G271), N277 (≠ T272), N278 (≠ E273), Y279 (≠ L274), P280 (≠ A275), F281 (≠ E276), D298 (= D297), I299 (= I298), K303 (≠ Q302), D317 (= D316), A318 (= A317), N409 (≠ T407)
- binding magnesium ion: D439 (= D442), N466 (= N469), Q468 (≠ G471)
- binding thiamine diphosphate: D388 (≠ Q385), M414 (≠ L412), G440 (= G443), N466 (= N469), Q468 (≠ G471), Y469 (= Y472), G470 (≠ E473), F471 (≠ E474), I472 (= I475)
Sites not aligning to the query:
Query Sequence
>PP_1394 FitnessBrowser__Putida:PP_1394
MATCGEVLVKLLEGYGVDHVFGIPGVHTVELYRGLAGSSIRHITPRHEQGAGFMADGYAR
TRGKPGVCFIITGPGMTNITTAMGQAYADSIPMLVISSVQSRDQLGGGRGKLHELPNQAA
LVSGVAAFSHTLMSAADLPQVLARAFAVFDSARPRPVHIEIPLDVLVEPADFLLPGRPVR
GSRAGAAPQAVAQMAERLASARRPLILAGGGALAAGAALARLAEHLQAPVALTINAKGLL
PASHPLQIGSTQSLPATRALVAEADVVLAIGTELAETDYDVTFKGGFEIPGRLLRIDIDP
DQTVRNYLPELALVADAELAAEALLGAVQAQPQPVHESTWGVARVADLRKVLAADWDQPT
LSQTRLLSAILERLPDAILVGDSTQPVYTGNLTLDMQQPRRWFNASTGYGTLGYALPAAM
GAWLGSAEQAVERAPAVCLIGDGGLQFTLPELASAVEAQVPLIVLLWNNQGYEEIKKYMV
NRAIEPVGVDIHTPDFIGVARALGAAAENVADIAQLQAALGQAVERKGPTLIQVDQNQWQ
AAVLG
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory