SitesBLAST
Comparing PP_2198 PP_2198 aldose sugar dehydrogenase to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 16 hits to proteins with known functional sites (download)
7cdyA Crystal structure of glucose dehydrogenase
69% identity, 90% coverage: 36:378/381 of query aligns to 2:344/346 of 7cdyA
P75804 Aldose sugar dehydrogenase YliI; Asd; Soluble aldose sugar dehydrogenase YliI; EC 1.1.5.- from Escherichia coli (strain K12) (see paper)
60% identity, 95% coverage: 15:377/381 of query aligns to 8:367/371 of P75804
- Q82 (= Q92) binding
- E240 (= E250) binding
- Y250 (= Y260) binding
- Y261 (= Y271) binding
2g8sA Crystal structure of the soluble aldose sugar dehydrogenase (asd) from escherichia coli in the apo-form (see paper)
62% identity, 90% coverage: 34:377/381 of query aligns to 2:345/348 of 2g8sA
7cgzA Glucose dehydrogenase
63% identity, 90% coverage: 36:378/381 of query aligns to 2:319/321 of 7cgzA
2ismB Crystal structure of the putative oxidoreductase (glucose dehydrogenase) (ttha0570) from thermus theromophilus hb8
38% identity, 89% coverage: 35:372/381 of query aligns to 2:318/333 of 2ismB
3a9hA Crystal structure of pqq-dependent sugar dehydrogenase holo-form (see paper)
35% identity, 88% coverage: 37:372/381 of query aligns to 6:319/338 of 3a9hA
- active site: H120 (= H157), D139 (≠ E176), R182 (= R224), T224 (= T266), K226 (≠ P277), G228 (≠ A279)
- binding calcium ion: E208 (= E250), Y218 (= Y260)
- binding alpha-D-glucopyranose: R144 (≠ P181), D148 (= D185), G228 (≠ A279), R229 (≠ K280), G230 (= G281), F232 (≠ H283), V233 (= V284), D234 (= D285)
- binding pyrroloquinoline quinone: E57 (≠ Q92), H120 (= H157), R182 (= R224), N183 (= N225), Q185 (= Q227), H201 (= H243), V204 (≠ R246), T243 (≠ V293), A245 (≠ E295), L269 (= L323), R270 (≠ A324), R298 (= R351), R300 (= R353)
Sites not aligning to the query:
3a9gA Crystal structure of pqq-dependent sugar dehydrogenase apo-form (see paper)
35% identity, 88% coverage: 37:372/381 of query aligns to 6:319/338 of 3a9gA
- active site: H120 (= H157), D139 (≠ E176), R182 (= R224), T224 (= T266), K226 (≠ P277), G228 (≠ A279)
- binding calcium ion: E208 (= E250), Y218 (= Y260)
- binding alpha-D-glucopyranose: R144 (≠ P181), D148 (= D185), G228 (≠ A279), R229 (≠ K280), G230 (= G281), F232 (≠ H283), V233 (= V284), D234 (= D285)
3dasA Structure of the pqq-bound form of aldose sugar dehydrogenase (adh) from streptomyces coelicolor
33% identity, 90% coverage: 29:372/381 of query aligns to 3:317/334 of 3dasA
- active site: H127 (= H157), E146 (= E176), R189 (= R224), E230 (= E278), K232 (= K280), G234 (≠ E282)
- binding alpha-L-arabinopyranose: K199 (≠ T235), R201 (≠ Q237), D248 (vs. gap), R268 (≠ A324), G269 (≠ T325), E270 (≠ Q326), R271 (≠ E327), L277 (= L333), K278 (≠ D334), G279 (= G335), E291 (≠ G346)
- binding calcium ion: R189 (= R224), G208 (= G244), Q209 (≠ P245), E214 (= E250), Y224 (= Y260)
- binding pyrroloquinoline quinone: E66 (≠ Q92), H127 (= H157), R189 (= R224), N190 (= N225), Q192 (= Q227), F207 (≠ H243), T247 (vs. gap), S251 (= S297), L267 (= L323), R268 (≠ A324), R296 (= R351), R298 (= R353)
Sites not aligning to the query:
P13650 Quinoprotein glucose dehydrogenase B; Glucose dehydrogenase B [pyrroloquinoline-quinone]; Soluble glucose dehydrogenase; s-GDH; EC 1.1.5.2 from Acinetobacter calcoaceticus (see paper)
27% identity, 97% coverage: 1:368/381 of query aligns to 11:448/478 of P13650
- Q100 (= Q92) binding
- D167 (≠ N156) binding
- Q192 (vs. gap) binding
- R252 (= R224) binding
- G271 (= G244) binding
- P272 (= P245) binding
- E277 (= E250) binding
- Y287 (= Y260) binding
- A293 (vs. gap) binding
- Y295 (vs. gap) binding
- D297 (vs. gap) binding
- E333 (≠ A279) binding
- Y367 (≠ F305) binding
- T372 (= T310) binding
- K401 (≠ A324) binding
5minB Apo form of the soluble pqq-dependent glucose dehydrogenase from acinetobacter calcoaceticus
27% identity, 86% coverage: 40:368/381 of query aligns to 22:424/453 of 5minB
- active site: H144 (= H157), D163 (≠ E176), R228 (= R224), A269 (vs. gap), Y271 (vs. gap), D273 (vs. gap), E309 (≠ A279)
- binding calcium ion: E253 (= E250), Y263 (= Y260), A269 (vs. gap), Y271 (vs. gap), D273 (vs. gap), E309 (≠ A279)
1cruA Soluble quinoprotein glucose dehydrogenase from acinetobacter calcoaceticus in complex with pqq and methylhydrazine (see paper)
26% identity, 86% coverage: 40:368/381 of query aligns to 22:422/448 of 1cruA
- active site: H142 (= H157), D161 (≠ E176), R226 (= R224), A267 (vs. gap), Y269 (vs. gap), D271 (vs. gap), E307 (≠ A279)
- binding calcium ion: G245 (= G244), P246 (= P245), E251 (= E250), Y261 (= Y260), A267 (vs. gap), Y269 (vs. gap), D271 (vs. gap), E307 (≠ A279)
- binding methylhydrazine: Y341 (≠ F305), W344 (≠ S308)
- binding pyrroloquinoline quinone: Q76 (= Q92), H142 (= H157), R226 (= R224), N227 (= N225), Q229 (= Q227), Q244 (≠ H243), Y341 (≠ F305), W344 (≠ S308), T346 (= T310), A348 (vs. gap), L374 (= L323), K375 (≠ A324), R404 (= R351), R406 (= R353)
1cq1A Soluble quinoprotein glucose dehydrogenase from acinetobacter calcoaceticus in complex with pqqh2 and glucose (see paper)
27% identity, 86% coverage: 40:368/381 of query aligns to 22:418/444 of 1cq1A
- active site: H138 (= H157), D157 (≠ E176), R222 (= R224), A263 (vs. gap), Y265 (vs. gap), D267 (vs. gap), E303 (≠ A279)
- binding beta-D-glucopyranose: Q76 (= Q92), D137 (≠ N156), H138 (= H157), Q162 (vs. gap), R222 (= R224), Y337 (≠ F305), W340 (≠ S308)
- binding calcium ion: R222 (= R224), G241 (= G244), P242 (= P245), E247 (= E250), Y257 (= Y260), A263 (vs. gap), Y265 (vs. gap), D267 (vs. gap), E303 (≠ A279)
- binding pyrroloquinoline quinone: Q76 (= Q92), H138 (= H157), R222 (= R224), N223 (= N225), Q225 (= Q227), Q240 (≠ H243), Y337 (≠ F305), W340 (≠ S308), T342 (= T310), A344 (vs. gap), L370 (= L323), K371 (≠ A324), R400 (= R351), R402 (= R353)
1c9uA Crystal structure of the soluble quinoprotein glucose dehydrogenase in complex with pqq (see paper)
27% identity, 86% coverage: 40:368/381 of query aligns to 22:418/444 of 1c9uA