Comparing PP_2056 PP_2056 C4-dicarboxylate transport protein to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
O59010 Glutamate transporter homolog; Glt(Ph); Sodium-aspartate symporter Glt(Ph); Sodium-dependent aspartate transporter from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see 3 papers)
29% identity, 93% coverage: 3:405/435 of query aligns to 13:421/425 of O59010
2nwwA Crystal structure of gltph in complex with tboa (see paper)
29% identity, 91% coverage: 3:400/435 of query aligns to 4:407/407 of 2nwwA
6x15A Inward-facing state of the glutamate transporter homologue gltph in complex with l-aspartate and sodium ions (see paper)
29% identity, 91% coverage: 3:400/435 of query aligns to 13:416/419 of 6x15A
Sites not aligning to the query:
6x14A Inward-facing state of the glutamate transporter homologue gltph in complex with tfb-tboa (see paper)
28% identity, 90% coverage: 11:400/435 of query aligns to 17:413/413 of 6x14A
Sites not aligning to the query:
5e9sA Crystal structure of substrate-bound glutamate transporter homologue glttk (see paper)
30% identity, 94% coverage: 3:411/435 of query aligns to 11:427/427 of 5e9sA
6r7rA Crystal structure of the glutamate transporter homologue glttk in complex with d-aspartate (see paper)
30% identity, 94% coverage: 3:411/435 of query aligns to 4:416/416 of 6r7rA
6xwnB Structure of glutamate transporter homologue glttk in the presence of tboa inhibitor (see paper)
30% identity, 93% coverage: 3:406/435 of query aligns to 11:422/426 of 6xwnB
6zl4A The structure of glutamate transporter homologue glttk in complex with the photo switchable compound (cis) (see paper)
30% identity, 94% coverage: 3:411/435 of query aligns to 8:424/424 of 6zl4A
Sites not aligning to the query:
6zgbA Glutamate transporter homologue glttk in complex with a photo cage compound (see paper)
30% identity, 94% coverage: 3:411/435 of query aligns to 9:425/425 of 6zgbA
6bavA Crystal structure of gltph r397c in complex with s-benzyl-l-cysteine (see paper)
29% identity, 91% coverage: 3:400/435 of query aligns to 5:408/409 of 6bavA
6bauA Crystal structure of gltph r397c in complex with l-cysteine (see paper)
29% identity, 91% coverage: 3:400/435 of query aligns to 5:408/408 of 6bauA
6bmiA Crystal structure of gltph r397c in complex with l-serine (see paper)
27% identity, 89% coverage: 16:400/435 of query aligns to 17:396/396 of 6bmiA
7awmA Structure of the thermostabilized eaat1 cryst mutant in complex with l-asp, three sodium ions and the allosteric inhibitor ucph101 (see paper)
27% identity, 85% coverage: 36:406/435 of query aligns to 57:409/412 of 7awmA
5mjuA Structure of the thermostabilized eaat1 cryst mutant in complex with the competititve inhibitor tfb-tboa and the allosteric inhibitor ucph101 (see paper)
26% identity, 85% coverage: 36:406/435 of query aligns to 49:395/397 of 5mjuA
P31596 Excitatory amino acid transporter 2; GLT-1; Sodium-dependent glutamate/aspartate transporter 2; GLUT-R; Solute carrier family 1 member 2 from Rattus norvegicus (Rat) (see paper)
25% identity, 92% coverage: 36:434/435 of query aligns to 82:530/573 of P31596
P43006 Excitatory amino acid transporter 2; GLT-1; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2 from Mus musculus (Mouse) (see paper)
25% identity, 92% coverage: 36:434/435 of query aligns to 82:529/572 of P43006
Sites not aligning to the query:
7xr4A Structure of human excitatory amino acid transporter 2 (eaat2) in complex with glutamate (see paper)
26% identity, 85% coverage: 36:404/435 of query aligns to 46:420/425 of 7xr4A
7xr6A Structure of human excitatory amino acid transporter 2 (eaat2) in complex with way-213613 (see paper)
26% identity, 85% coverage: 36:404/435 of query aligns to 47:419/424 of 7xr6A
Sites not aligning to the query:
O35874 Neutral amino acid transporter A; Alanine/serine/cysteine/threonine transporter 1; ASCT-1; Solute carrier family 1 member 4 from Mus musculus (Mouse) (see 2 papers)
28% identity, 82% coverage: 36:391/435 of query aligns to 79:469/532 of O35874
P56564 Excitatory amino acid transporter 1; Glial high affinity glutamate transporter; High-affinity neuronal glutamate transporter; GluT-1; Sodium-dependent glutamate/aspartate transporter 1; GLAST-1; Solute carrier family 1 member 3 from Mus musculus (Mouse) (see paper)
26% identity, 92% coverage: 12:411/435 of query aligns to 55:505/543 of P56564
>PP_2056 PP_2056 C4-dicarboxylate transport protein
MRLAKSLYFQILCAVLLGVVVGHFWAQQAVALKPLGDAFIKLIKMMIAPVVFCTIVTGIA
GMTDKRSLGRLMSKTLLLFLGLTVVSLVIGLAAVYLFKPGAGMNIDPATLSTAGLSQYTA
SAAKLSVVDFFMHIIPDTFIGAFNKGEVLPVLFIAVLSGFALSSMGEKGKPVLDVLESAS
TMVFRIFGYLMRFAPIGAFGALAFTVGQYGITSLGALAKLVGTLYIACAFFVLVVLGGIC
RAHGFSLWKLLRYFREEFLVVLGTSSTEPVLPRMLEKLEKLGCKKGVVGLVLPTGYSFNL
DGTAIYLSLAAVFIAQACNIDLSLGQVVTMLAIMLLSSKGAAGVTGSGFVALASTLTVIH
DIPLAGLALLIGVDRFMSEARALTSLASNAVATVVVSLSENACDRQTLHSRLNGEPVVTP
VAETADWVAEPHRHG
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory